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PubMed code 18155554

Compile data set for download or QSAR
Found 87 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374777
PNG
(CHEMBL428255)
Show SMILES Cc1cc(SCc2csnc2-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C20H16F3NO3S2/c1-12-8-16(6-7-17(12)27-9-18(25)26)28-10-14-11-29-24-19(14)13-2-4-15(5-3-13)20(21,22)23/h2-8,11H,9-10H2,1H3,(H,25,26)
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n/an/an/an/a 150n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM28750
PNG
(2-methyl-2-{2-methyl-4-[({3-[4-(trifluoromethyl)ph...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O3S2/c1-12-10-15(8-9-16(12)29-20(2,3)19(27)28)30-11-17-25-18(26-31-17)13-4-6-14(7-5-13)21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a 407n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM28758
PNG
(1-{2-methyl-4-[({3-[4-(trifluoromethoxy)phenyl]-1,...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(OC(F)(F)F)cc2)ccc1OC1(CCCC1)C(O)=O
Show InChI InChI=1S/C23H21F3N2O4S2/c1-14-12-17(8-9-18(14)32-22(21(29)30)10-2-3-11-22)33-13-19-27-20(28-34-19)15-4-6-16(7-5-15)31-23(24,25)26/h4-9,12H,2-3,10-11,13H2,1H3,(H,29,30)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374785
PNG
(CHEMBL258766)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(c(F)c2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H18F4N2O4S/c1-11-8-13(5-7-16(11)31-20(2,3)19(28)29)30-10-17-26-18(27-32-17)12-4-6-14(15(22)9-12)21(23,24)25/h4-9H,10H2,1-3H3,(H,28,29)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM28755
PNG
(2-methyl-2-{2-methyl-4-[({5-[4-(trifluoromethoxy)p...)
Show SMILES Cc1cc(SCc2nsc(n2)-c2ccc(OC(F)(F)F)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O4S2/c1-12-10-15(8-9-16(12)30-20(2,3)19(27)28)31-11-17-25-18(32-26-17)13-4-6-14(7-5-13)29-21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374793
PNG
(CHEMBL258832)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(c(F)c2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H18F4N2O3S2/c1-11-8-13(5-7-16(11)30-20(2,3)19(28)29)31-10-17-26-18(27-32-17)12-4-6-14(15(22)9-12)21(23,24)25/h4-9H,10H2,1-3H3,(H,28,29)
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n/an/an/an/a 640n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374782
PNG
(CHEMBL260839)
Show SMILES Cc1ccc(cc1C)-c1nsc(COc2ccc(OC(C)(C)C(O)=O)c(C)c2)n1
Show InChI InChI=1S/C22H24N2O4S/c1-13-6-7-16(10-14(13)2)20-23-19(29-24-20)12-27-17-8-9-18(15(3)11-17)28-22(4,5)21(25)26/h6-11H,12H2,1-5H3,(H,25,26)
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n/an/an/an/a 643n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374783
PNG
(CHEMBL409215)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(Cl)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H18Cl2N2O4S/c1-11-8-13(5-7-16(11)28-20(2,3)19(25)26)27-10-17-23-18(24-29-17)12-4-6-14(21)15(22)9-12/h4-9H,10H2,1-3H3,(H,25,26)
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n/an/an/an/a 504n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM28749
PNG
(2-{2-methyl-4-[({3-[4-(trifluoromethyl)phenyl]-1,2...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C19H15F3N2O3S2/c1-11-8-14(6-7-15(11)27-9-17(25)26)28-10-16-23-18(24-29-16)12-2-4-13(5-3-12)19(20,21)22/h2-8H,9-10H2,1H3,(H,25,26)
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n/an/an/an/a 468n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM28757
PNG
(2-methyl-2-[2-methyl-4-({3-[4-(trifluoromethoxy)ph...)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(OC(F)(F)F)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O5S/c1-12-10-15(8-9-16(12)31-20(2,3)19(27)28)29-11-17-25-18(26-32-17)13-4-6-14(7-5-13)30-21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a 12n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM28752
PNG
(2-[4-({[3-(4-chlorophenyl)-1,2,4-thiadiazol-5-yl]m...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(Cl)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H19ClN2O3S2/c1-12-10-15(8-9-16(12)26-20(2,3)19(24)25)27-11-17-22-18(23-28-17)13-4-6-14(21)7-5-13/h4-10H,11H2,1-3H3,(H,24,25)
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n/an/an/an/a 18n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374790
PNG
(CHEMBL409513)
Show SMILES Cc1ccc(cc1C)-c1nsc(CSc2ccc(OC(C)(C)C(O)=O)c(C)c2)n1
Show InChI InChI=1S/C22H24N2O3S2/c1-13-6-7-16(10-14(13)2)20-23-19(29-24-20)12-28-17-8-9-18(15(3)11-17)27-22(4,5)21(25)26/h6-11H,12H2,1-5H3,(H,25,26)
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n/an/an/an/a 115n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374786
PNG
(CHEMBL259973)
Show SMILES Cc1cc(SCCc2nc(ns2)-c2ccc(Cl)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3S2/c1-12-10-14(5-7-17(12)28-21(2,3)20(26)27)29-9-8-18-24-19(25-30-18)13-4-6-15(22)16(23)11-13/h4-7,10-11H,8-9H2,1-3H3,(H,26,27)
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n/an/an/an/a 9n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374796
PNG
(CHEMBL259055)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(OC(F)(F)F)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H18ClF3N2O4S2/c1-11-8-13(5-7-15(11)30-20(2,3)19(28)29)32-10-17-26-18(27-33-17)12-4-6-16(14(22)9-12)31-21(23,24)25/h4-9H,10H2,1-3H3,(H,28,29)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374776
PNG
(CHEMBL407201)
Show SMILES Cc1cc(SCc2cc(no2)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C20H16F3NO4S/c1-12-8-16(6-7-18(12)27-10-19(25)26)29-11-15-9-17(24-28-15)13-2-4-14(5-3-13)20(21,22)23/h2-9H,10-11H2,1H3,(H,25,26)
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n/an/an/an/a 20n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374779
PNG
(CHEMBL258519)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(Cl)c(Cl)c2)ccc1OC1(CCCC1)C(O)=O
Show InChI InChI=1S/C22H20Cl2N2O3S2/c1-13-10-15(5-7-18(13)29-22(21(27)28)8-2-3-9-22)30-12-19-25-20(26-31-19)14-4-6-16(23)17(24)11-14/h4-7,10-11H,2-3,8-9,12H2,1H3,(H,27,28)
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Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM28756
PNG
(2-methyl-2-[2-methyl-4-({3-[4-(trifluoromethyl)phe...)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O4S/c1-12-10-15(8-9-16(12)30-20(2,3)19(27)28)29-11-17-25-18(26-31-17)13-4-6-14(7-5-13)21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374789
PNG
(CHEMBL406944)
Show SMILES Cc1cc(SCc2nsc(n2)-c2ccc(Cl)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H19ClN2O3S2/c1-12-10-15(8-9-16(12)26-20(2,3)19(24)25)27-11-17-22-18(28-23-17)13-4-6-14(21)7-5-13/h4-10H,11H2,1-3H3,(H,24,25)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM28757
PNG
(2-methyl-2-[2-methyl-4-({3-[4-(trifluoromethoxy)ph...)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(OC(F)(F)F)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O5S/c1-12-10-15(8-9-16(12)31-20(2,3)19(27)28)29-11-17-25-18(26-32-17)13-4-6-14(7-5-13)30-21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a 94n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374786
PNG
(CHEMBL259973)
Show SMILES Cc1cc(SCCc2nc(ns2)-c2ccc(Cl)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3S2/c1-12-10-14(5-7-17(12)28-21(2,3)20(26)27)29-9-8-18-24-19(25-30-18)13-4-6-15(22)16(23)11-13/h4-7,10-11H,8-9H2,1-3H3,(H,26,27)
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n/an/an/an/a 123n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374791
PNG
(CHEMBL408941)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(Cl)cc2Cl)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H18Cl2N2O3S2/c1-11-8-13(5-7-16(11)27-20(2,3)19(25)26)28-10-17-23-18(24-29-17)14-6-4-12(21)9-15(14)22/h4-9H,10H2,1-3H3,(H,25,26)
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n/an/an/an/a 476n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374796
PNG
(CHEMBL259055)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(OC(F)(F)F)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H18ClF3N2O4S2/c1-11-8-13(5-7-15(11)30-20(2,3)19(28)29)32-10-17-26-18(27-33-17)12-4-6-16(14(22)9-12)31-21(23,24)25/h4-9H,10H2,1-3H3,(H,28,29)
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n/an/an/an/a 28n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374794
PNG
(CHEMBL258732)
Show SMILES Cc1cc(SCc2cc(sn2)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C20H16F3NO3S2/c1-12-8-16(6-7-17(12)27-10-19(25)26)28-11-15-9-18(29-24-15)13-2-4-14(5-3-13)20(21,22)23/h2-9H,10-11H2,1H3,(H,25,26)
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n/an/an/an/a 2n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374795
PNG
(CHEMBL409355)
Show SMILES Cc1ccc(cc1Cl)-c1nsc(CSc2ccc(OC(C)(C)C(O)=O)c(C)c2)n1
Show InChI InChI=1S/C21H21ClN2O3S2/c1-12-5-6-14(10-16(12)22)19-23-18(29-24-19)11-28-15-7-8-17(13(2)9-15)27-21(3,4)20(25)26/h5-10H,11H2,1-4H3,(H,25,26)
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n/an/an/an/a 25n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM28750
PNG
(2-methyl-2-{2-methyl-4-[({3-[4-(trifluoromethyl)ph...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O3S2/c1-12-10-15(8-9-16(12)29-20(2,3)19(27)28)30-11-17-25-18(26-31-17)13-4-6-14(7-5-13)21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a 79n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374781
PNG
(CHEMBL260840)
Show SMILES Cc1ccc(cc1Cl)-c1nsc(COc2ccc(OC(C)(C)C(O)=O)c(C)c2)n1
Show InChI InChI=1S/C21H21ClN2O4S/c1-12-5-6-14(10-16(12)22)19-23-18(29-24-19)11-27-15-7-8-17(13(2)9-15)28-21(3,4)20(25)26/h5-10H,11H2,1-4H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM28752
PNG
(2-[4-({[3-(4-chlorophenyl)-1,2,4-thiadiazol-5-yl]m...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(Cl)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H19ClN2O3S2/c1-12-10-15(8-9-16(12)26-20(2,3)19(24)25)27-11-17-22-18(23-28-17)13-4-6-14(21)7-5-13/h4-10H,11H2,1-3H3,(H,24,25)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374778
PNG
(CHEMBL265421)
Show SMILES Cc1cc(SCc2cc(ns2)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C20H16F3NO3S2/c1-12-8-15(6-7-18(12)27-10-19(25)26)28-11-16-9-17(24-29-16)13-2-4-14(5-3-13)20(21,22)23/h2-9H,10-11H2,1H3,(H,25,26)
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n/an/an/an/a 1.29E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM28758
PNG
(1-{2-methyl-4-[({3-[4-(trifluoromethoxy)phenyl]-1,...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(OC(F)(F)F)cc2)ccc1OC1(CCCC1)C(O)=O
Show InChI InChI=1S/C23H21F3N2O4S2/c1-14-12-17(8-9-18(14)32-22(21(29)30)10-2-3-11-22)33-13-19-27-20(28-34-19)15-4-6-16(7-5-15)31-23(24,25)26/h4-9,12H,2-3,10-11,13H2,1H3,(H,29,30)
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n/an/an/an/a 736n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374780
PNG
(CHEMBL260627)
Show SMILES CC(Oc1ccc(SCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C19H15F3N2O3S2/c1-11(18(25)26)27-14-6-8-15(9-7-14)28-10-16-23-17(24-29-16)12-2-4-13(5-3-12)19(20,21)22/h2-9,11H,10H2,1H3,(H,25,26)
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n/an/an/an/a 155n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374784
PNG
(CHEMBL261555)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(OC(F)(F)F)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H18ClF3N2O5S/c1-11-8-13(5-7-15(11)31-20(2,3)19(28)29)30-10-17-26-18(27-33-17)12-4-6-16(14(22)9-12)32-21(23,24)25/h4-9H,10H2,1-3H3,(H,28,29)
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n/an/an/an/a 97n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM28752
PNG
(2-[4-({[3-(4-chlorophenyl)-1,2,4-thiadiazol-5-yl]m...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(Cl)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H19ClN2O3S2/c1-12-10-15(8-9-16(12)26-20(2,3)19(24)25)27-11-17-22-18(23-28-17)13-4-6-14(21)7-5-13/h4-10H,11H2,1-3H3,(H,24,25)
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n/an/an/an/a 186n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374787
PNG
(CHEMBL411045)
Show SMILES Cc1cc(SCCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C22H21F3N2O3S2/c1-13-12-16(8-9-17(13)30-21(2,3)20(28)29)31-11-10-18-26-19(27-32-18)14-4-6-15(7-5-14)22(23,24)25/h4-9,12H,10-11H2,1-3H3,(H,28,29)
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n/an/an/an/a 2n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374792
PNG
(CHEMBL259856)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(Cl)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H18Cl2N2O3S2/c1-11-8-13(5-7-16(11)27-20(2,3)19(25)26)28-10-17-23-18(24-29-17)12-4-6-14(21)15(22)9-12/h4-9H,10H2,1-3H3,(H,25,26)
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n/an/an/an/a 8n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374793
PNG
(CHEMBL258832)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(c(F)c2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H18F4N2O3S2/c1-11-8-13(5-7-16(11)30-20(2,3)19(28)29)31-10-17-26-18(27-32-17)12-4-6-14(15(22)9-12)21(23,24)25/h4-9H,10H2,1-3H3,(H,28,29)
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n/an/an/an/a 5n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM28750
PNG
(2-methyl-2-{2-methyl-4-[({3-[4-(trifluoromethyl)ph...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O3S2/c1-12-10-15(8-9-16(12)29-20(2,3)19(27)28)30-11-17-25-18(26-31-17)13-4-6-14(7-5-13)21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a 6n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374786
PNG
(CHEMBL259973)
Show SMILES Cc1cc(SCCc2nc(ns2)-c2ccc(Cl)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H20Cl2N2O3S2/c1-12-10-14(5-7-17(12)28-21(2,3)20(26)27)29-9-8-18-24-19(25-30-18)13-4-6-15(22)16(23)11-13/h4-7,10-11H,8-9H2,1-3H3,(H,26,27)
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n/an/an/an/a 815n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374790
PNG
(CHEMBL409513)
Show SMILES Cc1ccc(cc1C)-c1nsc(CSc2ccc(OC(C)(C)C(O)=O)c(C)c2)n1
Show InChI InChI=1S/C22H24N2O3S2/c1-13-6-7-16(10-14(13)2)20-23-19(29-24-20)12-28-17-8-9-18(15(3)11-17)27-22(4,5)21(25)26/h6-11H,12H2,1-5H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374781
PNG
(CHEMBL260840)
Show SMILES Cc1ccc(cc1Cl)-c1nsc(COc2ccc(OC(C)(C)C(O)=O)c(C)c2)n1
Show InChI InChI=1S/C21H21ClN2O4S/c1-12-5-6-14(10-16(12)22)19-23-18(29-24-19)11-27-15-7-8-17(13(2)9-15)28-21(3,4)20(25)26/h5-10H,11H2,1-4H3,(H,25,26)
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n/an/an/an/a 297n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM28754
PNG
(2-methyl-2-{2-methyl-4-[({5-[4-(trifluoromethyl)ph...)
Show SMILES Cc1cc(SCc2nsc(n2)-c2ccc(cc2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O3S2/c1-12-10-15(8-9-16(12)29-20(2,3)19(27)28)30-11-17-25-18(31-26-17)13-4-6-14(7-5-13)21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a 425n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374783
PNG
(CHEMBL409215)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(Cl)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H18Cl2N2O4S/c1-11-8-13(5-7-16(11)28-20(2,3)19(25)26)27-10-17-23-18(24-29-17)12-4-6-14(21)15(22)9-12/h4-9H,10H2,1-3H3,(H,25,26)
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n/an/an/an/a 114n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374788
PNG
(CHEMBL260494)
Show SMILES Cc1cc(SCc2nsc(n2)-c2ccc(Cl)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H18Cl2N2O3S2/c1-11-8-13(5-7-16(11)27-20(2,3)19(25)26)28-10-17-23-18(29-24-17)12-4-6-14(21)15(22)9-12/h4-9H,10H2,1-3H3,(H,25,26)
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n/an/an/an/a 229n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM28755
PNG
(2-methyl-2-{2-methyl-4-[({5-[4-(trifluoromethoxy)p...)
Show SMILES Cc1cc(SCc2nsc(n2)-c2ccc(OC(F)(F)F)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O4S2/c1-12-10-15(8-9-16(12)30-20(2,3)19(27)28)31-11-17-25-18(32-26-17)13-4-6-14(7-5-13)29-21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a 58n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM28754
PNG
(2-methyl-2-{2-methyl-4-[({5-[4-(trifluoromethyl)ph...)
Show SMILES Cc1cc(SCc2nsc(n2)-c2ccc(cc2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O3S2/c1-12-10-15(8-9-16(12)29-20(2,3)19(27)28)30-11-17-25-18(31-26-17)13-4-6-14(7-5-13)21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a 26n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374797
PNG
(CHEMBL259873)
Show SMILES Cc1cc(SCc2cc(on2)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C20H16F3NO4S/c1-12-8-16(6-7-17(12)27-10-19(25)26)29-11-15-9-18(28-24-15)13-2-4-14(5-3-13)20(21,22)23/h2-9H,10-11H2,1H3,(H,25,26)
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n/an/an/an/a 2n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374789
PNG
(CHEMBL406944)
Show SMILES Cc1cc(SCc2nsc(n2)-c2ccc(Cl)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H19ClN2O3S2/c1-12-10-15(8-9-16(12)26-20(2,3)19(24)25)27-11-17-22-18(28-23-17)13-4-6-14(21)7-5-13/h4-10H,11H2,1-3H3,(H,24,25)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374784
PNG
(CHEMBL261555)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(OC(F)(F)F)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H18ClF3N2O5S/c1-11-8-13(5-7-15(11)31-20(2,3)19(28)29)30-10-17-26-18(27-33-17)12-4-6-16(14(22)9-12)32-21(23,24)25/h4-9H,10H2,1-3H3,(H,28,29)
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n/an/an/an/a 13n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374789
PNG
(CHEMBL406944)
Show SMILES Cc1cc(SCc2nsc(n2)-c2ccc(Cl)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H19ClN2O3S2/c1-12-10-15(8-9-16(12)26-20(2,3)19(24)25)27-11-17-22-18(28-23-17)13-4-6-14(21)7-5-13/h4-10H,11H2,1-3H3,(H,24,25)
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n/an/an/an/a 237n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374790
PNG
(CHEMBL409513)
Show SMILES Cc1ccc(cc1C)-c1nsc(CSc2ccc(OC(C)(C)C(O)=O)c(C)c2)n1
Show InChI InChI=1S/C22H24N2O3S2/c1-13-6-7-16(10-14(13)2)20-23-19(29-24-20)12-28-17-8-9-18(15(3)11-17)27-22(4,5)21(25)26/h6-11H,12H2,1-5H3,(H,25,26)
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n/an/an/an/a 93n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374778
PNG
(CHEMBL265421)
Show SMILES Cc1cc(SCc2cc(ns2)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C20H16F3NO3S2/c1-12-8-15(6-7-18(12)27-10-19(25)26)28-11-16-9-17(24-29-16)13-2-4-14(5-3-13)20(21,22)23/h2-9H,10-11H2,1H3,(H,25,26)
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n/an/an/an/a 5n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374783
PNG
(CHEMBL409215)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(Cl)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H18Cl2N2O4S/c1-11-8-13(5-7-16(11)28-20(2,3)19(25)26)27-10-17-23-18(24-29-17)12-4-6-14(21)15(22)9-12/h4-9H,10H2,1-3H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374784
PNG
(CHEMBL261555)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(OC(F)(F)F)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H18ClF3N2O5S/c1-11-8-13(5-7-15(11)31-20(2,3)19(28)29)30-10-17-26-18(27-33-17)12-4-6-16(14(22)9-12)32-21(23,24)25/h4-9H,10H2,1-3H3,(H,28,29)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374792
PNG
(CHEMBL259856)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(Cl)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H18Cl2N2O3S2/c1-11-8-13(5-7-16(11)27-20(2,3)19(25)26)28-10-17-23-18(24-29-17)12-4-6-14(21)15(22)9-12/h4-9H,10H2,1-3H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374787
PNG
(CHEMBL411045)
Show SMILES Cc1cc(SCCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C22H21F3N2O3S2/c1-13-12-16(8-9-17(13)30-21(2,3)20(28)29)31-11-10-18-26-19(27-32-18)14-4-6-15(7-5-14)22(23,24)25/h4-9,12H,10-11H2,1-3H3,(H,28,29)
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n/an/an/an/a 37n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374788
PNG
(CHEMBL260494)
Show SMILES Cc1cc(SCc2nsc(n2)-c2ccc(Cl)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H18Cl2N2O3S2/c1-11-8-13(5-7-16(11)27-20(2,3)19(25)26)28-10-17-23-18(29-24-17)12-4-6-14(21)15(22)9-12/h4-9H,10H2,1-3H3,(H,25,26)
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Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374781
PNG
(CHEMBL260840)
Show SMILES Cc1ccc(cc1Cl)-c1nsc(COc2ccc(OC(C)(C)C(O)=O)c(C)c2)n1
Show InChI InChI=1S/C21H21ClN2O4S/c1-12-5-6-14(10-16(12)22)19-23-18(29-24-19)11-27-15-7-8-17(13(2)9-15)28-21(3,4)20(25)26/h5-10H,11H2,1-4H3,(H,25,26)
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n/an/an/an/a 148n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374782
PNG
(CHEMBL260839)
Show SMILES Cc1ccc(cc1C)-c1nsc(COc2ccc(OC(C)(C)C(O)=O)c(C)c2)n1
Show InChI InChI=1S/C22H24N2O4S/c1-13-6-7-16(10-14(13)2)20-23-19(29-24-20)12-27-17-8-9-18(15(3)11-17)28-22(4,5)21(25)26/h6-11H,12H2,1-5H3,(H,25,26)
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n/an/an/an/a 534n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM28756
PNG
(2-methyl-2-[2-methyl-4-({3-[4-(trifluoromethyl)phe...)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O4S/c1-12-10-15(8-9-16(12)30-20(2,3)19(27)28)29-11-17-25-18(26-31-17)13-4-6-14(7-5-13)21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a 3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374780
PNG
(CHEMBL260627)
Show SMILES CC(Oc1ccc(SCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C19H15F3N2O3S2/c1-11(18(25)26)27-14-6-8-15(9-7-14)28-10-16-23-17(24-29-16)12-2-4-13(5-3-12)19(20,21)22/h2-9,11H,10H2,1H3,(H,25,26)
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n/an/an/an/a 20n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374795
PNG
(CHEMBL409355)
Show SMILES Cc1ccc(cc1Cl)-c1nsc(CSc2ccc(OC(C)(C)C(O)=O)c(C)c2)n1
Show InChI InChI=1S/C21H21ClN2O3S2/c1-12-5-6-14(10-16(12)22)19-23-18(29-24-19)11-28-15-7-8-17(13(2)9-15)27-21(3,4)20(25)26/h5-10H,11H2,1-4H3,(H,25,26)
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n/an/an/an/a 669n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM28751
PNG
(2-methyl-2-{2-methyl-4-[({3-[4-(trifluoromethoxy)p...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(OC(F)(F)F)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O4S2/c1-12-10-15(8-9-16(12)30-20(2,3)19(27)28)31-11-17-25-18(26-32-17)13-4-6-14(7-5-13)29-21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374780
PNG
(CHEMBL260627)
Show SMILES CC(Oc1ccc(SCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)cc1)C(O)=O
Show InChI InChI=1S/C19H15F3N2O3S2/c1-11(18(25)26)27-14-6-8-15(9-7-14)28-10-16-23-17(24-29-16)12-2-4-13(5-3-12)19(20,21)22/h2-9,11H,10H2,1H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374782
PNG
(CHEMBL260839)
Show SMILES Cc1ccc(cc1C)-c1nsc(COc2ccc(OC(C)(C)C(O)=O)c(C)c2)n1
Show InChI InChI=1S/C22H24N2O4S/c1-13-6-7-16(10-14(13)2)20-23-19(29-24-20)12-27-17-8-9-18(15(3)11-17)28-22(4,5)21(25)26/h6-11H,12H2,1-5H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374787
PNG
(CHEMBL411045)
Show SMILES Cc1cc(SCCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C22H21F3N2O3S2/c1-13-12-16(8-9-17(13)30-21(2,3)20(28)29)31-11-10-18-26-19(27-32-18)14-4-6-15(7-5-14)22(23,24)25/h4-9,12H,10-11H2,1-3H3,(H,28,29)
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n/an/an/an/a 465n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374794
PNG
(CHEMBL258732)
Show SMILES Cc1cc(SCc2cc(sn2)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C20H16F3NO3S2/c1-12-8-16(6-7-17(12)27-10-19(25)26)28-11-15-9-18(29-24-15)13-2-4-14(5-3-13)20(21,22)23/h2-9H,10-11H2,1H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM28756
PNG
(2-methyl-2-[2-methyl-4-({3-[4-(trifluoromethyl)phe...)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O4S/c1-12-10-15(8-9-16(12)30-20(2,3)19(27)28)29-11-17-25-18(26-31-17)13-4-6-14(7-5-13)21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a 94n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM28751
PNG
(2-methyl-2-{2-methyl-4-[({3-[4-(trifluoromethoxy)p...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(OC(F)(F)F)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O4S2/c1-12-10-15(8-9-16(12)30-20(2,3)19(27)28)31-11-17-25-18(26-32-17)13-4-6-14(7-5-13)29-21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a 33n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM28758
PNG
(1-{2-methyl-4-[({3-[4-(trifluoromethoxy)phenyl]-1,...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(OC(F)(F)F)cc2)ccc1OC1(CCCC1)C(O)=O
Show InChI InChI=1S/C23H21F3N2O4S2/c1-14-12-17(8-9-18(14)32-22(21(29)30)10-2-3-11-22)33-13-19-27-20(28-34-19)15-4-6-16(7-5-15)31-23(24,25)26/h4-9,12H,2-3,10-11,13H2,1H3,(H,29,30)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM28751
PNG
(2-methyl-2-{2-methyl-4-[({3-[4-(trifluoromethoxy)p...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(OC(F)(F)F)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O4S2/c1-12-10-15(8-9-16(12)30-20(2,3)19(27)28)31-11-17-25-18(26-32-17)13-4-6-14(7-5-13)29-21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a 3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM28757
PNG
(2-methyl-2-[2-methyl-4-({3-[4-(trifluoromethoxy)ph...)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(OC(F)(F)F)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O5S/c1-12-10-15(8-9-16(12)31-20(2,3)19(27)28)29-11-17-25-18(26-32-17)13-4-6-14(7-5-13)30-21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374785
PNG
(CHEMBL258766)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(c(F)c2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H18F4N2O4S/c1-11-8-13(5-7-16(11)31-20(2,3)19(28)29)30-10-17-26-18(27-32-17)12-4-6-14(15(22)9-12)21(23,24)25/h4-9H,10H2,1-3H3,(H,28,29)
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n/an/an/an/a 86n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374797
PNG
(CHEMBL259873)
Show SMILES Cc1cc(SCc2cc(on2)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C20H16F3NO4S/c1-12-8-16(6-7-17(12)27-10-19(25)26)29-11-15-9-18(28-24-15)13-2-4-14(5-3-13)20(21,22)23/h2-9H,10-11H2,1H3,(H,25,26)
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n/an/an/an/a 2.21E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374779
PNG
(CHEMBL258519)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(Cl)c(Cl)c2)ccc1OC1(CCCC1)C(O)=O
Show InChI InChI=1S/C22H20Cl2N2O3S2/c1-13-10-15(5-7-18(13)29-22(21(27)28)8-2-3-9-22)30-12-19-25-20(26-31-19)14-4-6-16(23)17(24)11-14/h4-7,10-11H,2-3,8-9,12H2,1H3,(H,27,28)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM28749
PNG
(2-{2-methyl-4-[({3-[4-(trifluoromethyl)phenyl]-1,2...)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C19H15F3N2O3S2/c1-11-8-14(6-7-15(11)27-9-17(25)26)28-10-16-23-18(24-29-16)12-2-4-13(5-3-12)19(20,21)22/h2-8H,9-10H2,1H3,(H,25,26)
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n/an/an/an/a 10n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374793
PNG
(CHEMBL258832)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(c(F)c2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H18F4N2O3S2/c1-11-8-13(5-7-16(11)30-20(2,3)19(28)29)31-10-17-26-18(27-32-17)12-4-6-14(15(22)9-12)21(23,24)25/h4-9H,10H2,1-3H3,(H,28,29)
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n/an/an/an/a 34n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374788
PNG
(CHEMBL260494)
Show SMILES Cc1cc(SCc2nsc(n2)-c2ccc(Cl)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H18Cl2N2O3S2/c1-11-8-13(5-7-16(11)27-20(2,3)19(25)26)28-10-17-23-18(29-24-17)12-4-6-14(21)15(22)9-12/h4-9H,10H2,1-3H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM28754
PNG
(2-methyl-2-{2-methyl-4-[({5-[4-(trifluoromethyl)ph...)
Show SMILES Cc1cc(SCc2nsc(n2)-c2ccc(cc2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O3S2/c1-12-10-15(8-9-16(12)29-20(2,3)19(27)28)30-11-17-25-18(31-26-17)13-4-6-14(7-5-13)21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor


(Homo sapiens (Human))
BDBM50374791
PNG
(CHEMBL408941)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(Cl)cc2Cl)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H18Cl2N2O3S2/c1-11-8-13(5-7-16(11)27-20(2,3)19(25)26)28-10-17-23-18(24-29-17)14-6-4-12(21)9-15(14)22/h4-9H,10H2,1-3H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARgamma-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374779
PNG
(CHEMBL258519)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(Cl)c(Cl)c2)ccc1OC1(CCCC1)C(O)=O
Show InChI InChI=1S/C22H20Cl2N2O3S2/c1-13-10-15(5-7-18(13)29-22(21(27)28)8-2-3-9-22)30-12-19-25-20(26-31-19)14-4-6-16(23)17(24)11-14/h4-7,10-11H,2-3,8-9,12H2,1H3,(H,27,28)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM28755
PNG
(2-methyl-2-{2-methyl-4-[({5-[4-(trifluoromethoxy)p...)
Show SMILES Cc1cc(SCc2nsc(n2)-c2ccc(OC(F)(F)F)cc2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H19F3N2O4S2/c1-12-10-15(8-9-16(12)30-20(2,3)19(27)28)31-11-17-25-18(32-26-17)13-4-6-14(7-5-13)29-21(22,23)24/h4-10H,11H2,1-3H3,(H,27,28)
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n/an/an/an/a 656n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374795
PNG
(CHEMBL409355)
Show SMILES Cc1ccc(cc1Cl)-c1nsc(CSc2ccc(OC(C)(C)C(O)=O)c(C)c2)n1
Show InChI InChI=1S/C21H21ClN2O3S2/c1-12-5-6-14(10-16(12)22)19-23-18(29-24-19)11-28-15-7-8-17(13(2)9-15)27-21(3,4)20(25)26/h5-10H,11H2,1-4H3,(H,25,26)
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n/an/an/an/a 70n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374792
PNG
(CHEMBL259856)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(Cl)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H18Cl2N2O3S2/c1-11-8-13(5-7-16(11)27-20(2,3)19(25)26)28-10-17-23-18(24-29-17)12-4-6-14(21)15(22)9-12/h4-9H,10H2,1-3H3,(H,25,26)
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n/an/an/an/a 100n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374776
PNG
(CHEMBL407201)
Show SMILES Cc1cc(SCc2cc(no2)-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C20H16F3NO4S/c1-12-8-16(6-7-18(12)27-10-19(25)26)29-11-15-9-17(24-28-15)13-2-4-14(5-3-13)20(21,22)23/h2-9H,10-11H2,1H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374785
PNG
(CHEMBL258766)
Show SMILES Cc1cc(OCc2nc(ns2)-c2ccc(c(F)c2)C(F)(F)F)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H18F4N2O4S/c1-11-8-13(5-7-16(11)31-20(2,3)19(28)29)30-10-17-26-18(27-32-17)12-4-6-14(15(22)9-12)21(23,24)25/h4-9H,10H2,1-3H3,(H,28,29)
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n/an/an/an/a 3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374791
PNG
(CHEMBL408941)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(Cl)cc2Cl)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C20H18Cl2N2O3S2/c1-11-8-13(5-7-16(11)27-20(2,3)19(25)26)28-10-17-23-18(24-29-17)14-6-4-12(21)9-15(14)22/h4-9H,10H2,1-3H3,(H,25,26)
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n/an/an/an/a 102n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor delta


(Homo sapiens (Human))
BDBM50374796
PNG
(CHEMBL259055)
Show SMILES Cc1cc(SCc2nc(ns2)-c2ccc(OC(F)(F)F)c(Cl)c2)ccc1OC(C)(C)C(O)=O
Show InChI InChI=1S/C21H18ClF3N2O4S2/c1-11-8-13(5-7-15(11)30-20(2,3)19(28)29)32-10-17-26-18(27-33-17)12-4-6-16(14(22)9-12)31-21(23,24)25/h4-9H,10H2,1-3H3,(H,28,29)
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n/an/an/an/a 3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARdelta-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
Peroxisome proliferator-activated receptor alpha (PPAR alpha)


(Homo sapiens (Human))
BDBM50374777
PNG
(CHEMBL428255)
Show SMILES Cc1cc(SCc2csnc2-c2ccc(cc2)C(F)(F)F)ccc1OCC(O)=O
Show InChI InChI=1S/C20H16F3NO3S2/c1-12-8-16(6-7-17(12)27-9-18(25)26)28-10-14-11-29-24-19(14)13-2-4-15(5-3-13)20(21,22)23/h2-8,11H,9-10H2,1H3,(H,25,26)
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n/an/an/an/a>3.00E+3n/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human PPARalpha-Gal4 in HEK293 cells by luciferase reporter assay


Bioorg Med Chem 16: 3321-41 (2008)


Article DOI: 10.1016/j.bmc.2007.12.005
BindingDB Entry DOI: 10.7270/Q28W3F5T
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%