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Found 20 Enz. Inhib. hit(s) with all data for entry = 50036931
TargetSmall conductance calcium-activated potassium channel protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50092131(1,7-diazonia-15,21-diazapentacyclo[20.6.2.27,14.08...)
Affinity DataIC50:  1nMAssay Description:Inhibition of hSK1 calcium activated potassium channel (SKCa channel); Range is 1-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50061977(17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...)
Affinity DataIC50:  3nMAssay Description:Inhibition of hSK1 calcium activated potassium channel (SKCa channel)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human SUR1/Kir6.2 expressed in CHO cellsMore data for this Ligand-Target Pair
LigandPNGBDBM50099566((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)
Affinity DataIC50:  9nMAssay Description:Selectivity for gardos channel; (Gardos channel vs 2000 nM for the cardiac IKs channel).)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Affinity DataIC50:  14nMAssay Description:Inhibition of hERG currents Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099583(5-isopropenyloxy-1b,3a,10b-trimethyl-2,3-di(methyl...)
Affinity DataIC50:  86nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099581(CHEMBL288131 | N-((2R,3R)-3-(4-ethylphenylsulfonam...)
Affinity DataIC50:  100nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099582((3R,4S)N-[3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluor...)
Affinity DataIC50:  120nMAssay Description:Inhibition of IKs currents in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099574(2-(3,4-Dimethyl-phenyl)-3-[2-(4-methoxy-phenyl)-et...)
Affinity DataIC50:  200nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human SUR2A/Kir6.2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099574(2-(3,4-Dimethyl-phenyl)-3-[2-(4-methoxy-phenyl)-et...)
Affinity DataIC50:  900nMAssay Description:The inhibitory concentration for 50% was measured on cation fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50083518(4'-Chloro-4-((E)-4-phenyl-but-1-enyl)-biphenyl-2-c...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro immunosuppression in stimulated T cells expressing Voltage-gated potassium channel subunit Kv1.3; Range is 1-10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily D member 3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099567((3S,4R)-Ethanesulfonic acid (6-cyano-3-hydroxy-2,2...)
Affinity DataIC50:  1.40E+3nMAssay Description:The inhibitory concentration for 50% was measured on potassium channel complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50001786(1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099566((2-fluorophenyl)-(4-fluorophenyl)phenylacetamide |...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Iks current KvLQT1 potassium channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50099573(1N-[4-methoxy-3-methylamino(thioxo)methylsulfamoyl...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human SUR2A/Kir6.2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50099573(1N-[4-methoxy-3-methylamino(thioxo)methylsulfamoyl...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of human SUR1/Kir6.2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50099576(1-(4-Imidazol-1-yl-benzoyl)-cyclobutanecarbothioic...)
Affinity DataKd:  8.50E+3nMAssay Description:Inhibition of SUR2B/Kir6.2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 3(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50030522(CHEMBL554816 | CHEMBL55791 | [1-Benzyl-7-chloro-1H...)
Affinity DataEC50:  1.00E+3nMAssay Description:In vitro immunosuppression in stimulated T cells expressing Voltage-gated potassium channel subunit Kv1.3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50099576(1-(4-Imidazol-1-yl-benzoyl)-cyclobutanecarbothioic...)
Affinity DataKd:  5.20E+3nMAssay Description:Inhibition of SUR2B/Kir6.2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed