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PubMed code 16078829

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171332
PNG
(1-(2-Bromo-4-isopropyl-phenyl)-7-methyl-5-(1-propy...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(cc1Br)C(C)C)c2=O
Show InChI InChI=1S/C25H33BrN4O/c1-6-8-19(9-7-2)28-12-13-29-23-22(28)14-17(5)27-24(23)30(25(29)31)21-11-10-18(16(3)4)15-20(21)26/h10-11,14-16,19H,6-9,12-13H2,1-5H3
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1.10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171318
PNG
(1-(4-Methoxy-phenyl)-7-methyl-5-(1-propyl-butyl)-4...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(OC)cc1)c2=O
Show InChI InChI=1S/C23H30N4O2/c1-5-7-17(8-6-2)25-13-14-26-21-20(25)15-16(3)24-22(21)27(23(26)28)18-9-11-19(29-4)12-10-18/h9-12,15,17H,5-8,13-14H2,1-4H3
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2n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50074501
PNG
(Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-ph...)
Show SMILES CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3
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3.10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171325
PNG
(2-(2,4-Dichloro-phenyl)-4-methyl-6-(1-propyl-butyl...)
Show SMILES CCCC(CCC)N1CCn2nc(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c23
Show InChI InChI=1S/C22H26Cl2N4/c1-4-6-16(7-5-2)27-10-11-28-22-19(27)12-14(3)25-21(22)20(26-28)17-9-8-15(23)13-18(17)24/h8-9,12-13,16H,4-7,10-11H2,1-3H3
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4.5n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171322
PNG
(1-(2,4-Dichloro-phenyl)-7-methyl-5-(1-propyl-butyl...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(Cl)cc1Cl)c2=O
Show InChI InChI=1S/C22H26Cl2N4O/c1-4-6-16(7-5-2)26-10-11-27-20-19(26)12-14(3)25-21(20)28(22(27)29)18-9-8-15(23)13-17(18)24/h8-9,12-13,16H,4-7,10-11H2,1-3H3
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5.10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171316
PNG
(5-(1-Ethyl-propyl)-1-(4-methoxy-phenyl)-7-methyl-4...)
Show SMILES CCC(CC)N1CCn2c3c1cc(C)nc3n(-c1ccc(OC)cc1)c2=O
Show InChI InChI=1S/C21H26N4O2/c1-5-15(6-2)23-11-12-24-19-18(23)13-14(3)22-20(19)25(21(24)26)16-7-9-17(27-4)10-8-16/h7-10,13,15H,5-6,11-12H2,1-4H3
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8n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171328
PNG
(1-(4-Chloro-phenyl)-7-methyl-5-(1-propyl-butyl)-4,...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(Cl)cc1)c2=O
Show InChI InChI=1S/C22H27ClN4O/c1-4-6-17(7-5-2)25-12-13-26-20-19(25)14-15(3)24-21(20)27(22(26)28)18-10-8-16(23)9-11-18/h8-11,14,17H,4-7,12-13H2,1-3H3
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12n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171334
PNG
(7-Methyl-5-(1-propyl-butyl)-1-(4-trifluoromethyl-p...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(cc1)C(F)(F)F)c2=O
Show InChI InChI=1S/C23H27F3N4O/c1-4-6-17(7-5-2)28-12-13-29-20-19(28)14-15(3)27-21(20)30(22(29)31)18-10-8-16(9-11-18)23(24,25)26/h8-11,14,17H,4-7,12-13H2,1-3H3
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17n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171321
PNG
(5-(1-Ethyl-propyl)-1-(4-methoxy-2-methyl-phenyl)-7...)
Show SMILES CCC(CC)N1CCn2c3c1cc(C)nc3n(-c1ccc(OC)cc1C)c2=O
Show InChI InChI=1S/C22H28N4O2/c1-6-16(7-2)24-10-11-25-20-19(24)13-15(4)23-21(20)26(22(25)27)18-9-8-17(28-5)12-14(18)3/h8-9,12-13,16H,6-7,10-11H2,1-5H3
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20n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171315
PNG
(1-(5-Chloro-pyridin-2-yl)-7-methyl-5-(1-propyl-but...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(Cl)cn1)c2=O
Show InChI InChI=1S/C21H26ClN5O/c1-4-6-16(7-5-2)25-10-11-26-19-17(25)12-14(3)24-20(19)27(21(26)28)18-9-8-15(22)13-23-18/h8-9,12-13,16H,4-7,10-11H2,1-3H3
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23n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171320
PNG
(1-(2-Methoxy-phenyl)-7-methyl-5-(1-propyl-butyl)-4...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccccc1OC)c2=O
Show InChI InChI=1S/C23H30N4O2/c1-5-9-17(10-6-2)25-13-14-26-21-19(25)15-16(3)24-22(21)27(23(26)28)18-11-7-8-12-20(18)29-4/h7-8,11-12,15,17H,5-6,9-10,13-14H2,1-4H3
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44n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171319
PNG
(1-(4-Chloro-phenyl)-5-(1-ethyl-propyl)-7-methyl-4,...)
Show SMILES CCC(CC)N1CCn2c3c1cc(C)nc3n(-c1ccc(Cl)cc1)c2=O
Show InChI InChI=1S/C20H23ClN4O/c1-4-15(5-2)23-10-11-24-18-17(23)12-13(3)22-19(18)25(20(24)26)16-8-6-14(21)7-9-16/h6-9,12,15H,4-5,10-11H2,1-3H3
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58n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171331
PNG
(1-(6-Methoxy-pyridin-3-yl)-7-methyl-5-(1-propyl-bu...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(OC)nc1)c2=O
Show InChI InChI=1S/C22H29N5O2/c1-5-7-16(8-6-2)25-11-12-26-20-18(25)13-15(3)24-21(20)27(22(26)28)17-9-10-19(29-4)23-14-17/h9-10,13-14,16H,5-8,11-12H2,1-4H3
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60n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171314
PNG
(1-(3-Methoxy-phenyl)-7-methyl-5-(1-propyl-butyl)-4...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1cccc(OC)c1)c2=O
Show InChI InChI=1S/C23H30N4O2/c1-5-8-17(9-6-2)25-12-13-26-21-20(25)14-16(3)24-22(21)27(23(26)28)18-10-7-11-19(15-18)29-4/h7,10-11,14-15,17H,5-6,8-9,12-13H2,1-4H3
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130n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171333
PNG
(1-(4-Ethoxy-phenyl)-7-methyl-5-(1-propyl-butyl)-4,...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(OCC)cc1)c2=O
Show InChI InChI=1S/C24H32N4O2/c1-5-8-18(9-6-2)26-14-15-27-22-21(26)16-17(4)25-23(22)28(24(27)29)19-10-12-20(13-11-19)30-7-3/h10-13,16,18H,5-9,14-15H2,1-4H3
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140n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171336
PNG
(5-(1-Methoxy-butyl)-1-(4-methoxy-phenyl)-7-methyl-...)
Show SMILES CCCC(OC)N1CCn2c3c1cc(C)nc3n(-c1ccc(OC)cc1)c2=O
Show InChI InChI=1/C21H26N4O3/c1-5-6-18(28-4)23-11-12-24-19-17(23)13-14(2)22-20(19)25(21(24)26)15-7-9-16(27-3)10-8-15/h7-10,13,18H,5-6,11-12H2,1-4H3
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150n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171317
PNG
(5-(1-Ethyl-propyl)-7-methyl-1-(4-trifluoromethyl-p...)
Show SMILES CCC(CC)N1CCn2c3c1cc(C)nc3n(-c1ccc(cc1)C(F)(F)F)c2=O
Show InChI InChI=1S/C21H23F3N4O/c1-4-15(5-2)26-10-11-27-18-17(26)12-13(3)25-19(18)28(20(27)29)16-8-6-14(7-9-16)21(22,23)24/h6-9,12,15H,4-5,10-11H2,1-3H3
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170n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171335
PNG
(5-(1-Methoxy-butyl)-7-methyl-1-(4-trifluoromethyl-...)
Show SMILES CCCC(OC)N1CCn2c3c1cc(C)nc3n(-c1ccc(cc1)C(F)(F)F)c2=O
Show InChI InChI=1/C21H23F3N4O2/c1-4-5-17(30-3)26-10-11-27-18-16(26)12-13(2)25-19(18)28(20(27)29)15-8-6-14(7-9-15)21(22,23)24/h6-9,12,17H,4-5,10-11H2,1-3H3
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190n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171326
PNG
(1-(4-Chloro-phenyl)-5-(1-methoxy-butyl)-7-methyl-4...)
Show SMILES CCCC(OC)N1CCn2c3c1cc(C)nc3n(-c1ccc(Cl)cc1)c2=O
Show InChI InChI=1/C20H23ClN4O2/c1-4-5-17(27-3)23-10-11-24-18-16(23)12-13(2)22-19(18)25(20(24)26)15-8-6-14(21)7-9-15/h6-9,12,17H,4-5,10-11H2,1-3H3
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200n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171330
PNG
(1-(4-Methanesulfonyl-phenyl)-7-methyl-5-(1-propyl-...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(cc1)S(C)(=O)=O)c2=O
Show InChI InChI=1S/C23H30N4O3S/c1-5-7-17(8-6-2)25-13-14-26-21-20(25)15-16(3)24-22(21)27(23(26)28)18-9-11-19(12-10-18)31(4,29)30/h9-12,15,17H,5-8,13-14H2,1-4H3
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460n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171327
PNG
(4-[7-Methyl-2-oxo-5-(1-propyl-butyl)-4,5-dihydro-3...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(cc1)C(=O)OC)c2=O
Show InChI InChI=1S/C24H30N4O3/c1-5-7-18(8-6-2)26-13-14-27-21-20(26)15-16(3)25-22(21)28(24(27)30)19-11-9-17(10-12-19)23(29)31-4/h9-12,15,18H,5-8,13-14H2,1-4H3
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920n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171329
PNG
(5-(1-Methoxy-butyl)-1-(4-methoxy-2-methyl-phenyl)-...)
Show SMILES CCCC(OC)N1CCn2c3c1cc(C)nc3n(-c1ccc(OC)cc1C)c2=O
Show InChI InChI=1/C22H28N4O3/c1-6-7-19(29-5)24-10-11-25-20-18(24)13-15(3)23-21(20)26(22(25)27)17-9-8-16(28-4)12-14(17)2/h8-9,12-13,19H,6-7,10-11H2,1-5H3
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1.00E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171324
PNG
(5-Butyl-1-(4-methoxy-phenyl)-7-methyl-4,5-dihydro-...)
Show SMILES CCCCN1CCn2c3c1cc(C)nc3n(-c1ccc(OC)cc1)c2=O
Show InChI InChI=1S/C20H24N4O2/c1-4-5-10-22-11-12-23-18-17(22)13-14(2)21-19(18)24(20(23)25)15-6-8-16(26-3)9-7-15/h6-9,13H,4-5,10-12H2,1-3H3
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8.80E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171323
PNG
(5-Isopropyl-1-(4-methoxy-phenyl)-7-methyl-4,5-dihy...)
Show SMILES COc1ccc(cc1)-n1c2nc(C)cc3N(CCn(c23)c1=O)C(C)C
Show InChI InChI=1S/C19H22N4O2/c1-12(2)21-9-10-22-17-16(21)11-13(3)20-18(17)23(19(22)24)14-5-7-15(25-4)8-6-14/h5-8,11-12H,9-10H2,1-4H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cells


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50116105
PNG
(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C
Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3
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n/an/a 50n/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of CRF stimulated cAMP production in CHO cells expressing CRF1 receptor


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50171318
PNG
(1-(4-Methoxy-phenyl)-7-methyl-5-(1-propyl-butyl)-4...)
Show SMILES CCCC(CCC)N1CCn2c3c1cc(C)nc3n(-c1ccc(OC)cc1)c2=O
Show InChI InChI=1S/C23H30N4O2/c1-5-7-17(8-6-2)25-13-14-26-21-20(25)15-16(3)24-22(21)27(23(26)28)18-9-11-19(29-4)12-10-18/h9-12,15,17H,5-8,13-14H2,1-4H3
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n/an/a 71n/an/an/an/an/an/a



Neurocrine Biosciences Inc.

Curated by ChEMBL


Assay Description
Inhibition of CRF stimulated cAMP production in CHO cells expressing CRF1 receptor


J Med Chem 48: 5104-7 (2005)


Article DOI: 10.1021/jm050384+
BindingDB Entry DOI: 10.7270/Q2610ZVM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%