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PubMed code 19539481

Compile data set for download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35738
PNG
(sulfonamide deriv., 7f)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)c(Br)c1
Show InChI InChI=1S/C14H13BrN2O3S/c15-12-9-11(21(16,19)20)6-7-13(12)17-14(18)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
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5.90 -47.0n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35742
PNG
(sulfonamide deriv., 8)
Show SMILES NS(=O)(=O)c1nnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C10H10N4O3S2/c11-19(16,17)10-14-13-9(18-10)12-8(15)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,11,16,17)(H,12,13,15)
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PubMed
6.10 -46.9n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35733
PNG
(sulfonamide deriv., 7a)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O3S/c15-20(18,19)13-8-6-12(7-9-13)16-14(17)10-11-4-2-1-3-5-11/h1-9H,10H2,(H,16,17)(H2,15,18,19)
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6.70 -46.7n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35739
PNG
(sulfonamide deriv., 7g)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccn2)cc1
Show InChI InChI=1S/C13H13N3O3S/c14-20(18,19)12-6-4-10(5-7-12)16-13(17)9-11-3-1-2-8-15-11/h1-8H,9H2,(H,16,17)(H2,14,18,19)
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6.80 -46.6n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35739
PNG
(sulfonamide deriv., 7g)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccn2)cc1
Show InChI InChI=1S/C13H13N3O3S/c14-20(18,19)12-6-4-10(5-7-12)16-13(17)9-11-3-1-2-8-15-11/h1-8H,9H2,(H,16,17)(H2,14,18,19)
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6.80 -46.6n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35727
PNG
(sulfonamide deriv., 5b)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)c(F)c1
Show InChI InChI=1S/C12H11FN2O3S2/c13-10-7-9(20(14,17)18)3-4-11(10)15-12(16)6-8-2-1-5-19-8/h1-5,7H,6H2,(H,15,16)(H2,14,17,18)
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6.90 -46.6n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35726
PNG
(sulfonamide deriv., 5a)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)cc1
Show InChI InChI=1S/C12H12N2O3S2/c13-19(16,17)11-5-3-9(4-6-11)14-12(15)8-10-2-1-7-18-10/h1-7H,8H2,(H,14,15)(H2,13,16,17)
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7 -46.5n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35738
PNG
(sulfonamide deriv., 7f)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)c(Br)c1
Show InChI InChI=1S/C14H13BrN2O3S/c15-12-9-11(21(16,19)20)6-7-13(12)17-14(18)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
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7.10 -46.5n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35730
PNG
(cid_694792 | sulfonamide deriv., 5e)
Show SMILES NS(=O)(=O)c1ccc(CNC(=O)Cc2cccs2)cc1
Show InChI InChI=1S/C13H14N2O3S2/c14-20(17,18)12-5-3-10(4-6-12)9-15-13(16)8-11-2-1-7-19-11/h1-7H,8-9H2,(H,15,16)(H2,14,17,18)
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7.20 -46.5n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35726
PNG
(sulfonamide deriv., 5a)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)cc1
Show InChI InChI=1S/C12H12N2O3S2/c13-19(16,17)11-5-3-9(4-6-11)14-12(15)8-10-2-1-7-18-10/h1-7H,8H2,(H,14,15)(H2,13,16,17)
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7.20 -46.5n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35740
PNG
(sulfonamide deriv., 7h)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccncc2)cc1
Show InChI InChI=1S/C13H13N3O3S/c14-20(18,19)12-3-1-11(2-4-12)16-13(17)9-10-5-7-15-8-6-10/h1-8H,9H2,(H,16,17)(H2,14,18,19)
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7.30 -46.4n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35732
PNG
(sulfonamide deriv., 6)
Show SMILES NS(=O)(=O)c1nnc(NC(=O)Cc2cccs2)s1
Show InChI InChI=1S/C8H8N4O3S3/c9-18(14,15)8-12-11-7(17-8)10-6(13)4-5-2-1-3-16-5/h1-3H,4H2,(H2,9,14,15)(H,10,11,13)
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7.40 -46.4n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35729
PNG
(sulfonamide deriv., 5d)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)c(Br)c1
Show InChI InChI=1S/C12H11BrN2O3S2/c13-10-7-9(20(14,17)18)3-4-11(10)15-12(16)6-8-2-1-5-19-8/h1-5,7H,6H2,(H,15,16)(H2,14,17,18)
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7.5 -46.4n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35741
PNG
(sulfonamide deriv., 7i)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)Cc2ccncc2)cc1
Show InChI InChI=1S/C15H17N3O3S/c16-22(20,21)14-3-1-12(2-4-14)7-10-18-15(19)11-13-5-8-17-9-6-13/h1-6,8-9H,7,10-11H2,(H,18,19)(H2,16,20,21)
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7.60 -46.3n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35732
PNG
(sulfonamide deriv., 6)
Show SMILES NS(=O)(=O)c1nnc(NC(=O)Cc2cccs2)s1
Show InChI InChI=1S/C8H8N4O3S3/c9-18(14,15)8-12-11-7(17-8)10-6(13)4-5-2-1-3-16-5/h1-3H,4H2,(H2,9,14,15)(H,10,11,13)
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7.60 -46.3n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35728
PNG
(sulfonamide deriv., 5c)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)c(Cl)c1
Show InChI InChI=1S/C12H11ClN2O3S2/c13-10-7-9(20(14,17)18)3-4-11(10)15-12(16)6-8-2-1-5-19-8/h1-5,7H,6H2,(H,15,16)(H2,14,17,18)
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7.70 -46.3n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35727
PNG
(sulfonamide deriv., 5b)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)c(F)c1
Show InChI InChI=1S/C12H11FN2O3S2/c13-10-7-9(20(14,17)18)3-4-11(10)15-12(16)6-8-2-1-5-19-8/h1-5,7H,6H2,(H,15,16)(H2,14,17,18)
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7.90 -46.2n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35733
PNG
(sulfonamide deriv., 7a)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O3S/c15-20(18,19)13-8-6-12(7-9-13)16-14(17)10-11-4-2-1-3-5-11/h1-9H,10H2,(H,16,17)(H2,15,18,19)
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7.90 -46.2n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35731
PNG
(sulfonamide deriv., 5f)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)Cc2cccs2)cc1
Show InChI InChI=1S/C14H16N2O3S2/c15-21(18,19)13-5-3-11(4-6-13)7-8-16-14(17)10-12-2-1-9-20-12/h1-6,9H,7-8,10H2,(H,16,17)(H2,15,18,19)
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8 -46.2n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35735
PNG
(sulfonamide deriv., 7c)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C16H18N2O3S/c17-22(20,21)15-8-6-13(7-9-15)10-11-18-16(19)12-14-4-2-1-3-5-14/h1-9H,10-12H2,(H,18,19)(H2,17,20,21)
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8.10 -46.2n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35736
PNG
(sulfonamide deriv., 7d)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)c(F)c1
Show InChI InChI=1S/C14H13FN2O3S/c15-12-9-11(21(16,19)20)6-7-13(12)17-14(18)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
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8.10 -46.2n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35737
PNG
(sulfonamide deriv., 7e)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C14H13ClN2O3S/c15-12-9-11(21(16,19)20)6-7-13(12)17-14(18)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
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8.10 -46.2n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35737
PNG
(sulfonamide deriv., 7e)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C14H13ClN2O3S/c15-12-9-11(21(16,19)20)6-7-13(12)17-14(18)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
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8.20 -46.2n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35735
PNG
(sulfonamide deriv., 7c)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C16H18N2O3S/c17-22(20,21)15-8-6-13(7-9-15)10-11-18-16(19)12-14-4-2-1-3-5-14/h1-9H,10-12H2,(H,18,19)(H2,17,20,21)
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8.20 -46.2n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35736
PNG
(sulfonamide deriv., 7d)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)c(F)c1
Show InChI InChI=1S/C14H13FN2O3S/c15-12-9-11(21(16,19)20)6-7-13(12)17-14(18)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
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8.30 -46.1n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35734
PNG
(sulfonamide deriv., 7b)
Show SMILES NS(=O)(=O)c1ccc(CNC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O3S/c16-21(19,20)14-8-6-13(7-9-14)11-17-15(18)10-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,17,18)(H2,16,19,20)
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8.30 -46.1n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35742
PNG
(sulfonamide deriv., 8)
Show SMILES NS(=O)(=O)c1nnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C10H10N4O3S2/c11-19(16,17)10-14-13-9(18-10)12-8(15)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,11,16,17)(H,12,13,15)
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8.40 -46.1n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35728
PNG
(sulfonamide deriv., 5c)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)c(Cl)c1
Show InChI InChI=1S/C12H11ClN2O3S2/c13-10-7-9(20(14,17)18)3-4-11(10)15-12(16)6-8-2-1-5-19-8/h1-5,7H,6H2,(H,15,16)(H2,14,17,18)
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8.60 -46.0n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35734
PNG
(sulfonamide deriv., 7b)
Show SMILES NS(=O)(=O)c1ccc(CNC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O3S/c16-21(19,20)14-8-6-13(7-9-14)11-17-15(18)10-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,17,18)(H2,16,19,20)
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8.60 -46.0n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35729
PNG
(sulfonamide deriv., 5d)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)c(Br)c1
Show InChI InChI=1S/C12H11BrN2O3S2/c13-10-7-9(20(14,17)18)3-4-11(10)15-12(16)6-8-2-1-5-19-8/h1-5,7H,6H2,(H,15,16)(H2,14,17,18)
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8.70 -46.0n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35740
PNG
(sulfonamide deriv., 7h)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccncc2)cc1
Show InChI InChI=1S/C13H13N3O3S/c14-20(18,19)12-3-1-11(2-4-12)16-13(17)9-10-5-7-15-8-6-10/h1-8H,9H2,(H,16,17)(H2,14,18,19)
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9 -45.9n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35730
PNG
(cid_694792 | sulfonamide deriv., 5e)
Show SMILES NS(=O)(=O)c1ccc(CNC(=O)Cc2cccs2)cc1
Show InChI InChI=1S/C13H14N2O3S2/c14-20(17,18)12-5-3-10(4-6-12)9-15-13(16)8-11-2-1-7-19-11/h1-7H,8-9H2,(H,15,16)(H2,14,17,18)
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9.10 -45.9n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VB


(Homo sapiens (Human))
BDBM35741
PNG
(sulfonamide deriv., 7i)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)Cc2ccncc2)cc1
Show InChI InChI=1S/C15H17N3O3S/c16-22(20,21)14-3-1-12(2-4-14)7-10-18-15(19)11-13-5-8-17-9-6-13/h1-6,8-9H,7,10-11H2,(H,18,19)(H2,16,20,21)
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9.30 -45.8n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic Anhydrase VA


(Homo sapiens (Human))
BDBM35731
PNG
(sulfonamide deriv., 5f)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)Cc2cccs2)cc1
Show InChI InChI=1S/C14H16N2O3S2/c15-21(18,19)13-5-3-11(4-6-13)7-8-16-14(17)10-12-2-1-9-20-12/h1-6,9H,7-8,10H2,(H,16,17)(H2,15,18,19)
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10.2 -45.6n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35728
PNG
(sulfonamide deriv., 5c)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)c(Cl)c1
Show InChI InChI=1S/C12H11ClN2O3S2/c13-10-7-9(20(14,17)18)3-4-11(10)15-12(16)6-8-2-1-5-19-8/h1-5,7H,6H2,(H,15,16)(H2,14,17,18)
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50 -41.7n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35726
PNG
(sulfonamide deriv., 5a)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)cc1
Show InChI InChI=1S/C12H12N2O3S2/c13-19(16,17)11-5-3-9(4-6-11)14-12(15)8-10-2-1-7-18-10/h1-7H,8H2,(H,14,15)(H2,13,16,17)
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50 -41.7n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35732
PNG
(sulfonamide deriv., 6)
Show SMILES NS(=O)(=O)c1nnc(NC(=O)Cc2cccs2)s1
Show InChI InChI=1S/C8H8N4O3S3/c9-18(14,15)8-12-11-7(17-8)10-6(13)4-5-2-1-3-16-5/h1-3H,4H2,(H2,9,14,15)(H,10,11,13)
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51 -41.6n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35742
PNG
(sulfonamide deriv., 8)
Show SMILES NS(=O)(=O)c1nnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C10H10N4O3S2/c11-19(16,17)10-14-13-9(18-10)12-8(15)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,11,16,17)(H,12,13,15)
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51 -41.6n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35729
PNG
(sulfonamide deriv., 5d)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)c(Br)c1
Show InChI InChI=1S/C12H11BrN2O3S2/c13-10-7-9(20(14,17)18)3-4-11(10)15-12(16)6-8-2-1-5-19-8/h1-5,7H,6H2,(H,15,16)(H2,14,17,18)
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52 -41.6n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35730
PNG
(cid_694792 | sulfonamide deriv., 5e)
Show SMILES NS(=O)(=O)c1ccc(CNC(=O)Cc2cccs2)cc1
Show InChI InChI=1S/C13H14N2O3S2/c14-20(17,18)12-5-3-10(4-6-12)9-15-13(16)8-11-2-1-7-19-11/h1-7H,8-9H2,(H,15,16)(H2,14,17,18)
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52 -41.6n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35731
PNG
(sulfonamide deriv., 5f)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)Cc2cccs2)cc1
Show InChI InChI=1S/C14H16N2O3S2/c15-21(18,19)13-5-3-11(4-6-13)7-8-16-14(17)10-12-2-1-9-20-12/h1-6,9H,7-8,10H2,(H,16,17)(H2,15,18,19)
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53 -41.5n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35734
PNG
(sulfonamide deriv., 7b)
Show SMILES NS(=O)(=O)c1ccc(CNC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O3S/c16-21(19,20)14-8-6-13(7-9-14)11-17-15(18)10-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,17,18)(H2,16,19,20)
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54 -41.5n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35737
PNG
(sulfonamide deriv., 7e)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C14H13ClN2O3S/c15-12-9-11(21(16,19)20)6-7-13(12)17-14(18)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
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58 -41.3n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35735
PNG
(sulfonamide deriv., 7c)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C16H18N2O3S/c17-22(20,21)15-8-6-13(7-9-15)10-11-18-16(19)12-14-4-2-1-3-5-14/h1-9H,10-12H2,(H,18,19)(H2,17,20,21)
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60 -41.2n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35730
PNG
(cid_694792 | sulfonamide deriv., 5e)
Show SMILES NS(=O)(=O)c1ccc(CNC(=O)Cc2cccs2)cc1
Show InChI InChI=1S/C13H14N2O3S2/c14-20(17,18)12-5-3-10(4-6-12)9-15-13(16)8-11-2-1-7-19-11/h1-7H,8-9H2,(H,15,16)(H2,14,17,18)
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60 -41.2n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35736
PNG
(sulfonamide deriv., 7d)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)c(F)c1
Show InChI InChI=1S/C14H13FN2O3S/c15-12-9-11(21(16,19)20)6-7-13(12)17-14(18)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
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61 -41.2n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35737
PNG
(sulfonamide deriv., 7e)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C14H13ClN2O3S/c15-12-9-11(21(16,19)20)6-7-13(12)17-14(18)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
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61 -41.2n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35726
PNG
(sulfonamide deriv., 5a)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)cc1
Show InChI InChI=1S/C12H12N2O3S2/c13-19(16,17)11-5-3-9(4-6-11)14-12(15)8-10-2-1-7-18-10/h1-7H,8H2,(H,14,15)(H2,13,16,17)
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61 -41.2n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35742
PNG
(sulfonamide deriv., 8)
Show SMILES NS(=O)(=O)c1nnc(NC(=O)Cc2ccccc2)s1
Show InChI InChI=1S/C10H10N4O3S2/c11-19(16,17)10-14-13-9(18-10)12-8(15)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,11,16,17)(H,12,13,15)
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63 -41.1n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35735
PNG
(sulfonamide deriv., 7c)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C16H18N2O3S/c17-22(20,21)15-8-6-13(7-9-15)10-11-18-16(19)12-14-4-2-1-3-5-14/h1-9H,10-12H2,(H,18,19)(H2,17,20,21)
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67 -40.9n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35736
PNG
(sulfonamide deriv., 7d)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)c(F)c1
Show InChI InChI=1S/C14H13FN2O3S/c15-12-9-11(21(16,19)20)6-7-13(12)17-14(18)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
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67 -40.9n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35731
PNG
(sulfonamide deriv., 5f)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)Cc2cccs2)cc1
Show InChI InChI=1S/C14H16N2O3S2/c15-21(18,19)13-5-3-11(4-6-13)7-8-16-14(17)10-12-2-1-9-20-12/h1-6,9H,7-8,10H2,(H,16,17)(H2,15,18,19)
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68 -40.9n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35739
PNG
(sulfonamide deriv., 7g)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccn2)cc1
Show InChI InChI=1S/C13H13N3O3S/c14-20(18,19)12-6-4-10(5-7-12)16-13(17)9-11-3-1-2-8-15-11/h1-8H,9H2,(H,16,17)(H2,14,18,19)
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69 -40.9n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35740
PNG
(sulfonamide deriv., 7h)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccncc2)cc1
Show InChI InChI=1S/C13H13N3O3S/c14-20(18,19)12-3-1-11(2-4-12)16-13(17)9-10-5-7-15-8-6-10/h1-8H,9H2,(H,16,17)(H2,14,18,19)
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71 -40.8n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35732
PNG
(sulfonamide deriv., 6)
Show SMILES NS(=O)(=O)c1nnc(NC(=O)Cc2cccs2)s1
Show InChI InChI=1S/C8H8N4O3S3/c9-18(14,15)8-12-11-7(17-8)10-6(13)4-5-2-1-3-16-5/h1-3H,4H2,(H2,9,14,15)(H,10,11,13)
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72 -40.8n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35741
PNG
(sulfonamide deriv., 7i)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)Cc2ccncc2)cc1
Show InChI InChI=1S/C15H17N3O3S/c16-22(20,21)14-3-1-12(2-4-14)7-10-18-15(19)11-13-5-8-17-9-6-13/h1-6,8-9H,7,10-11H2,(H,18,19)(H2,16,20,21)
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73 -40.7n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35740
PNG
(sulfonamide deriv., 7h)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccncc2)cc1
Show InChI InChI=1S/C13H13N3O3S/c14-20(18,19)12-3-1-11(2-4-12)16-13(17)9-10-5-7-15-8-6-10/h1-8H,9H2,(H,16,17)(H2,14,18,19)
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74 -40.7n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35734
PNG
(sulfonamide deriv., 7b)
Show SMILES NS(=O)(=O)c1ccc(CNC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C15H16N2O3S/c16-21(19,20)14-8-6-13(7-9-14)11-17-15(18)10-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,17,18)(H2,16,19,20)
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75 -40.7n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35739
PNG
(sulfonamide deriv., 7g)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccn2)cc1
Show InChI InChI=1S/C13H13N3O3S/c14-20(18,19)12-6-4-10(5-7-12)16-13(17)9-11-3-1-2-8-15-11/h1-8H,9H2,(H,16,17)(H2,14,18,19)
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75 -40.7n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35728
PNG
(sulfonamide deriv., 5c)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)c(Cl)c1
Show InChI InChI=1S/C12H11ClN2O3S2/c13-10-7-9(20(14,17)18)3-4-11(10)15-12(16)6-8-2-1-5-19-8/h1-5,7H,6H2,(H,15,16)(H2,14,17,18)
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77 -40.6n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35729
PNG
(sulfonamide deriv., 5d)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)c(Br)c1
Show InChI InChI=1S/C12H11BrN2O3S2/c13-10-7-9(20(14,17)18)3-4-11(10)15-12(16)6-8-2-1-5-19-8/h1-5,7H,6H2,(H,15,16)(H2,14,17,18)
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84 -40.4n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35741
PNG
(sulfonamide deriv., 7i)
Show SMILES NS(=O)(=O)c1ccc(CCNC(=O)Cc2ccncc2)cc1
Show InChI InChI=1S/C15H17N3O3S/c16-22(20,21)14-3-1-12(2-4-14)7-10-18-15(19)11-13-5-8-17-9-6-13/h1-6,8-9H,7,10-11H2,(H,18,19)(H2,16,20,21)
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97 -40.0n/an/an/an/an/an/a25



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35733
PNG
(sulfonamide deriv., 7a)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O3S/c15-20(18,19)13-8-6-12(7-9-13)16-14(17)10-11-4-2-1-3-5-11/h1-9H,10H2,(H,16,17)(H2,15,18,19)
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107 -39.8n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35733
PNG
(sulfonamide deriv., 7a)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O3S/c15-20(18,19)13-8-6-12(7-9-13)16-14(17)10-11-4-2-1-3-5-11/h1-9H,10H2,(H,16,17)(H2,15,18,19)
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108 -39.8n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35727
PNG
(sulfonamide deriv., 5b)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)c(F)c1
Show InChI InChI=1S/C12H11FN2O3S2/c13-10-7-9(20(14,17)18)3-4-11(10)15-12(16)6-8-2-1-5-19-8/h1-5,7H,6H2,(H,15,16)(H2,14,17,18)
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PubMed
161 -38.8n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 1


(Homo sapiens (Human))
BDBM35738
PNG
(sulfonamide deriv., 7f)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)c(Br)c1
Show InChI InChI=1S/C14H13BrN2O3S/c15-12-9-11(21(16,19)20)6-7-13(12)17-14(18)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
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PubMed
263 -37.6n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35727
PNG
(sulfonamide deriv., 5b)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2cccs2)c(F)c1
Show InChI InChI=1S/C12H11FN2O3S2/c13-10-7-9(20(14,17)18)3-4-11(10)15-12(16)6-8-2-1-5-19-8/h1-5,7H,6H2,(H,15,16)(H2,14,17,18)
PDB
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Article
PubMed
390 -36.6n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM35738
PNG
(sulfonamide deriv., 7f)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)c(Br)c1
Show InChI InChI=1S/C14H13BrN2O3S/c15-12-9-11(21(16,19)20)6-7-13(12)17-14(18)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H,17,18)(H2,16,19,20)
PDB
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Article
PubMed
395 -36.5n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 4894-9 (2009)


Article DOI: 10.1016/j.bmc.2009.06.006
BindingDB Entry DOI: 10.7270/Q2RJ4GT1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
* indicates data uncertainty>20%