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PubMed code 27994726

Compile data set for download or QSAR
Found 19 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50200981
PNG
(CHEMBL3960148 | US10138212, Example 6)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(n1)C1CCC1
Show InChI InChI=1S/C20H21N5O2/c1-27-16-10-4-8-14-17(16)24-20(21)25-18(14)19(26)22-11-13-7-3-9-15(23-13)12-5-2-6-12/h3-4,7-10,12H,2,5-6,11H2,1H3,(H,22,26)(H2,21,24,25)
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0.200n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50201019
PNG
(CHEMBL3973920 | US10138212, Example 44)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(COc2ccccc2F)n1
Show InChI InChI=1S/C23H20FN5O3/c1-31-19-11-5-8-16-20(19)28-23(25)29-21(16)22(30)26-12-14-6-4-7-15(27-14)13-32-18-10-3-2-9-17(18)24/h2-11H,12-13H2,1H3,(H,26,30)(H2,25,28,29)
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0.200n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50201006
PNG
(CHEMBL3923709 | US10138212, Example 5)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(n1)C(C)C
Show InChI InChI=1S/C19H21N5O2/c1-11(2)14-8-4-6-12(22-14)10-21-18(25)17-13-7-5-9-15(26-3)16(13)23-19(20)24-17/h4-9,11H,10H2,1-3H3,(H,21,25)(H2,20,23,24)
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0.200n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50200989
PNG
(CHEMBL3906827 | US10138212, Example 18)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(n1)C(F)(F)F
Show InChI InChI=1S/C17H14F3N5O2/c1-27-11-6-3-5-10-13(11)24-16(21)25-14(10)15(26)22-8-9-4-2-7-12(23-9)17(18,19)20/h2-7H,8H2,1H3,(H,22,26)(H2,21,24,25)
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0.400n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50200984
PNG
(CHEMBL3932655 | US10138212, Example 9)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(n1)C(C)(C)O
Show InChI InChI=1S/C19H21N5O3/c1-19(2,26)14-9-4-6-11(22-14)10-21-17(25)16-12-7-5-8-13(27-3)15(12)23-18(20)24-16/h4-9,26H,10H2,1-3H3,(H,21,25)(H2,20,23,24)
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0.400n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50201017
PNG
(CHEMBL3941632 | US10138212, Example 15)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(C)n1
Show InChI InChI=1S/C17H17N5O2/c1-10-5-3-6-11(20-10)9-19-16(23)15-12-7-4-8-13(24-2)14(12)21-17(18)22-15/h3-8H,9H2,1-2H3,(H,19,23)(H2,18,21,22)
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0.5n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50200986
PNG
(CHEMBL3902955 | US10138212, Example 48)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(COC2CCCC2)n1
Show InChI InChI=1S/C22H25N5O3/c1-29-18-11-5-10-17-19(18)26-22(23)27-20(17)21(28)24-12-14-6-4-7-15(25-14)13-30-16-8-2-3-9-16/h4-7,10-11,16H,2-3,8-9,12-13H2,1H3,(H,24,28)(H2,23,26,27)
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0.5n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50201020
PNG
(CHEMBL3951425 | US10138212, Example 2)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1nc(ccc1C)C(C)(C)O
Show InChI InChI=1S/C20H23N5O3/c1-11-8-9-15(20(2,3)27)23-13(11)10-22-18(26)17-12-6-5-7-14(28-4)16(12)24-19(21)25-17/h5-9,27H,10H2,1-4H3,(H,22,26)(H2,21,24,25)
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0.600n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50200988
PNG
(CHEMBL3977457 | US10138212, Example 21)
Show SMILES COc1cccc(CNC(=O)c2nc(N)nc3c(OC)cccc23)n1
Show InChI InChI=1S/C17H17N5O3/c1-24-12-7-4-6-11-14(12)21-17(18)22-15(11)16(23)19-9-10-5-3-8-13(20-10)25-2/h3-8H,9H2,1-2H3,(H,19,23)(H2,18,21,22)
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0.800n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50200982
PNG
(CHEMBL3911977)
Show SMILES CC(C)OCc1cccc(CNC(=O)c2nc(N)nc3c(F)cccc23)n1
Show InChI InChI=1S/C19H20FN5O2/c1-11(2)27-10-13-6-3-5-12(23-13)9-22-18(26)17-14-7-4-8-15(20)16(14)24-19(21)25-17/h3-8,11H,9-10H2,1-2H3,(H,22,26)(H2,21,24,25)
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1n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50201016
PNG
(CHEMBL3901883 | US10138212, Example 27)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(F)n1
Show InChI InChI=1S/C16H14FN5O2/c1-24-11-6-3-5-10-13(11)21-16(18)22-14(10)15(23)19-8-9-4-2-7-12(17)20-9/h2-7H,8H2,1H3,(H,19,23)(H2,18,21,22)
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1.5n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50200985
PNG
(CHEMBL3965187 | US10138212, Example 107)
Show SMILES [2H]C([2H])(NC(=O)c1nc(N)nc2c(OC)cccc12)c1cccc(n1)C([2H])([2H])c1cncc(OCCOC)c1
Show InChI InChI=1S/C25H26N6O4/c1-33-9-10-35-19-12-16(13-27-15-19)11-17-5-3-6-18(29-17)14-28-24(32)23-20-7-4-8-21(34-2)22(20)30-25(26)31-23/h3-8,12-13,15H,9-11,14H2,1-2H3,(H,28,32)(H2,26,30,31)/i11D2,14D2
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2n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50200987
PNG
(CHEMBL3920917 | US10138212, Example 23)
Show SMILES COc1cccnc1CNC(=O)c1nc(N)nc2c(OC)cccc12
Show InChI InChI=1S/C17H17N5O3/c1-24-12-7-4-8-19-11(12)9-20-16(23)15-10-5-3-6-13(25-2)14(10)21-17(18)22-15/h3-8H,9H2,1-2H3,(H,20,23)(H2,18,21,22)
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3n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50201009
PNG
(CHEMBL3971217 | US10138212, Example 14)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(CO)n1
Show InChI InChI=1S/C17H17N5O3/c1-25-13-7-3-6-12-14(13)21-17(18)22-15(12)16(24)19-8-10-4-2-5-11(9-23)20-10/h2-7,23H,8-9H2,1H3,(H,19,24)(H2,18,21,22)
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4.60n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50201007
PNG
(CHEMBL3939976 | US10138212, Example 104)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)NCc1cccc(Cc2cccnc2)n1
Show InChI InChI=1S/C22H20N6O2/c1-30-18-9-3-8-17-19(18)27-22(23)28-20(17)21(29)25-13-16-7-2-6-15(26-16)11-14-5-4-10-24-12-14/h2-10,12H,11,13H2,1H3,(H,25,29)(H2,23,27,28)
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5n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50201008
PNG
(CHEMBL3892905 | US10138212, Example 22)
Show SMILES COc1ccc(CNC(=O)c2nc(N)nc3c(OC)cccc23)nc1
Show InChI InChI=1S/C17H17N5O3/c1-24-11-7-6-10(19-9-11)8-20-16(23)15-12-4-3-5-13(25-2)14(12)21-17(18)22-15/h3-7,9H,8H2,1-2H3,(H,20,23)(H2,18,21,22)
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7.80n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50200983
PNG
(CHEMBL3981924 | US10138212, Example 57)
Show SMILES Nc1nc(C(=O)NCc2cccc(CO)n2)c2cccc(F)c2n1
Show InChI InChI=1S/C16H14FN5O2/c17-12-6-2-5-11-13(12)21-16(18)22-14(11)15(24)19-7-9-3-1-4-10(8-23)20-9/h1-6,23H,7-8H2,(H,19,24)(H2,18,21,22)
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9.60n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50201018
PNG
(CHEMBL3914681)
Show SMILES COc1ccc(nc1CNC(=O)c1nc(N)nc2c(OC)cccc12)C(C)(C)O
Show InChI InChI=1S/C20H23N5O4/c1-20(2,27)15-9-8-13(28-3)12(23-15)10-22-18(26)17-11-6-5-7-14(29-4)16(11)24-19(21)25-17/h5-9,27H,10H2,1-4H3,(H,22,26)(H2,21,24,25)
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10n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
Adenosine receptor A2a


(Homo sapiens (Human))
BDBM50200980
PNG
(CHEMBL3929822 | US10138212, Example 35)
Show SMILES COc1cccc2c(nc(N)nc12)C(=O)N[C@H]1CCCc2cccnc12
Show InChI InChI=1/C19H19N5O2/c1-26-14-9-3-7-12-16(14)23-19(20)24-17(12)18(25)22-13-8-2-5-11-6-4-10-21-15(11)13/h3-4,6-7,9-10,13H,2,5,8H2,1H3,(H,22,25)(H2,20,23,24)/t13-/s2
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180n/an/an/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]5-amino-7-[2- phenethyl]-2-(furan-2-yl)-7H-pyrazolo[4,3-e][l,2,4]triazolo[l,5-c]pyrimidine from human adenosine A2A receptor expr...


ACS Med Chem Lett 7: 1014-1015 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00407
BindingDB Entry DOI: 10.7270/Q2H9976C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%