BindingDB logo
myBDB logout

PubMed code 10639281

Compile data set for download or QSAR
Found 13 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50084137
PNG
(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Show SMILES Cc1cccc(n1)C#Cc1ccccc1
Show InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 36n/an/an/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for it's antagonist activity against Ser152 and Thr175 (Metabotropic glutamate receptor 5)


J Med Chem 42: 5390-401 (2000)


Article DOI: 10.1021/jm990353c
BindingDB Entry DOI: 10.7270/Q2ZG6RGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50084141
PNG
((E)-2-methyl-6-styrylpyridine | 2-Methyl-6-((E)-st...)
Show SMILES Cc1cccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 290n/an/an/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for it's antagonist activity against Ser152 and Thr175 (Metabotropic glutamate receptor 5)


J Med Chem 42: 5390-401 (2000)


Article DOI: 10.1021/jm990353c
BindingDB Entry DOI: 10.7270/Q2ZG6RGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM86717
PNG
(CAS_5218788 | CHEMBL88553 | NSC_5218788 | SIB-1757)
Show SMILES Cc1ccc(O)c(N=Nc2ccccc2)n1
Show InChI InChI=1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 370n/an/an/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for it's antagonist activity against Ser152 and Thr175 (Metabotropic glutamate receptor 5)


J Med Chem 42: 5390-401 (2000)


Article DOI: 10.1021/jm990353c
BindingDB Entry DOI: 10.7270/Q2ZG6RGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50084140
PNG
(4-((S)-Amino-carboxy-methyl)-3-methyl-benzoic acid...)
Show SMILES Cc1cc(ccc1[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.80E+3n/an/an/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for its agonist activity against Ser165 and Thr188 (Metabotropic glutamate receptor 1) receptor.


J Med Chem 42: 5390-401 (2000)


Article DOI: 10.1021/jm990353c
BindingDB Entry DOI: 10.7270/Q2ZG6RGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50084139
PNG
(3-[amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-ca...)
Show SMILES NC(C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for its agonist activity against Ser165 and Thr188 (Metabotropic glutamate receptor 1) receptor.


J Med Chem 42: 5390-401 (2000)


Article DOI: 10.1021/jm990353c
BindingDB Entry DOI: 10.7270/Q2ZG6RGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50084140
PNG
(4-((S)-Amino-carboxy-methyl)-3-methyl-benzoic acid...)
Show SMILES Cc1cc(ccc1[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for it's antagonist activity against Ser152 and Thr175 (Metabotropic glutamate receptor 5)


J Med Chem 42: 5390-401 (2000)


Article DOI: 10.1021/jm990353c
BindingDB Entry DOI: 10.7270/Q2ZG6RGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50084141
PNG
((E)-2-methyl-6-styrylpyridine | 2-Methyl-6-((E)-st...)
Show SMILES Cc1cccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for its agonist activity against Ser165 and Thr188 (Metabotropic glutamate receptor 1) receptor.


J Med Chem 42: 5390-401 (2000)


Article DOI: 10.1021/jm990353c
BindingDB Entry DOI: 10.7270/Q2ZG6RGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM86717
PNG
(CAS_5218788 | CHEMBL88553 | NSC_5218788 | SIB-1757)
Show SMILES Cc1ccc(O)c(N=Nc2ccccc2)n1
Show InChI InChI=1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for its agonist activity against Ser165 and Thr188 (Metabotropic glutamate receptor 1) receptor.


J Med Chem 42: 5390-401 (2000)


Article DOI: 10.1021/jm990353c
BindingDB Entry DOI: 10.7270/Q2ZG6RGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50084136
PNG
((R)-1-Amino-indan-1,5-dicarboxylic acid | CHEMBL35...)
Show SMILES N[C@@]1(CCc2cc(ccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H11NO4/c12-11(10(15)16)4-3-6-5-7(9(13)14)1-2-8(6)11/h1-2,5H,3-4,12H2,(H,13,14)(H,15,16)/t11-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.14E+5n/an/an/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for its agonist activity against Ser165 and Thr188 (Metabotropic glutamate receptor 1) receptor.


J Med Chem 42: 5390-401 (2000)


Article DOI: 10.1021/jm990353c
BindingDB Entry DOI: 10.7270/Q2ZG6RGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50084136
PNG
((R)-1-Amino-indan-1,5-dicarboxylic acid | CHEMBL35...)
Show SMILES N[C@@]1(CCc2cc(ccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H11NO4/c12-11(10(15)16)4-3-6-5-7(9(13)14)1-2-8(6)11/h1-2,5H,3-4,12H2,(H,13,14)(H,15,16)/t11-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+6n/an/an/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for it's antagonist activity against Ser152 and Thr175 (Metabotropic glutamate receptor 5)


J Med Chem 42: 5390-401 (2000)


Article DOI: 10.1021/jm990353c
BindingDB Entry DOI: 10.7270/Q2ZG6RGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50084139
PNG
(3-[amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-ca...)
Show SMILES NC(C(O)=O)C12CC(C1)(C2)C(O)=O
Show InChI InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.03E+5n/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for it's antagonist activity against Ser152 and Thr175 (Metabotropic glutamate receptor 5)


J Med Chem 42: 5390-401 (2000)


Article DOI: 10.1021/jm990353c
BindingDB Entry DOI: 10.7270/Q2ZG6RGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))
BDBM50084142
PNG
(Amino-(2-chloro-5-hydroxy-phenyl)-acetic acid | CH...)
Show SMILES NC(C(O)=O)c1cc(O)ccc1Cl
Show InChI InChI=1/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 7.50E+5n/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for it's antagonist activity against Ser152 and Thr175 (Metabotropic glutamate receptor 5)


J Med Chem 42: 5390-401 (2000)


Article DOI: 10.1021/jm990353c
BindingDB Entry DOI: 10.7270/Q2ZG6RGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))
BDBM50079183
PNG
((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Show SMILES N[C@H](C(O)=O)c1cc(O)cc(O)c1
Show InChI InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)/t7-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/an/an/a 6.60E+3n/an/an/an/a



Universit¿a di Perugia

Curated by ChEMBL


Assay Description
Compound was tested for its agonist activity against Ser165 and Thr188 (Metabotropic glutamate receptor 1) receptor.


J Med Chem 42: 5390-401 (2000)


Article DOI: 10.1021/jm990353c
BindingDB Entry DOI: 10.7270/Q2ZG6RGS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%