BindingDB logo
myBDB logout

PubMed code 16206837

Compile data set for download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosinase


(Homo sapiens (Human))
BDBM50218211
PNG
(1'-(4-Methyl-benzyl)-[1,4']bipiperidinyl | CHEMBL3...)
Show SMILES Cc1ccc(CN2CCC(CC2)N2CCCCC2)cc1
Show InChI InChI=1S/C18H28N2/c1-16-5-7-17(8-6-16)15-19-13-9-18(10-14-19)20-11-3-2-4-12-20/h5-8,18H,2-4,9-15H2,1H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.72E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50198715
PNG
((2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)pr...)
Show SMILES N[C@@H](Cn1ccc(=O)c(O)c1)C(O)=O
Show InChI InChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

DrugBank
Article
PubMed
n/an/a 3.68E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50218209
PNG
(CHEMBL250773 | Tyrosinase Inhibitor, 3 | naphthale...)
Show SMILES O=C(N1CCC(CC1)N1CCCCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C21H26N2O/c24-21(19-9-8-17-6-2-3-7-18(17)16-19)23-14-10-20(11-15-23)22-12-4-1-5-13-22/h2-3,6-9,16,20H,1,4-5,10-15H2
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.64E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM85773
PNG
(Tyrosinase Inhibitor, 8)
Show SMILES O=N(=O)c1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C16H23N3O4S/c20-19(21)15-4-6-16(7-5-15)24(22,23)18-12-8-14(9-13-18)17-10-2-1-3-11-17/h4-7,14H,1-3,8-13H2
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.76E+3n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.67E+4n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50218210
PNG
(2,2,2-trifluoro-1-(4-(piperidin-1-yl)piperidin-1-y...)
Show SMILES FC(F)(F)C(=O)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C12H19F3N2O/c13-12(14,15)11(18)17-8-4-10(5-9-17)16-6-2-1-3-7-16/h10H,1-9H2
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.81E+4n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM85774
PNG
(Tyrosinase Inhibitor, 10)
Show SMILES C(CCN1CCC(CC1)N1CCCCC1)COc1ccccc1
Show InChI InChI=1S/C20H32N2O/c1-3-9-20(10-4-1)23-18-8-7-13-21-16-11-19(12-17-21)22-14-5-2-6-15-22/h1,3-4,9-10,19H,2,5-8,11-18H2
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.95E+4n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50218205
PNG
(1-(4-(piperidin-1-yl)piperidin-1-yl)ethanone | CHE...)
Show SMILES CC(=O)N1CCC(CC1)N1CCCCC1
Show InChI InChI=1S/C12H22N2O/c1-11(15)13-9-5-12(6-10-13)14-7-3-2-4-8-14/h12H,2-10H2,1H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 2.99E+4n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
Tyrosinase


(Homo sapiens (Human))
BDBM50218206
PNG
(1,4'-bipiperidine | 1,4'-bipiperidyl | 4-PIPERIDIN...)
Show SMILES C1CCN(CC1)C1CCNCC1
Show InChI InChI=1S/C10H20N2/c1-2-8-12(9-3-1)10-4-6-11-7-5-10/h10-11H,1-9H2
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.11E+5n/an/an/an/a6.837



University of Karachi



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using SpectraMax 340 (Molecular Devices, CA, USA) microplate reader accord...


J Enzyme Inhib Med Chem 20: 401-7 (2005)


Article DOI: 10.1080/14756360500179333
BindingDB Entry DOI: 10.7270/Q29G5KBN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%