Compile Data Set for Download or QSAR
maximum 50k data
Found 43 Enz. Inhib. hit(s) with all data for entry = 50022081
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231481(3-bromo-N-(4-(1-(2-guanidino-2-oxoethyl)-5-phenyl-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231500(CHEMBL254057 | N-{2-[2-(4-methoxy-phenyl)-5-(4-phe...)
Affinity DataIC50:  500nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231481(3-bromo-N-(4-(1-(2-guanidino-2-oxoethyl)-5-phenyl-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231495(CHEMBL399083 | N-{2-[2-(4-phenoxy-phenyl)-5-(4-tri...)
Affinity DataIC50:  600nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231489(CHEMBL398316 | N-{2-[2-(3-cyano-phenyl)-5-(4-pheno...)
Affinity DataIC50:  600nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231492(CHEMBL254058 | N-{2-[2-[4-(4-acetyl-phenoxy)-pheny...)
Affinity DataIC50:  600nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50:  700nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231475(CHEMBL254891 | N-{2-[2-benzo[b]thiophen-3-yl-5-(4-...)
Affinity DataIC50:  700nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231496(CHEMBL400087 | N-{2-[2-[4-(4-acetyl-phenoxy)-pheny...)
Affinity DataIC50:  800nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231487(CHEMBL401172 | N-(2-{2-[4-(3-cyano-propoxy)-phenyl...)
Affinity DataIC50:  900nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231470(CHEMBL252007 | N-{2-[2-[4-(4-acetyl-phenoxy)-pheny...)
Affinity DataIC50:  900nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231483(CHEMBL401289 | N-(2-{2-[4-(4-acetyl-phenoxy)-pheny...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231502(CHEMBL398315 | N-{2-[2-(2-chloro-phenyl)-5-(4-phen...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231478(CHEMBL253241 | N-{2-[2-[4-(4-acetyl-phenoxy)-pheny...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231503(2,4-dichloro-N-{4-[1-(2-guanidino-2-oxo-ethyl)-5-p...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231498(CHEMBL254092 | N-{2-[2-[4-(4-acetyl-phenoxy)-pheny...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231490(CHEMBL253863 | N-{2-[2-(4-phenoxy-phenyl)-5-phenyl...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231484(CHEMBL252026 | N-{2-[2-[4-(4-acetyl-phenoxy)-pheny...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231494(CHEMBL252218 | N-{2-[2-(2-methoxy-phenyl)-5-(4-phe...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231493(CHEMBL253449 | N-{2-[2-(3-chloro-phenyl)-5-(4-phen...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231504(CHEMBL252025 | N-{2-[2-(4-fluoro-phenyl)-5-(4-phen...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231491(4-bromo-N-{4-[1-(2-guanidino-2-oxo-ethyl)-5-phenyl...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231473(CHEMBL253031 | N-{2-[2-(3-fluoro-phenyl)-5-(4-phen...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231497(CHEMBL254091 | N-{2-[2-(3-methoxy-phenyl)-5-(4-phe...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231482(CHEMBL252219 | N-{2-[2-[4-(4-acetyl-phenoxy)-pheny...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231488(CHEMBL253214 | N-{2-[2-(4-ethoxy-phenyl)-5-phenyl-...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231486(CHEMBL401171 | N-{2-[2-(4-allyloxy-phenyl)-5-pheny...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231479(CHEMBL252190 | N-{4-[1-(2-guanidino-2-oxo-ethyl)-5...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231485(CHEMBL253420 | N-{2-[2-(4-butoxy-phenyl)-5-phenyl-...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231499(CHEMBL253421 | N-(2-{2-[4-(4-cyano-benzyloxy)-phen...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231501(CHEMBL251828 | N-{2-[2-(2,5-dichloro-phenyl)-5-(4-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231474(CHEMBL252626 | N-{2-[2-(2-chloro-phenyl)-5-(4-fluo...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231481(3-bromo-N-(4-(1-(2-guanidino-2-oxoethyl)-5-phenyl-...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231477(CHEMBL404860 | N-{2-[2-(2-chloro-phenyl)-5-phenyl-...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231472(CHEMBL399837 | N-{2-[2-(2,5-dichloro-phenyl)-5-phe...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM16751((N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-ac...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of BACE1 assessed as reduction of total cellular amyloid beta formation by ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231476(CHEMBL399423 | N-[2-(2-Phenyl-5-m-tolyl-pyrrol-1-y...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50231481(3-bromo-N-(4-(1-(2-guanidino-2-oxoethyl)-5-phenyl-...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of BACE1 assessed as reduction of total cellular amyloid beta formation by ELISAMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50:  1.89E+4nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM16751((N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-ac...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM16751((N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-ac...)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed