Compile Data Set for Download or QSAR
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Found 40 Enz. Inhib. hit(s) with all data for entry = 2247
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18161((1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethy...)
Affinity DataKi:  0.200nM EC50:  5.10nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18561(6-alkyl, 7-amino-2-quinolinone, 11c | 7-amino-6-pr...)
Affinity DataKi:  9nM IC50:  19nM EC50:  83nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18538(8-ethyl-4-(trifluoromethyl)-1H,2H,6H,7H,8H,9H-pyri...)
Affinity DataKi:  11nM ΔG°:  -47.3kJ/mole IC50:  14nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18562(6-alkyl, 7-amino-2-quinolinone, 11d (+/-) | 7-amin...)
Affinity DataKi:  13nM IC50:  14nM EC50:  65nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18552(7-[(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl...)
Affinity DataKi:  15nM ΔG°:  -46.5kJ/mole IC50:  21nM EC50:  905nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18571(6-[(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl...)
Affinity DataKi:  16nM IC50:  18nM EC50:  108nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18560(6-alkyl, 7-amino-2-quinolinone, 11b | 7-amino-6-et...)
Affinity DataKi:  20nM IC50:  23nM EC50:  593nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18542(7-(ethylamino)-4-(trifluoromethyl)-1,2-dihydroquin...)
Affinity DataKi:  29nM ΔG°:  -44.8kJ/mole IC50:  35nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18557(7-[ethyl(2,2,2-trifluoroethyl)amino]-4-(trifluorom...)
Affinity DataKi:  30nM ΔG°:  -44.7kJ/mole IC50:  42nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18559(6-alkyl, 7-amino-2-quinolinone, 11a | 7-amino-6-me...)
Affinity DataKi:  30nM IC50:  76nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18553(7-[(2,2,3,3,3-pentafluoropropyl)amino]-4-(trifluor...)
Affinity DataKi:  36nM ΔG°:  -44.2kJ/mole IC50:  58nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18539(7-(propylamino)-4-(trifluoromethyl)-1,2-dihydroqui...)
Affinity DataKi:  37nM ΔG°:  -44.1kJ/mole IC50:  32nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18543(7-(butylamino)-4-(trifluoromethyl)-1,2-dihydroquin...)
Affinity DataKi:  50nM ΔG°:  -43.3kJ/mole IC50:  67nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18575(6-[(2,2-dimethylpropyl)amino]-4-(trifluoromethyl)-...)
Affinity DataKi:  56nM IC50:  27nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18574(6-[(2-methylpropyl)amino]-4-(trifluoromethyl)-1,2-...)
Affinity DataKi:  59nM IC50:  22nM EC50:  404nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18545(7-[(2-methylpropyl)amino]-4-(trifluoromethyl)-1,2-...)
Affinity DataKi:  65nM ΔG°:  -42.7kJ/mole IC50:  74nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18537(8,8-dimethyl-4-(trifluoromethyl)-1H,2H,8H,9H-pyrid...)
Affinity DataKi:  73nM ΔG°:  -42.4kJ/mole IC50:  27nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18573(6-(cyclopentylamino)-4-(trifluoromethyl)-1,2-dihyd...)
Affinity DataKi:  74nM IC50:  42nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18572(6-[(2,2,3,3,3-pentafluoropropyl)amino]-4-(trifluor...)
Affinity DataKi:  78nM IC50:  17nM EC50:  246nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18544(7-(propan-2-ylamino)-4-(trifluoromethyl)-1,2-dihyd...)
Affinity DataKi:  79nM ΔG°:  -42.2kJ/mole IC50:  56nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18541(7-(methylamino)-4-(trifluoromethyl)-1,2-dihydroqui...)
Affinity DataKi:  83nM ΔG°:  -42.0kJ/mole IC50:  30nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18547(7-[(2-methylbutan-2-yl)amino]-4-(trifluoromethyl)-...)
Affinity DataKi:  110nM ΔG°:  -41.3kJ/mole IC50:  209nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18548(7-[(2-methylbut-3-en-2-yl)amino]-4-(trifluoromethy...)
Affinity DataKi:  118nM ΔG°:  -41.1kJ/mole IC50:  122nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18546(7-[(2,2-dimethylpropyl)amino]-4-(trifluoromethyl)-...)
Affinity DataKi:  134nM ΔG°:  -40.8kJ/mole IC50:  98nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataKi:  151nM IC50:  162nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18566(6-alkyl, 7-alkylamino-2-quinolinone, 11h | 6-ethyl...)
Affinity DataKi:  157nM IC50:  216nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18549(7-(cyclobutylamino)-4-(trifluoromethyl)-1,2-dihydr...)
Affinity DataKi:  161nM ΔG°:  -40.3kJ/mole IC50:  43nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18554(7-(benzylamino)-4-(trifluoromethyl)-1,2-dihydroqui...)
Affinity DataKi:  163nM ΔG°:  -40.3kJ/mole IC50:  294nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18558(7-[propyl(2,2,2-trifluoroethyl)amino]-4-(trifluoro...)
Affinity DataKi:  241nM IC50:  549nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18540(7-amino-4-(trifluoromethyl)-1,2-dihydroquinolin-2-...)
Affinity DataKi:  407nM ΔG°:  -37.9kJ/mole IC50:  28nM EC50:  1.30E+3nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18556(7-(diethylamino)-4-(trifluoromethyl)-1,2-dihydroqu...)
Affinity DataKi:  463nM ΔG°:  -37.6kJ/mole IC50:  591nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18563(6-alkyl, 7-alkylamino-2-quinolinone, 11e | 6-methy...)
Affinity DataKi:  641nM IC50:  674nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18564(6-alkyl, 7-alkylamino-2-quinolinone, 11f | 6-methy...)
Affinity DataKi:  650nM IC50:  301nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18555(7-(dimethylamino)-4-(trifluoromethyl)-1,2-dihydroq...)
Affinity DataKi:  761nM ΔG°:  -36.3kJ/mole IC50:  1.16E+3nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18565(6-alkyl, 7-alkylamino-2-quinolinone, 11g | 6-ethyl...)
Affinity DataKi:  869nM IC50:  504nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18550(7-(cyclopentylamino)-4-(trifluoromethyl)-1,2-dihyd...)
Affinity DataKi:  1.00E+3nM ΔG°:  -35.6kJ/mole IC50:  149nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18551(7-(cyclohexylamino)-4-(trifluoromethyl)-1,2-dihydr...)
Affinity DataKi:  1.00E+3nM ΔG°:  -35.6kJ/mole IC50:  507nMpH: 7.4 T: 2°CAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18567(7-[(2,2,2-trifluoroethyl)amino]-4-(trifluoromethyl...)
Affinity DataIC50:  50nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18568(7-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)
Affinity DataIC50:  63nM EC50:  73nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18570(6-(ethylamino)-4-(trifluoromethyl)-1,2-dihydroquin...)
Affinity DataIC50:  111nMAssay Description:The compounds were evaluated in a transcriptional activation assay with hAR in a mammalian cell background (CV-1) as the primary in vitro assay. Rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed