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PubMed code 22595176

Compile data set for download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384120
PNG
(CHEMBL2029565)
Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12
Show InChI InChI=1S/C21H18N6O2S/c1-12-8-19(30-24-12)26-7-6-18-20(21(26)28)27(25-23-18)13(2)14-4-5-17-15(9-14)10-16(29-3)11-22-17/h4-11,13H,1-3H3/t13-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384118
PNG
(CHEMBL2029563)
Show SMILES COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cc(C)ns5)c(=O)c34)cc2c1
Show InChI InChI=1S/C22H20N6O3S/c1-14-9-20(32-25-14)27-6-5-19-21(22(27)29)28(26-24-19)13-15-3-4-18-16(10-15)11-17(12-23-18)31-8-7-30-2/h3-6,9-12H,7-8,13H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384121
PNG
(CHEMBL2029678)
Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12
Show InChI InChI=1S/C23H22N6O3S/c1-14-10-21(33-26-14)28-7-6-20-22(23(28)30)29(27-25-20)15(2)16-4-5-19-17(11-16)12-18(13-24-19)32-9-8-31-3/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384128
PNG
(CHEMBL2029686)
Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(F)cc(F)c3)c(=O)c12
Show InChI InChI=1S/C25H21F2N5O3/c1-15(16-3-4-22-17(9-16)10-21(14-28-22)35-8-7-34-2)32-24-23(29-30-32)5-6-31(25(24)33)20-12-18(26)11-19(27)13-20/h3-6,9-15H,7-8H2,1-2H3/t15-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384121
PNG
(CHEMBL2029678)
Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12
Show InChI InChI=1S/C23H22N6O3S/c1-14-10-21(33-26-14)28-7-6-20-22(23(28)30)29(27-25-20)15(2)16-4-5-19-17(11-16)12-18(13-24-19)32-9-8-31-3/h4-7,10-13,15H,8-9H2,1-3H3/t15-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384120
PNG
(CHEMBL2029565)
Show SMILES COc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12
Show InChI InChI=1S/C21H18N6O2S/c1-12-8-19(30-24-12)26-7-6-18-20(21(26)28)27(25-23-18)13(2)14-4-5-17-15(9-14)10-16(29-3)11-22-17/h4-11,13H,1-3H3/t13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384114
PNG
(CHEMBL2029680)
Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cccs3)c(=O)c12
Show InChI InChI=1S/C23H21N5O3S/c1-15(16-5-6-19-17(12-16)13-18(14-24-19)31-10-9-30-2)28-22-20(25-26-28)7-8-27(23(22)29)21-4-3-11-32-21/h3-8,11-15H,9-10H2,1-2H3/t15-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384119
PNG
(CHEMBL2029564)
Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12
Show InChI InChI=1S/C20H16N6OS/c1-12-10-18(28-23-12)25-9-7-17-19(20(25)27)26(24-22-17)13(2)14-5-6-16-15(11-14)4-3-8-21-16/h3-11,13H,1-2H3/t13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384118
PNG
(CHEMBL2029563)
Show SMILES COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cc(C)ns5)c(=O)c34)cc2c1
Show InChI InChI=1S/C22H20N6O3S/c1-14-9-20(32-25-14)27-6-5-19-21(22(27)29)28(26-24-19)13-15-3-4-18-16(10-15)11-17(12-23-18)31-8-7-30-2/h3-6,9-12H,7-8,13H2,1-2H3
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n/an/a 2n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384129
PNG
(CHEMBL2029687)
Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3ccc(F)c(F)c3)c(=O)c12
Show InChI InChI=1S/C25H21F2N5O3/c1-15(16-3-6-22-17(11-16)12-19(14-28-22)35-10-9-34-2)32-24-23(29-30-32)7-8-31(25(24)33)18-4-5-20(26)21(27)13-18/h3-8,11-15H,9-10H2,1-2H3/t15-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384117
PNG
(CHEMBL2029562)
Show SMILES COc1cnc2ccc(Cn3nnc4ccn(-c5cc(C)ns5)c(=O)c34)cc2c1
Show InChI InChI=1S/C20H16N6O2S/c1-12-7-18(29-23-12)25-6-5-17-19(20(25)27)26(24-22-17)11-13-3-4-16-14(8-13)9-15(28-2)10-21-16/h3-10H,11H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384119
PNG
(CHEMBL2029564)
Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3cc(C)ns3)c(=O)c12
Show InChI InChI=1S/C20H16N6OS/c1-12-10-18(28-23-12)25-9-7-17-19(20(25)27)26(24-22-17)13(2)14-5-6-16-15(11-14)4-3-8-21-16/h3-11,13H,1-2H3/t13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384117
PNG
(CHEMBL2029562)
Show SMILES COc1cnc2ccc(Cn3nnc4ccn(-c5cc(C)ns5)c(=O)c34)cc2c1
Show InChI InChI=1S/C20H16N6O2S/c1-12-7-18(29-23-12)25-6-5-17-19(20(25)27)26(24-22-17)11-13-3-4-16-14(8-13)9-15(28-2)10-21-16/h3-10H,11H2,1-2H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384116
PNG
(CHEMBL2029561)
Show SMILES Cc1cc(sn1)-n1ccc2nnn(Cc3ccc4ncccc4c3)c2c1=O
Show InChI InChI=1S/C19H14N6OS/c1-12-9-17(27-22-12)24-8-6-16-18(19(24)26)25(23-21-16)11-13-4-5-15-14(10-13)3-2-7-20-15/h2-10H,11H2,1H3
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384128
PNG
(CHEMBL2029686)
Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cc(F)cc(F)c3)c(=O)c12
Show InChI InChI=1S/C25H21F2N5O3/c1-15(16-3-4-22-17(9-16)10-21(14-28-22)35-8-7-34-2)32-24-23(29-30-32)5-6-31(25(24)33)20-12-18(26)11-19(27)13-20/h3-6,9-15H,7-8H2,1-2H3/t15-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384129
PNG
(CHEMBL2029687)
Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3ccc(F)c(F)c3)c(=O)c12
Show InChI InChI=1S/C25H21F2N5O3/c1-15(16-3-6-22-17(11-16)12-19(14-28-22)35-10-9-34-2)32-24-23(29-30-32)7-8-31(25(24)33)18-4-5-20(26)21(27)13-18/h3-8,11-15H,9-10H2,1-2H3/t15-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384125
PNG
(CHEMBL2029683)
Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3cnn(C)c3)c(=O)c12
Show InChI InChI=1S/C20H17N7O/c1-13(14-5-6-17-15(10-14)4-3-8-21-17)27-19-18(23-24-27)7-9-26(20(19)28)16-11-22-25(2)12-16/h3-13H,1-2H3/t13-/m0/s1
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Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384116
PNG
(CHEMBL2029561)
Show SMILES Cc1cc(sn1)-n1ccc2nnn(Cc3ccc4ncccc4c3)c2c1=O
Show InChI InChI=1S/C19H14N6OS/c1-12-9-17(27-22-12)24-8-6-16-18(19(24)26)25(23-21-16)11-13-4-5-15-14(10-13)3-2-7-20-15/h2-10H,11H2,1H3
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n/an/a 5n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384124
PNG
(CHEMBL2029682)
Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3ccc(C)s3)c(=O)c12
Show InChI InChI=1S/C21H17N5OS/c1-13-5-8-19(28-13)25-11-9-18-20(21(25)27)26(24-23-18)14(2)15-6-7-17-16(12-15)4-3-10-22-17/h3-12,14H,1-2H3/t14-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384123
PNG
(CHEMBL2029681)
Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3cc(C)cs3)c(=O)c12
Show InChI InChI=1S/C21H17N5OS/c1-13-10-19(28-12-13)25-9-7-18-20(21(25)27)26(24-23-18)14(2)15-5-6-17-16(11-15)4-3-8-22-17/h3-12,14H,1-2H3/t14-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384127
PNG
(CHEMBL2029685)
Show SMILES COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cc(F)cc(F)c5)c(=O)c34)cc2c1
Show InChI InChI=1S/C24H19F2N5O3/c1-33-6-7-34-20-9-16-8-15(2-3-21(16)27-13-20)14-31-23-22(28-29-31)4-5-30(24(23)32)19-11-17(25)10-18(26)12-19/h2-5,8-13H,6-7,14H2,1H3
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n/an/a 8n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384122
PNG
(CHEMBL2029679)
Show SMILES COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cccs5)c(=O)c34)cc2c1
Show InChI InChI=1S/C22H19N5O3S/c1-29-8-9-30-17-12-16-11-15(4-5-18(16)23-13-17)14-27-21-19(24-25-27)6-7-26(22(21)28)20-3-2-10-31-20/h2-7,10-13H,8-9,14H2,1H3
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384126
PNG
(CHEMBL2029684)
Show SMILES COc1cnc2ccc(Cn3nnc4ccn(-c5cc(F)cc(F)c5)c(=O)c34)cc2c1
Show InChI InChI=1S/C22H15F2N5O2/c1-31-18-7-14-6-13(2-3-19(14)25-11-18)12-29-21-20(26-27-29)4-5-28(22(21)30)17-9-15(23)8-16(24)10-17/h2-11H,12H2,1H3
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n/an/a 12n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384114
PNG
(CHEMBL2029680)
Show SMILES COCCOc1cnc2ccc(cc2c1)[C@H](C)n1nnc2ccn(-c3cccs3)c(=O)c12
Show InChI InChI=1S/C23H21N5O3S/c1-15(16-5-6-19-17(12-16)13-18(14-24-19)31-10-9-30-2)28-22-20(25-26-28)7-8-27(23(22)29)21-4-3-11-32-21/h3-8,11-15H,9-10H2,1-2H3/t15-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384127
PNG
(CHEMBL2029685)
Show SMILES COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cc(F)cc(F)c5)c(=O)c34)cc2c1
Show InChI InChI=1S/C24H19F2N5O3/c1-33-6-7-34-20-9-16-8-15(2-3-21(16)27-13-20)14-31-23-22(28-29-31)4-5-30(24(23)32)19-11-17(25)10-18(26)12-19/h2-5,8-13H,6-7,14H2,1H3
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n/an/a 14n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384123
PNG
(CHEMBL2029681)
Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3cc(C)cs3)c(=O)c12
Show InChI InChI=1S/C21H17N5OS/c1-13-10-19(28-12-13)25-9-7-18-20(21(25)27)26(24-23-18)14(2)15-5-6-17-16(11-15)4-3-8-22-17/h3-12,14H,1-2H3/t14-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384125
PNG
(CHEMBL2029683)
Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3cnn(C)c3)c(=O)c12
Show InChI InChI=1S/C20H17N7O/c1-13(14-5-6-17-15(10-14)4-3-8-21-17)27-19-18(23-24-27)7-9-26(20(19)28)16-11-22-25(2)12-16/h3-13H,1-2H3/t13-/m0/s1
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n/an/a 37n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384124
PNG
(CHEMBL2029682)
Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ccn(-c3ccc(C)s3)c(=O)c12
Show InChI InChI=1S/C21H17N5OS/c1-13-5-8-19(28-13)25-11-9-18-20(21(25)27)26(24-23-18)14(2)15-6-7-17-16(12-15)4-3-10-22-17/h3-12,14H,1-2H3/t14-/m0/s1
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n/an/a 39n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384122
PNG
(CHEMBL2029679)
Show SMILES COCCOc1cnc2ccc(Cn3nnc4ccn(-c5cccs5)c(=O)c34)cc2c1
Show InChI InChI=1S/C22H19N5O3S/c1-29-8-9-30-17-12-16-11-15(4-5-18(16)23-13-17)14-27-21-19(24-25-27)6-7-26(22(21)28)20-3-2-10-31-20/h2-7,10-13H,8-9,14H2,1H3
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n/an/a 102n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384126
PNG
(CHEMBL2029684)
Show SMILES COc1cnc2ccc(Cn3nnc4ccn(-c5cc(F)cc(F)c5)c(=O)c34)cc2c1
Show InChI InChI=1S/C22H15F2N5O2/c1-31-18-7-14-6-13(2-3-19(14)25-11-18)12-29-21-20(26-27-29)4-5-28(22(21)30)17-9-15(23)8-16(24)10-17/h2-11H,12H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of HGF-induced autophosphorylation of c-Met in human PC3 cells


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50384115
PNG
(CHEMBL2029688)
Show SMILES O=C1N(CCc2nnn(Cc3ccc4ncccc4c3)c12)c1ccccc1
Show InChI InChI=1S/C21H17N5O/c27-21-20-19(10-12-25(21)17-6-2-1-3-7-17)23-24-26(20)14-15-8-9-18-16(13-15)5-4-11-22-18/h1-9,11,13H,10,12,14H2
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n/an/a 612n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met


Bioorg Med Chem Lett 22: 4089-93 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.072
BindingDB Entry DOI: 10.7270/Q2J67HZ2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
* indicates data uncertainty>20%