Compile Data Set for Download or QSAR
maximum 50k data
Found 57 Enz. Inhib. hit(s) with all data for entry = 50008857
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077960(4-[5-(3,4-Dichloro-phenyl)-2-phenyl-3H-imidazol-4-...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077961(3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-pheno...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077957(4-[2-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-...)
Affinity DataIC50:  29nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077974(4-(4-(4-chlorophenyl)-2-phenyl-1H-imidazol-5-yl)py...)
Affinity DataIC50:  56nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077958(4-[5-(4-Fluoro-phenyl)-2-piperidin-4-yl-3H-imidazo...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077964(4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-benzo...)
Affinity DataIC50:  86nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50237712(4-(4-(3-chlorophenyl)-2-phenyl-1H-imidazol-5-yl)py...)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077951(CHEMBL68572 | [4-(2,5-Diphenyl-3H-imidazol-4-yl)-p...)
Affinity DataIC50:  98nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077979(4-[5-(4-Fluoro-phenyl)-2-piperidin-3-yl-3H-imidazo...)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077963(4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyridine | CHEMB...)
Affinity DataIC50:  130nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077957(4-[2-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-...)
Affinity DataIC50:  135nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077979(4-[5-(4-Fluoro-phenyl)-2-piperidin-3-yl-3H-imidazo...)
Affinity DataIC50:  140nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077977(4-(2,4-diphenyl-1H-imidazol-5-yl)-N-methylpyrimidi...)
Affinity DataIC50:  175nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077962(4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyrimidin-2-ylam...)
Affinity DataIC50:  180nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50053410(4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole |...)
Affinity DataIC50:  195nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077958(4-[5-(4-Fluoro-phenyl)-2-piperidin-4-yl-3H-imidazo...)
Affinity DataIC50:  210nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077967(4-(4-(3-methoxyphenyl)-2-phenyl-1H-imidazol-5-yl)p...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataIC50:  290nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077969(((R)-1-Phenyl-ethyl)-{4-[2-piperidin-4-yl-5-(3-tri...)
Affinity DataIC50:  295nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077953(4-(1-methyl-2-(piperidin-4-yl)-4-(3-(trifluorometh...)
Affinity DataIC50:  300nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077959(4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-benzo...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human c-Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataIC50:  330nMAssay Description:Inhibition of human c-Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077963(4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyridine | CHEMB...)
Affinity DataIC50:  380nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077976(4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-pheno...)
Affinity DataIC50:  390nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077952(4-[5-(4-Cyclohexyl-phenyl)-2-phenyl-3H-imidazol-4-...)
Affinity DataIC50:  570nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50237711(4-(4-(2-chlorophenyl)-2-phenyl-1H-imidazol-5-yl)py...)
Affinity DataIC50:  610nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50:  675nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077970((4-Methoxy-benzyl)-{4-[2-piperidin-4-yl-5-(3-trifl...)
Affinity DataIC50:  735nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077962(4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyrimidin-2-ylam...)
Affinity DataIC50:  750nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50:  810nMAssay Description:Inhibition of human c-Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50237721(4-(4-(4-methoxyphenyl)-2-phenyl-1H-imidazol-5-yl)p...)
Affinity DataIC50:  950nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human c-Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077951(CHEMBL68572 | [4-(2,5-Diphenyl-3H-imidazol-4-yl)-p...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50053410(4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole |...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077968(4-[2-Phenyl-5-(4-trifluoromethyl-phenyl)-3H-imidaz...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077954(4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyrimidine | CHE...)
Affinity DataIC50:  1.42E+3nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077971(4-[5-(3,5-Dichloro-phenyl)-2-phenyl-3H-imidazol-4-...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077975(((S)-1-Phenyl-ethyl)-{4-[2-piperidin-4-yl-5-(3-tri...)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077977(4-(2,4-diphenyl-1H-imidazol-5-yl)-N-methylpyrimidi...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15459(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077978(4-(5-Biphenyl-4-yl-2-phenyl-3H-imidazol-4-yl)-pyri...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077956(4-(2-phenyl-4-(3-(trifluoromethyl)phenyl)-1H-imida...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human c-Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077955(4-[5-(3-Fluoro-phenyl)-2-phenyl-3H-imidazol-4-yl]-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077965(4-[2-Piperidin-4-yl-5-(3-trifluoromethyl-phenyl)-3...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataIC50:  3.45E+3nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077975(((S)-1-Phenyl-ethyl)-{4-[2-piperidin-4-yl-5-(3-tri...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human c-Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077969(((R)-1-Phenyl-ethyl)-{4-[2-piperidin-4-yl-5-(3-tri...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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