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PubMed code 10571170

Compile data set for download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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n/an/a 3.80n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50082336
PNG
(CHEMBL322378 | N-(4-Benzoyl-2-methyl-phenyl)-2-(R)...)
Show SMILES Cc1cc(ccc1NC(=O)CC1CCCN2CCCC[C@H]12)C(=O)c1ccccc1
Show InChI InChI=1S/C25H30N2O2/c1-18-16-21(25(29)19-8-3-2-4-9-19)12-13-22(18)26-24(28)17-20-10-7-15-27-14-6-5-11-23(20)27/h2-4,8-9,12-13,16,20,23H,5-7,10-11,14-15,17H2,1H3,(H,26,28)/t20?,23-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50082335
PNG
(11-((S)-2-Octahydro-quinolizin-1-yl-thioacetyl)-5,...)
Show SMILES O=C1Nc2cccnc2N(C(=S)CC2CCCN3CCCC[C@@H]23)c2ccccc12
Show InChI InChI=1S/C23H26N4OS/c28-23-17-8-1-2-11-20(17)27(22-18(25-23)9-5-12-24-22)21(29)15-16-7-6-14-26-13-4-3-10-19(16)26/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,28)/t16?,19-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50082333
PNG
(11-[2-(Octahydro-quinolizin-1-ylmethylsulfanyl)-ac...)
Show SMILES O=C(CSCC1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1/C24H28N4O2S/c29-22(16-31-15-17-7-6-14-27-13-4-3-10-20(17)27)28-21-11-2-1-8-18(21)24(30)26-19-9-5-12-25-23(19)28/h1-2,5,8-9,11-12,17,20H,3-4,6-7,10,13-16H2,(H,26,30)
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n/an/a 10n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50082334
PNG
(11-{2-[(Octahydro-quinolizin-1-ylmethyl)-amino]-ac...)
Show SMILES O=C(CNCC1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1/C24H29N5O2/c30-22(16-25-15-17-7-6-14-28-13-4-3-10-20(17)28)29-21-11-2-1-8-18(21)24(31)27-19-9-5-12-26-23(19)29/h1-2,5,8-9,11-12,17,20,25H,3-4,6-7,10,13-16H2,(H,27,31)
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n/an/a 28n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50450970
PNG
(CHEMBL2111621)
Show SMILES O=C(C[C@H]1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1/C23H26N4O2/c28-21(15-16-7-6-14-26-13-4-3-10-19(16)26)27-20-11-2-1-8-17(20)23(29)25-18-9-5-12-24-22(18)27/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,29)/t16-,19?/s2
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n/an/a 40n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50450971
PNG
(CHEMBL2112418)
Show SMILES O=C(C[C@@H]1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1/C23H26N4O2/c28-21(15-16-7-6-14-26-13-4-3-10-19(16)26)27-20-11-2-1-8-17(20)23(29)25-18-9-5-12-24-22(18)27/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,29)/t16-,19?/s2
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n/an/a 110n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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n/an/a 300n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50082338
PNG
(11-(2-Octahydro-quinolizin-1-yl-acetyl)-6,11-dihyd...)
Show SMILES O=C(CC1CCCN2CCCCC12)N1c2ccccc2NC(=O)c2cccnc12
Show InChI InChI=1/C23H26N4O2/c28-21(15-16-7-6-14-26-13-4-3-10-19(16)26)27-20-11-2-1-9-18(20)25-23(29)17-8-5-12-24-22(17)27/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,29)
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n/an/a 650n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM39341
PNG
(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Show SMILES CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc23)CC1
Show InChI InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
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n/an/a 690n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M2 receptor in rat heart.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50082335
PNG
(11-((S)-2-Octahydro-quinolizin-1-yl-thioacetyl)-5,...)
Show SMILES O=C1Nc2cccnc2N(C(=S)CC2CCCN3CCCC[C@@H]23)c2ccccc12
Show InChI InChI=1S/C23H26N4OS/c28-23-17-8-1-2-11-20(17)27(22-18(25-23)9-5-12-24-22)21(29)15-16-7-6-14-26-13-4-3-10-19(16)26/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,28)/t16?,19-/m0/s1
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n/an/a 760n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50082335
PNG
(11-((S)-2-Octahydro-quinolizin-1-yl-thioacetyl)-5,...)
Show SMILES O=C1Nc2cccnc2N(C(=S)CC2CCCN3CCCC[C@@H]23)c2ccccc12
Show InChI InChI=1S/C23H26N4OS/c28-23-17-8-1-2-11-20(17)27(22-18(25-23)9-5-12-24-22)21(29)15-16-7-6-14-26-13-4-3-10-19(16)26/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,28)/t16?,19-/m0/s1
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n/an/a 760n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M2 receptor in rat heart.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50082333
PNG
(11-[2-(Octahydro-quinolizin-1-ylmethylsulfanyl)-ac...)
Show SMILES O=C(CSCC1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1/C24H28N4O2S/c29-22(16-31-15-17-7-6-14-27-13-4-3-10-20(17)27)28-21-11-2-1-8-18(21)24(30)26-19-9-5-12-25-23(19)28/h1-2,5,8-9,11-12,17,20H,3-4,6-7,10,13-16H2,(H,26,30)
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Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M2 receptor in rat heart.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50082333
PNG
(11-[2-(Octahydro-quinolizin-1-ylmethylsulfanyl)-ac...)
Show SMILES O=C(CSCC1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1/C24H28N4O2S/c29-22(16-31-15-17-7-6-14-27-13-4-3-10-20(17)27)28-21-11-2-1-8-18(21)24(30)26-19-9-5-12-25-23(19)28/h1-2,5,8-9,11-12,17,20H,3-4,6-7,10,13-16H2,(H,26,30)
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Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50082334
PNG
(11-{2-[(Octahydro-quinolizin-1-ylmethyl)-amino]-ac...)
Show SMILES O=C(CNCC1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1/C24H29N5O2/c30-22(16-25-15-17-7-6-14-28-13-4-3-10-20(17)28)29-21-11-2-1-8-18(21)24(31)27-19-9-5-12-26-23(19)29/h1-2,5,8-9,11-12,17,20,25H,3-4,6-7,10,13-16H2,(H,27,31)
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n/an/a 800n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50082334
PNG
(11-{2-[(Octahydro-quinolizin-1-ylmethyl)-amino]-ac...)
Show SMILES O=C(CNCC1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1/C24H29N5O2/c30-22(16-25-15-17-7-6-14-28-13-4-3-10-20(17)28)29-21-11-2-1-8-18(21)24(31)27-19-9-5-12-26-23(19)29/h1-2,5,8-9,11-12,17,20,25H,3-4,6-7,10,13-16H2,(H,27,31)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M2 receptor in rat heart.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50450972
PNG
(CHEMBL2112432)
Show SMILES O=C1N(C[C@@H]2CCCN3CCCC[C@H]23)Cc2nc3cccnc3n2-c2ccccc12
Show InChI InChI=1S/C24H27N5O/c30-24-18-8-1-2-11-21(18)29-22(26-19-9-5-12-25-23(19)29)16-28(24)15-17-7-6-14-27-13-4-3-10-20(17)27/h1-2,5,8-9,11-12,17,20H,3-4,6-7,10,13-16H2/t17-,20+/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-pirenzepine binding to muscarinic M1 receptor in brain cortex of rat.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50082336
PNG
(CHEMBL322378 | N-(4-Benzoyl-2-methyl-phenyl)-2-(R)...)
Show SMILES Cc1cc(ccc1NC(=O)CC1CCCN2CCCC[C@H]12)C(=O)c1ccccc1
Show InChI InChI=1S/C25H30N2O2/c1-18-16-21(25(29)19-8-3-2-4-9-19)12-13-22(18)26-24(28)17-20-10-7-15-27-14-6-5-11-23(20)27/h2-4,8-9,12-13,16,20,23H,5-7,10-11,14-15,17H2,1H3,(H,26,28)/t20?,23-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50450970
PNG
(CHEMBL2111621)
Show SMILES O=C(C[C@H]1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1/C23H26N4O2/c28-21(15-16-7-6-14-26-13-4-3-10-19(16)26)27-20-11-2-1-8-17(20)23(29)25-18-9-5-12-24-22(18)27/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,29)/t16-,19?/s2
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n/an/a 1.90E+3n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M2 receptor in rat heart.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50082336
PNG
(CHEMBL322378 | N-(4-Benzoyl-2-methyl-phenyl)-2-(R)...)
Show SMILES Cc1cc(ccc1NC(=O)CC1CCCN2CCCC[C@H]12)C(=O)c1ccccc1
Show InChI InChI=1S/C25H30N2O2/c1-18-16-21(25(29)19-8-3-2-4-9-19)12-13-22(18)26-24(28)17-20-10-7-15-27-14-6-5-11-23(20)27/h2-4,8-9,12-13,16,20,23H,5-7,10-11,14-15,17H2,1H3,(H,26,28)/t20?,23-/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M2 receptor in rat heart.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50450970
PNG
(CHEMBL2111621)
Show SMILES O=C(C[C@H]1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1/C23H26N4O2/c28-21(15-16-7-6-14-26-13-4-3-10-19(16)26)27-20-11-2-1-8-17(20)23(29)25-18-9-5-12-24-22(18)27/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,29)/t16-,19?/s2
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n/an/a 3.50E+3n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50450971
PNG
(CHEMBL2112418)
Show SMILES O=C(C[C@@H]1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1/C23H26N4O2/c28-21(15-16-7-6-14-26-13-4-3-10-19(16)26)27-20-11-2-1-8-17(20)23(29)25-18-9-5-12-24-22(18)27/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,29)/t16-,19?/s2
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n/an/a 6.00E+3n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M2 receptor in rat heart.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50082338
PNG
(11-(2-Octahydro-quinolizin-1-yl-acetyl)-6,11-dihyd...)
Show SMILES O=C(CC1CCCN2CCCCC12)N1c2ccccc2NC(=O)c2cccnc12
Show InChI InChI=1/C23H26N4O2/c28-21(15-16-7-6-14-26-13-4-3-10-19(16)26)27-20-11-2-1-9-18(20)25-23(29)17-8-5-12-24-22(17)27/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,29)
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n/an/a 6.80E+3n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M2 receptor in rat heart.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50082338
PNG
(11-(2-Octahydro-quinolizin-1-yl-acetyl)-6,11-dihyd...)
Show SMILES O=C(CC1CCCN2CCCCC12)N1c2ccccc2NC(=O)c2cccnc12
Show InChI InChI=1/C23H26N4O2/c28-21(15-16-7-6-14-26-13-4-3-10-19(16)26)27-20-11-2-1-9-18(20)25-23(29)17-8-5-12-24-22(17)27/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50450972
PNG
(CHEMBL2112432)
Show SMILES O=C1N(C[C@@H]2CCCN3CCCC[C@H]23)Cc2nc3cccnc3n2-c2ccccc12
Show InChI InChI=1S/C24H27N5O/c30-24-18-8-1-2-11-21(18)29-22(26-19-9-5-12-25-23(19)29)16-28(24)15-17-7-6-14-27-13-4-3-10-20(17)27/h1-2,5,8-9,11-12,17,20H,3-4,6-7,10,13-16H2/t17-,20+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(RAT)
BDBM50450971
PNG
(CHEMBL2112418)
Show SMILES O=C(C[C@@H]1CCCN2CCCCC12)N1c2ccccc2C(=O)Nc2cccnc12
Show InChI InChI=1/C23H26N4O2/c28-21(15-16-7-6-14-26-13-4-3-10-19(16)26)27-20-11-2-1-8-17(20)23(29)25-18-9-5-12-24-22(18)27/h1-2,5,8-9,11-12,16,19H,3-4,6-7,10,13-15H2,(H,25,29)/t16-,19?/s2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M3 receptor in submaxillary salivary glands of rats.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M2


(RAT)
BDBM50450972
PNG
(CHEMBL2112432)
Show SMILES O=C1N(C[C@@H]2CCCN3CCCC[C@H]23)Cc2nc3cccnc3n2-c2ccccc12
Show InChI InChI=1S/C24H27N5O/c30-24-18-8-1-2-11-21(18)29-22(26-19-9-5-12-25-23(19)29)16-28(24)15-17-7-6-14-27-13-4-3-10-20(17)27/h1-2,5,8-9,11-12,17,20H,3-4,6-7,10,13-16H2/t17-,20+/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Dipartimento di Scienze Farmaceutiche - Università di Genova

Curated by ChEMBL


Assay Description
Displacement of [3H]-methylscopolamine binding to muscarinic M2 receptor in rat heart.


Bioorg Med Chem Lett 9: 3031-4 (1999)


Article DOI: 10.1016/s0960-894x(99)00528-4
BindingDB Entry DOI: 10.7270/Q2V40TD2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%