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Found 87 Enz. Inhib. hit(s) with all data for entry = 50016949
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175701((4-(4-(5-(3-amino-3-methylbutyl)thiophen-2-yl)pyri...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175690((4-(4-(5-(3-amino-3-ethylpentyl)thiophen-2-yl)pyri...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175690((4-(4-(5-(3-amino-3-ethylpentyl)thiophen-2-yl)pyri...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175701((4-(4-(5-(3-amino-3-methylbutyl)thiophen-2-yl)pyri...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175701((4-(4-(5-(3-amino-3-methylbutyl)thiophen-2-yl)pyri...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175687((4-(4-(5-(3-hydroxy-3-methylbutyl)thiophen-2-yl)py...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175700((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175687((4-(4-(5-(3-hydroxy-3-methylbutyl)thiophen-2-yl)py...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175690((4-(4-(5-(3-amino-3-ethylpentyl)thiophen-2-yl)pyri...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175698((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175700((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175695((4-(4-(5-(3-methoxypropyl)thiophen-2-yl)pyrimidin-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175695((4-(4-(5-(3-methoxypropyl)thiophen-2-yl)pyrimidin-...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175700((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175699(CHEMBL372160 | N-(2-methyl-4-(5-(2-(4-(4-(pyrrolid...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175697((4-(4-(5-(3-amino-3-methylbut-1-ynyl)thiophen-2-yl...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175697((4-(4-(5-(3-amino-3-methylbut-1-ynyl)thiophen-2-yl...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175685(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175698((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175685(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  300nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  300nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  300nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  300nMAssay Description:Inhibition of LPS-induced TNFalpha release from human PBMCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  400nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175693(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175698((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175695((4-(4-(5-(3-methoxypropyl)thiophen-2-yl)pyrimidin-...)
Affinity DataIC50:  400nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175689((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  400nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175687((4-(4-(5-(3-hydroxy-3-methylbutyl)thiophen-2-yl)py...)
Affinity DataIC50:  450nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175685(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175685(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175685(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175697((4-(4-(5-(3-amino-3-methylbut-1-ynyl)thiophen-2-yl...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175687((4-(4-(5-(3-hydroxy-3-methylbutyl)thiophen-2-yl)py...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50175686((4-(4-(5-(4-hydroxybutyl)thiophen-2-yl)pyrimidin-2...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175695((4-(4-(5-(3-methoxypropyl)thiophen-2-yl)pyrimidin-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175693(4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)-N...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against IKK complex isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50175688((4-(4-(benzo[b]thiophen-2-yl)pyrimidin-2-ylamino)p...)
Affinity DataIC50:  500nMAssay Description:Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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