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Found 19 Enz. Inhib. hit(s) with all data for entry = 1461
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11542((1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1...)
Affinity DataKi:  0.600nM ΔG°:  -52.1kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11541((1S,3S,5S)-2-[(2S)-2-(adamantan-1-yl)-2-aminoacety...)
Affinity DataKi:  0.900nM ΔG°:  -51.1kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11530((1S,3S,5S)-2-[(2S)-2-amino-2-(1-ethenylcyclohexyl)...)
Affinity DataKi:  1.40nM ΔG°:  -50.0kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11544((1S,3S,5S)-2-[(2S)-2-amino-2-(3-fluoroadamantan-1-...)
Affinity DataKi:  1.80nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11543((1S,3S,5S)-2-[(2S)-2-amino-2-(3,5-dihydroxyadamant...)
Affinity DataKi:  2.10nM ΔG°:  -49.0kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11529((1S,3S,5S)-2-[(2S)-2-amino-2-(1-ethenylcyclopentyl...)
Affinity DataKi:  3.90nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11535((1S,3S,5S)-2-[(2S)-2-amino-2-(1-ethylcyclopentyl)a...)
Affinity DataKi:  5.5nM ΔG°:  -46.7kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11533((1S,3S,5S)-2-[(2S)-2-amino-3,3-dimethylpentanoyl]-...)
Affinity DataKi:  7.10nM ΔG°:  -46.0kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11538((1S,3S,5S)-2-[(2S)-2-amino-2-[1-(hydroxymethyl)cyc...)
Affinity DataKi:  7.40nM ΔG°:  -45.9kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11539((1S,3S,5S)-2-[(2S)-2-amino-2-[1-(hydroxymethyl)cyc...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11532((1S,3S,5S)-2-[(2S)-2-amino-2-(4-ethenyloxan-4-yl)a...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11531((1S,3S,5S)-2-[(2S)-2-amino-2-(1-ethenylcycloheptyl...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11528((1S,3S,5S)-2-[(2S)-2-amino-2-(1-ethenylcyclobutyl)...)
Affinity DataKi:  12nM ΔG°:  -44.8kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11536((1S,3S,5S)-2-[(2S)-2-amino-2-(4-ethyloxan-4-yl)ace...)
Affinity DataKi:  21nM ΔG°:  -43.4kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11527((1S,3S,5S)-2-[(2S)-2-amino-3,3-diethylpent-4-enoyl...)
Affinity DataKi:  25nM ΔG°:  -43.0kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11534((1S,3S,5S)-2-[(2S)-2-amino-3,3-diethylpentanoyl]-2...)
Affinity DataKi:  31nM ΔG°:  -42.4kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11537((1S,3S,5S)-2-[(2S)-2-amino-2-[1-(hydroxymethyl)cyc...)
Affinity DataKi:  42nM ΔG°:  -41.7kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11525((1S,3S,5S)-2-[(2S)-2-amino-3,3-dimethylpent-4-enoy...)
Affinity DataKi:  57nM ΔG°:  -40.9kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM11540((1S,3S,5S)-2-[(2S)-2-amino-2-[1-(1,2-dihydroxyethy...)
Affinity DataKi:  143nM ΔG°:  -38.7kJ/molepH: 7.4 T: 2°CAssay Description:Inhibition of human DPP-IV activity was measured under steady-state conditions by following the absorbance increase at 405 nm upon the substrate clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed