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PubMed code 22863203

Compile data set for download or QSAR
Found 1 hit of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM50401284
PNG
(CHEMBL2204495)
Show SMILES Fc1cc(ccn1)-c1ccc(OCc2ccccc2)c(c1)C(=O)Nc1cccnc1
Show InChI InChI=1S/C24H18FN3O2/c25-23-14-19(10-12-27-23)18-8-9-22(30-16-17-5-2-1-3-6-17)21(13-18)24(29)28-20-7-4-11-26-15-20/h1-15H,16H2,(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 10.9n/an/an/an/an/an/a



GlaxoSmithKline Pharmaceuticals R&D

Curated by ChEMBL


Assay Description
Inhibition of recombinant His6-Tev-tagged LRRK2 expressed in baculovirus assessed as inhibition of LRRKtide phospohorylation by HTRF assay


Bioorg Med Chem Lett 22: 5625-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.06.104
BindingDB Entry DOI: 10.7270/Q2BZ6767
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%