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PubMed code 23078755

Compile data set for download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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12n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50428472
PNG
(CARBONOTRITHIOIC ACID | Carbonotrithioate)
Show SMILES SC(S)=S
Show InChI InChI=1S/CH2S3/c2-1(3)4/h(H2,2,3,4)
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8.80E+3n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26990
PNG
(CHEMBL1644699 | CHEMBL38703 | HS anion | HS(-1) | ...)
Show InChI InChI=1S/H2S/h1H2/p-1
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4.00E+4n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50428473
PNG
(CHEMBL2079226 | Isoselenocyanate)
Show SMILES [SeH]C#N
Show InChI InChI=1S/CHNSe/c2-1-3/h3H
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8.60E+4n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26994
PNG
(CHEMBL68253 | H2NSO3H | sulfamic acid)
Show SMILES NS(O)(=O)=O
Show InChI InChI=1S/H3NO3S/c1-5(2,3)4/h(H3,1,2,3,4)
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3.90E+5n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26983
PNG
(CHEMBL1644028 | SCN(-1) | Thiocyanate | cyanosulfa...)
Show SMILES [N-]=C=S
Show InChI InChI=1S/CNS/c2-1-3/q-1
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1.60E+6n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM50428474
PNG
(DITIOCARB | Diethyldithiocarbamate)
Show SMILES CCN(CC)C(S)=S
Show InChI InChI=1S/C5H11NS2/c1-3-6(4-2)5(7)8/h3-4H2,1-2H3,(H,7,8)
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3.10E+6n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26981
PNG
(CHEMBL1644695 | CHEMBL185537 | I- | IODIDE | POTAS...)
Show InChI InChI=1S/HI/h1H/p-1
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2.60E+7n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26980
PNG
(BROMIDE | Br- | CHEMBL11685 | CHEMBL1644030 | CHEM...)
Show InChI InChI=1S/BrH/h1H/p-1
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6.30E+7n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26986
PNG
(CHEMBL363707 | HCO3- | SODIUM BICARBONATE | bicarb...)
Show SMILES OC([O-])=O
Show InChI InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-1
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8.50E+7n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26991
PNG
(CHEMBL1689285 | HSO3- | bisulfite | hydrogen sulfi...)
Show SMILES OS([O-])=O
Show InChI InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1
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8.90E+7n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26979
PNG
(CHEMBL19429 | CHEMBL69710 | CHLORIDE | Cl- | POTAS...)
Show InChI InChI=1S/ClH/h1H/p-1
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2.00E+8n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26978
PNG
(BDBM50098540 | CHEMBL1362 | CHEMBL1528 | CHEMBL164...)
Show InChI InChI=1S/FH/h1H/p-1
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>3.00E+8n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
Carbonic anhydrase 2


(Homo sapiens (Human))
BDBM26992
PNG
(CHEMBL183495 | SO4(2-) | SODIUM SULFATE | sulfate ...)
Show SMILES [O-]S([O-])(=O)=O
Show InChI InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
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>3.00E+8n/an/an/an/an/an/an/an/a



Istituto di Biochimica delle Proteine (IBP)

Curated by ChEMBL


Assay Description
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay


Bioorg Med Chem 21: 1465-9 (2013)


Article DOI: 10.1016/j.bmc.2012.09.047
BindingDB Entry DOI: 10.7270/Q20R9QQQ
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
* indicates data uncertainty>20%