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PubMed code 10821708

Compile data set for download or QSAR
Found 138 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GRIK1


(Homo sapiens (Human))
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088223
PNG
(CHEMBL61751 | E-2-Amino-4-(3-naphthalen-1-yl-allyl...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1cccc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-14(17(20)21)9-4-8-13-7-3-6-12-5-1-2-10-15(12)13/h1-8,10,14,16H,9,11,19H2,(H,20,21)(H,22,23)/b8-4+/t14-,16+/m1/s1
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7n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088197
PNG
(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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8n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088197
PNG
(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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8n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]-kainate as radioligand;...


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Grik5


(Homo sapiens (Human))
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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8n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50031704
PNG
((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Show SMILES C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C6H11NO4/c1-3(5(8)9)2-4(7)6(10)11/h3-4H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,4+/m1/s1
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10n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(Homo sapiens (Human))
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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10n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088229
PNG
(2-Amino-4-prop-2-ynyl-pentanedioic acid | CHEMBL59...)
Show SMILES N[C@@H](C[C@@H](CC#C)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h1,5-6H,3-4,9H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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11.6n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088222
PNG
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1
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14n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]-kainate as radioligand;...


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088222
PNG
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1
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15n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]-kainate as radioligand;...


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088212
PNG
(2-Amino-4-but-2-enyl-pentanedioic acid(LY339180) |...)
Show SMILES C\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h2-3,6-7H,4-5,10H2,1H3,(H,11,12)(H,13,14)/b3-2+/t6-,7+/m1/s1
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21n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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26n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088228
PNG
(2-Amino-4-but-2-ynyl-pentanedioic acid | CHEMBL620...)
Show SMILES CC#CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h6-7H,4-5,10H2,1H3,(H,11,12)(H,13,14)/t6-,7+/m1/s1
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28.9n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088203
PNG
(CHEMBL301915 | E-2-Amino-4-[3-(4-bromo-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Br)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16BrNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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30n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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30n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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32n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
GRIK1


(Homo sapiens (Human))
BDBM50088235
PNG
(CHEMBL300368 | E-2-Amino-4-[3-(4-methylsulfanyl-ph...)
Show SMILES CSc1ccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C15H19NO4S/c1-21-12-7-5-10(6-8-12)3-2-4-11(14(17)18)9-13(16)15(19)20/h2-3,5-8,11,13H,4,9,16H2,1H3,(H,17,18)(H,19,20)/b3-2+/t11-,13+/m1/s1
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32n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088224
PNG
(CHEMBL305346 | E-2-Amino-4-[3-(3-methoxy-phenyl)-a...)
Show SMILES COc1cccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C15H19NO5/c1-21-12-7-3-5-10(8-12)4-2-6-11(14(17)18)9-13(16)15(19)20/h2-5,7-8,11,13H,6,9,16H2,1H3,(H,17,18)(H,19,20)/b4-2+/t11-,13+/m1/s1
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40n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088196
PNG
(2-Amino-4-(3-chloro-allyl)-pentanedioic acid | CHE...)
Show SMILES N[C@@H](C[C@@H](C\C=C\Cl)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H12ClNO4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h1,3,5-6H,2,4,10H2,(H,11,12)(H,13,14)/b3-1+/t5-,6+/m1/s1
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41n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(Homo sapiens (Human))
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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42n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 3 in HEK293 cells using [3H]-kainate as radio...


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088217
PNG
(CHEMBL58095 | E-2-Amino-4-(3-phenyl-allyl)-pentane...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-12(14(18)19)9-11(13(16)17)8-4-7-10-5-2-1-3-6-10/h1-7,11-12H,8-9,15H2,(H,16,17)(H,18,19)/b7-4+/t11-,12+/m1/s1
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44n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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48n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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48n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radio...


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088221
PNG
(CHEMBL293118 | E-2-Amino-4-[3-(3,4-dichloro-phenyl...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)c(Cl)c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H15Cl2NO4/c15-10-5-4-8(6-11(10)16)2-1-3-9(13(18)19)7-12(17)14(20)21/h1-2,4-6,9,12H,3,7,17H2,(H,18,19)(H,20,21)/b2-1+/t9-,12+/m1/s1
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49n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088200
PNG
(CHEMBL291491 | E-2-Amino-4-[3-(4-trifluoromethyl-p...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(cc1)C(F)(F)F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H16F3NO4/c16-15(17,18)11-6-4-9(5-7-11)2-1-3-10(13(20)21)8-12(19)14(22)23/h1-2,4-7,10,12H,3,8,19H2,(H,20,21)(H,22,23)/b2-1+/t10-,12+/m1/s1
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52n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088213
PNG
((2S,4R)-4-allyl glutamate | 2-Allyl-4-amino-pentan...)
Show SMILES N[C@@H](C[C@@H](CC=C)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h2,5-6H,1,3-4,9H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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56n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088199
PNG
(CHEMBL302680 | E-2-Amino-4-[3-(4-isopropyl-phenyl)...)
Show SMILES CC(C)c1ccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C17H23NO4/c1-11(2)13-8-6-12(7-9-13)4-3-5-14(16(19)20)10-15(18)17(21)22/h3-4,6-9,11,14-15H,5,10,18H2,1-2H3,(H,19,20)(H,21,22)/b4-3+/t14-,15+/m1/s1
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58n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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59n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088234
PNG
(CHEMBL60168 | E-2-Amino-4-[3-(4-nitro-phenyl)-ally...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(cc1)[N+]([O-])=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16N2O6/c15-12(14(19)20)8-10(13(17)18)3-1-2-9-4-6-11(7-5-9)16(21)22/h1-2,4-7,10,12H,3,8,15H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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59n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088227
PNG
(CHEMBL58054 | E-2-Amino-4-[3-(3-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1cccc(Cl)c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-2-4-9(7-11)3-1-5-10(13(17)18)8-12(16)14(19)20/h1-4,6-7,10,12H,5,8,16H2,(H,17,18)(H,19,20)/b3-1+/t10-,12+/m1/s1
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60n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088205
PNG
(CHEMBL294683 | E-2-Amino-4-[3-(4-fluoro-phenyl)-al...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(F)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16FNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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78n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088230
PNG
((2S,4R)-4-propylglutamic acid | 2-Amino-4-propyl-p...)
Show SMILES CCC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H15NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h5-6H,2-4,9H2,1H3,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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123n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088198
PNG
(CHEMBL59297 | E-2-Amino-4-[3-(2,6-dichloro-phenyl)...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1c(Cl)cccc1Cl)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H15Cl2NO4/c15-10-5-2-6-11(16)9(10)4-1-3-8(13(18)19)7-12(17)14(20)21/h1-2,4-6,8,12H,3,7,17H2,(H,18,19)(H,20,21)/b4-1+/t8-,12+/m1/s1
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131n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088232
PNG
(CHEMBL292896 | E-2-Amino-4-(3-biphenyl-4-yl-allyl)...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(cc1)-c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C20H21NO4/c21-18(20(24)25)13-17(19(22)23)8-4-5-14-9-11-16(12-10-14)15-6-2-1-3-7-15/h1-7,9-12,17-18H,8,13,21H2,(H,22,23)(H,24,25)/b5-4+/t17-,18+/m1/s1
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133n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088225
PNG
(CHEMBL58808 | Z-2-Amino-4-(3-phenyl-allyl)-pentane...)
Show SMILES N[C@@H](C[C@@H](C\C=C/c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-12(14(18)19)9-11(13(16)17)8-4-7-10-5-2-1-3-6-10/h1-7,11-12H,8-9,15H2,(H,16,17)(H,18,19)/b7-4-/t11-,12+/m1/s1
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157n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088229
PNG
(2-Amino-4-prop-2-ynyl-pentanedioic acid | CHEMBL59...)
Show SMILES N[C@@H](C[C@@H](CC#C)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h1,5-6H,3-4,9H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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160n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088204
PNG
(2-Amino-4-pent-2-enyl-pentanedioic acid | CHEMBL30...)
Show SMILES CC\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-2-3-4-5-7(9(12)13)6-8(11)10(14)15/h3-4,7-8H,2,5-6,11H2,1H3,(H,12,13)(H,14,15)/b4-3+/t7-,8+/m1/s1
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161n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088231
PNG
(CHEMBL292745 | E-2-Amino-4-(3-p-tolyl-allyl)-penta...)
Show SMILES Cc1ccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C15H19NO4/c1-10-5-7-11(8-6-10)3-2-4-12(14(17)18)9-13(16)15(19)20/h2-3,5-8,12-13H,4,9,16H2,1H3,(H,17,18)(H,19,20)/b3-2+/t12-,13+/m1/s1
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172n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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177n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
GRIK1


(Homo sapiens (Human))
BDBM50088202
PNG
(CHEMBL60114 | E-2-Amino-4-[3-(4-trifluoromethoxy-p...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(OC(F)(F)F)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H16F3NO5/c16-15(17,18)24-11-6-4-9(5-7-11)2-1-3-10(13(20)21)8-12(19)14(22)23/h1-2,4-7,10,12H,3,8,19H2,(H,20,21)(H,22,23)/b2-1+/t10-,12+/m1/s1
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254n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088211
PNG
(CHEMBL293548 | E-2-Amino-4-[3-(2-chloro-phenyl)-al...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccccc1Cl)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-7-2-1-4-9(11)5-3-6-10(13(17)18)8-12(16)14(19)20/h1-5,7,10,12H,6,8,16H2,(H,17,18)(H,19,20)/b5-3+/t10-,12+/m1/s1
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254n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088220
PNG
((2S,4R)-4-pentylglutamic acid | 2-Amino-4-pentyl-p...)
Show SMILES CCCCC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H19NO4/c1-2-3-4-5-7(9(12)13)6-8(11)10(14)15/h7-8H,2-6,11H2,1H3,(H,12,13)(H,14,15)/t7-,8+/m1/s1
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267n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088226
PNG
(CHEMBL59299 | E-2-Amino-4-[3-(4-methoxy-phenyl)-al...)
Show SMILES COc1ccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C15H19NO5/c1-21-12-7-5-10(6-8-12)3-2-4-11(14(17)18)9-13(16)15(19)20/h2-3,5-8,11,13H,4,9,16H2,1H3,(H,17,18)(H,19,20)/b3-2+/t11-,13+/m1/s1
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284n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088206
PNG
(2-Amino-4-prop-2-ynyl-pentanedioic acid | CHEMBL58...)
Show SMILES N[C@@H](C[C@H](CC#C)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h1,5-6H,3-4,9H2,(H,10,11)(H,12,13)/t5-,6-/m0/s1
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307n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088237
PNG
(2-Amino-4-(3-phenyl-prop-2-ynyl)-pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CC#Cc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H15NO4/c15-12(14(18)19)9-11(13(16)17)8-4-7-10-5-2-1-3-6-10/h1-3,5-6,11-12H,8-9,15H2,(H,16,17)(H,18,19)/t11-,12+/m1/s1
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337n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088225
PNG
(CHEMBL58808 | Z-2-Amino-4-(3-phenyl-allyl)-pentane...)
Show SMILES N[C@@H](C[C@@H](C\C=C/c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-12(14(18)19)9-11(13(16)17)8-4-7-10-5-2-1-3-6-10/h1-7,11-12H,8-9,15H2,(H,16,17)(H,18,19)/b7-4-/t11-,12+/m1/s1
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339n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088236
PNG
(CHEMBL293829 | E-2-Amino-4-[3-(4-cyano-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(cc1)C#N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H16N2O4/c16-9-11-6-4-10(5-7-11)2-1-3-12(14(18)19)8-13(17)15(20)21/h1-2,4-7,12-13H,3,8,17H2,(H,18,19)(H,20,21)/b2-1+/t12-,13+/m1/s1
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367n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(Homo sapiens (Human))
BDBM50088197
PNG
(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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423n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088214
PNG
(2-Amino-4-(2-methyl-3-phenyl-allyl)-pentanedioic a...)
Show SMILES C\C(C[C@H](C[C@H](N)C(O)=O)C(O)=O)=C/c1ccccc1
Show InChI InChI=1S/C15H19NO4/c1-10(7-11-5-3-2-4-6-11)8-12(14(17)18)9-13(16)15(19)20/h2-7,12-13H,8-9,16H2,1H3,(H,17,18)(H,19,20)/b10-7+/t12-,13+/m1/s1
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500n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088201
PNG
(CHEMBL59948 | E-2-Amino-4-[3-(3,4-dimethoxy-phenyl...)
Show SMILES COc1ccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)cc1OC
Show InChI InChI=1S/C16H21NO6/c1-22-13-7-6-10(8-14(13)23-2)4-3-5-11(15(18)19)9-12(17)16(20)21/h3-4,6-8,11-12H,5,9,17H2,1-2H3,(H,18,19)(H,20,21)/b4-3+/t11-,12+/m1/s1
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540n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088205
PNG
(CHEMBL294683 | E-2-Amino-4-[3-(4-fluoro-phenyl)-al...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(F)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16FNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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559n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088218
PNG
(2-Amino-4-but-2-enyl-pentanedioic acid | CHEMBL613...)
Show SMILES C\C=C/C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h2-3,6-7H,4-5,10H2,1H3,(H,11,12)(H,13,14)/b3-2-/t6-,7+/m1/s1
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577n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(Homo sapiens (Human))
BDBM50088222
PNG
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1
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617n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088214
PNG
(2-Amino-4-(2-methyl-3-phenyl-allyl)-pentanedioic a...)
Show SMILES C\C(C[C@H](C[C@H](N)C(O)=O)C(O)=O)=C/c1ccccc1
Show InChI InChI=1S/C15H19NO4/c1-10(7-11-5-3-2-4-6-11)8-12(14(17)18)9-13(16)15(19)20/h2-7,12-13H,8-9,16H2,1H3,(H,17,18)(H,19,20)/b10-7+/t12-,13+/m1/s1
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670n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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701n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Grik5


(Homo sapiens (Human))
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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750n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate-Kainate 7


(Homo sapiens (Human))
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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789n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088206
PNG
(2-Amino-4-prop-2-ynyl-pentanedioic acid | CHEMBL58...)
Show SMILES N[C@@H](C[C@H](CC#C)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h1,5-6H,3-4,9H2,(H,10,11)(H,12,13)/t5-,6-/m0/s1
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823n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088215
PNG
(2-Amino-4-pent-2-ynyl-pentanedioic acid | CHEMBL58...)
Show SMILES CCC#CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-2-3-4-5-7(9(12)13)6-8(11)10(14)15/h7-8H,2,5-6,11H2,1H3,(H,12,13)(H,14,15)/t7-,8+/m1/s1
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831n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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868n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 4 in HEK293 cells using [3H]-AMPA as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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940n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 2 in HK293 cells using [3H]-AMPA as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088237
PNG
(2-Amino-4-(3-phenyl-prop-2-ynyl)-pentanedioic acid...)
Show SMILES N[C@@H](C[C@@H](CC#Cc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H15NO4/c15-12(14(18)19)9-11(13(16)17)8-4-7-10-5-2-1-3-6-10/h1-3,5-6,11-12H,8-9,15H2,(H,16,17)(H,18,19)/t11-,12+/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088209
PNG
(2-Amino-4-(3-methyl-but-2-enyl)-pentanedioic acid ...)
Show SMILES CC(C)=CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-6(2)3-4-7(9(12)13)5-8(11)10(14)15/h3,7-8H,4-5,11H2,1-2H3,(H,12,13)(H,14,15)/t7-,8+/m1/s1
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1.02E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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1.11E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human GluR6


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088227
PNG
(CHEMBL58054 | E-2-Amino-4-[3-(3-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1cccc(Cl)c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-2-4-9(7-11)3-1-5-10(13(17)18)8-12(16)14(19)20/h1-4,6-7,10,12H,5,8,16H2,(H,17,18)(H,19,20)/b3-1+/t10-,12+/m1/s1
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1.13E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50069130
PNG
((2S,4R)-2-Amino-4-(3-phenyl-propyl)-pentanedioic a...)
Show SMILES N[C@@H](C[C@@H](CCCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H19NO4/c15-12(14(18)19)9-11(13(16)17)8-4-7-10-5-2-1-3-6-10/h1-3,5-6,11-12H,4,7-9,15H2,(H,16,17)(H,18,19)/t11-,12+/m1/s1
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1.19E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088219
PNG
(2-Allyl-4-amino-pentanedioic acid | CHEMBL62055)
Show SMILES N[C@@H](C[C@H](CC=C)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h2,5-6H,1,3-4,9H2,(H,10,11)(H,12,13)/t5-,6-/m0/s1
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1.30E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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1.36E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 1 in HEK293 cells using [3H]-AMPA as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088211
PNG
(CHEMBL293548 | E-2-Amino-4-[3-(2-chloro-phenyl)-al...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccccc1Cl)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-7-2-1-4-9(11)5-3-6-10(13(17)18)8-12(16)14(19)20/h1-5,7,10,12H,6,8,16H2,(H,17,18)(H,19,20)/b5-3+/t10-,12+/m1/s1
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1.40E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088228
PNG
(2-Amino-4-but-2-ynyl-pentanedioic acid | CHEMBL620...)
Show SMILES CC#CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H13NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h6-7H,4-5,10H2,1H3,(H,11,12)(H,13,14)/t6-,7+/m1/s1
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1.46E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088208
PNG
(2-Amino-4-(2-chloro-allyl)-pentanedioic acid | CHE...)
Show SMILES N[C@@H](C[C@@H](CC(Cl)=C)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H12ClNO4/c1-4(9)2-5(7(11)12)3-6(10)8(13)14/h5-6H,1-3,10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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1.46E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088198
PNG
(CHEMBL59297 | E-2-Amino-4-[3-(2,6-dichloro-phenyl)...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1c(Cl)cccc1Cl)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H15Cl2NO4/c15-10-5-2-6-11(16)9(10)4-1-3-8(13(18)19)7-12(17)14(20)21/h1-2,4-6,8,12H,3,7,17H2,(H,18,19)(H,20,21)/b4-1+/t8-,12+/m1/s1
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1.57E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088217
PNG
(CHEMBL58095 | E-2-Amino-4-(3-phenyl-allyl)-pentane...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H17NO4/c15-12(14(18)19)9-11(13(16)17)8-4-7-10-5-2-1-3-6-10/h1-7,11-12H,8-9,15H2,(H,16,17)(H,18,19)/b7-4+/t11-,12+/m1/s1
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1.58E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radio...


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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1.71E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 4 in HEK293 cells using [3H]-AMPA as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088213
PNG
((2S,4R)-4-allyl glutamate | 2-Allyl-4-amino-pentan...)
Show SMILES N[C@@H](C[C@@H](CC=C)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h2,5-6H,1,3-4,9H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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1.84E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]-kainate as radiol...


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088207
PNG
(2-Amino-4-hexyl-pentanedioic acid | CHEMBL62053)
Show SMILES CCCCCC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H21NO4/c1-2-3-4-5-6-8(10(13)14)7-9(12)11(15)16/h8-9H,2-7,12H2,1H3,(H,13,14)(H,15,16)/t8-,9+/m1/s1
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2.38E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088230
PNG
((2S,4R)-4-propylglutamic acid | 2-Amino-4-propyl-p...)
Show SMILES CCC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H15NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h5-6H,2-4,9H2,1H3,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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2.45E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088196
PNG
(2-Amino-4-(3-chloro-allyl)-pentanedioic acid | CHE...)
Show SMILES N[C@@H](C[C@@H](C\C=C\Cl)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H12ClNO4/c9-3-1-2-5(7(11)12)4-6(10)8(13)14/h1,3,5-6H,2,4,10H2,(H,11,12)(H,13,14)/b3-1+/t5-,6+/m1/s1
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2.89E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088204
PNG
(2-Amino-4-pent-2-enyl-pentanedioic acid | CHEMBL30...)
Show SMILES CC\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-2-3-4-5-7(9(12)13)6-8(11)10(14)15/h3-4,7-8H,2,5-6,11H2,1H3,(H,12,13)(H,14,15)/b4-3+/t7-,8+/m1/s1
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2.98E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088212
PNG
(2-Amino-4-but-2-enyl-pentanedioic acid(LY339180) |...)
Show SMILES C\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h2-3,6-7H,4-5,10H2,1H3,(H,11,12)(H,13,14)/b3-2+/t6-,7+/m1/s1
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3.26E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088233
PNG
(CHEMBL61434 | E-2-Amino-4-[3-(4-carboxy-phenyl)-al...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(cc1)C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H17NO6/c16-12(15(21)22)8-11(14(19)20)3-1-2-9-4-6-10(7-5-9)13(17)18/h1-2,4-7,11-12H,3,8,16H2,(H,17,18)(H,19,20)(H,21,22)/b2-1+/t11-,12+/m1/s1
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3.59E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088210
PNG
(2-Amino-4-hex-2-ynyl-pentanedioic acid | CHEMBL302...)
Show SMILES CCCC#CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H17NO4/c1-2-3-4-5-6-8(10(13)14)7-9(12)11(15)16/h8-9H,2-3,6-7,12H2,1H3,(H,13,14)(H,15,16)/t8-,9+/m1/s1
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3.61E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088234
PNG
(CHEMBL60168 | E-2-Amino-4-[3-(4-nitro-phenyl)-ally...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(cc1)[N+]([O-])=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16N2O6/c15-12(14(19)20)8-10(13(17)18)3-1-2-9-4-6-11(7-5-9)16(21)22/h1-2,4-7,10,12H,3,8,15H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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3.85E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088197
PNG
(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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3.86E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]-AMPA as radioliga...


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088221
PNG
(CHEMBL293118 | E-2-Amino-4-[3-(3,4-dichloro-phenyl...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)c(Cl)c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H15Cl2NO4/c15-10-5-4-8(6-11(10)16)2-1-3-9(13(18)19)7-12(17)14(20)21/h1-2,4-6,9,12H,3,7,17H2,(H,18,19)(H,20,21)/b2-1+/t9-,12+/m1/s1
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3.99E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088223
PNG
(CHEMBL61751 | E-2-Amino-4-(3-naphthalen-1-yl-allyl...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1cccc2ccccc12)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-14(17(20)21)9-4-8-13-7-3-6-12-5-1-2-10-15(12)13/h1-8,10,14,16H,9,11,19H2,(H,20,21)(H,22,23)/b8-4+/t14-,16+/m1/s1
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4.37E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088231
PNG
(CHEMBL292745 | E-2-Amino-4-(3-p-tolyl-allyl)-penta...)
Show SMILES Cc1ccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C15H19NO4/c1-10-5-7-11(8-6-10)3-2-4-12(14(17)18)9-13(16)15(19)20/h2-3,5-8,12-13H,4,9,16H2,1H3,(H,17,18)(H,19,20)/b3-2+/t12-,13+/m1/s1
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4.38E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088236
PNG
(CHEMBL293829 | E-2-Amino-4-[3-(4-cyano-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(cc1)C#N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H16N2O4/c16-9-11-6-4-10(5-7-11)2-1-3-12(14(18)19)8-13(17)15(20)21/h1-2,4-7,12-13H,3,8,17H2,(H,18,19)(H,20,21)/b2-1+/t12-,13+/m1/s1
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4.49E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088197
PNG
(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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4.65E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]-AMPA as radioliga...


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088218
PNG
(2-Amino-4-but-2-enyl-pentanedioic acid | CHEMBL613...)
Show SMILES C\C=C/C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h2-3,6-7H,4-5,10H2,1H3,(H,11,12)(H,13,14)/b3-2-/t6-,7+/m1/s1
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5.37E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088232
PNG
(CHEMBL292896 | E-2-Amino-4-(3-biphenyl-4-yl-allyl)...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(cc1)-c1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C20H21NO4/c21-18(20(24)25)13-17(19(22)23)8-4-5-14-9-11-16(12-10-14)15-6-2-1-3-7-15/h1-7,9-12,17-18H,8,13,21H2,(H,22,23)(H,24,25)/b5-4+/t17-,18+/m1/s1
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5.65E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088235
PNG
(CHEMBL300368 | E-2-Amino-4-[3-(4-methylsulfanyl-ph...)
Show SMILES CSc1ccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C15H19NO4S/c1-21-12-7-5-10(6-8-12)3-2-4-11(14(17)18)9-13(16)15(19)20/h2-3,5-8,11,13H,4,9,16H2,1H3,(H,17,18)(H,19,20)/b3-2+/t11-,13+/m1/s1
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6.02E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088224
PNG
(CHEMBL305346 | E-2-Amino-4-[3-(3-methoxy-phenyl)-a...)
Show SMILES COc1cccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)c1
Show InChI InChI=1S/C15H19NO5/c1-21-12-7-3-5-10(8-12)4-2-6-11(14(17)18)9-13(16)15(19)20/h2-5,7-8,11,13H,6,9,16H2,1H3,(H,17,18)(H,19,20)/b4-2+/t11-,13+/m1/s1
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6.35E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088207
PNG
(2-Amino-4-hexyl-pentanedioic acid | CHEMBL62053)
Show SMILES CCCCCC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H21NO4/c1-2-3-4-5-6-8(10(13)14)7-9(12)11(15)16/h8-9H,2-7,12H2,1H3,(H,13,14)(H,15,16)/t8-,9+/m1/s1
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7.21E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088203
PNG
(CHEMBL301915 | E-2-Amino-4-[3-(4-bromo-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Br)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16BrNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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7.22E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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7.45E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 1 in HEK293 cells using [3H]-AMPA as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088208
PNG
(2-Amino-4-(2-chloro-allyl)-pentanedioic acid | CHE...)
Show SMILES N[C@@H](C[C@@H](CC(Cl)=C)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H12ClNO4/c1-4(9)2-5(7(11)12)3-6(10)8(13)14/h5-6H,1-3,10H2,(H,11,12)(H,13,14)/t5-,6+/m1/s1
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8.25E+3n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50088197
PNG
(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 1 in HEK293 cells using [3H]-AMPA as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088222
PNG
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088222
PNG
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]-AMPA as radioliga...


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 2 in HK293 cells using [3H]-AMPA as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 4 in HEK293 cells using [3H]-AMPA as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50069130
PNG
((2S,4R)-2-Amino-4-(3-phenyl-propyl)-pentanedioic a...)
Show SMILES N[C@@H](C[C@@H](CCCc1ccccc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H19NO4/c15-12(14(18)19)9-11(13(16)17)8-4-7-10-5-2-1-3-6-10/h1-3,5-6,11-12H,4,7-9,15H2,(H,16,17)(H,18,19)/t11-,12+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50088197
PNG
(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 3 in HK293 cells using [3H]-AMPA as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Grik5


(Homo sapiens (Human))
BDBM50088222
PNG
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50088222
PNG
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 4 in HEK293 cells using [3H]-AMPA as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 1 in HEK293 cells using [3H]-AMPA as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Grik5


(Homo sapiens (Human))
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against Ionotropic glutamate receptor kainate (KA2) in HK293 cells


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Grik5


(Homo sapiens (Human))
BDBM50088197
PNG
(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Ability of the compound to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50088197
PNG
(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 2 in HK293 cells using [3H]-AMPA as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088215
PNG
(2-Amino-4-pent-2-ynyl-pentanedioic acid | CHEMBL58...)
Show SMILES CCC#CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-2-3-4-5-7(9(12)13)6-8(11)10(14)15/h7-8H,2,5-6,11H2,1H3,(H,12,13)(H,14,15)/t7-,8+/m1/s1
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1.02E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088202
PNG
(CHEMBL60114 | E-2-Amino-4-[3-(4-trifluoromethoxy-p...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(OC(F)(F)F)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H16F3NO5/c16-15(17,18)24-11-6-4-9(5-7-11)2-1-3-10(13(20)21)8-12(19)14(22)23/h1-2,4-7,10,12H,3,8,19H2,(H,20,21)(H,22,23)/b2-1+/t10-,12+/m1/s1
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1.12E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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1.22E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 2 in HK293 cells using [3H]-AMPA as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088222
PNG
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1
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1.37E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]-kainate as radiol...


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088219
PNG
(2-Allyl-4-amino-pentanedioic acid | CHEMBL62055)
Show SMILES N[C@@H](C[C@H](CC=C)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h2,5-6H,1,3-4,9H2,(H,10,11)(H,12,13)/t5-,6-/m0/s1
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1.38E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088201
PNG
(CHEMBL59948 | E-2-Amino-4-[3-(3,4-dimethoxy-phenyl...)
Show SMILES COc1ccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)cc1OC
Show InChI InChI=1S/C16H21NO6/c1-22-13-7-6-10(8-14(13)23-2)4-3-5-11(15(18)19)9-12(17)16(20)21/h3-4,6-8,11-12H,5,9,17H2,1-2H3,(H,18,19)(H,20,21)/b4-3+/t11-,12+/m1/s1
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1.39E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088222
PNG
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1
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1.54E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against human Ionotropic glutamate receptor ionotropic kainate 2 in HK293 cells using [3H]-kainate as radiol...


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088226
PNG
(CHEMBL59299 | E-2-Amino-4-[3-(4-methoxy-phenyl)-al...)
Show SMILES COc1ccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C15H19NO5/c1-21-12-7-5-10(6-8-12)3-2-4-11(14(17)18)9-13(16)15(19)20/h2-3,5-8,11,13H,4,9,16H2,1H3,(H,17,18)(H,19,20)/b3-2+/t11-,13+/m1/s1
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2.23E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088233
PNG
(CHEMBL61434 | E-2-Amino-4-[3-(4-carboxy-phenyl)-al...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(cc1)C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H17NO6/c16-12(15(21)22)8-11(14(19)20)3-1-2-9-4-6-10(7-5-9)13(17)18/h1-2,4-7,11-12H,3,8,16H2,(H,17,18)(H,19,20)(H,21,22)/b2-1+/t11-,12+/m1/s1
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2.73E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088199
PNG
(CHEMBL302680 | E-2-Amino-4-[3-(4-isopropyl-phenyl)...)
Show SMILES CC(C)c1ccc(\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O)cc1
Show InChI InChI=1S/C17H23NO4/c1-11(2)13-8-6-12(7-9-13)4-3-5-14(16(19)20)10-15(18)17(21)22/h3-4,6-9,11,14-15H,5,10,18H2,1-2H3,(H,19,20)(H,21,22)/b4-3+/t14-,15+/m1/s1
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2.75E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088220
PNG
((2S,4R)-4-pentylglutamic acid | 2-Amino-4-pentyl-p...)
Show SMILES CCCCC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H19NO4/c1-2-3-4-5-7(9(12)13)6-8(11)10(14)15/h7-8H,2-6,11H2,1H3,(H,12,13)(H,14,15)/t7-,8+/m1/s1
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4.12E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088209
PNG
(2-Amino-4-(3-methyl-but-2-enyl)-pentanedioic acid ...)
Show SMILES CC(C)=CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C10H17NO4/c1-6(2)3-4-7(9(12)13)5-8(11)10(14)15/h3,7-8H,4-5,11H2,1-2H3,(H,12,13)(H,14,15)/t7-,8+/m1/s1
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4.28E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088200
PNG
(CHEMBL291491 | E-2-Amino-4-[3-(4-trifluoromethyl-p...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(cc1)C(F)(F)F)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H16F3NO4/c16-15(17,18)11-6-4-9(5-7-11)2-1-3-10(13(20)21)8-12(19)14(22)23/h1-2,4-7,10,12H,3,8,19H2,(H,20,21)(H,22,23)/b2-1+/t10-,12+/m1/s1
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4.39E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088210
PNG
(2-Amino-4-hex-2-ynyl-pentanedioic acid | CHEMBL302...)
Show SMILES CCCC#CC[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C11H17NO4/c1-2-3-4-5-6-8(10(13)14)7-9(12)11(15)16/h8-9H,2-3,6-7,12H2,1H3,(H,13,14)(H,15,16)/t8-,9+/m1/s1
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6.85E+4n/an/an/an/an/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligand


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088222
PNG
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration against human GluR6 expressed in HEK293 cells


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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n/an/an/an/a 7.50E+4n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration against GluR5 expressed in HEK293 cells


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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n/an/an/an/a 1.62E+4n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration against GluR5 expressed in HEK293 cells


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
GRIK1


(Homo sapiens (Human))
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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n/an/an/an/a 3.30E+3n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration against GluR5 expressed in HEK293 cells


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088212
PNG
(2-Amino-4-but-2-enyl-pentanedioic acid(LY339180) |...)
Show SMILES C\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h2-3,6-7H,4-5,10H2,1H3,(H,11,12)(H,13,14)/b3-2+/t6-,7+/m1/s1
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n/an/an/an/a 4.50E+3n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration of the compound required for evoking response in HEK293 cell


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088213
PNG
((2S,4R)-4-allyl glutamate | 2-Allyl-4-amino-pentan...)
Show SMILES N[C@@H](C[C@@H](CC=C)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h2,5-6H,1,3-4,9H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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n/an/an/an/a 4.40E+3n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration of the compound required for evoking response in HEK293 cell


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088222
PNG
((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc2ccccc2c1)C(O)=O)C(O)=O
Show InChI InChI=1S/C18H19NO4/c19-16(18(22)23)11-15(17(20)21)7-3-4-12-8-9-13-5-1-2-6-14(13)10-12/h1-6,8-10,15-16H,7,11,19H2,(H,20,21)(H,22,23)/b4-3+/t15-,16+/m1/s1
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n/an/an/an/a 2.50E+3n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration against GluR5 expressed in HEK293 cells


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088213
PNG
((2S,4R)-4-allyl glutamate | 2-Allyl-4-amino-pentan...)
Show SMILES N[C@@H](C[C@@H](CC=C)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H13NO4/c1-2-3-5(7(10)11)4-6(9)8(12)13/h2,5-6H,1,3-4,9H2,(H,10,11)(H,12,13)/t5-,6+/m1/s1
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n/an/an/an/a 8.30E+3n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration against human GluR6 expressed in HEK293 cells


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50002369
PNG
((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Show SMILES CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
Show InChI InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
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n/an/an/an/a 700n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration against human GluR6 expressed in HEK293 cells


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088212
PNG
(2-Amino-4-but-2-enyl-pentanedioic acid(LY339180) |...)
Show SMILES C\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C9H15NO4/c1-2-3-4-6(8(11)12)5-7(10)9(13)14/h2-3,6-7H,4-5,10H2,1H3,(H,11,12)(H,13,14)/b3-2+/t6-,7+/m1/s1
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n/an/an/an/a 5.83E+4n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration against human GluR6 expressed in HEK293 cells


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088216
PNG
(CHEMBL59284 | E-2-Amino-4-[3-(2-methoxy-phenyl)-al...)
Show SMILES COc1ccccc1\C=C\C[C@H](C[C@H](N)C(O)=O)C(O)=O
Show InChI InChI=1S/C15H19NO5/c1-21-13-8-3-2-5-10(13)6-4-7-11(14(17)18)9-12(16)15(19)20/h2-6,8,11-12H,7,9,16H2,1H3,(H,17,18)(H,19,20)/b6-4+/t11-,12+/m1/s1
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n/an/an/an/a 1.30E+3n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration against human GluR6 expressed in HEK293 cells


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50088197
PNG
(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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n/an/an/an/a 2.80E+3n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration of the compound required for evoking response in HEK293 cell


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM26431
PNG
((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)
Show SMILES N[C@H](CCC(O)=O)C(O)=O
Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1
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n/an/an/an/a 2.50E+4n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration against human GluR6 expressed in HEK293 cells


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50088197
PNG
(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Show SMILES N[C@@H](C[C@@H](C\C=C\c1ccc(Cl)cc1)C(O)=O)C(O)=O
Show InChI InChI=1S/C14H16ClNO4/c15-11-6-4-9(5-7-11)2-1-3-10(13(17)18)8-12(16)14(19)20/h1-2,4-7,10,12H,3,8,16H2,(H,17,18)(H,19,20)/b2-1+/t10-,12+/m1/s1
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n/an/an/an/a 7.08E+4n/an/an/an/a



Lilly, S.A.

Curated by ChEMBL


Assay Description
Effective concentration against human GluR6 expressed in HEK293 cells


J Med Chem 43: 1958-68 (2000)


Article DOI: 10.1021/jm9911682
BindingDB Entry DOI: 10.7270/Q2FX78QB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%