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PubMed code 16434192

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50181042
PNG
(7-nitro-N-(5-(piperidin-1-yl)pentyl)benzo[c][1,2,5...)
Show SMILES [O-][N+](=O)c1ccc(NCCCCCN2CCCCC2)c2nonc12
Show InChI InChI=1S/C16H23N5O3/c22-21(23)14-8-7-13(15-16(14)19-24-18-15)17-9-3-1-4-10-20-11-5-2-6-12-20/h7-8,17H,1-6,9-12H2
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PubMed
11n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-Universität

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 16: 1938-40 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.084
BindingDB Entry DOI: 10.7270/Q237789Z
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50181040
PNG
(2-(6-(piperidin-1-yl)hexyl)-2H-isoindole-1-carboni...)
Show SMILES N#Cc1n(CCCCCCN2CCCCC2)cc2ccccc12
Show InChI InChI=1S/C20H27N3/c21-16-20-19-11-5-4-10-18(19)17-23(20)15-9-2-1-6-12-22-13-7-3-8-14-22/h4-5,10-11,17H,1-3,6-9,12-15H2
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31n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-Universität

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 16: 1938-40 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.084
BindingDB Entry DOI: 10.7270/Q237789Z
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50181043
PNG
(2-(5-(piperidin-1-yl)pentyl)-2H-isoindole-1-carbon...)
Show SMILES N#Cc1n(CCCCCN2CCCCC2)cc2ccccc12
Show InChI InChI=1S/C19H25N3/c20-15-19-18-10-4-3-9-17(18)16-22(19)14-8-2-7-13-21-11-5-1-6-12-21/h3-4,9-10,16H,1-2,5-8,11-14H2
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31n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-Universität

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 16: 1938-40 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.084
BindingDB Entry DOI: 10.7270/Q237789Z
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50181041
PNG
(7-nitro-N-(4-(piperidin-1-yl)butyl)benzo[c][1,2,5]...)
Show SMILES [O-][N+](=O)c1ccc(NCCCCN2CCCCC2)c2nonc12
Show InChI InChI=1S/C15H21N5O3/c21-20(22)13-7-6-12(14-15(13)18-23-17-14)16-8-2-5-11-19-9-3-1-4-10-19/h6-7,16H,1-5,8-11H2
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170n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-Universität

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 16: 1938-40 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.084
BindingDB Entry DOI: 10.7270/Q237789Z
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50181045
PNG
(2-(4-(piperidin-1-yl)butyl)-2H-isoindole-1-carboni...)
Show SMILES N#Cc1n(CCCCN2CCCCC2)cc2ccccc12
Show InChI InChI=1S/C18H23N3/c19-14-18-17-9-3-2-8-16(17)15-21(18)13-7-6-12-20-10-4-1-5-11-20/h2-3,8-9,15H,1,4-7,10-13H2
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178n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-Universität

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 16: 1938-40 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.084
BindingDB Entry DOI: 10.7270/Q237789Z
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50181044
PNG
(2-(3-(piperidin-1-yl)propyl)-2H-isoindole-1-carbon...)
Show SMILES N#Cc1n(CCCN2CCCCC2)cc2ccccc12
Show InChI InChI=1S/C17H21N3/c18-13-17-16-8-3-2-7-15(16)14-20(17)12-6-11-19-9-4-1-5-10-19/h2-3,7-8,14H,1,4-6,9-12H2
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351n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-Universität

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHOK1 cells


Bioorg Med Chem Lett 16: 1938-40 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.084
BindingDB Entry DOI: 10.7270/Q237789Z
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%