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PubMed code 17279740

Compile data set for download or QSAR
Found 191 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204512
PNG
(2-(7-phenylheptanoyl)oxazole-5-carbonitrile | CHEM...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)C#N
Show InChI InChI=1S/C17H18N2O2/c18-12-15-13-19-17(21-15)16(20)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,13H,1-2,4,7-8,11H2
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0.400n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204478
PNG
(1-(5-(4-methylpyridin-2-yl)oxazol-2-yl)-7-phenylhe...)
Show SMILES Cc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O2/c1-17-13-14-23-19(15-17)21-16-24-22(26-21)20(25)12-8-3-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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0.600n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204483
PNG
(7-phenyl-1-(5-(trifluoromethyl)oxazol-2-yl)heptan-...)
Show SMILES FC(F)(F)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H18F3NO2/c18-17(19,20)15-12-21-16(23-15)14(22)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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0.800n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204510
PNG
(1-(5-(4-methoxypyridin-2-yl)oxazol-2-yl)-7-phenylh...)
Show SMILES COc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O3/c1-26-18-13-14-23-19(15-18)21-16-24-22(27-21)20(25)12-8-3-2-5-9-17-10-6-4-7-11-17/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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0.800n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204490
PNG
(CHEMBL220784 | methyl 2-(7-phenylheptanoyl)oxazole...)
Show SMILES COC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C18H21NO4/c1-22-18(21)16-13-19-17(23-16)15(20)12-8-3-2-5-9-14-10-6-4-7-11-14/h4,6-7,10-11,13H,2-3,5,8-9,12H2,1H3
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0.900n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204496
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)picolinamide |...)
Show SMILES NC(=O)c1cccc(n1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H23N3O3/c23-21(27)18-13-8-12-17(25-18)20-15-24-22(28-20)19(26)14-7-2-1-4-9-16-10-5-3-6-11-16/h3,5-6,8,10-13,15H,1-2,4,7,9,14H2,(H2,23,27)
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1n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204512
PNG
(2-(7-phenylheptanoyl)oxazole-5-carbonitrile | CHEM...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)C#N
Show InChI InChI=1S/C17H18N2O2/c18-12-15-13-19-17(21-15)16(20)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,13H,1-2,4,7-8,11H2
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1n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in COS7 cells by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204503
PNG
(2-(2-(7-phenylheptanoyl)oxazol-5-yl)isonicotinonit...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cc(ccn1)C#N
Show InChI InChI=1S/C22H21N3O2/c23-15-18-12-13-24-19(14-18)21-16-25-22(27-21)20(26)11-7-2-1-4-8-17-9-5-3-6-10-17/h3,5-6,9-10,12-14,16H,1-2,4,7-8,11H2
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1.10n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411285
PNG
(CHEMBL219943)
Show SMILES NC(=O)c1ccc(nc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H23N3O3/c23-21(27)17-12-13-18(24-14-17)20-15-25-22(28-20)19(26)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2,(H2,23,27)
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1.20n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204499
PNG
(CHEMBL220379 | methyl 2-(2-(7-phenylheptanoyl)oxaz...)
Show SMILES COC(=O)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H24N2O4/c1-28-23(27)18-13-14-24-19(15-18)21-16-25-22(29-21)20(26)12-8-3-2-5-9-17-10-6-4-7-11-17/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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1.30n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50400835
PNG
(CHEMBL219660)
Show SMILES CC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C18H21NO3/c1-14(20)17-13-19-18(22-17)16(21)12-8-3-2-5-9-15-10-6-4-7-11-15/h4,6-7,10-11,13H,2-3,5,8-9,12H2,1H3
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2n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204511
PNG
(3-(2-(7-phenylheptanoyl)oxazol-5-yl)benzenesulfona...)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O4S/c23-29(26,27)19-13-8-12-18(15-19)21-16-24-22(28-21)20(25)14-7-2-1-4-9-17-10-5-3-6-11-17/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2,(H2,23,26,27)
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2n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50400836
PNG
(CHEMBL219659)
Show SMILES CN(C)C(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C19H24N2O3/c1-21(2)19(23)17-14-20-18(24-17)16(22)13-9-4-3-6-10-15-11-7-5-8-12-15/h5,7-8,11-12,14H,3-4,6,9-10,13H2,1-2H3
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2n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204491
PNG
(1-(5-(4-fluoropyridin-2-yl)oxazol-2-yl)-7-phenylhe...)
Show SMILES Fc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H21FN2O2/c22-17-12-13-23-18(14-17)20-15-24-21(26-20)19(25)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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2n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50163177
PNG
(7-Phenyl-1-(5-pyrimidin-4-yl-oxazol-2-yl)-heptan-1...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccncn1
Show InChI InChI=1S/C20H21N3O2/c24-18(11-7-2-1-4-8-16-9-5-3-6-10-16)20-22-14-19(25-20)17-12-13-21-15-23-17/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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2.30n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411291
PNG
(CHEMBL220377)
Show SMILES Cc1ccc(nc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O2/c1-17-13-14-19(23-15-17)21-16-24-22(26-21)20(25)12-8-3-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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2.80n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50400832
PNG
(CHEMBL220555)
Show SMILES Ic1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C16H18INO2/c17-15-12-18-16(20-15)14(19)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204475
PNG
(1-(5-bromooxazol-2-yl)-7-phenylheptan-1-one | CHEM...)
Show SMILES Brc1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C16H18BrNO2/c17-15-12-18-16(20-15)14(19)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411287
PNG
(CHEMBL220312)
Show SMILES NS(=O)(=O)c1ccc(s1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C20H22N2O4S2/c21-28(24,25)19-13-12-18(27-19)17-14-22-20(26-17)16(23)11-7-2-1-4-8-15-9-5-3-6-10-15/h3,5-6,9-10,12-14H,1-2,4,7-8,11H2,(H2,21,24,25)
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3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204534
PNG
(1-(5-(4-nitropyridin-2-yl)oxazol-2-yl)-7-phenylhep...)
Show SMILES [O-][N+](=O)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H21N3O4/c25-19(11-7-2-1-4-8-16-9-5-3-6-10-16)21-23-15-20(28-21)18-14-17(24(26)27)12-13-22-18/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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3.20n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411295
PNG
(CHEMBL220783)
Show SMILES Cc1cccc(n1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O2/c1-17-10-9-14-19(24-17)21-16-23-22(26-21)20(25)15-8-3-2-5-11-18-12-6-4-7-13-18/h4,6-7,9-10,12-14,16H,2-3,5,8,11,15H2,1H3
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3.30n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411286
PNG
(CHEMBL374708)
Show SMILES COC(=O)c1ccc(nc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H24N2O4/c1-28-23(27)18-13-14-19(24-15-18)21-16-25-22(29-21)20(26)12-8-3-2-5-9-17-10-6-4-7-11-17/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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3.5n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204522
PNG
(7-phenyl-1-(5-(4-(trifluoromethyl)pyridin-2-yl)oxa...)
Show SMILES FC(F)(F)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H21F3N2O2/c23-22(24,25)17-12-13-26-18(14-17)20-15-27-21(29-20)19(28)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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3.5n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50400833
PNG
(CHEMBL220378)
Show SMILES FC(F)(F)C(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C18H18F3NO3/c19-18(20,21)16(24)15-12-22-17(25-15)14(23)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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4n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM23120
PNG
(7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]hepta...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccccn1
Show InChI InChI=1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2
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4.70n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50400831
PNG
(CHEMBL220613)
Show SMILES Clc1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C16H18ClNO2/c17-15-12-18-16(20-15)14(19)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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5n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204525
PNG
(2-(7-phenylheptanoyl)oxazole-5-carboxamide | CHEMB...)
Show SMILES NC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H20N2O3/c18-16(21)15-12-19-17(22-15)14(20)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2,(H2,18,21)
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5n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204509
PNG
(1-(5-(2,6-dimethoxypyrimidin-4-yl)oxazol-2-yl)-7-p...)
Show SMILES COc1cc(nc(OC)n1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H25N3O4/c1-27-20-14-17(24-22(25-20)28-2)19-15-23-21(29-19)18(26)13-9-4-3-6-10-16-11-7-5-8-12-16/h5,7-8,11-12,14-15H,3-4,6,9-10,13H2,1-2H3
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5n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204497
PNG
(3-(2-(7-phenylheptanoyl)oxazol-5-yl)benzoic acid |...)
Show SMILES OC(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H23NO4/c25-20(14-7-2-1-4-9-17-10-5-3-6-11-17)22-24-16-21(28-22)18-12-8-13-19(15-18)23(26)27/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2,(H,26,27)
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5n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50163207
PNG
(7-Phenyl-1-(5-pyrimidin-2-yl-oxazol-2-yl)-heptan-1...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ncccn1
Show InChI InChI=1S/C20H21N3O2/c24-17(12-7-2-1-4-9-16-10-5-3-6-11-16)20-23-15-18(25-20)19-21-13-8-14-22-19/h3,5-6,8,10-11,13-15H,1-2,4,7,9,12H2
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5.30n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411305
PNG
(CHEMBL220615)
Show SMILES COC(=O)c1ccc(o1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H23NO5/c1-26-22(25)19-14-13-18(27-19)20-15-23-21(28-20)17(24)12-8-3-2-5-9-16-10-6-4-7-11-16/h4,6-7,10-11,13-15H,2-3,5,8-9,12H2,1H3
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5.5n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50400834
PNG
(CHEMBL220727)
Show SMILES O=Cc1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H19NO3/c19-13-15-12-18-17(21-15)16(20)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2
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6n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204479
PNG
(3-(2-(7-phenylheptanoyl)oxazol-5-yl)benzamide | CH...)
Show SMILES NC(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H24N2O3/c24-22(27)19-13-8-12-18(15-19)21-16-25-23(28-21)20(26)14-7-2-1-4-9-17-10-5-3-6-11-17/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2,(H2,24,27)
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6n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204504
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)nicotinic acid...)
Show SMILES OC(=O)c1ccc(nc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-19(11-7-2-1-4-8-16-9-5-3-6-10-16)21-24-15-20(28-21)18-13-12-17(14-23-18)22(26)27/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2,(H,26,27)
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7n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411294
PNG
(CHEMBL219681)
Show SMILES CNC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C18H22N2O3/c1-19-17(22)16-13-20-18(23-16)15(21)12-8-3-2-5-9-14-10-6-4-7-11-14/h4,6-7,10-11,13H,2-3,5,8-9,12H2,1H3,(H,19,22)
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7n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411303
PNG
(CHEMBL219871)
Show SMILES COC(=O)c1ccc(s1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H23NO4S/c1-26-22(25)20-14-13-19(28-20)18-15-23-21(27-18)17(24)12-8-3-2-5-9-16-10-6-4-7-11-16/h4,6-7,10-11,13-15H,2-3,5,8-9,12H2,1H3
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7n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204485
PNG
(CHEMBL219880 | methyl 6-(2-(7-phenylheptanoyl)oxaz...)
Show SMILES COC(=O)c1cccc(n1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H24N2O4/c1-28-23(27)19-14-9-13-18(25-19)21-16-24-22(29-21)20(26)15-8-3-2-5-10-17-11-6-4-7-12-17/h4,6-7,9,11-14,16H,2-3,5,8,10,15H2,1H3
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8n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204524
PNG
(7-phenyl-1-(5-(piperidine-1-carbonyl)oxazol-2-yl)h...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)C(=O)N1CCCCC1
Show InChI InChI=1S/C22H28N2O3/c25-19(14-8-2-1-5-11-18-12-6-3-7-13-18)21-23-17-20(27-21)22(26)24-15-9-4-10-16-24/h3,6-7,12-13,17H,1-2,4-5,8-11,14-16H2
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8n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204504
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)nicotinic acid...)
Show SMILES OC(=O)c1ccc(nc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-19(11-7-2-1-4-8-16-9-5-3-6-10-16)21-24-15-20(28-21)18-13-12-17(14-23-18)22(26)27/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2,(H,26,27)
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8n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in COS7 cells by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204514
PNG
(4-(2-(7-phenylheptanoyl)oxazol-5-yl)benzenesulfona...)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O4S/c23-29(26,27)19-14-12-18(13-15-19)21-16-24-22(28-21)20(25)11-7-2-1-4-8-17-9-5-3-6-10-17/h3,5-6,9-10,12-16H,1-2,4,7-8,11H2,(H2,23,26,27)
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10n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411282
PNG
(CHEMBL220429)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)C(=O)N1CCSCC1
Show InChI InChI=1S/C21H26N2O3S/c24-18(11-7-2-1-4-8-17-9-5-3-6-10-17)20-22-16-19(26-20)21(25)23-12-14-27-15-13-23/h3,5-6,9-10,16H,1-2,4,7-8,11-15H2
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10n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204487
PNG
(4-(2-(7-phenylheptanoyl)oxazol-5-yl)benzamide | CH...)
Show SMILES NC(=O)c1ccc(cc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H24N2O3/c24-22(27)19-14-12-18(13-15-19)21-16-25-23(28-21)20(26)11-7-2-1-4-8-17-9-5-3-6-10-17/h3,5-6,9-10,12-16H,1-2,4,7-8,11H2,(H2,24,27)
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10n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411308
PNG
(CHEMBL373644)
Show SMILES OC(=O)c1ccc(s1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H21NO4S/c23-16(11-7-2-1-4-8-15-9-5-3-6-10-15)20-22-14-17(26-20)18-12-13-19(27-18)21(24)25/h3,5-6,9-10,12-14H,1-2,4,7-8,11H2,(H,24,25)
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11n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50157136
PNG
(1-(5-(furan-2-yl)oxazol-2-yl)-7-phenylheptan-1-one...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccco1
Show InChI InChI=1S/C20H21NO3/c22-17(20-21-15-19(24-20)18-13-8-14-23-18)12-7-2-1-4-9-16-10-5-3-6-11-16/h3,5-6,8,10-11,13-15H,1-2,4,7,9,12H2
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12n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204488
PNG
(CHEMBL223302 | methyl 3-(2-(7-phenylheptanoyl)oxaz...)
Show SMILES COC(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-28-24(27)20-14-9-13-19(16-20)22-17-25-23(29-22)21(26)15-8-3-2-5-10-18-11-6-4-7-12-18/h4,6-7,9,11-14,16-17H,2-3,5,8,10,15H2,1H3
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12n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204527
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)pyrimidine-2,4...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cc(=O)[nH]c(=O)[nH]1
Show InChI InChI=1S/C20H21N3O4/c24-16(11-7-2-1-4-8-14-9-5-3-6-10-14)19-21-13-17(27-19)15-12-18(25)23-20(26)22-15/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2,(H2,22,23,25,26)
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12n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204505
PNG
(5-(2-(7-phenylheptanoyl)oxazol-5-yl)furan-2-carbox...)
Show SMILES OC(=O)c1ccc(o1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H21NO5/c23-16(11-7-2-1-4-8-15-9-5-3-6-10-15)20-22-14-19(27-20)17-12-13-18(26-17)21(24)25/h3,5-6,9-10,12-14H,1-2,4,7-8,11H2,(H,24,25)
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15n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204539
PNG
(3-(2-(7-phenylheptanoyl)oxazol-5-yl)benzonitrile |...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cccc(c1)C#N
Show InChI InChI=1S/C23H22N2O2/c24-16-19-12-8-13-20(15-19)22-17-25-23(27-22)21(26)14-7-2-1-4-9-18-10-5-3-6-11-18/h3,5-6,8,10-13,15,17H,1-2,4,7,9,14H2
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15n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411297
PNG
(CHEMBL219632)
Show SMILES Cc1cccnc1-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O2/c1-17-10-9-15-23-21(17)20-16-24-22(26-20)19(25)14-8-3-2-5-11-18-12-6-4-7-13-18/h4,6-7,9-10,12-13,15-16H,2-3,5,8,11,14H2,1H3
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15n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411283
PNG
(CHEMBL374117)
Show SMILES FC(F)(F)C(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C24H22F3NO3/c25-24(26,27)22(30)19-13-8-12-18(15-19)21-16-28-23(31-21)20(29)14-7-2-1-4-9-17-10-5-3-6-11-17/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2
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16n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204557
PNG
(1-(5-(3-aminophenyl)oxazol-2-yl)-7-phenylheptan-1-...)
Show SMILES Nc1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O2/c23-19-13-8-12-18(15-19)21-16-24-22(26-21)20(25)14-7-2-1-4-9-17-10-5-3-6-11-17/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14,23H2
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19n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204516
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)picolinic acid...)
Show SMILES OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-19(14-7-2-1-4-9-16-10-5-3-6-11-16)21-23-15-20(28-21)17-12-8-13-18(24-17)22(26)27/h3,5-6,8,10-13,15H,1-2,4,7,9,14H2,(H,26,27)
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20n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50163195
PNG
(7-Phenyl-1-(5-pyrimidin-5-yl-oxazol-2-yl)-heptan-1...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cncnc1
Show InChI InChI=1S/C20H21N3O2/c24-18(11-7-2-1-4-8-16-9-5-3-6-10-16)20-23-14-19(25-20)17-12-21-15-22-13-17/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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22n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411296
PNG
(CHEMBL375746)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)C(=O)N1CCOCC1
Show InChI InChI=1S/C21H26N2O4/c24-18(11-7-2-1-4-8-17-9-5-3-6-10-17)20-22-16-19(27-20)21(25)23-12-14-26-15-13-23/h3,5-6,9-10,16H,1-2,4,7-8,11-15H2
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24n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204523
PNG
(1-(5-(4-aminopyridin-2-yl)oxazol-2-yl)-7-phenylhep...)
Show SMILES Nc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H23N3O2/c22-17-12-13-23-18(14-17)20-15-24-21(26-20)19(25)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2,(H2,22,23)
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25n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50073987
PNG
(1,1,1-Trifluoro-9-phenyl-nonan-2-one | 1,1,1-trifl...)
Show SMILES FC(F)(F)C(=O)CCCCCCCc1ccccc1
Show InChI InChI=1S/C15H19F3O/c16-15(17,18)14(19)12-8-3-1-2-5-9-13-10-6-4-7-11-13/h4,6-7,10-11H,1-3,5,8-9,12H2
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25n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50400830
PNG
(CHEMBL219954)
Show SMILES CSc1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H21NO2S/c1-21-16-13-18-17(20-16)15(19)12-8-3-2-5-9-14-10-6-4-7-11-14/h4,6-7,10-11,13H,2-3,5,8-9,12H2,1H3
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25n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204492
PNG
(1-(5-(2,4-dimethoxypyrimidin-5-yl)oxazol-2-yl)-7-p...)
Show SMILES COc1ncc(-c2cnc(o2)C(=O)CCCCCCc2ccccc2)c(OC)n1
Show InChI InChI=1S/C22H25N3O4/c1-27-20-17(14-24-22(25-20)28-2)19-15-23-21(29-19)18(26)13-9-4-3-6-10-16-11-7-5-8-12-16/h5,7-8,11-12,14-15H,3-4,6,9-10,13H2,1-2H3
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26n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204516
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)picolinic acid...)
Show SMILES OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-19(14-7-2-1-4-9-16-10-5-3-6-11-16)21-23-15-20(28-21)17-12-8-13-18(24-17)22(26)27/h3,5-6,8,10-13,15H,1-2,4,7,9,14H2,(H,26,27)
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26n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in COS7 cells by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204559
PNG
(1-(5-(3-nitrophenyl)oxazol-2-yl)-7-phenylheptan-1-...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-20(14-7-2-1-4-9-17-10-5-3-6-11-17)22-23-16-21(28-22)18-12-8-13-19(15-18)24(26)27/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2
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28n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204506
PNG
(2-(7-phenylheptanoyl)oxazole-5-carboxylic acid | C...)
Show SMILES OC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H19NO4/c19-14(16-18-12-15(22-16)17(20)21)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2,(H,20,21)
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30n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50374375
PNG
(CHEMBL373906)
Show SMILES Fc1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C16H18FNO2/c17-15-12-18-16(20-15)14(19)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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30n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204506
PNG
(2-(7-phenylheptanoyl)oxazole-5-carboxylic acid | C...)
Show SMILES OC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H19NO4/c19-14(16-18-12-15(22-16)17(20)21)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2,(H,20,21)
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32n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human FAAH expressed in COS7 cells by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204500
PNG
(CHEMBL220005 | methyl 4-(2-(7-phenylheptanoyl)oxaz...)
Show SMILES COC(=O)c1ccc(cc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-28-24(27)20-15-13-19(14-16-20)22-17-25-23(29-22)21(26)12-8-3-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-11,13-17H,2-3,5,8-9,12H2,1H3
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40n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204513
PNG
(4-(2-(7-phenylheptanoyl)oxazol-5-yl)benzonitrile |...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H22N2O2/c24-16-19-12-14-20(15-13-19)22-17-25-23(27-22)21(26)11-7-2-1-4-8-18-9-5-3-6-10-18/h3,5-6,9-10,12-15,17H,1-2,4,7-8,11H2
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40n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204531
PNG
(1-(5-(3-methoxyphenyl)oxazol-2-yl)-7-phenylheptan-...)
Show SMILES COc1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H25NO3/c1-26-20-14-9-13-19(16-20)22-17-24-23(27-22)21(25)15-8-3-2-5-10-18-11-6-4-7-12-18/h4,6-7,9,11-14,16-17H,2-3,5,8,10,15H2,1H3
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40n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204493
PNG
(1-(oxazol-2-yl)-7-phenylheptan-1-one | CHEMBL22012...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncco1
Show InChI InChI=1S/C16H19NO2/c18-15(16-17-12-13-19-16)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2
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48n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204549
PNG
(1-(5-(3-fluorophenyl)oxazol-2-yl)-7-phenylheptan-1...)
Show SMILES Fc1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22FNO2/c23-19-13-8-12-18(15-19)21-16-24-22(26-21)20(25)14-7-2-1-4-9-17-10-5-3-6-11-17/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2
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50n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204542
PNG
(1-(5-(3-hydroxyphenyl)oxazol-2-yl)-7-phenylheptan-...)
Show SMILES Oc1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H23NO3/c24-19-13-8-12-18(15-19)21-16-23-22(26-21)20(25)14-7-2-1-4-9-17-10-5-3-6-11-17/h3,5-6,8,10-13,15-16,24H,1-2,4,7,9,14H2
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50n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411280
PNG
(CHEMBL219931)
Show SMILES OC(=O)c1cccnc1-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-18(13-7-2-1-4-9-16-10-5-3-6-11-16)21-24-15-19(28-21)20-17(22(26)27)12-8-14-23-20/h3,5-6,8,10-12,14-15H,1-2,4,7,9,13H2,(H,26,27)
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>50n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204530
PNG
(1-(5-(4-nitrophenyl)oxazol-2-yl)-7-phenylheptan-1-...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-20(11-7-2-1-4-8-17-9-5-3-6-10-17)22-23-16-21(28-22)18-12-14-19(15-13-18)24(26)27/h3,5-6,9-10,12-16H,1-2,4,7-8,11H2
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50n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411293
PNG
(CHEMBL220892)
Show SMILES OC(=O)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-19(11-7-2-1-4-8-16-9-5-3-6-10-16)21-24-15-20(28-21)18-14-17(22(26)27)12-13-23-18/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2,(H,26,27)
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50n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50163166
PNG
(7-Phenyl-1-(5-thiophen-2-yl-oxazol-2-yl)-heptan-1-...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cccs1
Show InChI InChI=1S/C20H21NO2S/c22-17(20-21-15-18(23-20)19-13-8-14-24-19)12-7-2-1-4-9-16-10-5-3-6-11-16/h3,5-6,8,10-11,13-15H,1-2,4,7,9,12H2
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55n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204561
PNG
(4-(2-(7-phenylheptanoyl)oxazol-5-yl)benzoic acid |...)
Show SMILES OC(=O)c1ccc(cc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H23NO4/c25-20(11-7-2-1-4-8-17-9-5-3-6-10-17)22-24-16-21(28-22)18-12-14-19(15-13-18)23(26)27/h3,5-6,9-10,12-16H,1-2,4,7-8,11H2,(H,26,27)
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60n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204501
PNG
(CHEMBL223435 | methyl 2-(2-(7-phenylheptanoyl)oxaz...)
Show SMILES COC(=O)c1ccccc1-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C24H25NO4/c1-28-24(27)20-15-10-9-14-19(20)22-17-25-23(29-22)21(26)16-8-3-2-5-11-18-12-6-4-7-13-18/h4,6-7,9-10,12-15,17H,2-3,5,8,11,16H2,1H3
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60n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204521
PNG
(1-(5-(4-fluorophenyl)oxazol-2-yl)-7-phenylheptan-1...)
Show SMILES Fc1ccc(cc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22FNO2/c23-19-14-12-18(13-15-19)21-16-24-22(26-21)20(25)11-7-2-1-4-8-17-9-5-3-6-10-17/h3,5-6,9-10,12-16H,1-2,4,7-8,11H2
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62n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411299
PNG
(CHEMBL220730)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1nnn[nH]1
Show InChI InChI=1S/C17H19N5O2/c23-14(17-18-12-15(24-17)16-19-21-22-20-16)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2,(H,19,20,21,22)
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63n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411284
PNG
(CHEMBL220326)
Show SMILES FC(F)(F)C(=O)c1ccc(cc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C24H22F3NO3/c25-24(26,27)22(30)19-14-12-18(13-15-19)21-16-28-23(31-21)20(29)11-7-2-1-4-8-17-9-5-3-6-10-17/h3,5-6,9-10,12-16H,1-2,4,7-8,11H2
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65n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411304
PNG
(CHEMBL220680)
Show SMILES CN1CCN(CC1)C(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H29N3O3/c1-24-13-15-25(16-14-24)22(27)20-17-23-21(28-20)19(26)12-8-3-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-11,17H,2-3,5,8-9,12-16H2,1H3
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80n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50374374
PNG
(CHEMBL220938)
Show SMILES Cc1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H21NO2/c1-14-13-18-17(20-14)16(19)12-8-3-2-5-9-15-10-6-4-7-11-15/h4,6-7,10-11,13H,2-3,5,8-9,12H2,1H3
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80n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50163187
PNG
(7-Phenyl-1-(5-phenyl-oxazol-2-yl)-heptan-1-one | 7...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccccc1
Show InChI InChI=1S/C22H23NO2/c24-20(16-10-2-1-5-11-18-12-6-3-7-13-18)22-23-17-21(25-22)19-14-8-4-9-15-19/h3-4,6-9,12-15,17H,1-2,5,10-11,16H2
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80n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204566
PNG
(1-(5-(4-aminophenyl)oxazol-2-yl)-7-phenylheptan-1-...)
Show SMILES Nc1ccc(cc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O2/c23-19-14-12-18(13-15-19)21-16-24-22(26-21)20(25)11-7-2-1-4-8-17-9-5-3-6-10-17/h3,5-6,9-10,12-16H,1-2,4,7-8,11,23H2
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90n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204563
PNG
(1-(5-(4-methoxyphenyl)oxazol-2-yl)-7-phenylheptan-...)
Show SMILES COc1ccc(cc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H25NO3/c1-26-20-15-13-19(14-16-20)22-17-24-23(27-22)21(25)12-8-3-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-11,13-17H,2-3,5,8-9,12H2,1H3
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100n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204570
PNG
(1-(5-(2-fluorophenyl)oxazol-2-yl)-7-phenylheptan-1...)
Show SMILES Fc1ccccc1-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22FNO2/c23-19-14-9-8-13-18(19)21-16-24-22(26-21)20(25)15-7-2-1-4-10-17-11-5-3-6-12-17/h3,5-6,8-9,11-14,16H,1-2,4,7,10,15H2
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110n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50374376
PNG
(CHEMBL220612)
Show SMILES COC(=O)c1cccnc1-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H24N2O4/c1-28-23(27)18-13-9-15-24-21(18)20-16-25-22(29-20)19(26)14-8-3-2-5-10-17-11-6-4-7-12-17/h4,6-7,9,11-13,15-16H,2-3,5,8,10,14H2,1H3
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130n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204554
PNG
(1-(5-(2-nitrophenyl)oxazol-2-yl)-7-phenylheptan-1-...)
Show SMILES [O-][N+](=O)c1ccccc1-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-20(15-7-2-1-4-10-17-11-5-3-6-12-17)22-23-16-21(28-22)18-13-8-9-14-19(18)24(26)27/h3,5-6,8-9,11-14,16H,1-2,4,7,10,15H2
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130n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204486
PNG
(2-(2-(7-phenylheptanoyl)oxazol-5-yl)benzonitrile |...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccccc1C#N
Show InChI InChI=1S/C23H22N2O2/c24-16-19-13-8-9-14-20(19)22-17-25-23(27-22)21(26)15-7-2-1-4-10-18-11-5-3-6-12-18/h3,5-6,8-9,11-14,17H,1-2,4,7,10,15H2
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130n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204526
PNG
(1-(5-(4-hydroxyphenyl)oxazol-2-yl)-7-phenylheptan-...)
Show SMILES Oc1ccc(cc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H23NO3/c24-19-14-12-18(13-15-19)21-16-23-22(26-21)20(25)11-7-2-1-4-8-17-9-5-3-6-10-17/h3,5-6,9-10,12-16,24H,1-2,4,7-8,11H2
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140n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204571
PNG
(1-(5-(2-hydroxyphenyl)oxazol-2-yl)-7-phenylheptan-...)
Show SMILES Oc1ccccc1-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H23NO3/c24-19-14-9-8-13-18(19)21-16-23-22(26-21)20(25)15-7-2-1-4-10-17-11-5-3-6-12-17/h3,5-6,8-9,11-14,16,24H,1-2,4,7,10,15H2
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170n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204562
PNG
(2-(2-(7-phenylheptanoyl)oxazol-5-yl)benzamide | CH...)
Show SMILES NC(=O)c1ccccc1-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H24N2O3/c24-22(27)19-14-9-8-13-18(19)21-16-25-23(28-21)20(26)15-7-2-1-4-10-17-11-5-3-6-12-17/h3,5-6,8-9,11-14,16H,1-2,4,7,10,15H2,(H2,24,27)
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300n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204529
PNG
(5-(2-(7-phenylheptanoyl)oxazol-5-yl)pyrimidine-2,4...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1c[nH]c(=O)[nH]c1=O
Show InChI InChI=1S/C20H21N3O4/c24-16(11-7-2-1-4-8-14-9-5-3-6-10-14)19-21-13-17(27-19)15-12-22-20(26)23-18(15)25/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2,(H2,22,23,25,26)
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350n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204476
PNG
(1-(5-(2-methoxyphenyl)oxazol-2-yl)-7-phenylheptan-...)
Show SMILES COc1ccccc1-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H25NO3/c1-26-21-16-10-9-14-19(21)22-17-24-23(27-22)20(25)15-8-3-2-5-11-18-12-6-4-7-13-18/h4,6-7,9-10,12-14,16-17H,2-3,5,8,11,15H2,1H3
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400n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204546
PNG
(1-(5-(2-aminophenyl)oxazol-2-yl)-7-phenylheptan-1-...)
Show SMILES Nc1ccccc1-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O2/c23-19-14-9-8-13-18(19)21-16-24-22(26-21)20(25)15-7-2-1-4-10-17-11-5-3-6-12-17/h3,5-6,8-9,11-14,16H,1-2,4,7,10,15,23H2
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750n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50069269
PNG
((R)-octan-2-yl 4-bromo-3-oxobutanoate | 4-Bromo-3-...)
Show SMILES CCCCCC[C@@H](C)OC(=O)CC(=O)CBr
Show InChI InChI=1S/C12H21BrO3/c1-3-4-5-6-7-10(2)16-12(15)8-11(14)9-13/h10H,3-9H2,1-2H3/t10-/m1/s1
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800n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204480
PNG
(2-(2-(7-phenylheptanoyl)oxazol-5-yl)benzenesulfona...)
Show SMILES NS(=O)(=O)c1ccccc1-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O4S/c23-29(26,27)21-15-9-8-13-18(21)20-16-24-22(28-20)19(25)14-7-2-1-4-10-17-11-5-3-6-12-17/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2,(H2,23,26,27)
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1.50E+3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411292
PNG
(CHEMBL375804)
Show SMILES COC(=O)c1cnc(o1)C(O)CCCCCCc1ccccc1
Show InChI InChI=1/C18H23NO4/c1-22-18(21)16-13-19-17(23-16)15(20)12-8-3-2-5-9-14-10-6-4-7-11-14/h4,6-7,10-11,13,15,20H,2-3,5,8-9,12H2,1H3
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2.00E+3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411278
PNG
(CHEMBL220447)
Show SMILES NC(=O)c1cccc(n1)-c1cnc(o1)C(O)CCCCCCc1ccccc1
Show InChI InChI=1/C22H25N3O3/c23-21(27)18-13-8-12-17(25-18)20-15-24-22(28-20)19(26)14-7-2-1-4-9-16-10-5-3-6-11-16/h3,5-6,8,10-13,15,19,26H,1-2,4,7,9,14H2,(H2,23,27)
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2.10E+3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411306
PNG
(CHEMBL220094)
Show SMILES OC(CCCCCCc1ccccc1)c1ncc(o1)C(F)(F)F
Show InChI InChI=1/C17H20F3NO2/c18-17(19,20)15-12-21-16(23-15)14(22)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12,14,22H,1-2,4,7-8,11H2
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2.30E+3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411277
PNG
(CHEMBL268184)
Show SMILES COC(=O)c1cccc(n1)-c1cnc(o1)C(O)CCCCCCc1ccccc1
Show InChI InChI=1/C23H26N2O4/c1-28-23(27)19-14-9-13-18(25-19)21-16-24-22(29-21)20(26)15-8-3-2-5-10-17-11-6-4-7-12-17/h4,6-7,9,11-14,16,20,26H,2-3,5,8,10,15H2,1H3
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2.30E+3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411290
PNG
(CHEMBL220991)
Show SMILES OC(CCCCCCc1ccccc1)c1ncc(o1)-c1cc(=O)[nH]c(=O)[nH]1
Show InChI InChI=1/C20H23N3O4/c24-16(11-7-2-1-4-8-14-9-5-3-6-10-14)19-21-13-17(27-19)15-12-18(25)23-20(26)22-15/h3,5-6,9-10,12-13,16,24H,1-2,4,7-8,11H2,(H2,22,23,25,26)
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2.50E+3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411289
PNG
(CHEMBL220067)
Show SMILES NC(=O)c1ccc(nc1)-c1cnc(o1)C(O)CCCCCCc1ccccc1
Show InChI InChI=1/C22H25N3O3/c23-21(27)17-12-13-18(24-14-17)20-15-25-22(28-20)19(26)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15,19,26H,1-2,4,7-8,11H2,(H2,23,27)
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3.00E+3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411281
PNG
(CHEMBL376536)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C32H36N2O4/c35-27(21-13-3-1-7-15-25-17-9-5-10-18-25)31-33-23-29(37-31)30-24-34-32(38-30)28(36)22-14-4-2-8-16-26-19-11-6-12-20-26/h5-6,9-12,17-20,23-24H,1-4,7-8,13-16,21-22H2
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3.50E+3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411301
PNG
(CHEMBL220572)
Show SMILES OC(CCCCCCc1ccccc1)c1ncc(o1)C#N
Show InChI InChI=1/C17H20N2O2/c18-12-15-13-19-17(21-15)16(20)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,13,16,20H,1-2,4,7-8,11H2
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4.20E+3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411279
PNG
(CHEMBL220012)
Show SMILES FC(F)(F)C(=O)c1ccccc1-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C24H22F3NO3/c25-24(26,27)22(30)19-14-9-8-13-18(19)21-16-28-23(31-21)20(29)15-7-2-1-4-10-17-11-5-3-6-12-17/h3,5-6,8-9,11-14,16H,1-2,4,7,10,15H2
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5.00E+3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204567
PNG
(2-(2-(7-phenylheptanoyl)oxazol-5-yl)benzoic acid |...)
Show SMILES OC(=O)c1ccccc1-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H23NO4/c25-20(15-7-2-1-4-10-17-11-5-3-6-12-17)22-24-16-21(28-22)18-13-8-9-14-19(18)23(26)27/h3,5-6,8-9,11-14,16H,1-2,4,7,10,15H2,(H,26,27)
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6.00E+3n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411300
PNG
(CHEMBL219741)
Show SMILES OC(CCCCCCc1ccccc1)c1ncc(o1)-c1cccc(n1)C(O)=O
Show InChI InChI=1/C22H24N2O4/c25-19(14-7-2-1-4-9-16-10-5-3-6-11-16)21-23-15-20(28-21)17-12-8-13-18(24-17)22(26)27/h3,5-6,8,10-13,15,19,25H,1-2,4,7,9,14H2,(H,26,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411298
PNG
(CHEMBL219740)
Show SMILES COC(=O)c1ccc(nc1)-c1cnc(o1)C(O)CCCCCCc1ccccc1
Show InChI InChI=1/C23H26N2O4/c1-28-23(27)18-13-14-19(24-15-18)21-16-25-22(29-21)20(26)12-8-3-2-5-9-17-10-6-4-7-11-17/h4,6-7,10-11,13-16,20,26H,2-3,5,8-9,12H2,1H3
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>1.00E+4n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411288
PNG
(CHEMBL219616)
Show SMILES CN(C)C(=O)c1cnc(o1)C(O)CCCCCCc1ccccc1
Show InChI InChI=1/C19H26N2O3/c1-21(2)19(23)17-14-20-18(24-17)16(22)13-9-4-3-6-10-15-11-7-5-8-12-15/h5,7-8,11-12,14,16,22H,3-4,6,9-10,13H2,1-2H3
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1.60E+4n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411307
PNG
(CHEMBL219615)
Show SMILES NC(=O)c1cnc(o1)C(O)CCCCCCc1ccccc1
Show InChI InChI=1/C17H22N2O3/c18-16(21)15-12-19-17(22-15)14(20)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12,14,20H,1-2,4,7-8,11H2,(H2,18,21)
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2.50E+4n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50411302
PNG
(CHEMBL424762)
Show SMILES OC(CCCCCCc1ccccc1)c1ncc(o1)-c1ccc(cn1)C(O)=O
Show InChI InChI=1/C22H24N2O4/c25-19(11-7-2-1-4-8-16-9-5-3-6-10-16)21-24-15-20(28-21)18-13-12-17(14-23-18)22(26)27/h3,5-6,9-10,12-15,19,25H,1-2,4,7-8,11H2,(H,26,27)
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4.50E+4n/an/an/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204499
PNG
(CHEMBL220379 | methyl 2-(2-(7-phenylheptanoyl)oxaz...)
Show SMILES COC(=O)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H24N2O4/c1-28-23(27)18-13-14-24-19(15-18)21-16-25-22(29-21)20(26)12-8-3-2-5-9-17-10-6-4-7-11-17/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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n/an/a 0.600n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204503
PNG
(2-(2-(7-phenylheptanoyl)oxazol-5-yl)isonicotinonit...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cc(ccn1)C#N
Show InChI InChI=1S/C22H21N3O2/c23-15-18-12-13-24-19(14-18)21-16-25-22(27-21)20(26)11-7-2-1-4-8-17-9-5-3-6-10-17/h3,5-6,9-10,12-14,16H,1-2,4,7-8,11H2
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n/an/a 0.800n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204478
PNG
(1-(5-(4-methylpyridin-2-yl)oxazol-2-yl)-7-phenylhe...)
Show SMILES Cc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O2/c1-17-13-14-23-19(15-17)21-16-24-22(26-21)20(25)12-8-3-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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n/an/a 1n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204522
PNG
(7-phenyl-1-(5-(4-(trifluoromethyl)pyridin-2-yl)oxa...)
Show SMILES FC(F)(F)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H21F3N2O2/c23-22(24,25)17-12-13-26-18(14-17)20-15-27-21(29-20)19(28)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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n/an/a 1.5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204534
PNG
(1-(5-(4-nitropyridin-2-yl)oxazol-2-yl)-7-phenylhep...)
Show SMILES [O-][N+](=O)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H21N3O4/c25-19(11-7-2-1-4-8-16-9-5-3-6-10-16)21-23-15-20(28-21)18-14-17(24(26)27)12-13-22-18/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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n/an/a 1.60n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204510
PNG
(1-(5-(4-methoxypyridin-2-yl)oxazol-2-yl)-7-phenylh...)
Show SMILES COc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O3/c1-26-18-13-14-23-19(15-18)21-16-24-22(27-21)20(25)12-8-3-2-5-9-17-10-6-4-7-11-17/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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n/an/a 1.70n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM23120
PNG
(7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]hepta...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccccn1
Show InChI InChI=1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2
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n/an/a 2n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204491
PNG
(1-(5-(4-fluoropyridin-2-yl)oxazol-2-yl)-7-phenylhe...)
Show SMILES Fc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H21FN2O2/c22-17-12-13-23-18(14-17)20-15-24-21(26-20)19(25)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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n/an/a 2.5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204527
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)pyrimidine-2,4...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cc(=O)[nH]c(=O)[nH]1
Show InChI InChI=1S/C20H21N3O4/c24-16(11-7-2-1-4-8-14-9-5-3-6-10-14)19-21-13-17(27-19)15-12-18(25)23-20(26)22-15/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2,(H2,22,23,25,26)
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n/an/a 5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204512
PNG
(2-(7-phenylheptanoyl)oxazole-5-carbonitrile | CHEM...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)C#N
Show InChI InChI=1S/C17H18N2O2/c18-12-15-13-19-17(21-15)16(20)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,13H,1-2,4,7-8,11H2
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n/an/a 6.5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204512
PNG
(2-(7-phenylheptanoyl)oxazole-5-carbonitrile | CHEM...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)C#N
Show InChI InChI=1S/C17H18N2O2/c18-12-15-13-19-17(21-15)16(20)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,13H,1-2,4,7-8,11H2
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n/an/a 20n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204493
PNG
(1-(oxazol-2-yl)-7-phenylheptan-1-one | CHEMBL22012...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncco1
Show InChI InChI=1S/C16H19NO2/c18-15(16-17-12-13-19-16)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2
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n/an/a 20n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204490
PNG
(CHEMBL220784 | methyl 2-(7-phenylheptanoyl)oxazole...)
Show SMILES COC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C18H21NO4/c1-22-18(21)16-13-19-17(23-16)15(20)12-8-3-2-5-9-14-10-6-4-7-11-14/h4,6-7,10-11,13H,2-3,5,8-9,12H2,1H3
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n/an/a 30n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204504
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)nicotinic acid...)
Show SMILES OC(=O)c1ccc(nc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-19(11-7-2-1-4-8-16-9-5-3-6-10-16)21-24-15-20(28-21)18-13-12-17(14-23-18)22(26)27/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2,(H,26,27)
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n/an/a 50n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204509
PNG
(1-(5-(2,6-dimethoxypyrimidin-4-yl)oxazol-2-yl)-7-p...)
Show SMILES COc1cc(nc(OC)n1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H25N3O4/c1-27-20-14-17(24-22(25-20)28-2)19-15-23-21(29-19)18(26)13-9-4-3-6-10-16-11-7-5-8-12-16/h5,7-8,11-12,14-15H,3-4,6,9-10,13H2,1-2H3
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n/an/a 70n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204483
PNG
(7-phenyl-1-(5-(trifluoromethyl)oxazol-2-yl)heptan-...)
Show SMILES FC(F)(F)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H18F3NO2/c18-17(19,20)15-12-21-16(23-15)14(22)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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n/an/a 77n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204475
PNG
(1-(5-bromooxazol-2-yl)-7-phenylheptan-1-one | CHEM...)
Show SMILES Brc1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C16H18BrNO2/c17-15-12-18-16(20-15)14(19)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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n/an/a 100n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204516
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)picolinic acid...)
Show SMILES OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-19(14-7-2-1-4-9-16-10-5-3-6-11-16)21-23-15-20(28-21)17-12-8-13-18(24-17)22(26)27/h3,5-6,8,10-13,15H,1-2,4,7,9,14H2,(H,26,27)
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n/an/a 100n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204475
PNG
(1-(5-bromooxazol-2-yl)-7-phenylheptan-1-one | CHEM...)
Show SMILES Brc1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C16H18BrNO2/c17-15-12-18-16(20-15)14(19)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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n/an/a 190n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204483
PNG
(7-phenyl-1-(5-(trifluoromethyl)oxazol-2-yl)heptan-...)
Show SMILES FC(F)(F)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H18F3NO2/c18-17(19,20)15-12-21-16(23-15)14(22)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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n/an/a 200n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204534
PNG
(1-(5-(4-nitropyridin-2-yl)oxazol-2-yl)-7-phenylhep...)
Show SMILES [O-][N+](=O)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H21N3O4/c25-19(11-7-2-1-4-8-16-9-5-3-6-10-16)21-23-15-20(28-21)18-14-17(24(26)27)12-13-22-18/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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n/an/a 200n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204511
PNG
(3-(2-(7-phenylheptanoyl)oxazol-5-yl)benzenesulfona...)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O4S/c23-29(26,27)19-13-8-12-18(15-19)21-16-24-22(28-21)20(25)14-7-2-1-4-9-17-10-5-3-6-11-17/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2,(H2,23,26,27)
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n/an/a 200n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204490
PNG
(CHEMBL220784 | methyl 2-(7-phenylheptanoyl)oxazole...)
Show SMILES COC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C18H21NO4/c1-22-18(21)16-13-19-17(23-16)15(20)12-8-3-2-5-9-14-10-6-4-7-11-14/h4,6-7,10-11,13H,2-3,5,8-9,12H2,1H3
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n/an/a 300n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204523
PNG
(1-(5-(4-aminopyridin-2-yl)oxazol-2-yl)-7-phenylhep...)
Show SMILES Nc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H23N3O2/c22-17-12-13-23-18(14-17)20-15-24-21(26-20)19(25)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2,(H2,22,23)
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n/an/a 340n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204525
PNG
(2-(7-phenylheptanoyl)oxazole-5-carboxamide | CHEMB...)
Show SMILES NC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H20N2O3/c18-16(21)15-12-19-17(22-15)14(20)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2,(H2,18,21)
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n/an/a 350n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204503
PNG
(2-(2-(7-phenylheptanoyl)oxazol-5-yl)isonicotinonit...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cc(ccn1)C#N
Show InChI InChI=1S/C22H21N3O2/c23-15-18-12-13-24-19(14-18)21-16-25-22(27-21)20(26)11-7-2-1-4-8-17-9-5-3-6-10-17/h3,5-6,9-10,12-14,16H,1-2,4,7-8,11H2
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n/an/a 400n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204509
PNG
(1-(5-(2,6-dimethoxypyrimidin-4-yl)oxazol-2-yl)-7-p...)
Show SMILES COc1cc(nc(OC)n1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H25N3O4/c1-27-20-14-17(24-22(25-20)28-2)19-15-23-21(29-19)18(26)13-9-4-3-6-10-16-11-7-5-8-12-16/h5,7-8,11-12,14-15H,3-4,6,9-10,13H2,1-2H3
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n/an/a 400n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204511
PNG
(3-(2-(7-phenylheptanoyl)oxazol-5-yl)benzenesulfona...)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O4S/c23-29(26,27)19-13-8-12-18(15-19)21-16-24-22(28-21)20(25)14-7-2-1-4-9-17-10-5-3-6-11-17/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2,(H2,23,26,27)
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n/an/a 400n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204524
PNG
(7-phenyl-1-(5-(piperidine-1-carbonyl)oxazol-2-yl)h...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)C(=O)N1CCCCC1
Show InChI InChI=1S/C22H28N2O3/c25-19(14-8-2-1-5-11-18-12-6-3-7-13-18)21-23-17-20(27-21)22(26)24-15-9-4-10-16-24/h3,6-7,12-13,17H,1-2,4-5,8-11,14-16H2
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n/an/a 450n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204510
PNG
(1-(5-(4-methoxypyridin-2-yl)oxazol-2-yl)-7-phenylh...)
Show SMILES COc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O3/c1-26-18-13-14-23-19(15-18)21-16-24-22(27-21)20(25)12-8-3-2-5-9-17-10-6-4-7-11-17/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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n/an/a 500n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM23120
PNG
(7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]hepta...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccccn1
Show InChI InChI=1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2
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n/an/a 600n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204491
PNG
(1-(5-(4-fluoropyridin-2-yl)oxazol-2-yl)-7-phenylhe...)
Show SMILES Fc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H21FN2O2/c22-17-12-13-23-18(14-17)20-15-24-21(26-20)19(25)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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n/an/a 600n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204529
PNG
(5-(2-(7-phenylheptanoyl)oxazol-5-yl)pyrimidine-2,4...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1c[nH]c(=O)[nH]c1=O
Show InChI InChI=1S/C20H21N3O4/c24-16(11-7-2-1-4-8-14-9-5-3-6-10-14)19-21-13-17(27-19)15-12-22-20(26)23-18(15)25/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2,(H2,22,23,25,26)
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n/an/a 680n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204505
PNG
(5-(2-(7-phenylheptanoyl)oxazol-5-yl)furan-2-carbox...)
Show SMILES OC(=O)c1ccc(o1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H21NO5/c23-16(11-7-2-1-4-8-15-9-5-3-6-10-15)20-22-14-19(27-20)17-12-13-18(26-17)21(24)25/h3,5-6,9-10,12-14H,1-2,4,7-8,11H2,(H,24,25)
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n/an/a 850n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204499
PNG
(CHEMBL220379 | methyl 2-(2-(7-phenylheptanoyl)oxaz...)
Show SMILES COC(=O)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H24N2O4/c1-28-23(27)18-13-14-24-19(15-18)21-16-25-22(29-21)20(26)12-8-3-2-5-9-17-10-6-4-7-11-17/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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n/an/a 900n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204506
PNG
(2-(7-phenylheptanoyl)oxazole-5-carboxylic acid | C...)
Show SMILES OC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H19NO4/c19-14(16-18-12-15(22-16)17(20)21)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2,(H,20,21)
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n/an/a 970n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204497
PNG
(3-(2-(7-phenylheptanoyl)oxazol-5-yl)benzoic acid |...)
Show SMILES OC(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H23NO4/c25-20(14-7-2-1-4-9-17-10-5-3-6-11-17)22-24-16-21(28-22)18-12-8-13-19(15-18)23(26)27/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2,(H,26,27)
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n/an/a 1.40E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204478
PNG
(1-(5-(4-methylpyridin-2-yl)oxazol-2-yl)-7-phenylhe...)
Show SMILES Cc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O2/c1-17-13-14-23-19(15-17)21-16-24-22(26-21)20(25)12-8-3-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204522
PNG
(7-phenyl-1-(5-(4-(trifluoromethyl)pyridin-2-yl)oxa...)
Show SMILES FC(F)(F)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H21F3N2O2/c23-22(24,25)17-12-13-26-18(14-17)20-15-27-21(29-20)19(28)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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n/an/a 2.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204493
PNG
(1-(oxazol-2-yl)-7-phenylheptan-1-one | CHEMBL22012...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncco1
Show InChI InChI=1S/C16H19NO2/c18-15(16-17-12-13-19-16)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2
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n/an/a 2.50E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204479
PNG
(3-(2-(7-phenylheptanoyl)oxazol-5-yl)benzamide | CH...)
Show SMILES NC(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H24N2O3/c24-22(27)19-13-8-12-18(15-19)21-16-25-23(28-21)20(26)14-7-2-1-4-9-17-10-5-3-6-11-17/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2,(H2,24,27)
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n/an/a 2.70E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204492
PNG
(1-(5-(2,4-dimethoxypyrimidin-5-yl)oxazol-2-yl)-7-p...)
Show SMILES COc1ncc(-c2cnc(o2)C(=O)CCCCCCc2ccccc2)c(OC)n1
Show InChI InChI=1S/C22H25N3O4/c1-27-20-17(14-24-22(25-20)28-2)19-15-23-21(29-19)18(26)13-9-4-3-6-10-16-11-7-5-8-12-16/h5,7-8,11-12,14-15H,3-4,6,9-10,13H2,1-2H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204504
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)nicotinic acid...)
Show SMILES OC(=O)c1ccc(nc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-19(11-7-2-1-4-8-16-9-5-3-6-10-16)21-24-15-20(28-21)18-13-12-17(14-23-18)22(26)27/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2,(H,26,27)
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n/an/a 3.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204525
PNG
(2-(7-phenylheptanoyl)oxazole-5-carboxamide | CHEMB...)
Show SMILES NC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H20N2O3/c18-16(21)15-12-19-17(22-15)14(20)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2,(H2,18,21)
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n/an/a 7.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204524
PNG
(7-phenyl-1-(5-(piperidine-1-carbonyl)oxazol-2-yl)h...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)C(=O)N1CCCCC1
Show InChI InChI=1S/C22H28N2O3/c25-19(14-8-2-1-5-11-18-12-6-3-7-13-18)21-23-17-20(27-21)22(26)24-15-9-4-10-16-24/h3,6-7,12-13,17H,1-2,4-5,8-11,14-16H2
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n/an/a 8.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50204492
PNG
(1-(5-(2,4-dimethoxypyrimidin-5-yl)oxazol-2-yl)-7-p...)
Show SMILES COc1ncc(-c2cnc(o2)C(=O)CCCCCCc2ccccc2)c(OC)n1
Show InChI InChI=1S/C22H25N3O4/c1-27-20-17(14-24-22(25-20)28-2)19-15-23-21(29-19)18(26)13-9-4-3-6-10-16-11-7-5-8-12-16/h5,7-8,11-12,14-15H,3-4,6,9-10,13H2,1-2H3
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n/an/a 9.00E+3n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant FAAH expressed in Escherichia coli by [14C]oleamide breakdown


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204475
PNG
(1-(5-bromooxazol-2-yl)-7-phenylheptan-1-one | CHEM...)
Show SMILES Brc1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C16H18BrNO2/c17-15-12-18-16(20-15)14(19)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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n/an/a 1.30E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204493
PNG
(1-(oxazol-2-yl)-7-phenylheptan-1-one | CHEMBL22012...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncco1
Show InChI InChI=1S/C16H19NO2/c18-15(16-17-12-13-19-16)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2
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n/an/a 1.90E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204529
PNG
(5-(2-(7-phenylheptanoyl)oxazol-5-yl)pyrimidine-2,4...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1c[nH]c(=O)[nH]c1=O
Show InChI InChI=1S/C20H21N3O4/c24-16(11-7-2-1-4-8-14-9-5-3-6-10-14)19-21-13-17(27-19)15-12-22-20(26)23-18(15)25/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2,(H2,22,23,25,26)
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n/an/a 3.00E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204527
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)pyrimidine-2,4...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cc(=O)[nH]c(=O)[nH]1
Show InChI InChI=1S/C20H21N3O4/c24-16(11-7-2-1-4-8-14-9-5-3-6-10-14)19-21-13-17(27-19)15-12-18(25)23-20(26)22-15/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2,(H2,22,23,25,26)
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n/an/a 3.00E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204523
PNG
(1-(5-(4-aminopyridin-2-yl)oxazol-2-yl)-7-phenylhep...)
Show SMILES Nc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H23N3O2/c22-17-12-13-23-18(14-17)20-15-24-21(26-20)19(25)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2,(H2,22,23)
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n/an/a 3.40E+4n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204497
PNG
(3-(2-(7-phenylheptanoyl)oxazol-5-yl)benzoic acid |...)
Show SMILES OC(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H23NO4/c25-20(14-7-2-1-4-9-17-10-5-3-6-11-17)22-24-16-21(28-22)18-12-8-13-19(15-18)23(26)27/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2,(H,26,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204505
PNG
(5-(2-(7-phenylheptanoyl)oxazol-5-yl)furan-2-carbox...)
Show SMILES OC(=O)c1ccc(o1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H21NO5/c23-16(11-7-2-1-4-8-15-9-5-3-6-10-15)20-22-14-19(27-20)17-12-13-18(26-17)21(24)25/h3,5-6,9-10,12-14H,1-2,4,7-8,11H2,(H,24,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204497
PNG
(3-(2-(7-phenylheptanoyl)oxazol-5-yl)benzoic acid |...)
Show SMILES OC(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H23NO4/c25-20(14-7-2-1-4-9-17-10-5-3-6-11-17)22-24-16-21(28-22)18-12-8-13-19(15-18)23(26)27/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2,(H,26,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204534
PNG
(1-(5-(4-nitropyridin-2-yl)oxazol-2-yl)-7-phenylhep...)
Show SMILES [O-][N+](=O)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H21N3O4/c25-19(11-7-2-1-4-8-16-9-5-3-6-10-16)21-23-15-20(28-21)18-14-17(24(26)27)12-13-22-18/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204491
PNG
(1-(5-(4-fluoropyridin-2-yl)oxazol-2-yl)-7-phenylhe...)
Show SMILES Fc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H21FN2O2/c22-17-12-13-23-18(14-17)20-15-24-21(26-20)19(25)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204506
PNG
(2-(7-phenylheptanoyl)oxazole-5-carboxylic acid | C...)
Show SMILES OC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H19NO4/c19-14(16-18-12-15(22-16)17(20)21)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2,(H,20,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204523
PNG
(1-(5-(4-aminopyridin-2-yl)oxazol-2-yl)-7-phenylhep...)
Show SMILES Nc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H23N3O2/c22-17-12-13-23-18(14-17)20-15-24-21(26-20)19(25)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2,(H2,22,23)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204504
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)nicotinic acid...)
Show SMILES OC(=O)c1ccc(nc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-19(11-7-2-1-4-8-16-9-5-3-6-10-16)21-24-15-20(28-21)18-13-12-17(14-23-18)22(26)27/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2,(H,26,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204525
PNG
(2-(7-phenylheptanoyl)oxazole-5-carboxamide | CHEMB...)
Show SMILES NC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H20N2O3/c18-16(21)15-12-19-17(22-15)14(20)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2,(H2,18,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204503
PNG
(2-(2-(7-phenylheptanoyl)oxazol-5-yl)isonicotinonit...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cc(ccn1)C#N
Show InChI InChI=1S/C22H21N3O2/c23-15-18-12-13-24-19(14-18)21-16-25-22(27-21)20(26)11-7-2-1-4-8-17-9-5-3-6-10-17/h3,5-6,9-10,12-14,16H,1-2,4,7-8,11H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204499
PNG
(CHEMBL220379 | methyl 2-(2-(7-phenylheptanoyl)oxaz...)
Show SMILES COC(=O)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H24N2O4/c1-28-23(27)18-13-14-24-19(15-18)21-16-25-22(29-21)20(26)12-8-3-2-5-9-17-10-6-4-7-11-17/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204479
PNG
(3-(2-(7-phenylheptanoyl)oxazol-5-yl)benzamide | CH...)
Show SMILES NC(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H24N2O3/c24-22(27)19-13-8-12-18(15-19)21-16-25-23(28-21)20(26)14-7-2-1-4-9-17-10-5-3-6-11-17/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2,(H2,24,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204529
PNG
(5-(2-(7-phenylheptanoyl)oxazol-5-yl)pyrimidine-2,4...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1c[nH]c(=O)[nH]c1=O
Show InChI InChI=1S/C20H21N3O4/c24-16(11-7-2-1-4-8-14-9-5-3-6-10-14)19-21-13-17(27-19)15-12-22-20(26)23-18(15)25/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2,(H2,22,23,25,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204510
PNG
(1-(5-(4-methoxypyridin-2-yl)oxazol-2-yl)-7-phenylh...)
Show SMILES COc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O3/c1-26-18-13-14-23-19(15-18)21-16-24-22(27-21)20(25)12-8-3-2-5-9-17-10-6-4-7-11-17/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204479
PNG
(3-(2-(7-phenylheptanoyl)oxazol-5-yl)benzamide | CH...)
Show SMILES NC(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C23H24N2O3/c24-22(27)19-13-8-12-18(15-19)21-16-25-23(28-21)20(26)14-7-2-1-4-9-17-10-5-3-6-11-17/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2,(H2,24,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM23120
PNG
(7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]hepta...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1ccccn1
Show InChI InChI=1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204478
PNG
(1-(5-(4-methylpyridin-2-yl)oxazol-2-yl)-7-phenylhe...)
Show SMILES Cc1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O2/c1-17-13-14-23-19(15-17)21-16-24-22(26-21)20(25)12-8-3-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-11,13-16H,2-3,5,8-9,12H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204512
PNG
(2-(7-phenylheptanoyl)oxazole-5-carbonitrile | CHEM...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)C#N
Show InChI InChI=1S/C17H18N2O2/c18-12-15-13-19-17(21-15)16(20)11-7-2-1-4-8-14-9-5-3-6-10-14/h3,5-6,9-10,13H,1-2,4,7-8,11H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204509
PNG
(1-(5-(2,6-dimethoxypyrimidin-4-yl)oxazol-2-yl)-7-p...)
Show SMILES COc1cc(nc(OC)n1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H25N3O4/c1-27-20-14-17(24-22(25-20)28-2)19-15-23-21(29-19)18(26)13-9-4-3-6-10-16-11-7-5-8-12-16/h5,7-8,11-12,14-15H,3-4,6,9-10,13H2,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204505
PNG
(5-(2-(7-phenylheptanoyl)oxazol-5-yl)furan-2-carbox...)
Show SMILES OC(=O)c1ccc(o1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C21H21NO5/c23-16(11-7-2-1-4-8-15-9-5-3-6-10-15)20-22-14-19(27-20)17-12-13-18(26-17)21(24)25/h3,5-6,9-10,12-14H,1-2,4,7-8,11H2,(H,24,25)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204527
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)pyrimidine-2,4...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cc(=O)[nH]c(=O)[nH]1
Show InChI InChI=1S/C20H21N3O4/c24-16(11-7-2-1-4-8-14-9-5-3-6-10-14)19-21-13-17(27-19)15-12-18(25)23-20(26)22-15/h3,5-6,9-10,12-13H,1-2,4,7-8,11H2,(H2,22,23,25,26)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204524
PNG
(7-phenyl-1-(5-(piperidine-1-carbonyl)oxazol-2-yl)h...)
Show SMILES O=C(CCCCCCc1ccccc1)c1ncc(o1)C(=O)N1CCCCC1
Show InChI InChI=1S/C22H28N2O3/c25-19(14-8-2-1-5-11-18-12-6-3-7-13-18)21-23-17-20(27-21)22(26)24-15-9-4-10-16-24/h3,6-7,12-13,17H,1-2,4-5,8-11,14-16H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204483
PNG
(7-phenyl-1-(5-(trifluoromethyl)oxazol-2-yl)heptan-...)
Show SMILES FC(F)(F)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H18F3NO2/c18-17(19,20)15-12-21-16(23-15)14(22)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204511
PNG
(3-(2-(7-phenylheptanoyl)oxazol-5-yl)benzenesulfona...)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H24N2O4S/c23-29(26,27)19-13-8-12-18(15-19)21-16-24-22(28-21)20(25)14-7-2-1-4-9-17-10-5-3-6-11-17/h3,5-6,8,10-13,15-16H,1-2,4,7,9,14H2,(H2,23,26,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204516
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)picolinic acid...)
Show SMILES OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-19(14-7-2-1-4-9-16-10-5-3-6-11-16)21-23-15-20(28-21)17-12-8-13-18(24-17)22(26)27/h3,5-6,8,10-13,15H,1-2,4,7,9,14H2,(H,26,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204522
PNG
(7-phenyl-1-(5-(4-(trifluoromethyl)pyridin-2-yl)oxa...)
Show SMILES FC(F)(F)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H21F3N2O2/c23-22(24,25)17-12-13-26-18(14-17)20-15-27-21(29-20)19(28)11-7-2-1-4-8-16-9-5-3-6-10-16/h3,5-6,9-10,12-15H,1-2,4,7-8,11H2
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The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204516
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)picolinic acid...)
Show SMILES OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-19(14-7-2-1-4-9-16-10-5-3-6-11-16)21-23-15-20(28-21)17-12-8-13-18(24-17)22(26)27/h3,5-6,8,10-13,15H,1-2,4,7,9,14H2,(H,26,27)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204490
PNG
(CHEMBL220784 | methyl 2-(7-phenylheptanoyl)oxazole...)
Show SMILES COC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C18H21NO4/c1-22-18(21)16-13-19-17(23-16)15(20)12-8-3-2-5-9-14-10-6-4-7-11-14/h4,6-7,10-11,13H,2-3,5,8-9,12H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Acyl-CoA: cholesterol acyltransferase (ACAT)


(Homo sapiens (Human))
BDBM50204506
PNG
(2-(7-phenylheptanoyl)oxazole-5-carboxylic acid | C...)
Show SMILES OC(=O)c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C17H19NO4/c19-14(16-18-12-15(22-16)17(20)21)11-7-2-1-4-8-13-9-5-3-6-10-13/h3,5-6,9-10,12H,1-2,4,7-8,11H2,(H,20,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of TGH


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
Neutral cholesterol ester hydrolase 1


(Homo sapiens (Human))
BDBM50204492
PNG
(1-(5-(2,4-dimethoxypyrimidin-5-yl)oxazol-2-yl)-7-p...)
Show SMILES COc1ncc(-c2cnc(o2)C(=O)CCCCCCc2ccccc2)c(OC)n1
Show InChI InChI=1S/C22H25N3O4/c1-27-20-17(14-24-22(25-20)28-2)19-15-23-21(29-19)18(26)13-9-4-3-6-10-16-11-7-5-8-12-16/h5,7-8,11-12,14-15H,3-4,6,9-10,13H2,1-2H3
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



The Scripps Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KIAA1363


J Med Chem 50: 1058-68 (2007)


Article DOI: 10.1021/jm0611509
BindingDB Entry DOI: 10.7270/Q26H4J6G
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%