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PubMed code 18242992

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233716
PNG
(5-cyano-N-(4-(4-(2-hydroxyethyl)piperazin-1-yl)-2-...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(CCO)CC1
Show InChI InChI=1S/C24H31N5O3/c1-18-6-8-29(9-7-18)22-16-19(28-12-10-27(11-13-28)14-15-30)2-4-21(22)26-24(31)23-5-3-20(17-25)32-23/h2-5,16,18,30H,6-15H2,1H3,(H,26,31)
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n/an/a 0.600n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233701
PNG
(5-cyano-furan-2-carboxylic acid [4-(1,1-dioxo-1lam...)
Show SMILES O=C(Nc1ccc(cc1N1CCCCC1)N1CCS(=O)(=O)CC1)c1ccc(o1)C#N
Show InChI InChI=1S/C21H24N4O4S/c22-15-17-5-7-20(29-17)21(26)23-18-6-4-16(24-10-12-30(27,28)13-11-24)14-19(18)25-8-2-1-3-9-25/h4-7,14H,1-3,8-13H2,(H,23,26)
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n/an/a 0.700n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233720
PNG
(CHEMBL254909 | N-(4-(4-acetylpiperazin-1-yl)-2-(4-...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C24H30N6O2/c1-17-5-7-30(8-6-17)23-14-20(29-11-9-28(10-12-29)18(2)31)3-4-21(23)27-24(32)22-13-19(15-25)16-26-22/h3-4,13-14,16-17,26H,5-12H2,1-2H3,(H,27,32)
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n/an/a 0.700n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27917
PNG
(4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)
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n/an/a 0.780n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233715
PNG
(5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin...)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCCC1
Show InChI InChI=1S/C22H27N5O2/c1-25-11-13-26(14-12-25)17-5-7-19(20(15-17)27-9-3-2-4-10-27)24-22(28)21-8-6-18(16-23)29-21/h5-8,15H,2-4,9-14H2,1H3,(H,24,28)
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n/an/a 0.800n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233713
PNG
(5-cyano-N-(2-(4-methylpiperidin-1-yl)-4-(4-(methyl...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H29N5O4S/c1-17-7-9-27(10-8-17)21-15-18(26-11-13-28(14-12-26)33(2,30)31)3-5-20(21)25-23(29)22-6-4-19(16-24)32-22/h3-6,15,17H,7-14H2,1-2H3,(H,25,29)
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n/an/a 0.900n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233705
PNG
(4-cyano-N-(2-(4-methylpiperidin-1-yl)-4-(piperazin...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCNCC1
Show InChI InChI=1S/C22H28N6O/c1-16-4-8-28(9-5-16)21-13-18(27-10-6-24-7-11-27)2-3-19(21)26-22(29)20-12-17(14-23)15-25-20/h2-3,12-13,15-16,24-25H,4-11H2,1H3,(H,26,29)
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233707
PNG
(5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H29N5O2/c1-17-7-9-28(10-8-17)21-15-18(27-13-11-26(2)12-14-27)3-5-20(21)25-23(29)22-6-4-19(16-24)30-22/h3-6,15,17H,7-14H2,1-2H3,(H,25,29)
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233697
PNG
(4-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin...)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2cc(c[nH]2)C#N)c(c1)N1CCCCC1
Show InChI InChI=1S/C22H28N6O/c1-26-9-11-27(12-10-26)18-5-6-19(21(14-18)28-7-3-2-4-8-28)25-22(29)20-13-17(15-23)16-24-20/h5-6,13-14,16,24H,2-4,7-12H2,1H3,(H,25,29)
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n/an/a 1.70n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233709
PNG
(CHEMBL253027 | N-(4-(1H-imidazol-1-yl)-2-(piperidi...)
Show SMILES O=C(Nc1ccc(cc1N1CCCCC1)-n1ccnc1)c1ccc(o1)C#N
Show InChI InChI=1S/C20H19N5O2/c21-13-16-5-7-19(27-16)20(26)23-17-6-4-15(25-11-8-22-14-25)12-18(17)24-9-2-1-3-10-24/h4-8,11-12,14H,1-3,9-10H2,(H,23,26)
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM27917
PNG
(4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Kit after 30 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233718
PNG
(5-cyano-N-(2-(3-fluoropiperidin-1-yl)-4-(4-methylp...)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCC(F)C1
Show InChI InChI=1/C22H26FN5O2/c1-26-9-11-27(12-10-26)17-4-6-19(20(13-17)28-8-2-3-16(23)15-28)25-22(29)21-7-5-18(14-24)30-21/h4-7,13,16H,2-3,8-12,15H2,1H3,(H,25,29)
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM27917
PNG
(4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Axl after 11 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233700
PNG
(5-cyano-N-(6-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1nc(ccc1NC(=O)c1ccc(o1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C22H28N6O2/c1-16-7-9-28(10-8-16)21-18(24-22(29)19-5-3-17(15-23)30-19)4-6-20(25-21)27-13-11-26(2)12-14-27/h3-6,16H,7-14H2,1-2H3,(H,24,29)
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM27917
PNG
(4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)
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n/an/a 11n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of TrkA after 27 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233719
PNG
(5-cyano-N-(2-(4-methylpiperidin-1-yl)-4-morpholino...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1ccc(o1)C#N)N1CCOCC1
Show InChI InChI=1S/C22H26N4O3/c1-16-6-8-26(9-7-16)20-14-17(25-10-12-28-13-11-25)2-4-19(20)24-22(27)21-5-3-18(15-23)29-21/h2-5,14,16H,6-13H2,1H3,(H,24,27)
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Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233714
PNG
(5-cyano-N-(2,4-di(piperidin-1-yl)phenyl)furan-2-ca...)
Show SMILES O=C(Nc1ccc(cc1N1CCCCC1)N1CCCCC1)c1ccc(o1)C#N
Show InChI InChI=1S/C22H26N4O2/c23-16-18-8-10-21(28-18)22(27)24-19-9-7-17(25-11-3-1-4-12-25)15-20(19)26-13-5-2-6-14-26/h7-10,15H,1-6,11-14H2,(H,24,27)
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n/an/a 17n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM27917
PNG
(4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)
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n/an/a 18n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Flt3 after 25 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233717
PNG
(5-cyano-N-(4-ethoxy-2-(piperidin-1-yl)phenyl)furan...)
Show SMILES CCOc1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCCC1
Show InChI InChI=1S/C19H21N3O3/c1-2-24-14-6-8-16(17(12-14)22-10-4-3-5-11-22)21-19(23)18-9-7-15(13-20)25-18/h6-9,12H,2-5,10-11H2,1H3,(H,21,23)
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n/an/a 21n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM17750
PNG
(5-cyano-N-[5-(hydroxymethyl)-2-(4-methylpiperidin-...)
Show SMILES CC1CCN(CC1)c1ccc(CO)cc1NC(=O)c1ccc(o1)C#N
Show InChI InChI=1S/C19H21N3O3/c1-13-6-8-22(9-7-13)17-4-2-14(12-23)10-16(17)21-19(24)18-5-3-15(11-20)25-18/h2-5,10,13,23H,6-9,12H2,1H3,(H,21,24)
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n/an/a 24n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233706
PNG
(5-cyano-N-(4-(N-methylmethan-2-ylsulfonamido)-2-(p...)
Show SMILES CN(c1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCCC1)S(C)(=O)=O
Show InChI InChI=1S/C19H22N4O4S/c1-22(28(2,25)26)14-6-8-16(17(12-14)23-10-4-3-5-11-23)21-19(24)18-9-7-15(13-20)27-18/h6-9,12H,3-5,10-11H2,1-2H3,(H,21,24)
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n/an/a 25n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233702
PNG
(5-cyano-N-(4-(3-(ethyl(methyl)amino)propyl)-2-(pip...)
Show SMILES CCN(C)CCCc1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCCC1
Show InChI InChI=1S/C23H30N4O2/c1-3-26(2)13-7-8-18-9-11-20(21(16-18)27-14-5-4-6-15-27)25-23(28)22-12-10-19(17-24)29-22/h9-12,16H,3-8,13-15H2,1-2H3,(H,25,28)
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n/an/a 52n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233699
PNG
(5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(2-oxopipe...)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCCC1=O
Show InChI InChI=1S/C22H25N5O3/c1-25-10-12-26(13-11-25)16-5-7-18(19(14-16)27-9-3-2-4-21(27)28)24-22(29)20-8-6-17(15-23)30-20/h5-8,14H,2-4,9-13H2,1H3,(H,24,29)
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n/an/a>60n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233711
PNG
(5-cyano-N-(4-fluoro-2-(piperidin-1-yl)phenyl)furan...)
Show SMILES Fc1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCCC1
Show InChI InChI=1S/C17H16FN3O2/c18-12-4-6-14(15(10-12)21-8-2-1-3-9-21)20-17(22)16-7-5-13(11-19)23-16/h4-7,10H,1-3,8-9H2,(H,20,22)
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n/an/a 63n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233704
PNG
(5-cyano-N-(4-(4-methyl-1H-pyrazol-1-yl)-2-(piperid...)
Show SMILES Cc1cnn(c1)-c1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCCC1
Show InChI InChI=1S/C21H21N5O2/c1-15-13-23-26(14-15)16-5-7-18(19(11-16)25-9-3-2-4-10-25)24-21(27)20-8-6-17(12-22)28-20/h5-8,11,13-14H,2-4,9-10H2,1H3,(H,24,27)
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n/an/a 64n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233712
PNG
(5-cyano-N-(4-(methylsulfonamido)-2-(piperidin-1-yl...)
Show SMILES CS(=O)(=O)Nc1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCCC1
Show InChI InChI=1S/C18H20N4O4S/c1-27(24,25)21-13-5-7-15(16(11-13)22-9-3-2-4-10-22)20-18(23)17-8-6-14(12-19)26-17/h5-8,11,21H,2-4,9-10H2,1H3,(H,20,23)
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n/an/a 71n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233710
PNG
(5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-morpholino...)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCOCC1
Show InChI InChI=1S/C21H25N5O3/c1-24-6-8-25(9-7-24)16-2-4-18(19(14-16)26-10-12-28-13-11-26)23-21(27)20-5-3-17(15-22)29-20/h2-5,14H,6-13H2,1H3,(H,23,27)
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n/an/a 80n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233698
PNG
(CHEMBL254498 | N-(4-(2-cyanofuran-5-carboxamido)-3...)
Show SMILES CN(C(=O)N1CCN(C)CC1)c1ccc(NC(=O)c2ccc(o2)C#N)c(c1)N1CCCCC1
Show InChI InChI=1S/C24H30N6O3/c1-27-12-14-30(15-13-27)24(32)28(2)18-6-8-20(21(16-18)29-10-4-3-5-11-29)26-23(31)22-9-7-19(17-25)33-22/h6-9,16H,3-5,10-15H2,1-2H3,(H,26,31)
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n/an/a 83n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233708
PNG
(CHEMBL253864 | N-(2-(piperidin-1-yl)phenyl)isoxazo...)
Show SMILES O=C(Nc1ccccc1N1CCCCC1)c1ccno1
Show InChI InChI=1S/C15H17N3O2/c19-15(14-8-9-16-20-14)17-12-6-2-3-7-13(12)18-10-4-1-5-11-18/h2-3,6-9H,1,4-5,10-11H2,(H,17,19)
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n/an/a 400n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50233703
PNG
(5-cyano-N-(5-(4-methylpiperazin-1-yl)-3-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(cnc1NC(=O)c1ccc(o1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C22H28N6O2/c1-16-5-7-28(8-6-16)19-13-17(27-11-9-26(2)10-12-27)15-24-21(19)25-22(29)20-4-3-18(14-23)30-20/h3-4,13,15-16H,5-12H2,1-2H3,(H,24,25,29)
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n/an/a 720n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization


Bioorg Med Chem Lett 18: 1642-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.059
BindingDB Entry DOI: 10.7270/Q2FB52PS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%