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PubMed code 18947221

Compile data set for download or QSAR
Found 19 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413154
PNG
(CHEMBL473459)
Show SMILES OC(=O)COc1ccc(cc1)C#Cc1ccccc1
Show InChI InChI=1S/C16H12O3/c17-16(18)12-19-15-10-8-14(9-11-15)7-6-13-4-2-1-3-5-13/h1-5,8-11H,12H2,(H,17,18)
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n/an/an/an/a 1.26E+3n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413165
PNG
(CHEMBL485738)
Show SMILES Cc1ccc(cc1)C#Cc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C18H16O2/c1-14-2-4-15(5-3-14)6-7-16-8-10-17(11-9-16)12-13-18(19)20/h2-5,8-11H,12-13H2,1H3,(H,19,20)
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n/an/an/an/a 107n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413158
PNG
(CHEMBL488385)
Show SMILES OCc1cccc(c1)C#Cc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C18H16O3/c19-13-17-3-1-2-16(12-17)9-8-14-4-6-15(7-5-14)10-11-18(20)21/h1-7,12,19H,10-11,13H2,(H,20,21)
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n/an/an/an/a 891n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413164
PNG
(CHEMBL454257)
Show SMILES Cc1cccc(c1)C#Cc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C18H16O2/c1-14-3-2-4-17(13-14)10-9-15-5-7-16(8-6-15)11-12-18(19)20/h2-8,13H,11-12H2,1H3,(H,19,20)
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n/an/an/an/a 43.6n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413168
PNG
(CHEMBL486139)
Show SMILES Cc1cc(C)cc(c1)C#Cc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C19H18O2/c1-14-11-15(2)13-18(12-14)8-7-16-3-5-17(6-4-16)9-10-19(20)21/h3-6,11-13H,9-10H2,1-2H3,(H,20,21)
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n/an/an/an/a 74.1n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50275597
PNG
(3-(4-(o-Tolylethynyl)phenyl)propanoic acid | CHEMB...)
Show SMILES Cc1ccccc1C#Cc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C18H16O2/c1-14-4-2-3-5-17(14)12-10-15-6-8-16(9-7-15)11-13-18(19)20/h2-9H,11,13H2,1H3,(H,19,20)
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n/an/an/an/a 32n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413155
PNG
(CHEMBL486145)
Show SMILES Cc1ccccc1C#Cc1ccc(OCC(O)=O)cc1
Show InChI InChI=1S/C17H14O3/c1-13-4-2-3-5-15(13)9-6-14-7-10-16(11-8-14)20-12-17(18)19/h2-5,7-8,10-11H,12H2,1H3,(H,18,19)
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n/an/an/an/a 3.72E+3n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413163
PNG
(CHEMBL487365)
Show SMILES OC(=O)CCc1ccc(cc1)C#Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C18H13F3O2/c19-18(20,21)16-3-1-2-15(12-16)9-8-13-4-6-14(7-5-13)10-11-17(22)23/h1-7,12H,10-11H2,(H,22,23)
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n/an/an/an/a 89.1n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413157
PNG
(CHEMBL446575)
Show SMILES Nc1cccc(c1)C#Cc1ccc(CCC(O)=O)cc1
Show InChI InChI=1S/C17H15NO2/c18-16-3-1-2-15(12-16)9-8-13-4-6-14(7-5-13)10-11-17(19)20/h1-7,12H,10-11,18H2,(H,19,20)
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n/an/an/an/a 1.10E+3n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413159
PNG
(CHEMBL488395)
Show SMILES OC(=O)CCc1ccc(cc1)C#Cc1cccc(C=O)c1
Show InChI InChI=1S/C18H14O3/c19-13-17-3-1-2-16(12-17)9-8-14-4-6-15(7-5-14)10-11-18(20)21/h1-7,12-13H,10-11H2,(H,20,21)
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n/an/an/an/a 355n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413160
PNG
(CHEMBL488396)
Show SMILES OC(=O)CCc1ccc(cc1)C#Cc1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C17H13NO4/c19-17(20)11-10-14-6-4-13(5-7-14)8-9-15-2-1-3-16(12-15)18(21)22/h1-7,12H,10-11H2,(H,19,20)
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n/an/an/an/a 58.9n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413161
PNG
(CHEMBL526510)
Show SMILES OC(=O)CCc1ccc(cc1)C#Cc1cccc(c1)C#N
Show InChI InChI=1S/C18H13NO2/c19-13-17-3-1-2-16(12-17)9-8-14-4-6-15(7-5-14)10-11-18(20)21/h1-7,12H,10-11H2,(H,20,21)
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n/an/an/an/a 91.2n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413162
PNG
(CHEMBL487570)
Show SMILES OC(=O)CCc1ccc(cc1)C#Cc1cccc(c1)C#C
Show InChI InChI=1S/C19H14O2/c1-2-15-4-3-5-18(14-15)11-10-16-6-8-17(9-7-16)12-13-19(20)21/h1,3-9,14H,12-13H2,(H,20,21)
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n/an/an/an/a 155n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413167
PNG
(CHEMBL519548)
Show SMILES OC(=O)CCc1ccc(cc1)C#Cc1cccc(\C=C\C=C)c1\C=C\C=C
Show InChI InChI=1S/C25H22O2/c1-3-5-8-22-9-7-10-23(24(22)11-6-4-2)18-16-20-12-14-21(15-13-20)17-19-25(26)27/h3-15H,1-2,17,19H2,(H,26,27)/b8-5+,11-6+
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n/an/an/an/a 85.1n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413169
PNG
(CHEMBL485713)
Show SMILES Cc1cccc(c1)C#Cc1ccc(OCC(O)=O)cc1
Show InChI InChI=1S/C17H14O3/c1-13-3-2-4-15(11-13)6-5-14-7-9-16(10-8-14)20-12-17(18)19/h2-4,7-11H,12H2,1H3,(H,18,19)
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n/an/an/an/a 513n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM22496
PNG
(3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propan...)
Show SMILES OC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1
Show InChI InChI=1S/C22H21NO3/c24-22(25)14-11-17-9-12-19(13-10-17)23-16-18-5-4-8-21(15-18)26-20-6-2-1-3-7-20/h1-10,12-13,15,23H,11,14,16H2,(H,24,25)
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n/an/an/an/a 47.9n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in CHO cells by Gal4 luciferase reporter gene assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413166
PNG
(CHEMBL485935)
Show SMILES Cc1cccc(C#Cc2ccc(CCC(O)=O)cc2)c1C
Show InChI InChI=1S/C19H18O2/c1-14-4-3-5-18(15(14)2)12-10-16-6-8-17(9-7-16)11-13-19(20)21/h3-9H,11,13H2,1-2H3,(H,20,21)
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n/an/an/an/a 87.1n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50275510
PNG
(3-(4-(Phenylethynyl)phenyl)propanoic acid | CHEMBL...)
Show SMILES OC(=O)CCc1ccc(cc1)C#Cc1ccccc1
Show InChI InChI=1S/C17H14O2/c18-17(19)13-12-16-10-8-15(9-11-16)7-6-14-4-2-1-3-5-14/h1-5,8-11H,12-13H2,(H,18,19)
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n/an/an/an/a 96n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
Free fatty acid receptor 1


(Homo sapiens (Human))
BDBM50413156
PNG
(CHEMBL449321)
Show SMILES OC(=O)COc1ccc(cc1)C#Cc1cccc(O)c1
Show InChI InChI=1S/C16H12O4/c17-14-3-1-2-13(10-14)5-4-12-6-8-15(9-7-12)20-11-16(18)19/h1-3,6-10,17H,11H2,(H,18,19)
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n/an/an/an/a 5.62E+3n/an/an/an/a



University of Southern Denmark

Curated by ChEMBL


Assay Description
Agonist activity at human FFA1 expressed in human 1321N1 cells by calcium fluorescence assay


J Med Chem 51: 7061-4 (2009)


Article DOI: 10.1021/jm8010178
BindingDB Entry DOI: 10.7270/Q2D79B8W
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%