Compile Data Set for Download or QSAR
maximum 50k data
Found 98 Enz. Inhib. hit(s) with all data for entry = 50030739
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM16047((4S)-4-[(2S)-2-[(2R,4S,5S)-5-[(2S)-2-[(2S)-2-[(4S)...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300733((8R)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300711(8-(3-(2-fluoropyridin-3-yl)phenyl)-8-(4-(trifluoro...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300732((8R)-8-(3-Pyrimidin-5-ylphenyl)-8-[4-(trifluoromet...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300719((8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300720(8-(3-(2-fluoropyridin-3-yl)phenyl)-8-(4-methoxyphe...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300713(9-(3-(2-fluoropyridin-3-yl)phenyl)-9-(4-(trifluoro...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300714(7-(3-(2-fluoropyridin-3-yl)phenyl)-7-(4-(trifluoro...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300715(8-(3,4-diethoxyphenyl)-8-(3-(2-fluoropyridin-3-yl)...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300725(8-(3-(pyrimidin-5-yl)phenyl)-8-(4-(trifluoromethox...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300721(8-(4-methoxyphenyl)-8-(3-(pyrimidin-5-yl)phenyl)-2...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM16755(Acylguanidine, 10d | N-[(1Z)-amino[(3-hydroxypropy...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300712(10-(3-(2-fluoropyridin-3-yl)phenyl)-10-(4-(trifluo...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300718(8-(benzo[d][1,3]dioxol-5-yl)-8-(3-(2-fluoropyridin...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300724(7-(3-(2-fluoropyridin-3-yl)phenyl)-2,2-dimethyl-7-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300717(8-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-8-(3-(2-fl...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300722(8-(3-(2-cyclopropylethyl)phenyl)-8-(4-(trifluorome...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300719((8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50:  370nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300716(8-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-8-(3-(2-f...)
Affinity DataIC50:  740nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300730((8S)-8-(3-Pyrimidin-5-ylphenyl)-8-[4-(trifluoromet...)
Affinity DataIC50:  790nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300708(8-(3-propylphenyl)-8-(4-(trifluoromethoxy)phenyl)-...)
Affinity DataIC50:  1.43E+3nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300711(8-(3-(2-fluoropyridin-3-yl)phenyl)-8-(4-(trifluoro...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300711(8-(3-(2-fluoropyridin-3-yl)phenyl)-8-(4-(trifluoro...)
Affinity DataIC50:  2.04E+3nMAssay Description:Inhibition of human recombinant renin by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300711(8-(3-(2-fluoropyridin-3-yl)phenyl)-8-(4-(trifluoro...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300709(8-(3-bromophenyl)-8-(4-(trifluoromethoxy)phenyl)-2...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300733((8R)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300722(8-(3-(2-cyclopropylethyl)phenyl)-8-(4-(trifluorome...)
Affinity DataIC50:  3.78E+3nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300718(8-(benzo[d][1,3]dioxol-5-yl)-8-(3-(2-fluoropyridin...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300727(8-(3-benzylphenyl)-8-phenyl-2,3,4,8-tetrahydroimid...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300720(8-(3-(2-fluoropyridin-3-yl)phenyl)-8-(4-methoxyphe...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300733((8R)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300726(8-(3-(4-fluorobenzyl)phenyl)-8-phenyl-2,3,4,8-tetr...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300728(8-(3-(4-methoxybenzyl)phenyl)-8-phenyl-2,3,4,8-tet...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300713(9-(3-(2-fluoropyridin-3-yl)phenyl)-9-(4-(trifluoro...)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300726(8-(3-(4-fluorobenzyl)phenyl)-8-phenyl-2,3,4,8-tetr...)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300726(8-(3-(4-fluorobenzyl)phenyl)-8-phenyl-2,3,4,8-tetr...)
Affinity DataIC50:  9.20E+3nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300717(8-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-8-(3-(2-fl...)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300715(8-(3,4-diethoxyphenyl)-8-(3-(2-fluoropyridin-3-yl)...)
Affinity DataIC50:  9.90E+3nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300717(8-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-8-(3-(2-fl...)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300732((8R)-8-(3-Pyrimidin-5-ylphenyl)-8-[4-(trifluoromet...)
Affinity DataIC50:  1.07E+4nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300714(7-(3-(2-fluoropyridin-3-yl)phenyl)-7-(4-(trifluoro...)
Affinity DataIC50:  1.07E+4nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300713(9-(3-(2-fluoropyridin-3-yl)phenyl)-9-(4-(trifluoro...)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300712(10-(3-(2-fluoropyridin-3-yl)phenyl)-10-(4-(trifluo...)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300727(8-(3-benzylphenyl)-8-phenyl-2,3,4,8-tetrahydroimid...)
Affinity DataIC50:  1.09E+4nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300712(10-(3-(2-fluoropyridin-3-yl)phenyl)-10-(4-(trifluo...)
Affinity DataIC50:  1.13E+4nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300719((8S)-8-[3-(2-Fluoropyridin-3-yl)phenyl]-8-[4-(trif...)
Affinity DataIC50:  1.14E+4nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300714(7-(3-(2-fluoropyridin-3-yl)phenyl)-7-(4-(trifluoro...)
Affinity DataIC50:  1.22E+4nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300718(8-(benzo[d][1,3]dioxol-5-yl)-8-(3-(2-fluoropyridin...)
Affinity DataIC50:  1.54E+4nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300721(8-(4-methoxyphenyl)-8-(3-(pyrimidin-5-yl)phenyl)-2...)
Affinity DataIC50:  1.62E+4nMAssay Description:Inhibition of human BACE2 by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300722(8-(3-(2-cyclopropylethyl)phenyl)-8-(4-(trifluorome...)
Affinity DataIC50:  1.64E+4nMAssay Description:Inhibition of human cathepsin D by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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