Compile Data Set for Download or QSAR
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Found 22 Enz. Inhib. hit(s) with all data for entry = 50013327
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataKi:  0.200nMAssay Description:Concentration of the compound required for the neuroprotective effect determined by inhibition of GCP IIMore data for this Ligand-Target Pair
TargetBacterial leucyl aminopeptidase(Vibrio proteolyticus)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129200((R)-2-Amino-4-methyl-pentanoic acid hydroxyamide |...)
Affinity DataKi:  2nMAssay Description:Inhibition of metalloprotease from family M28, Aeromonas proteolytica aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBacterial leucyl aminopeptidase(Vibrio proteolyticus)
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129202((S)-2-Amino-4-methyl-pentanoic acid hydroxyamide |...)
Affinity DataKi:  350nMAssay Description:Inhibition of metalloprotease from family M28, Aeromonas proteolytica aminopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17752(2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...)
Affinity DataIC50:  82nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17755(2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...)
Affinity DataIC50:  90nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17779(2-[(hydroxycarbamoyl)methyl]pentanedioic acid | CH...)
Affinity DataIC50:  220nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129199(2-(3-Hydroxycarbamoyl-propyl)-pentanedioic acid | ...)
Affinity DataIC50:  940nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129195(2-(2-Hydroxycarbamoyl-ethyl)-pentanedioic acid | C...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129193(2-Hydroxycarbamoyl-pentanedioic acid | CHEMBL43272...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17781(CHEMBL65860 | butane-1,2,4-tricarboxylic acid | ca...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129197(4-(Hydroxyamino)-4-oxobutanoic acid | CHEMBL51979 ...)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129203((R)-3-Acetylamino-N-hydroxy-succinamic acid | CHEM...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129201((S)-3-Acetylamino-N-hydroxy-succinamic acid | CHEM...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129198((R)-2-Amino-N-hydroxy-succinamic acid | CHEMBL4139...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129194((2S)-2-amino-4-(hydroxyamino)-4-oxobutanoic acidN(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129196((S)-2-Amino-4-hydroxycarbamoyl-butyric acid | (S)-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17779(2-[(hydroxycarbamoyl)methyl]pentanedioic acid | CH...)
Affinity DataEC50:  220nMAssay Description:Concentration of the compound required for the neuroprotective effect determined by inhibition of GCP IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17752(2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)methyl]ph...)
Affinity DataEC50:  9.5nMAssay Description:Inhibitory concentration required against Glutamate carboxypeptidase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataEC50:  0.620nMAssay Description:Concentration of the compound required for the neuroprotective effect determined by inhibition of GCP IIMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM17755(2-(3-sulfanylpropyl)pentanedioic acid | 2-MPPA | C...)
Affinity DataEC50:  13nMAssay Description:Concentration of the compound required for the neuroprotective effect determined by inhibition of GCP IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50129199(2-(3-Hydroxycarbamoyl-propyl)-pentanedioic acid | ...)
Affinity DataEC50:  1.10E+3nMAssay Description:Concentration of the compound required for the neuroprotective effect determined by inhibition of GCP IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed