Compile Data Set for Download or QSAR
maximum 50k data
Found 32 Enz. Inhib. hit(s) with all data for entry = 50016087
TargetCaspase-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24065(1-[(5S)-3-(2,5-difluorophenyl)-5-(3-hydroxyphenyl)...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration towards caspase-3 induction in human A2780 ovarian carcinoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24065(1-[(5S)-3-(2,5-difluorophenyl)-5-(3-hydroxyphenyl)...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164860(1-[3-(2,5-Difluoro-phenyl)-5-(3-hydroxy-phenyl)-4,...)
Affinity DataIC50:  51nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24053(3-(2,5-difluorophenyl)-N,N-dimethyl-5-phenyl-4,5-d...)
Affinity DataIC50:  84nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24049(1-[3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydro-1H-...)
Affinity DataIC50:  94nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164856(1-(3-(2,5-difluorophenyl)-5-phenyl-4,5-dihydropyra...)
Affinity DataIC50:  250nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24066(1-[(5S)-3-(2-chlorophenyl)-5-(3-hydroxyphenyl)-4,5...)
Affinity DataIC50:  450nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164876(1-[3-(2-Chloro-phenyl)-5-(3-hydroxy-phenyl)-4,5-di...)
Affinity DataIC50:  460nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164853(1-[3-(2-Chloro-phenyl)-5-(3-hydroxy-phenyl)-4,5-di...)
Affinity DataIC50:  1.10E+3nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164857(1-[3-(2-Chloro-phenyl)-5-(3-hydroxy-phenyl)-4,5-di...)
Affinity DataIC50:  1.20E+3nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164861(1-(3-(2,5-difluorophenyl)-5-(thiophen-2-yl)-4,5-di...)
Affinity DataIC50:  1.80E+3nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164864(3-(2,5-Difluoro-phenyl)-1-methanesulfonyl-5-phenyl...)
Affinity DataIC50:  1.80E+3nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24067(3,5-diaryl-4,5-dihydropyrazole, 8a | 3-(2,5-difluo...)
Affinity DataIC50:  3.10E+3nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164867(1-(3-(2-fluorophenyl)-5-phenyl-4,5-dihydropyrazol-...)
Affinity DataIC50:  3.60E+3nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164869(1-(3-(2-chlorophenyl)-5-phenyl-4,5-dihydropyrazol-...)
Affinity DataIC50:  3.60E+3nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164874(1-[3-(3,5-Difluoro-phenyl)-5-phenyl-4,5-dihydro-py...)
Affinity DataIC50: >5.00E+3nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164872(4-Amino-1-[3-(2-chloro-phenyl)-5-(3-hydroxy-phenyl...)
Affinity DataIC50:  6.00E+3nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164875(1-[5-(3-Hydroxy-phenyl)-3-phenyl-4,5-dihydro-pyraz...)
Affinity DataIC50:  6.90E+3nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164866(1-(3-(3-chlorophenyl)-5-phenyl-4,5-dihydropyrazol-...)
Affinity DataIC50:  9.80E+3nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50198309((S)-4-(3-Hydroxy-phenyl)-6-methyl-2-thioxo-1,2,3,4...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164865(1-[3-(2,6-Difluoro-phenyl)-5-phenyl-4,5-dihydro-py...)
Affinity DataIC50:  1.09E+4nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164868(1-[3-(2,3-Difluoro-phenyl)-5-phenyl-4,5-dihydro-py...)
Affinity DataIC50:  1.27E+4nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164873(CHEMBL195659 | [3-(2-Chloro-phenyl)-5-(3-hydroxy-p...)
Affinity DataIC50:  1.35E+4nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164877(1-[3-(2-Bromo-phenyl)-5-phenyl-4,5-dihydro-pyrazol...)
Affinity DataIC50:  2.33E+4nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164852(1-[3-(2,4-Dichloro-phenyl)-5-phenyl-4,5-dihydro-py...)
Affinity DataIC50:  3.76E+4nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164862(1-(5-Phenyl-3-o-tolyl-4,5-dihydro-pyrazol-1-yl)-et...)
Affinity DataIC50:  4.62E+4nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164871(1-(3,5-Diphenyl-4,5-dihydro-pyrazol-1-yl)-ethanone...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164863(3-(2-Chloro-phenyl)-5-(3-hydroxy-phenyl)-4,5-dihyd...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164870(1-(3-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyra...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164854(1-[5-Phenyl-3-(2-trifluoromethyl-phenyl)-4,5-dihyd...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164858(3-[5-(2-Chloro-phenyl)-2-methyl-3,4-dihydro-2H-pyr...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164859(1-[3-(2-Methoxy-phenyl)-5-phenyl-4,5-dihydro-pyraz...)
Affinity DataIC50: >5.00E+4nMAssay Description:In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed