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PubMed code 10691697

Compile data set for download or QSAR
Found 133 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50105264
PNG
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Show SMILES C[C@H](NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C([O-])=O
Show InChI InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)/p-1/t9-,11+/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085261
PNG
(CHEMBL163478 | [2-(4-Benzyl-phenoxy)-ethyl]-dimeth...)
Show SMILES CN(C)CCOc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C17H21NO/c1-18(2)12-13-19-17-10-8-16(9-11-17)14-15-6-4-3-5-7-15/h3-11H,12-14H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085288
PNG
(1-{2-[4-(Biphenyl-4-yloxy)-phenoxy]-ethyl}-pyrroli...)
Show SMILES C(CN1CCCC1)Oc1ccc(Oc2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C24H25NO2/c1-2-6-20(7-3-1)21-8-10-23(11-9-21)27-24-14-12-22(13-15-24)26-19-18-25-16-4-5-17-25/h1-3,6-15H,4-5,16-19H2
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n/an/a 6.60n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085282
PNG
(5-Benzyl-2-(2-pyrrolidin-1-yl-ethoxy)-pyridine | C...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccccc2)cn1
Show InChI InChI=1S/C18H22N2O/c1-2-6-16(7-3-1)14-17-8-9-18(19-15-17)21-13-12-20-10-4-5-11-20/h1-3,6-9,15H,4-5,10-14H2
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n/an/a 7n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085290
PNG
(2-(4-Benzyl-phenoxy)-ethylamine | 2-(4-benzylpheno...)
Show SMILES NCCOc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C15H17NO/c16-10-11-17-15-8-6-14(7-9-15)12-13-4-2-1-3-5-13/h1-9H,10-12,16H2
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n/an/a 9n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085277
PNG
(1-{2-[4-(Difluoro-phenyl-methyl)-phenoxy]-ethyl}-p...)
Show SMILES FC(F)(c1ccccc1)c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C19H21F2NO/c20-19(21,16-6-2-1-3-7-16)17-8-10-18(11-9-17)23-15-14-22-12-4-5-13-22/h1-3,6-11H,4-5,12-15H2
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n/an/a 11n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085270
PNG
(2-[2-(4-Benzyl-phenoxy)-ethyl]-2,5-diaza-bicyclo[2...)
Show SMILES C(CN1CC2CC1CN2)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C20H24N2O/c1-2-4-16(5-3-1)12-17-6-8-20(9-7-17)23-11-10-22-15-18-13-19(22)14-21-18/h1-9,18-19,21H,10-15H2
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n/an/a 17n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085297
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-2,6-dimethyl-piperi...)
Show SMILES CC1CCCC(C)N1CCOc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C22H29NO/c1-18-7-6-8-19(2)23(18)15-16-24-22-13-11-21(12-14-22)17-20-9-4-3-5-10-20/h3-5,9-14,18-19H,6-8,15-17H2,1-2H3
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n/an/a 20n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085279
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-pyrrolidine | 1-[2-...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H23NO/c1-2-6-17(7-3-1)16-18-8-10-19(11-9-18)21-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 26n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085252
PNG
(CHEMBL162180 | Phenyl-[4-(2-pyrrolidin-1-yl-ethoxy...)
Show SMILES C(CN1CCCC1)Oc1ccc(CNc2ccccc2)cc1
Show InChI InChI=1S/C19H24N2O/c1-2-6-18(7-3-1)20-16-17-8-10-19(11-9-17)22-15-14-21-12-4-5-13-21/h1-3,6-11,20H,4-5,12-16H2
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n/an/a 27n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085248
PNG
(1-[2-(4-Benzyloxy-phenoxy)-ethyl]-pyrrolidine | CH...)
Show SMILES C(CN1CCCC1)Oc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C19H23NO2/c1-2-6-17(7-3-1)16-22-19-10-8-18(9-11-19)21-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 30n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085245
PNG
(1-[2-(4-Phenoxy-phenoxy)-ethyl]-pyrrolidine | CHEM...)
Show SMILES C(CN1CCCC1)Oc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C18H21NO2/c1-2-6-17(7-3-1)21-18-10-8-16(9-11-18)20-15-14-19-12-4-5-13-19/h1-3,6-11H,4-5,12-15H2
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n/an/a 30n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085299
PNG
(1-[2-(4-Thiophen-3-ylmethyl-phenoxy)-ethyl]-pyrrol...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccsc2)cc1
Show InChI InChI=1S/C17H21NOS/c1-2-9-18(8-1)10-11-19-17-5-3-15(4-6-17)13-16-7-12-20-14-16/h3-7,12,14H,1-2,8-11,13H2
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n/an/a 33n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085262
PNG
(1-[2-(5-Benzyl-thiophen-2-yloxy)-ethyl]-pyrrolidin...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccccc2)s1
Show InChI InChI=1S/C17H21NOS/c1-2-6-15(7-3-1)14-16-8-9-17(20-16)19-13-12-18-10-4-5-11-18/h1-3,6-9H,4-5,10-14H2
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n/an/a 36n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085283
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-azepane | CHEMBL159...)
Show SMILES C(CN1CCCCCC1)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C21H27NO/c1-2-7-15-22(14-6-1)16-17-23-21-12-10-20(11-13-21)18-19-8-4-3-5-9-19/h3-5,8-13H,1-2,6-7,14-18H2
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n/an/a 37n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085276
PNG
(1-[2-(4-Cyclohexylmethyl-phenoxy)-ethyl]-pyrrolidi...)
Show SMILES C(CN1CCCC1)Oc1ccc(CC2CCCCC2)cc1
Show InChI InChI=1S/C19H29NO/c1-2-6-17(7-3-1)16-18-8-10-19(11-9-18)21-15-14-20-12-4-5-13-20/h8-11,17H,1-7,12-16H2
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n/an/a 40n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085255
PNG
(2-{4-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenoxy]-phenyl...)
Show SMILES C(CN1CCCC1)Oc1ccc(Oc2ccc(cc2)-c2ncco2)cc1
Show InChI InChI=1S/C21H22N2O3/c1-2-13-23(12-1)14-16-24-18-7-9-20(10-8-18)26-19-5-3-17(4-6-19)21-22-11-15-25-21/h3-11,15H,1-2,12-14,16H2
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n/an/a 43n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085292
PNG
(1-[2-(4-Furan-2-ylmethyl-phenoxy)-ethyl]-pyrrolidi...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccco2)cc1
Show InChI InChI=1S/C17H21NO2/c1-2-10-18(9-1)11-13-20-16-7-5-15(6-8-16)14-17-4-3-12-19-17/h3-8,12H,1-2,9-11,13-14H2
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n/an/a 47n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085268
PNG
(1-[2-(4-Benzyl-3-fluoro-phenoxy)-ethyl]-pyrrolidin...)
Show SMILES Fc1cc(OCCN2CCCC2)ccc1Cc1ccccc1
Show InChI InChI=1S/C19H22FNO/c20-19-15-18(22-13-12-21-10-4-5-11-21)9-8-17(19)14-16-6-2-1-3-7-16/h1-3,6-9,15H,4-5,10-14H2
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n/an/a 53n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085285
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-piperidine | CHEMBL...)
Show SMILES C(CN1CCCCC1)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C20H25NO/c1-3-7-18(8-4-1)17-19-9-11-20(12-10-19)22-16-15-21-13-5-2-6-14-21/h1,3-4,7-12H,2,5-6,13-17H2
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n/an/a 55n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085255
PNG
(2-{4-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenoxy]-phenyl...)
Show SMILES C(CN1CCCC1)Oc1ccc(Oc2ccc(cc2)-c2ncco2)cc1
Show InChI InChI=1S/C21H22N2O3/c1-2-13-23(12-1)14-16-24-18-7-9-20(10-8-18)26-19-5-3-17(4-6-19)21-22-11-15-25-21/h3-11,15H,1-2,12-14,16H2
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n/an/a 55n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085281
PNG
(1-{2-[4-(4-Chloro-benzyl)-phenoxy]-ethyl}-pyrrolid...)
Show SMILES Clc1ccc(Cc2ccc(OCCN3CCCC3)cc2)cc1
Show InChI InChI=1S/C19H22ClNO/c20-18-7-3-16(4-8-18)15-17-5-9-19(10-6-17)22-14-13-21-11-1-2-12-21/h3-10H,1-2,11-15H2
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n/an/a 60n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085253
PNG
(1-[2-(4-Benzyl-2-fluoro-phenoxy)-ethyl]-pyrrolidin...)
Show SMILES Fc1cc(Cc2ccccc2)ccc1OCCN1CCCC1
Show InChI InChI=1S/C19H22FNO/c20-18-15-17(14-16-6-2-1-3-7-16)8-9-19(18)22-13-12-21-10-4-5-11-21/h1-3,6-9,15H,4-5,10-14H2
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n/an/a 60n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085311
PNG
(1-[2-(4-Phenylsulfanylmethyl-phenoxy)-ethyl]-pyrro...)
Show SMILES C(CN1CCCC1)Oc1ccc(CSc2ccccc2)cc1
Show InChI InChI=1S/C19H23NOS/c1-2-6-19(7-3-1)22-16-17-8-10-18(11-9-17)21-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 67n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085291
PNG
(2-[4-(2-Pyrrolidin-1-yl-ethoxy)-benzyl]-thiazole |...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2nccs2)cc1
Show InChI InChI=1S/C16H20N2OS/c1-2-9-18(8-1)10-11-19-15-5-3-14(4-6-15)13-16-17-7-12-20-16/h3-7,12H,1-2,8-11,13H2
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n/an/a 69n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085308
PNG
(1-{2-[4-(4-Methoxy-benzyl)-phenoxy]-ethyl}-pyrroli...)
Show SMILES COc1ccc(Cc2ccc(OCCN3CCCC3)cc2)cc1
Show InChI InChI=1S/C20H25NO2/c1-22-19-8-4-17(5-9-19)16-18-6-10-20(11-7-18)23-15-14-21-12-2-3-13-21/h4-11H,2-3,12-16H2,1H3
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n/an/a 70n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085261
PNG
(CHEMBL163478 | [2-(4-Benzyl-phenoxy)-ethyl]-dimeth...)
Show SMILES CN(C)CCOc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C17H21NO/c1-18(2)12-13-19-17-10-8-16(9-11-17)14-15-6-4-3-5-7-15/h3-11H,12-14H2,1-2H3
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n/an/a 73n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085292
PNG
(1-[2-(4-Furan-2-ylmethyl-phenoxy)-ethyl]-pyrrolidi...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccco2)cc1
Show InChI InChI=1S/C17H21NO2/c1-2-10-18(9-1)11-13-20-16-7-5-15(6-8-16)14-17-4-3-12-19-17/h3-8,12H,1-2,9-11,13-14H2
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n/an/a 75n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085289
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-piperazine | CHEMBL...)
Show SMILES C(CN1CCNCC1)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H24N2O/c1-2-4-17(5-3-1)16-18-6-8-19(9-7-18)22-15-14-21-12-10-20-11-13-21/h1-9,20H,10-16H2
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n/an/a 75n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085301
PNG
(5-[4-(2-Pyrrolidin-1-yl-ethoxy)-benzyl]-thiazole |...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2cncs2)cc1
Show InChI InChI=1S/C16H20N2OS/c1-2-8-18(7-1)9-10-19-15-5-3-14(4-6-15)11-16-12-17-13-20-16/h3-6,12-13H,1-2,7-11H2
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n/an/a 77n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085298
PNG
(1-[2-(4-Furan-3-ylmethyl-phenoxy)-ethyl]-pyrrolidi...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccoc2)cc1
Show InChI InChI=1S/C17H21NO2/c1-2-9-18(8-1)10-12-20-17-5-3-15(4-6-17)13-16-7-11-19-14-16/h3-7,11,14H,1-2,8-10,12-13H2
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n/an/a 77n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085245
PNG
(1-[2-(4-Phenoxy-phenoxy)-ethyl]-pyrrolidine | CHEM...)
Show SMILES C(CN1CCCC1)Oc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C18H21NO2/c1-2-6-17(7-3-1)21-18-10-8-16(9-11-18)20-15-14-19-12-4-5-13-19/h1-3,6-11H,4-5,12-15H2
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n/an/a 79n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085305
PNG
(1-{2-[4-(3-Chloro-benzyl)-phenoxy]-ethyl}-pyrrolid...)
Show SMILES Clc1cccc(Cc2ccc(OCCN3CCCC3)cc2)c1
Show InChI InChI=1S/C19H22ClNO/c20-18-5-3-4-17(15-18)14-16-6-8-19(9-7-16)22-13-12-21-10-1-2-11-21/h3-9,15H,1-2,10-14H2
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n/an/a 80n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085282
PNG
(5-Benzyl-2-(2-pyrrolidin-1-yl-ethoxy)-pyridine | C...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccccc2)cn1
Show InChI InChI=1S/C18H22N2O/c1-2-6-16(7-3-1)14-17-8-9-18(19-15-17)21-13-12-20-10-4-5-11-20/h1-3,6-9,15H,4-5,10-14H2
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n/an/a 82n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085246
PNG
(3-[4-(2-Pyrrolidin-1-yl-ethoxy)-benzyl]-pyridine |...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2cccnc2)cc1
Show InChI InChI=1S/C18H22N2O/c1-2-11-20(10-1)12-13-21-18-7-5-16(6-8-18)14-17-4-3-9-19-15-17/h3-9,15H,1-2,10-14H2
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n/an/a 87n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085263
PNG
(2-[2-(4-Benzyl-phenoxy)-ethyl]-2-aza-bicyclo[2.2.2...)
Show SMILES C(CN1CC2CCC1C=C2)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C22H25NO/c1-2-4-18(5-3-1)16-19-8-12-22(13-9-19)24-15-14-23-17-20-6-10-21(23)11-7-20/h1-6,8-10,12-13,20-21H,7,11,14-17H2
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n/an/a 100n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085306
PNG
(CHEMBL164168 | [2-(4-Benzyl-phenoxy)-ethyl]-diisop...)
Show SMILES CC(C)N(CCOc1ccc(Cc2ccccc2)cc1)C(C)C
Show InChI InChI=1S/C21H29NO/c1-17(2)22(18(3)4)14-15-23-21-12-10-20(11-13-21)16-19-8-6-5-7-9-19/h5-13,17-18H,14-16H2,1-4H3
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n/an/a 100n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085299
PNG
(1-[2-(4-Thiophen-3-ylmethyl-phenoxy)-ethyl]-pyrrol...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccsc2)cc1
Show InChI InChI=1S/C17H21NOS/c1-2-9-18(8-1)10-11-19-17-5-3-15(4-6-17)13-16-7-12-20-14-16/h3-7,12,14H,1-2,8-11,13H2
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n/an/a 100n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085283
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-azepane | CHEMBL159...)
Show SMILES C(CN1CCCCCC1)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C21H27NO/c1-2-7-15-22(14-6-1)16-17-23-21-12-10-20(11-13-21)18-19-8-4-3-5-9-19/h3-5,8-13H,1-2,6-7,14-18H2
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n/an/a 120n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085279
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-pyrrolidine | 1-[2-...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H23NO/c1-2-6-17(7-3-1)16-18-8-10-19(11-9-18)21-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 120n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085306
PNG
(CHEMBL164168 | [2-(4-Benzyl-phenoxy)-ethyl]-diisop...)
Show SMILES CC(C)N(CCOc1ccc(Cc2ccccc2)cc1)C(C)C
Show InChI InChI=1S/C21H29NO/c1-17(2)22(18(3)4)14-15-23-21-12-10-20(11-13-21)16-19-8-6-5-7-9-19/h5-13,17-18H,14-16H2,1-4H3
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n/an/a 140n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085288
PNG
(1-{2-[4-(Biphenyl-4-yloxy)-phenoxy]-ethyl}-pyrroli...)
Show SMILES C(CN1CCCC1)Oc1ccc(Oc2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C24H25NO2/c1-2-6-20(7-3-1)21-8-10-23(11-9-21)27-24-14-12-22(13-15-24)26-19-18-25-16-4-5-17-25/h1-3,6-15H,4-5,16-19H2
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n/an/a 140n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085252
PNG
(CHEMBL162180 | Phenyl-[4-(2-pyrrolidin-1-yl-ethoxy...)
Show SMILES C(CN1CCCC1)Oc1ccc(CNc2ccccc2)cc1
Show InChI InChI=1S/C19H24N2O/c1-2-6-18(7-3-1)20-16-17-8-10-19(11-9-17)22-15-14-21-12-4-5-13-21/h1-3,6-11,20H,4-5,12-16H2
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n/an/a 150n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085309
PNG
(Benzyl-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine...)
Show SMILES C(CN1CCCC1)Oc1ccc(NCc2ccccc2)cc1
Show InChI InChI=1S/C19H24N2O/c1-2-6-17(7-3-1)16-20-18-8-10-19(11-9-18)22-15-14-21-12-4-5-13-21/h1-3,6-11,20H,4-5,12-16H2
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n/an/a 150n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085307
PNG
(1-[2-(4-Benzylsulfanyl-phenoxy)-ethyl]-pyrrolidine...)
Show SMILES C(CN1CCCC1)Oc1ccc(SCc2ccccc2)cc1
Show InChI InChI=1S/C19H23NOS/c1-2-6-17(7-3-1)16-22-19-10-8-18(9-11-19)21-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 150n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085260
PNG
(CHEMBL26424 | Tesmilifene | [2-(4-Benzyl-phenoxy)-...)
Show SMILES CCN(CC)CCOc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H25NO/c1-3-20(4-2)14-15-21-19-12-10-18(11-13-19)16-17-8-6-5-7-9-17/h5-13H,3-4,14-16H2,1-2H3
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n/an/a 160n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085305
PNG
(1-{2-[4-(3-Chloro-benzyl)-phenoxy]-ethyl}-pyrrolid...)
Show SMILES Clc1cccc(Cc2ccc(OCCN3CCCC3)cc2)c1
Show InChI InChI=1S/C19H22ClNO/c20-18-5-3-4-17(15-18)14-16-6-8-19(9-7-16)22-13-12-21-10-1-2-11-21/h3-9,15H,1-2,10-14H2
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n/an/a 160n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085277
PNG
(1-{2-[4-(Difluoro-phenyl-methyl)-phenoxy]-ethyl}-p...)
Show SMILES FC(F)(c1ccccc1)c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C19H21F2NO/c20-19(21,16-6-2-1-3-7-16)17-8-10-18(11-9-17)23-15-14-22-12-4-5-13-22/h1-3,6-11H,4-5,12-15H2
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n/an/a 170n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085285
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-piperidine | CHEMBL...)
Show SMILES C(CN1CCCCC1)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C20H25NO/c1-3-7-18(8-4-1)17-19-9-11-20(12-10-19)22-16-15-21-13-5-2-6-14-21/h1,3-4,7-12H,2,5-6,13-17H2
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n/an/a 170n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085297
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-2,6-dimethyl-piperi...)
Show SMILES CC1CCCC(C)N1CCOc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C22H29NO/c1-18-7-6-8-19(2)23(18)15-16-24-22-13-11-21(12-14-22)17-20-9-4-3-5-10-20/h3-5,9-14,18-19H,6-8,15-17H2,1-2H3
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n/an/a 180n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085284
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-4-methyl-piperazine...)
Show SMILES CN1CCN(CCOc2ccc(Cc3ccccc3)cc2)CC1
Show InChI InChI=1S/C20H26N2O/c1-21-11-13-22(14-12-21)15-16-23-20-9-7-19(8-10-20)17-18-5-3-2-4-6-18/h2-10H,11-17H2,1H3
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n/an/a 190n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085311
PNG
(1-[2-(4-Phenylsulfanylmethyl-phenoxy)-ethyl]-pyrro...)
Show SMILES C(CN1CCCC1)Oc1ccc(CSc2ccccc2)cc1
Show InChI InChI=1S/C19H23NOS/c1-2-6-19(7-3-1)22-16-17-8-10-18(11-9-17)21-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 190n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085253
PNG
(1-[2-(4-Benzyl-2-fluoro-phenoxy)-ethyl]-pyrrolidin...)
Show SMILES Fc1cc(Cc2ccccc2)ccc1OCCN1CCCC1
Show InChI InChI=1S/C19H22FNO/c20-18-15-17(14-16-6-2-1-3-7-16)8-9-19(18)22-13-12-21-10-4-5-11-21/h1-3,6-9,15H,4-5,10-14H2
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n/an/a 190n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085263
PNG
(2-[2-(4-Benzyl-phenoxy)-ethyl]-2-aza-bicyclo[2.2.2...)
Show SMILES C(CN1CC2CCC1C=C2)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C22H25NO/c1-2-4-18(5-3-1)16-19-8-12-22(13-9-19)24-15-14-23-17-20-6-10-21(23)11-7-20/h1-6,8-10,12-13,20-21H,7,11,14-17H2
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n/an/a 190n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085266
PNG
(4-[4-(2-Pyrrolidin-1-yl-ethoxy)-benzyl]-thiazole |...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2cscn2)cc1
Show InChI InChI=1S/C16H20N2OS/c1-2-8-18(7-1)9-10-19-16-5-3-14(4-6-16)11-15-12-20-13-17-15/h3-6,12-13H,1-2,7-11H2
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n/an/a 190n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085251
PNG
(1-[2-(Biphenyl-4-yloxy)-ethyl]-pyrrolidine | 1-[2-...)
Show SMILES C(CN1CCCC1)Oc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H21NO/c1-2-6-16(7-3-1)17-8-10-18(11-9-17)20-15-14-19-12-4-5-13-19/h1-3,6-11H,4-5,12-15H2
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n/an/a 200n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085301
PNG
(5-[4-(2-Pyrrolidin-1-yl-ethoxy)-benzyl]-thiazole |...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2cncs2)cc1
Show InChI InChI=1S/C16H20N2OS/c1-2-8-18(7-1)9-10-19-15-5-3-14(4-6-15)11-16-12-17-13-20-16/h3-6,12-13H,1-2,7-11H2
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n/an/a 220n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085310
PNG
(1-[2-(4-Phenethyl-phenoxy)-ethyl]-pyrrolidine | CH...)
Show SMILES C(CN1CCCC1)Oc1ccc(CCc2ccccc2)cc1
Show InChI InChI=1S/C20H25NO/c1-2-6-18(7-3-1)8-9-19-10-12-20(13-11-19)22-17-16-21-14-4-5-15-21/h1-3,6-7,10-13H,4-5,8-9,14-17H2
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n/an/a 220n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085310
PNG
(1-[2-(4-Phenethyl-phenoxy)-ethyl]-pyrrolidine | CH...)
Show SMILES C(CN1CCCC1)Oc1ccc(CCc2ccccc2)cc1
Show InChI InChI=1S/C20H25NO/c1-2-6-18(7-3-1)8-9-19-10-12-20(13-11-19)22-17-16-21-14-4-5-15-21/h1-3,6-7,10-13H,4-5,8-9,14-17H2
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n/an/a 220n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085294
PNG
(4-[2-(4-Benzyl-phenoxy)-ethyl]-morpholine | CHEMBL...)
Show SMILES C(CN1CCOCC1)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H23NO2/c1-2-4-17(5-3-1)16-18-6-8-19(9-7-18)22-15-12-20-10-13-21-14-11-20/h1-9H,10-16H2
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n/an/a 230n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085266
PNG
(4-[4-(2-Pyrrolidin-1-yl-ethoxy)-benzyl]-thiazole |...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2cscn2)cc1
Show InChI InChI=1S/C16H20N2OS/c1-2-8-18(7-1)9-10-19-16-5-3-14(4-6-16)11-15-12-20-13-17-15/h3-6,12-13H,1-2,7-11H2
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n/an/a 240n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085298
PNG
(1-[2-(4-Furan-3-ylmethyl-phenoxy)-ethyl]-pyrrolidi...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccoc2)cc1
Show InChI InChI=1S/C17H21NO2/c1-2-9-18(8-1)10-12-20-17-5-3-15(4-6-17)13-16-7-11-19-14-16/h3-7,11,14H,1-2,8-10,12-13H2
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n/an/a 250n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085280
PNG
(1-[3-(4-Benzyl-phenyl)-allyl]-pyrrolidine | CHEMBL...)
Show SMILES C(\C=C\c1ccc(Cc2ccccc2)cc1)N1CCCC1
Show InChI InChI=1S/C20H23N/c1-2-7-19(8-3-1)17-20-12-10-18(11-13-20)9-6-16-21-14-4-5-15-21/h1-3,6-13H,4-5,14-17H2/b9-6+
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n/an/a 260n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085246
PNG
(3-[4-(2-Pyrrolidin-1-yl-ethoxy)-benzyl]-pyridine |...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2cccnc2)cc1
Show InChI InChI=1S/C18H22N2O/c1-2-11-20(10-1)12-13-21-18-7-5-16(6-8-18)14-17-4-3-9-19-15-17/h3-9,15H,1-2,10-14H2
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n/an/a 260n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085290
PNG
(2-(4-Benzyl-phenoxy)-ethylamine | 2-(4-benzylpheno...)
Show SMILES NCCOc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C15H17NO/c16-10-11-17-15-8-6-14(7-9-15)12-13-4-2-1-3-5-13/h1-9H,10-12,16H2
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n/an/a 280n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085248
PNG
(1-[2-(4-Benzyloxy-phenoxy)-ethyl]-pyrrolidine | CH...)
Show SMILES C(CN1CCCC1)Oc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C19H23NO2/c1-2-6-17(7-3-1)16-22-19-10-8-18(9-11-19)21-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 310n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085307
PNG
(1-[2-(4-Benzylsulfanyl-phenoxy)-ethyl]-pyrrolidine...)
Show SMILES C(CN1CCCC1)Oc1ccc(SCc2ccccc2)cc1
Show InChI InChI=1S/C19H23NOS/c1-2-6-17(7-3-1)16-22-19-10-8-18(9-11-19)21-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 310n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085280
PNG
(1-[3-(4-Benzyl-phenyl)-allyl]-pyrrolidine | CHEMBL...)
Show SMILES C(\C=C\c1ccc(Cc2ccccc2)cc1)N1CCCC1
Show InChI InChI=1S/C20H23N/c1-2-7-19(8-3-1)17-20-12-10-18(11-13-20)9-6-16-21-14-4-5-15-21/h1-3,6-13H,4-5,14-17H2/b9-6+
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n/an/a 320n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085291
PNG
(2-[4-(2-Pyrrolidin-1-yl-ethoxy)-benzyl]-thiazole |...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2nccs2)cc1
Show InChI InChI=1S/C16H20N2OS/c1-2-9-18(8-1)10-11-19-15-5-3-14(4-6-15)13-16-17-7-12-20-16/h3-7,12H,1-2,8-11,13H2
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n/an/a 370n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085244
PNG
(1-[3-(4-Benzyl-phenyl)-cyclobutyl]-pyrrolidine | C...)
Show SMILES C(c1ccccc1)c1ccc(cc1)C1C[C@@H](C1)N1CCCC1
Show InChI InChI=1S/C21H25N/c1-2-6-17(7-3-1)14-18-8-10-19(11-9-18)20-15-21(16-20)22-12-4-5-13-22/h1-3,6-11,20-21H,4-5,12-16H2/t20?,21-
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n/an/a 370n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085260
PNG
(CHEMBL26424 | Tesmilifene | [2-(4-Benzyl-phenoxy)-...)
Show SMILES CCN(CC)CCOc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H25NO/c1-3-20(4-2)14-15-21-19-12-10-18(11-13-19)16-17-8-6-5-7-9-17/h5-13H,3-4,14-16H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085270
PNG
(2-[2-(4-Benzyl-phenoxy)-ethyl]-2,5-diaza-bicyclo[2...)
Show SMILES C(CN1CC2CC1CN2)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C20H24N2O/c1-2-4-16(5-3-1)12-17-6-8-20(9-7-17)23-11-10-22-15-18-13-19(22)14-21-18/h1-9,18-19,21H,10-15H2
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n/an/a 410n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085309
PNG
(Benzyl-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine...)
Show SMILES C(CN1CCCC1)Oc1ccc(NCc2ccccc2)cc1
Show InChI InChI=1S/C19H24N2O/c1-2-6-17(7-3-1)16-20-18-8-10-19(11-9-18)22-15-14-21-12-4-5-13-21/h1-3,6-11,20H,4-5,12-16H2
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n/an/a 420n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085259
PNG
(1-[2-(4-Benzyl-phenylsulfanyl)-ethyl]-pyrrolidine ...)
Show SMILES C(CN1CCCC1)Sc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H23NS/c1-2-6-17(7-3-1)16-18-8-10-19(11-9-18)21-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 480n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085244
PNG
(1-[3-(4-Benzyl-phenyl)-cyclobutyl]-pyrrolidine | C...)
Show SMILES C(c1ccccc1)c1ccc(cc1)C1C[C@@H](C1)N1CCCC1
Show InChI InChI=1S/C21H25N/c1-2-6-17(7-3-1)14-18-8-10-19(11-9-18)20-15-21(16-20)22-12-4-5-13-22/h1-3,6-11,20-21H,4-5,12-16H2/t20?,21-
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n/an/a 510n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085262
PNG
(1-[2-(5-Benzyl-thiophen-2-yloxy)-ethyl]-pyrrolidin...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccccc2)s1
Show InChI InChI=1S/C17H21NOS/c1-2-6-15(7-3-1)14-16-8-9-17(20-16)19-13-12-18-10-4-5-11-18/h1-3,6-9H,4-5,10-14H2
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n/an/a 530n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085276
PNG
(1-[2-(4-Cyclohexylmethyl-phenoxy)-ethyl]-pyrrolidi...)
Show SMILES C(CN1CCCC1)Oc1ccc(CC2CCCCC2)cc1
Show InChI InChI=1S/C19H29NO/c1-2-6-17(7-3-1)16-18-8-10-19(11-9-18)21-15-14-20-12-4-5-13-20/h8-11,17H,1-7,12-16H2
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n/an/a 530n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085258
PNG
(2-{4-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenoxy]-phenyl...)
Show SMILES C(CN1CCCC1)Oc1ccc(Oc2ccc(cc2)C2=NCCO2)cc1
Show InChI InChI=1S/C21H24N2O3/c1-2-13-23(12-1)14-16-24-18-7-9-20(10-8-18)26-19-5-3-17(4-6-19)21-22-11-15-25-21/h3-10H,1-2,11-16H2
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n/an/a 550n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085258
PNG
(2-{4-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenoxy]-phenyl...)
Show SMILES C(CN1CCCC1)Oc1ccc(Oc2ccc(cc2)C2=NCCO2)cc1
Show InChI InChI=1S/C21H24N2O3/c1-2-13-23(12-1)14-16-24-18-7-9-20(10-8-18)26-19-5-3-17(4-6-19)21-22-11-15-25-21/h3-10H,1-2,11-16H2
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n/an/a 590n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085289
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-piperazine | CHEMBL...)
Show SMILES C(CN1CCNCC1)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H24N2O/c1-2-4-17(5-3-1)16-18-6-8-19(9-7-18)22-15-14-21-12-10-20-11-13-21/h1-9,20H,10-16H2
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n/an/a 620n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085274
PNG
(4-[4-(2-Pyrrolidin-1-yl-ethoxy)-benzyl]-pyridine |...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccncc2)cc1
Show InChI InChI=1S/C18H22N2O/c1-2-12-20(11-1)13-14-21-18-5-3-16(4-6-18)15-17-7-9-19-10-8-17/h3-10H,1-2,11-15H2
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n/an/a 630n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085264
PNG
(1-[3-(4-Benzyl-phenyl)-propyl]-pyrrolidine | CHEMB...)
Show SMILES C(CN1CCCC1)Cc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C20H25N/c1-2-7-19(8-3-1)17-20-12-10-18(11-13-20)9-6-16-21-14-4-5-15-21/h1-3,7-8,10-13H,4-6,9,14-17H2
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n/an/a 670n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085243
PNG
(1-[2-(4-Benzyl-phenoxy)-propyl]-pyrrolidine | CHEM...)
Show SMILES CC(CN1CCCC1)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C20H25NO/c1-17(16-21-13-5-6-14-21)22-20-11-9-19(10-12-20)15-18-7-3-2-4-8-18/h2-4,7-12,17H,5-6,13-16H2,1H3
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n/an/a 700n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085303
PNG
(1-[2-(Biphenyl-3-yloxy)-ethyl]-pyrrolidine | CHEMB...)
Show SMILES C(CN1CCCC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C18H21NO/c1-2-7-16(8-3-1)17-9-6-10-18(15-17)20-14-13-19-11-4-5-12-19/h1-3,6-10,15H,4-5,11-14H2
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n/an/a 700n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085251
PNG
(1-[2-(Biphenyl-4-yloxy)-ethyl]-pyrrolidine | 1-[2-...)
Show SMILES C(CN1CCCC1)Oc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C18H21NO/c1-2-6-16(7-3-1)17-8-10-18(11-9-17)20-15-14-19-12-4-5-13-19/h1-3,6-11H,4-5,12-15H2
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n/an/a 790n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085243
PNG
(1-[2-(4-Benzyl-phenoxy)-propyl]-pyrrolidine | CHEM...)
Show SMILES CC(CN1CCCC1)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C20H25NO/c1-17(16-21-13-5-6-14-21)22-20-11-9-19(10-12-20)15-18-7-3-2-4-8-18/h2-4,7-12,17H,5-6,13-16H2,1H3
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n/an/a 790n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085256
PNG
(1-{2-[4-(3-Methoxy-benzyl)-phenoxy]-ethyl}-pyrroli...)
Show SMILES COc1cccc(Cc2ccc(OCCN3CCCC3)cc2)c1
Show InChI InChI=1S/C20H25NO2/c1-22-20-6-4-5-18(16-20)15-17-7-9-19(10-8-17)23-14-13-21-11-2-3-12-21/h4-10,16H,2-3,11-15H2,1H3
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n/an/a 840n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50000541
PNG
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Show SMILES CC(N(O)C(N)=O)c1cc2ccccc2s1
Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
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n/an/a 850n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085308
PNG
(1-{2-[4-(4-Methoxy-benzyl)-phenoxy]-ethyl}-pyrroli...)
Show SMILES COc1ccc(Cc2ccc(OCCN3CCCC3)cc2)cc1
Show InChI InChI=1S/C20H25NO2/c1-22-19-8-4-17(5-9-19)16-18-6-10-20(11-7-18)23-15-14-21-12-2-3-13-21/h4-11H,2-3,12-16H2,1H3
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n/an/a 890n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085295
PNG
(1-[2-(4-Heptyloxy-phenoxy)-ethyl]-pyrrolidine | CH...)
Show SMILES CCCCCCCOc1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C19H31NO2/c1-2-3-4-5-8-16-21-18-9-11-19(12-10-18)22-17-15-20-13-6-7-14-20/h9-12H,2-8,13-17H2,1H3
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n/an/a 900n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085259
PNG
(1-[2-(4-Benzyl-phenylsulfanyl)-ethyl]-pyrrolidine ...)
Show SMILES C(CN1CCCC1)Sc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H23NS/c1-2-6-17(7-3-1)16-18-8-10-19(11-9-18)21-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 940n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085281
PNG
(1-{2-[4-(4-Chloro-benzyl)-phenoxy]-ethyl}-pyrrolid...)
Show SMILES Clc1ccc(Cc2ccc(OCCN3CCCC3)cc2)cc1
Show InChI InChI=1S/C19H22ClNO/c20-18-7-3-16(4-8-18)15-17-5-9-19(10-6-17)22-14-13-21-11-1-2-12-21/h3-10H,1-2,11-15H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085268
PNG
(1-[2-(4-Benzyl-3-fluoro-phenoxy)-ethyl]-pyrrolidin...)
Show SMILES Fc1cc(OCCN2CCCC2)ccc1Cc1ccccc1
Show InChI InChI=1S/C19H22FNO/c20-19-15-18(22-13-12-21-10-4-5-11-21)9-8-17(19)14-16-6-2-1-3-7-16/h1-3,6-9,15H,4-5,10-14H2
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n/an/a 1.09E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085254
PNG
(1-[2-(4-Benzyl-2-chloro-phenoxy)-ethyl]-pyrrolidin...)
Show SMILES Clc1cc(Cc2ccccc2)ccc1OCCN1CCCC1
Show InChI InChI=1S/C19H22ClNO/c20-18-15-17(14-16-6-2-1-3-7-16)8-9-19(18)22-13-12-21-10-4-5-11-21/h1-3,6-9,15H,4-5,10-14H2
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n/an/a 1.23E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085264
PNG
(1-[3-(4-Benzyl-phenyl)-propyl]-pyrrolidine | CHEMB...)
Show SMILES C(CN1CCCC1)Cc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C20H25N/c1-2-7-19(8-3-1)17-20-12-10-18(11-13-20)9-6-16-21-14-4-5-15-21/h1-3,7-8,10-13H,4-6,9,14-17H2
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n/an/a 1.30E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085294
PNG
(4-[2-(4-Benzyl-phenoxy)-ethyl]-morpholine | CHEMBL...)
Show SMILES C(CN1CCOCC1)Oc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H23NO2/c1-2-4-17(5-3-1)16-18-6-8-19(9-7-18)22-15-12-20-10-13-21-14-11-20/h1-9H,10-16H2
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n/an/a 1.32E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085269
PNG
(1-[2-(4-Styryl-phenoxy)-ethyl]-pyrrolidine | CHEMB...)
Show SMILES C(CN1CCCC1)Oc1ccc(\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C20H23NO/c1-2-6-18(7-3-1)8-9-19-10-12-20(13-11-19)22-17-16-21-14-4-5-15-21/h1-3,6-13H,4-5,14-17H2/b9-8+
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n/an/a 1.35E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085269
PNG
(1-[2-(4-Styryl-phenoxy)-ethyl]-pyrrolidine | CHEMB...)
Show SMILES C(CN1CCCC1)Oc1ccc(\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C20H23NO/c1-2-6-18(7-3-1)8-9-19-10-12-20(13-11-19)22-17-16-21-14-4-5-15-21/h1-3,6-13H,4-5,14-17H2/b9-8+
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n/an/a 1.50E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085274
PNG
(4-[4-(2-Pyrrolidin-1-yl-ethoxy)-benzyl]-pyridine |...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccncc2)cc1
Show InChI InChI=1S/C18H22N2O/c1-2-12-20(11-1)13-14-21-18-5-3-16(4-6-18)15-17-7-9-19-10-8-17/h3-10H,1-2,11-15H2
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n/an/a 1.56E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085267
PNG
(1-[2-(4-Benzyl-benzyloxy)-ethyl]-pyrrolidine | CHE...)
Show SMILES C(CN1CCCC1)OCc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C20H25NO/c1-2-6-18(7-3-1)16-19-8-10-20(11-9-19)17-22-15-14-21-12-4-5-13-21/h1-3,6-11H,4-5,12-17H2
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n/an/a 1.60E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085284
PNG
(1-[2-(4-Benzyl-phenoxy)-ethyl]-4-methyl-piperazine...)
Show SMILES CN1CCN(CCOc2ccc(Cc3ccccc3)cc2)CC1
Show InChI InChI=1S/C20H26N2O/c1-21-11-13-22(14-12-21)15-16-23-20-9-7-19(8-10-20)17-18-5-3-2-4-6-18/h2-10H,11-17H2,1H3
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n/an/a 1.65E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085286
PNG
(2-Benzyl-5-(2-pyrrolidin-1-yl-ethoxy)-pyridine | C...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccccc2)nc1
Show InChI InChI=1S/C18H22N2O/c1-2-6-16(7-3-1)14-17-8-9-18(15-19-17)21-13-12-20-10-4-5-11-20/h1-3,6-9,15H,4-5,10-14H2
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n/an/a 1.80E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085287
PNG
(CHEMBL162844 | Phenyl-[4-(2-pyrrolidin-1-yl-ethoxy...)
Show SMILES OC(c1ccccc1)c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C19H23NO2/c21-19(16-6-2-1-3-7-16)17-8-10-18(11-9-17)22-15-14-20-12-4-5-13-20/h1-3,6-11,19,21H,4-5,12-15H2
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n/an/a 1.80E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085273
PNG
(CHEMBL163396 | Phenyl-[4-(2-pyrrolidin-1-yl-ethoxy...)
Show SMILES O=C(c1ccccc1)c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C19H21NO2/c21-19(16-6-2-1-3-7-16)17-8-10-18(11-9-17)22-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-15H2
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n/an/a 1.80E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085254
PNG
(1-[2-(4-Benzyl-2-chloro-phenoxy)-ethyl]-pyrrolidin...)
Show SMILES Clc1cc(Cc2ccccc2)ccc1OCCN1CCCC1
Show InChI InChI=1S/C19H22ClNO/c20-18-15-17(14-16-6-2-1-3-7-16)8-9-19(18)22-13-12-21-10-4-5-11-21/h1-3,6-9,15H,4-5,10-14H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085295
PNG
(1-[2-(4-Heptyloxy-phenoxy)-ethyl]-pyrrolidine | CH...)
Show SMILES CCCCCCCOc1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C19H31NO2/c1-2-3-4-5-8-16-21-18-9-11-19(12-10-18)22-17-15-20-13-6-7-14-20/h9-12H,2-8,13-17H2,1H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085256
PNG
(1-{2-[4-(3-Methoxy-benzyl)-phenoxy]-ethyl}-pyrroli...)
Show SMILES COc1cccc(Cc2ccc(OCCN3CCCC3)cc2)c1
Show InChI InChI=1S/C20H25NO2/c1-22-20-6-4-5-18(16-20)15-17-7-9-19(10-8-17)23-14-13-21-11-2-3-12-21/h4-10,16H,2-3,11-15H2,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085267
PNG
(1-[2-(4-Benzyl-benzyloxy)-ethyl]-pyrrolidine | CHE...)
Show SMILES C(CN1CCCC1)OCc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C20H25NO/c1-2-6-18(7-3-1)16-19-8-10-20(11-9-19)17-22-15-14-21-12-4-5-13-21/h1-3,6-11H,4-5,12-17H2
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n/an/a 2.80E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085272
PNG
(5-Benzyl-2-(2-pyrrolidin-1-yl-ethoxy)-thiazole | C...)
Show SMILES C(CN1CCCC1)Oc1ncc(Cc2ccccc2)s1
Show InChI InChI=1S/C16H20N2OS/c1-2-6-14(7-3-1)12-15-13-17-16(20-15)19-11-10-18-8-4-5-9-18/h1-3,6-7,13H,4-5,8-12H2
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n/an/a 2.90E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085312
PNG
((4-Benzyl-phenyl)-(2-pyrrolidin-1-yl-ethyl)-amine ...)
Show SMILES C(CN1CCCC1)Nc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H24N2/c1-2-6-17(7-3-1)16-18-8-10-19(11-9-18)20-12-15-21-13-4-5-14-21/h1-3,6-11,20H,4-5,12-16H2
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n/an/a>3.00E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085249
PNG
(1-[2-(4-Benzyl-3-methyl-phenoxy)-ethyl]-pyrrolidin...)
Show SMILES Cc1cc(OCCN2CCCC2)ccc1Cc1ccccc1
Show InChI InChI=1S/C20H25NO/c1-17-15-20(22-14-13-21-11-5-6-12-21)10-9-19(17)16-18-7-3-2-4-8-18/h2-4,7-10,15H,5-6,11-14,16H2,1H3
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n/an/a>3.00E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085250
PNG
(1-[2-(4-Benzyl-2-methyl-phenoxy)-ethyl]-pyrrolidin...)
Show SMILES Cc1cc(Cc2ccccc2)ccc1OCCN1CCCC1
Show InChI InChI=1S/C20H25NO/c1-17-15-19(16-18-7-3-2-4-8-18)9-10-20(17)22-14-13-21-11-5-6-12-21/h2-4,7-10,15H,5-6,11-14,16H2,1H3
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n/an/a>3.00E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085304
PNG
(1-[2-(4-Phenyl-cyclohexyloxy)-ethyl]-pyrrolidine |...)
Show SMILES C(CN1CCCC1)O[C@H]1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C18H27NO/c1-2-6-16(7-3-1)17-8-10-18(11-9-17)20-15-14-19-12-4-5-13-19/h1-3,6-7,17-18H,4-5,8-15H2/t17?,18-
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n/an/a>3.00E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085296
PNG
(5-Benzyl-2-(2-pyrrolidin-1-yl-ethoxy)-oxazole | CH...)
Show SMILES C(CN1CCCC1)Oc1ncc(Cc2ccccc2)o1
Show InChI InChI=1S/C16H20N2O2/c1-2-6-14(7-3-1)12-15-13-17-16(20-15)19-11-10-18-8-4-5-9-18/h1-3,6-7,13H,4-5,8-12H2
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n/an/a>3.00E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085250
PNG
(1-[2-(4-Benzyl-2-methyl-phenoxy)-ethyl]-pyrrolidin...)
Show SMILES Cc1cc(Cc2ccccc2)ccc1OCCN1CCCC1
Show InChI InChI=1S/C20H25NO/c1-17-15-19(16-18-7-3-2-4-8-18)9-10-20(17)22-14-13-21-11-5-6-12-21/h2-4,7-10,15H,5-6,11-14,16H2,1H3
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n/an/a>3.00E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085257
PNG
(1-[2-(4-Phenylmethanesulfonyl-phenoxy)-ethyl]-pyrr...)
Show SMILES O=S(=O)(Cc1ccccc1)c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C19H23NO3S/c21-24(22,16-17-6-2-1-3-7-17)19-10-8-18(9-11-19)23-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 4.00E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085272
PNG
(5-Benzyl-2-(2-pyrrolidin-1-yl-ethoxy)-thiazole | C...)
Show SMILES C(CN1CCCC1)Oc1ncc(Cc2ccccc2)s1
Show InChI InChI=1S/C16H20N2OS/c1-2-6-14(7-3-1)12-15-13-17-16(20-15)19-11-10-18-8-4-5-9-18/h1-3,6-7,13H,4-5,8-12H2
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n/an/a 4.30E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085287
PNG
(CHEMBL162844 | Phenyl-[4-(2-pyrrolidin-1-yl-ethoxy...)
Show SMILES OC(c1ccccc1)c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C19H23NO2/c21-19(16-6-2-1-3-7-16)17-8-10-18(11-9-17)22-15-14-20-12-4-5-13-20/h1-3,6-11,19,21H,4-5,12-15H2
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n/an/a 4.60E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085286
PNG
(2-Benzyl-5-(2-pyrrolidin-1-yl-ethoxy)-pyridine | C...)
Show SMILES C(CN1CCCC1)Oc1ccc(Cc2ccccc2)nc1
Show InChI InChI=1S/C18H22N2O/c1-2-6-16(7-3-1)14-17-8-9-18(15-19-17)21-13-12-20-10-4-5-11-20/h1-3,6-9,15H,4-5,10-14H2
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n/an/a 6.70E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085300
PNG
(1-[2-(4-Phenylmethanesulfinyl-phenoxy)-ethyl]-pyrr...)
Show SMILES O=S(Cc1ccccc1)c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C19H23NO2S/c21-23(16-17-6-2-1-3-7-17)19-10-8-18(9-11-19)22-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 7.50E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085257
PNG
(1-[2-(4-Phenylmethanesulfonyl-phenoxy)-ethyl]-pyrr...)
Show SMILES O=S(=O)(Cc1ccccc1)c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C19H23NO3S/c21-24(22,16-17-6-2-1-3-7-17)19-10-8-18(9-11-19)23-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 7.70E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085303
PNG
(1-[2-(Biphenyl-3-yloxy)-ethyl]-pyrrolidine | CHEMB...)
Show SMILES C(CN1CCCC1)Oc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C18H21NO/c1-2-7-16(8-3-1)17-9-6-10-18(15-17)20-14-13-19-11-4-5-12-19/h1-3,6-10,15H,4-5,11-14H2
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n/an/a 8.20E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085247
PNG
(1-[2-(4-Benzyl-2-methoxy-phenoxy)-ethyl]-pyrrolidi...)
Show SMILES COc1cc(Cc2ccccc2)ccc1OCCN1CCCC1
Show InChI InChI=1S/C20H25NO2/c1-22-20-16-18(15-17-7-3-2-4-8-17)9-10-19(20)23-14-13-21-11-5-6-12-21/h2-4,7-10,16H,5-6,11-15H2,1H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085271
PNG
(1-[2-(4-Benzyl-benzenesulfinyl)-ethyl]-pyrrolidine...)
Show SMILES O=S(CCN1CCCC1)c1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H23NOS/c21-22(15-14-20-12-4-5-13-20)19-10-8-18(9-11-19)16-17-6-2-1-3-7-17/h1-3,6-11H,4-5,12-16H2
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n/an/a 9.70E+3n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085265
PNG
(1-{2-[4-(2-Methoxy-benzyl)-phenoxy]-ethyl}-pyrroli...)
Show SMILES COc1ccccc1Cc1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C20H25NO2/c1-22-20-7-3-2-6-18(20)16-17-8-10-19(11-9-17)23-15-14-21-12-4-5-13-21/h2-3,6-11H,4-5,12-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085271
PNG
(1-[2-(4-Benzyl-benzenesulfinyl)-ethyl]-pyrrolidine...)
Show SMILES O=S(CCN1CCCC1)c1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C19H23NOS/c21-22(15-14-20-12-4-5-13-20)19-10-8-18(9-11-19)16-17-6-2-1-3-7-17/h1-3,6-11H,4-5,12-16H2
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n/an/a 1.40E+4n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085300
PNG
(1-[2-(4-Phenylmethanesulfinyl-phenoxy)-ethyl]-pyrr...)
Show SMILES O=S(Cc1ccccc1)c1ccc(OCCN2CCCC2)cc1
Show InChI InChI=1S/C19H23NO2S/c21-23(16-17-6-2-1-3-7-17)19-10-8-18(9-11-19)22-15-14-20-12-4-5-13-20/h1-3,6-11H,4-5,12-16H2
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n/an/a 2.45E+4n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085247
PNG
(1-[2-(4-Benzyl-2-methoxy-phenoxy)-ethyl]-pyrrolidi...)
Show SMILES COc1cc(Cc2ccccc2)ccc1OCCN1CCCC1
Show InChI InChI=1S/C20H25NO2/c1-22-20-16-18(15-17-7-3-2-4-8-17)9-10-19(20)23-14-13-21-11-5-6-12-21/h2-4,7-10,16H,5-6,11-15H2,1H3
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n/an/a 2.47E+4n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085278
PNG
(CHEMBL162984 | N-[4-(2-Pyrrolidin-1-yl-ethoxy)-phe...)
Show SMILES O=C(Nc1ccc(OCCN2CCCC2)cc1)c1ccccc1
Show InChI InChI=1S/C19H22N2O2/c22-19(16-6-2-1-3-7-16)20-17-8-10-18(11-9-17)23-15-14-21-12-4-5-13-21/h1-3,6-11H,4-5,12-15H2,(H,20,22)
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PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085302
PNG
(1-{2-[4-(2-Phenyl-cyclopropyl)-phenoxy]-ethyl}-pyr...)
Show SMILES C(CN1CCCC1)Oc1ccc(cc1)[C@@H]1C[C@H]1c1ccccc1
Show InChI InChI=1S/C21H25NO/c1-2-6-17(7-3-1)20-16-21(20)18-8-10-19(11-9-18)23-15-14-22-12-4-5-13-22/h1-3,6-11,20-21H,4-5,12-16H2/t20-,21-/m0/s1
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PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50105264
PNG
(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Show SMILES C[C@H](NC(=O)[C@@H](CC(=O)NO)Cc1ccccc1)C([O-])=O
Show InChI InChI=1S/C14H18N2O5/c1-9(14(19)20)15-13(18)11(8-12(17)16-21)7-10-5-3-2-4-6-10/h2-6,9,11,21H,7-8H2,1H3,(H,15,18)(H,16,17)(H,19,20)/p-1/t9-,11+/m0/s1
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PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined for LTB4 production in human whole blood.


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50085275
PNG
(1-[2-(4-Benzyl-3-methoxy-phenoxy)-ethyl]-pyrrolidi...)
Show SMILES COc1cc(OCCN2CCCC2)ccc1Cc1ccccc1
Show InChI InChI=1S/C20H25NO2/c1-22-20-16-19(23-14-13-21-11-5-6-12-21)10-9-18(20)15-17-7-3-2-4-8-17/h2-4,7-10,16H,5-6,11-15H2,1H3
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PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
Leukotriene A4 hydrolase


(Homo sapiens (Human))
BDBM50000541
PNG
((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Show SMILES CC(N(O)C(N)=O)c1cc2ccccc2s1
Show InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
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Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Searle Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity was determined against Leukotriene A4 hydrolase


J Med Chem 43: 721-35 (2000)


Article DOI: 10.1021/jm990496z
BindingDB Entry DOI: 10.7270/Q2CN74MZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%