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PubMed code 15857151

Compile data set for download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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2.24n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 3 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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2.70n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 4 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
GRIA2


(Homo sapiens (Human))
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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3.89n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 2 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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5.22n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 1 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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16.8n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 2 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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20.6n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 3 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
GRIA1


(Homo sapiens (Human))
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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21.9n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 1 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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40n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 4 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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44.4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 4 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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44.8n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 3 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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80.2n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 2 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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81n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for kainate Glutamate receptor GluR5 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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145n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 1 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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732n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 4 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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1.15E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for kainate Glutamate receptor GluR5 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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1.18E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 3 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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1.61E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 2 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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2.35E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 4 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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2.92E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for kainate Glutamate receptor GluR5 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIA2


(Homo sapiens (Human))
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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2.93E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 2 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic AMPA


(Homo sapiens (Human))
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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3.71E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 3 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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5.15E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 1 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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5.45E+3n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for kainate Glutamate receptor GluR5 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIA1


(Homo sapiens (Human))
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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1.00E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for ionotropic Glutamate receptor AMPA 1 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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1.88E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for kainate Glutamate receptor GluR6 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
GRIK1


(Homo sapiens (Human))
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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3.42E+4n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for kainate Glutamate receptor GluR5 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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>1.00E+5n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for kainate Glutamate receptor GluR6 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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>1.00E+5n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for kainate Glutamate receptor GluR6 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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>1.00E+5n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for kainate Glutamate receptor GluR6 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Homo sapiens (Human))
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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>1.00E+6n/an/an/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
Binding affinity for kainate Glutamate receptor GluR6 expressed in Sf9 cells


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50166285
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-propyl-2H-5-tetrazo...)
Show SMILES CCCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-2-3-16-13-8(12-15-16)7-5(9(17)14-20-7)4-6(11)10(18)19/h6H,2-4,11H2,1H3,(H,14,17)(H,18,19)
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n/an/an/an/a 3.20E+4n/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
In vitro activity of the compound at Ionotropic glutamate receptor using cortical wedge assays in rat brain synaptosoma


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50059672
PNG
((S)-2-AMINO-3-[3-HYDROXY-5-(2-METHYL-2H-TETRAZOL-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)
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n/an/an/an/a 330n/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
In vitro activity of the compound at Ionotropic glutamate receptor using cortical wedge assays in rat brain synaptosoma


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50166287
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-isopropyl-2H-5-tetr...)
Show SMILES CC(C)n1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C10H14N6O4/c1-4(2)16-13-8(12-15-16)7-5(9(17)14-20-7)3-6(11)10(18)19/h4,6H,3,11H2,1-2H3,(H,14,17)(H,18,19)
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n/an/an/an/a 7.10E+4n/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
In vitro activity of the compound at Ionotropic glutamate receptor using cortical wedge assays in rat brain synaptosoma


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50166288
PNG
((S)-2-Amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5...)
Show SMILES Cn1nnc(n1)-c1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-11-6(10-13-14)5-3(7(15)12-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,12,15)(H,16,17)/t4-/m0/s1
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n/an/an/an/a 110n/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
In vitro activity of the compound at Ionotropic glutamate receptor using cortical wedge assays in rat brain synaptosoma


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50166286
PNG
((RS)-2-amino-3-[3-hydroxy-5-(2-ethyl-2H-5-tetrazol...)
Show SMILES CCn1nnc(n1)-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C9H12N6O4/c1-2-15-12-7(11-14-15)6-4(8(16)13-19-6)3-5(10)9(17)18/h5H,2-3,10H2,1H3,(H,13,16)(H,17,18)
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n/an/an/an/a 3.50E+3n/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
In vitro activity of the compound at Ionotropic glutamate receptor using cortical wedge assays in rat brain synaptosoma


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM50059674
PNG
((RS)-2-amino-3-[3-hydroxy-5-(1-methyl-2H-5-tetrazo...)
Show SMILES Cn1nnnc1-c1o[nH]c(=O)c1CC(N)C(O)=O
Show InChI InChI=1S/C8H10N6O4/c1-14-6(10-12-13-14)5-3(7(15)11-18-5)2-4(9)8(16)17/h4H,2,9H2,1H3,(H,11,15)(H,16,17)
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n/an/an/an/a>1.00E+6n/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
In vitro activity of the compound at Ionotropic glutamate receptor using cortical wedge assays in rat brain synaptosoma


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate


(Rattus norvegicus)
BDBM17662
PNG
((2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl...)
Show SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
Show InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
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n/an/an/an/a 3.80E+3n/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
In vitro activity of the compound at Ionotropic glutamate receptor using cortical wedge assays in rat brain synaptosoma


J Med Chem 48: 3438-42 (2005)


Article DOI: 10.1021/jm050014l
BindingDB Entry DOI: 10.7270/Q2H70FBJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%