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Found 36 Enz. Inhib. hit(s) with all data for entry = 50031544
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315095(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315097(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315088(4-(3-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-tri...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315087(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315096((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315082((R)-1-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315090((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315085(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315091((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315093((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315099(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315086(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315092((R)-1-(4-(4-(dimethylamino)piperidin-1-yl)phenyl)-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315098(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315083(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315084(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  2nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315089((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Rattus norvegicus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50315094(1-(4-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of rat brain mTOR assessed as p70S6k-GST protein phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315088(4-(3-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-tri...)
Affinity DataIC50:  41nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315093((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50:  43nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315087(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  55nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315086(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  76nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315082((R)-1-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)...)
Affinity DataIC50:  90nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315097(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  173nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315089((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50:  220nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315091((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50:  269nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315083(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  287nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315085(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  314nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315099(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  330nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315092((R)-1-(4-(4-(dimethylamino)piperidin-1-yl)phenyl)-...)
Affinity DataIC50:  402nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315084(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  413nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315090((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50:  414nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315096((R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-...)
Affinity DataIC50:  593nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315095(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  644nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315098(1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazi...)
Affinity DataIC50:  846nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50315094(1-(4-(4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of PI3Kalpha assessed as PIP3 accumulation after 24 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed