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PubMed code 3121857

Compile data set for download or QSAR
Found 128 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase


(Bos taurus (Cattle))
BDBM50227014
PNG
(CHEMBL432927)
Show SMILES Clc1cc2c3n(CCC22NC(=O)NC2=O)c(=O)ccc3c1
Show InChI InChI=1/C14H10ClN3O3/c15-8-5-7-1-2-10(19)18-4-3-14(9(6-8)11(7)18)12(20)16-13(21)17-14/h1-2,5-6H,3-4H2,(H2,16,17,20,21)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022470
PNG
(6',8'-dichlorospiro[tetrahydro-1H-imidazole-4,4'-(...)
Show SMILES Clc1cc(Cl)c2SCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C11H8Cl2N2O2S/c12-5-3-6-8(7(13)4-5)18-2-1-11(6)9(16)14-10(17)15-11/h3-4H,1-2H2,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase


(Bos taurus (Cattle))
BDBM50226991
PNG
(CHEMBL419474)
Show SMILES Clc1cc2c(OCCC22NC(=O)NC2=O)c2ccccc12
Show InChI InChI=1/C15H11ClN2O3/c16-11-7-10-12(9-4-2-1-3-8(9)11)21-6-5-15(10)13(19)17-14(20)18-15/h1-4,7H,5-6H2,(H2,17,18,19,20)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022415
PNG
(6-chloro-(4'S)-spiro[3,4-dihydro-2H-chromene-4,5'-...)
Show SMILES OC1=NC(=O)[C@@]2(CCOc3ccc(Cl)cc23)O1
Show InChI InChI=1S/C11H8ClNO4/c12-6-1-2-8-7(5-6)11(3-4-16-8)9(14)13-10(15)17-11/h1-2,5H,3-4H2,(H,13,14,15)/t11-/m0/s1
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase


(Bos taurus (Cattle))
BDBM50226987
PNG
(CHEMBL78819)
Show SMILES Cc1cc(Cl)cc2c1OCCC21NC(=O)NC1=O
Show InChI InChI=1/C12H11ClN2O3/c1-6-4-7(13)5-8-9(6)18-3-2-12(8)10(16)14-11(17)15-12/h4-5H,2-3H2,1H3,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022499
PNG
(7-methoxyspiro[3,4-dihydro-2H-benzo[h]chromene-4,4...)
Show SMILES COc1cccc2c3OCCC4(NC(=O)NC4=O)c3ccc12
Show InChI InChI=1/C16H14N2O4/c1-21-12-4-2-3-10-9(12)5-6-11-13(10)22-8-7-16(11)14(19)17-15(20)18-16/h2-6H,7-8H2,1H3,(H2,17,18,19,20)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022480
PNG
(CHEMBL78963 | c6-chlorospiro[3,4-dihydro-2H-chrome...)
Show SMILES Clc1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C11H9ClN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase


(Bos taurus (Cattle))
BDBM50226983
PNG
(CHEMBL79461)
Show SMILES Fc1ccc2SCC[C@]3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C11H9FN2O2S/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase


(Bos taurus (Cattle))
BDBM50226988
PNG
(CHEMBL81536)
Show SMILES Clc1cc2SCCC3(NC(=O)NC3=O)c2cc1Cl
Show InChI InChI=1/C11H8Cl2N2O2S/c12-6-3-5-8(4-7(6)13)18-2-1-11(5)9(16)14-10(17)15-11/h3-4H,1-2H2,(H2,14,15,16,17)
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Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase


(Bos taurus (Cattle))
BDBM50226985
PNG
(CHEMBL309288)
Show SMILES Clc1cc(Cl)c2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C11H8Cl2N2O3/c12-5-3-6-8(7(13)4-5)18-2-1-11(6)9(16)14-10(17)15-11/h3-4H,1-2H2,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase


(Bos taurus (Cattle))
BDBM50226984
PNG
(CHEMBL77679)
Show SMILES Clc1cc2OCCC3(NC(=O)NC3=O)c2cc1Cl
Show InChI InChI=1/C11H8Cl2N2O3/c12-6-3-5-8(4-7(6)13)18-2-1-11(5)9(16)14-10(17)15-11/h3-4H,1-2H2,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022424
PNG
(6',8'-dichlorospiro[tetrahydro-1H-imidazole-4,4'-(...)
Show SMILES Clc1cc(Cl)c2c(c1)C1(CCS2(=O)=O)NC(=O)NC1=O
Show InChI InChI=1/C11H8Cl2N2O4S/c12-5-3-6-8(7(13)4-5)20(18,19)2-1-11(6)9(16)14-10(17)15-11/h3-4H,1-2H2,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM16312
PNG
((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Show SMILES Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/s2
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards human placenta aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022473
PNG
(6-bromospiro[3,4-dihydro-2H-chromene-4,4'-(tetrahy...)
Show SMILES Brc1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C11H9BrN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022393
PNG
(5,8-dimethylspiro[3,4-dihydro-2H-chromene-4,4'-(te...)
Show SMILES Cc1ccc(C)c2c1OCCC21NC(=O)NC1=O
Show InChI InChI=1/C13H14N2O3/c1-7-3-4-8(2)10-9(7)13(5-6-18-10)11(16)14-12(17)15-13/h3-4H,5-6H2,1-2H3,(H2,14,15,16,17)
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Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022434
PNG
(CHEMBL81601 | spiro[tetrahydro-1H-imidazole-4,4'-(...)
Show SMILES O=C1NC(=O)C2(CCOc3c2ccc2ncccc32)N1
Show InChI InChI=1/C14H11N3O3/c18-12-14(17-13(19)16-12)5-7-20-11-8-2-1-6-15-10(8)4-3-9(11)14/h1-4,6H,5,7H2,(H2,16,17,18,19)
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Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022401
PNG
(8-phenylspiro[3,4-dihydro-2H-chromene-4,4'-(tetrah...)
Show SMILES O=C1NC(=O)C2(CCOc3c(cccc23)-c2ccccc2)N1
Show InChI InChI=1/C17H14N2O3/c20-15-17(19-16(21)18-15)9-10-22-14-12(7-4-8-13(14)17)11-5-2-1-3-6-11/h1-8H,9-10H2,(H2,18,19,20,21)
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Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022498
PNG
(6-Chloro-3,4-dihydro-2H-benzo[h]chromene-4-carboxy...)
Show SMILES OC(=O)C1CCOc2c1cc(Cl)c1ccccc21
Show InChI InChI=1/C14H11ClO3/c15-12-7-11-10(14(16)17)5-6-18-13(11)9-4-2-1-3-8(9)12/h1-4,7,10H,5-6H2,(H,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022423
PNG
(7'-chlorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Show SMILES Clc1ccc2c(SCCC22NC(=O)NC2=O)c1
Show InChI InChI=1/C11H9ClN2O2S/c12-6-1-2-7-8(5-6)17-4-3-11(7)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022435
PNG
(6'-fluorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Show SMILES Fc1ccc2SCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C11H9FN2O2S/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)
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Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022436
PNG
(CHEMBL312392 | spiro[tetrahydro-1H-imidazole-4,1'-...)
Show SMILES O=C1NC(=O)C2(CCn3c4c2cccc4ccc3=O)N1
Show InChI InChI=1/C14H11N3O3/c18-10-5-4-8-2-1-3-9-11(8)17(10)7-6-14(9)12(19)15-13(20)16-14/h1-5H,6-7H2,(H2,15,16,19,20)
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Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022458
PNG
(6'-chlorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Show SMILES Clc1ccc2SCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C11H9ClN2O2S/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)
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Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022398
PNG
((+)-6-chloro-2,3-dihydro-2'H,4'H-spiro[chromene-4,...)
Show SMILES OC1=NC(=O)C2(CCOc3ccc(Cl)cc23)O1
Show InChI InChI=1/C11H8ClNO4/c12-6-1-2-8-7(5-6)11(3-4-16-8)9(14)13-10(15)17-11/h1-2,5H,3-4H2,(H,13,14,15)
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Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM16312
PNG
((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Show SMILES Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/s2
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022407
PNG
(6'-fluorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Show SMILES Fc1ccc2c(c1)C1(CCS2(=O)=O)NC(=O)NC1=O
Show InChI InChI=1/C11H9FN2O4S/c12-6-1-2-8-7(5-6)11(3-4-19(8,17)18)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022492
PNG
(8-chlorospiro[3,4-dihydro-2H-chromene-4,4'-(tetrah...)
Show SMILES Clc1cccc2c1OCCC21NC(=O)NC1=O
Show InChI InChI=1/C11H9ClN2O3/c12-7-3-1-2-6-8(7)17-5-4-11(6)9(15)13-10(16)14-11/h1-3H,4-5H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022418
PNG
((1-Carboxymethyl-cyclopentyl)-acetic acid(TMG) | 3...)
Show SMILES OC(=O)CC1(CC(O)=O)CCCC1
Show InChI InChI=1S/C9H14O4/c10-7(11)5-9(6-8(12)13)3-1-2-4-9/h1-6H2,(H,10,11)(H,12,13)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022459
PNG
(6'-fluorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Show SMILES Fc1ccc2c(c1)C1(CCS2=O)NC(=O)NC1=O
Show InChI InChI=1/C11H9FN2O3S/c12-6-1-2-8-7(5-6)11(3-4-18(8)17)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022391
PNG
(6'-bromospiro[tetrahydro-1H-imidazole-4,4'-(3',4'-...)
Show SMILES Brc1ccc2SCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C11H9BrN2O2S/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022422
PNG
(6-methylsulfanylspiro[3,4-dihydro-2H-chromene-4,4'...)
Show SMILES CSc1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C12H12N2O3S/c1-18-7-2-3-9-8(6-7)12(4-5-17-9)10(15)13-11(16)14-12/h2-3,6H,4-5H2,1H3,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022396
PNG
(7-trifluoromethylspiro[3,4-dihydro-2H-chromene-4,4...)
Show SMILES FC(F)(F)c1ccc2c(OCCC22NC(=O)NC2=O)c1
Show InChI InChI=1/C12H9F3N2O3/c13-12(14,15)6-1-2-7-8(5-6)20-4-3-11(7)9(18)16-10(19)17-11/h1-2,5H,3-4H2,(H2,16,17,18,19)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022471
PNG
(5,7,8-trimethylspiro[3,4-dihydro-2H-chromene-4,4'-...)
Show SMILES Cc1cc(C)c2c(OCCC22NC(=O)NC2=O)c1C
Show InChI InChI=1/C14H16N2O3/c1-7-6-8(2)10-11(9(7)3)19-5-4-14(10)12(17)15-13(18)16-14/h6H,4-5H2,1-3H3,(H2,15,16,17,18)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50022494
PNG
(2-(2,5-Dioxo-imidazolidin-4-yl)-benzo[de]isoquinol...)
Show SMILES Oc1[nH]c(=O)[nH]c1N1C(=O)c2cccc3cccc(C1=O)c23
Show InChI InChI=1S/C15H9N3O4/c19-12-11(16-15(22)17-12)18-13(20)8-5-1-3-7-4-2-6-9(10(7)8)14(18)21/h1-6,19H,(H2,16,17,22)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified human placenta aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022464
PNG
(6-fluoro-(4'R)-spiro[3,4-dihydro-2H-chromene-4,4'-...)
Show SMILES Fc1ccc2OCC[C@@]3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m1/s1
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM84978
PNG
(Quercitrin | cid_5280459)
Show SMILES C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C21H20O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-18,21-24,26-29H,1H3/t7-,15-,17+,18+,21-/m0/s1
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022462
PNG
(5',6'-dimethoxyspiro[tetrahydro-1H-imidazole-4,1'-...)
Show SMILES COc1cc2CCC3(NC(=O)NC3=O)c2cc1OC
Show InChI InChI=1/C13H14N2O4/c1-18-9-5-7-3-4-13(8(7)6-10(9)19-2)11(16)14-12(17)15-13/h5-6H,3-4H2,1-2H3,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022486
PNG
(6-methylspiro[3,4-dihydro-2H-chromene-4,4'-(tetrah...)
Show SMILES Cc1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C12H12N2O3/c1-7-2-3-9-8(6-7)12(4-5-17-9)10(15)13-11(16)14-12/h2-3,6H,4-5H2,1H3,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022453
PNG
(6,8-dimethylspiro[3,4-dihydro-2H-chromene-4,4'-(te...)
Show SMILES Cc1cc(C)c2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C13H14N2O3/c1-7-5-8(2)10-9(6-7)13(3-4-18-10)11(16)14-12(17)15-13/h5-6H,3-4H2,1-2H3,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022487
PNG
(CHEMBL79015 | spiro[tetrahydro-1H-imidazole-4,4'-(...)
Show SMILES O=C1NC(=O)C2(CCOc3c2ccc2cccnc32)N1
Show InChI InChI=1/C14H11N3O3/c18-12-14(17-13(19)16-12)5-7-20-11-9(14)4-3-8-2-1-6-15-10(8)11/h1-4,6H,5,7H2,(H2,16,17,18,19)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022413
PNG
(6-Chloro-chroman-4-carboxylic acid | CHEMBL443271)
Show SMILES OC(=O)C1CCOc2ccc(Cl)cc12
Show InChI InChI=1/C10H9ClO3/c11-6-1-2-9-8(5-6)7(10(12)13)3-4-14-9/h1-2,5,7H,3-4H2,(H,12,13)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022447
PNG
(6-phenoxyspiro[3,4-dihydro-2H-chromene-4,4'-(tetra...)
Show SMILES O=C1NC(=O)C2(CCOc3ccc(Oc4ccccc4)cc23)N1
Show InChI InChI=1/C17H14N2O4/c20-15-17(19-16(21)18-15)8-9-22-14-7-6-12(10-13(14)17)23-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H2,18,19,20,21)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022461
PNG
(6'-methoxyspiro[tetrahydro-1H-imidazole-4,1'-(2',3...)
Show SMILES COc1ccc2CCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C12H12N2O3/c1-17-8-3-2-7-4-5-12(9(7)6-8)10(15)13-11(16)14-12/h2-3,6H,4-5H2,1H3,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022500
PNG
(2',3'-dihydro-2H,5H-spiro[imidazolidine-4,4'-thioc...)
Show SMILES O=C1NC(=O)C2(CCS(=O)(=O)c3ccccc23)N1
Show InChI InChI=1/C11H10N2O4S/c14-9-11(13-10(15)12-9)5-6-18(16,17)8-4-2-1-3-7(8)11/h1-4H,5-6H2,(H2,12,13,14,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022437
PNG
(5'-methoxyspiro[tetrahydro-1H-imidazole-4,1'-(2',3...)
Show SMILES COc1ccc2c(CCC22NC(=O)NC2=O)c1
Show InChI InChI=1/C12H12N2O3/c1-17-8-2-3-9-7(6-8)4-5-12(9)10(15)13-11(16)14-12/h2-3,6H,4-5H2,1H3,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022438
PNG
(3,4-dihydro-2H,2'H,4'H-spiro[naphthalene-1,5'-[1,3...)
Show SMILES OC1=NC(=O)C2(CCCc3ccccc23)O1
Show InChI InChI=1/C12H11NO3/c14-10-12(16-11(15)13-10)7-3-5-8-4-1-2-6-9(8)12/h1-2,4,6H,3,5,7H2,(H,13,14,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022440
PNG
(CHEMBL310731 | spiro[tetrahydro-1H-imidazole-4,5'-...)
Show SMILES O=C1NC(=O)C2(CCc3cc4OCOc4cc23)N1
Show InChI InChI=1/C12H10N2O4/c15-10-12(14-11(16)13-10)2-1-6-3-8-9(4-7(6)12)18-5-17-8/h3-4H,1-2,5H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022484
PNG
(6,8-Dichloro-chroman-4-carboxylic acid | CHEMBL811...)
Show SMILES OC(=O)C1CCOc2c(Cl)cc(Cl)cc12
Show InChI InChI=1/C10H8Cl2O3/c11-5-3-7-6(10(13)14)1-2-15-9(7)8(12)4-5/h3-4,6H,1-2H2,(H,13,14)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022397
PNG
(8-chloro-6-phenylspiro[3,4-dihydro-2H-chromene-4,4...)
Show SMILES Clc1cc(cc2c1OCCC21NC(=O)NC1=O)-c1ccccc1
Show InChI InChI=1/C17H13ClN2O3/c18-13-9-11(10-4-2-1-3-5-10)8-12-14(13)23-7-6-17(12)15(21)19-16(22)20-17/h1-5,8-9H,6-7H2,(H2,19,20,21,22)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase


(Bos taurus (Cattle))
BDBM50022418
PNG
((1-Carboxymethyl-cyclopentyl)-acetic acid(TMG) | 3...)
Show SMILES OC(=O)CC1(CC(O)=O)CCCC1
Show InChI InChI=1S/C9H14O4/c10-7(11)5-9(6-8(12)13)3-1-2-4-9/h1-6H2,(H,10,11)(H,12,13)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022501
PNG
(7',8'-dihydro-2H,5H,6'H-spiro[imidazolidine-4,5'-q...)
Show SMILES O=C1NC(=O)C2(CCCc3ncccc23)N1
Show InChI InChI=1/C11H11N3O2/c15-9-11(14-10(16)13-9)5-1-4-8-7(11)3-2-6-12-8/h2-3,6H,1,4-5H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022395
PNG
(6-methoxyspiro[3,4-dihydro-2H-chromene-4,4'-(tetra...)
Show SMILES COc1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C12H12N2O4/c1-17-7-2-3-9-8(6-7)12(4-5-18-9)10(15)13-11(16)14-12/h2-3,6H,4-5H2,1H3,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022425
PNG
(2,3-dihydro-2'H,5'H-spiro[chromene-4,4'-imidazolid...)
Show SMILES O=C1NC(=O)C2(CCOc3ccccc23)N1
Show InChI InChI=1/C11H10N2O3/c14-9-11(13-10(15)12-9)5-6-16-8-4-2-1-3-7(8)11/h1-4H,5-6H2,(H2,12,13,14,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022441
PNG
(6'-methoxyspiro[tetrahydro-1H-imidazole-4,4'-(3',4...)
Show SMILES COc1ccc2SCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C12H12N2O3S/c1-17-7-2-3-9-8(6-7)12(4-5-18-9)10(15)13-11(16)14-12/h2-3,6H,4-5H2,1H3,(H2,13,14,15,16)
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Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022456
PNG
(CHEMBL81718 | c5'-methoxyspiro[tetrahydro-1H-imida...)
Show SMILES COc1cccc2c1CCCC21NC(=O)NC1=O
Show InChI InChI=1/C13H14N2O3/c1-18-10-6-2-5-9-8(10)4-3-7-13(9)11(16)14-12(17)15-13/h2,5-6H,3-4,7H2,1H3,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM16415
PNG
((1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetic...)
Show SMILES OC(=O)CN1C(=O)c2cccc3cccc(C1=O)c23
Show InChI InChI=1S/C14H9NO4/c16-11(17)7-15-13(18)9-5-1-3-8-4-2-6-10(12(8)9)14(15)19/h1-6H,7H2,(H,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022426
PNG
(6'-fluoro-(4'R)-spiro[1H,2H-imidazole-4,4'-(3',4'-...)
Show SMILES Fc1ccc2SCC[C@@]3(NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C11H9FN2O2S/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m1/s1
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022410
PNG
(6-Chloro-8-methyl-chroman-4-carboxylic acid | CHEM...)
Show SMILES Cc1cc(Cl)cc2C(CCOc12)C(O)=O
Show InChI InChI=1/C11H11ClO3/c1-6-4-7(12)5-9-8(11(13)14)2-3-15-10(6)9/h4-5,8H,2-3H2,1H3,(H,13,14)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase; value ranges from 10E-5 to 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022406
PNG
(6-chlorospiro[3,4-dihydro-2H-chromene-4,4'-(tetrah...)
Show SMILES Clc1ccc2OCCC3(CNC(=O)N3)c2c1
Show InChI InChI=1/C11H11ClN2O2/c12-7-1-2-9-8(5-7)11(3-4-16-9)6-13-10(15)14-11/h1-2,5H,3-4,6H2,(H2,13,14,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022433
PNG
(6,7-Dichloro-thiochroman-4-carboxylic acid | CHEMB...)
Show SMILES OC(=O)C1CCSc2cc(Cl)c(Cl)cc12
Show InChI InChI=1/C10H8Cl2O2S/c11-7-3-6-5(10(13)14)1-2-15-9(6)4-8(7)12/h3-5H,1-2H2,(H,13,14)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022444
PNG
(2',3'-dihydro-2H,5H-spiro[imidazolidine-4,4'-thioc...)
Show SMILES O=C1NC(=O)C2(CCSc3ccccc23)N1
Show InChI InChI=1/C11H10N2O2S/c14-9-11(13-10(15)12-9)5-6-16-8-4-2-1-3-7(8)11/h1-4H,5-6H2,(H2,12,13,14,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022449
PNG
(2-Benzyl-2H-[1,2,4]triazine-3,5-dione | CHEMBL8197...)
Show SMILES O=c1cnn(Cc2ccccc2)c(=O)[nH]1
Show InChI InChI=1S/C10H9N3O2/c14-9-6-11-13(10(15)12-9)7-8-4-2-1-3-5-8/h1-6H,7H2,(H,12,14,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022490
PNG
(CHEMBL81353 | cspiro[2,3-dihydro-1H-benzo[f]chrome...)
Show SMILES O=C1NC(=O)C2(CCOc3ccc4ccccc4c23)N1
Show InChI InChI=1/C15H12N2O3/c18-13-15(17-14(19)16-13)7-8-20-11-6-5-9-3-1-2-4-10(9)12(11)15/h1-6H,7-8H2,(H2,16,17,18,19)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022485
PNG
(2-thioxospiro[tetrahydro-1H-imidazole-4,1'-(1',2',...)
Show SMILES O=C1NC(=S)NC11CCCc2ccccc12
Show InChI InChI=1/C12H12N2OS/c15-10-12(14-11(16)13-10)7-3-5-8-4-1-2-6-9(8)12/h1-2,4,6H,3,5,7H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022491
PNG
(4'-methylspiro[tetrahydro-1H-imidazole-4,1'-(1',2'...)
Show SMILES CC1CCC2(NC(=O)NC2=O)c2ccccc12
Show InChI InChI=1/C13H14N2O2/c1-8-6-7-13(11(16)14-12(17)15-13)10-5-3-2-4-9(8)10/h2-5,8H,6-7H2,1H3,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase


(Bos taurus (Cattle))
BDBM50226989
PNG
(CHEMBL309524)
Show SMILES Fc1cccc2c1OCCC21NC(=O)NC1=O
Show InChI InChI=1/C11H9FN2O3/c12-7-3-1-2-6-8(7)17-5-4-11(6)9(15)13-10(16)14-11/h1-3H,4-5H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022403
PNG
(CHEMBL82713 | spiro[1,2,3,4-tetrahydronaphthalene-...)
Show SMILES O=C1CC2(CCCc3ccccc23)C(=O)N1
Show InChI InChI=1/C13H13NO2/c15-11-8-13(12(16)14-11)7-3-5-9-4-1-2-6-10(9)13/h1-2,4,6H,3,5,7-8H2,(H,14,15,16)
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Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022416
PNG
(CHEMBL78661 | octahydro-2H,2'H,5H-spiro[imidazolid...)
Show SMILES O=C1NC(=O)C2(CCCC3CCCCC23)N1
Show InChI InChI=1/C12H18N2O2/c15-10-12(14-11(16)13-10)7-3-5-8-4-1-2-6-9(8)12/h8-9H,1-7H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50022419
PNG
(6-fluoro-1'-methyl-(4'S)-spiro[3,4-dihydro-2H-chro...)
Show SMILES CN1C(=O)N[C@]2(CCOc3ccc(F)cc23)C1=O
Show InChI InChI=1S/C12H11FN2O3/c1-15-10(16)12(14-11(15)17)4-5-18-9-3-2-7(13)6-8(9)12/h2-3,6H,4-5H2,1H3,(H,14,17)/t12-/m0/s1
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified human placenta aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022455
PNG
(8-chloro-5-methoxyspiro[3,4-dihydro-2H-chromene-4,...)
Show SMILES COc1ccc(Cl)c2OCCC3(NC(=O)NC3=O)c12
Show InChI InChI=1/C12H11ClN2O4/c1-18-7-3-2-6(13)9-8(7)12(4-5-19-9)10(16)14-11(17)15-12/h2-3H,4-5H2,1H3,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022394
PNG
(6'-fluorospiro[tetrahydro-1H-imidazole-4,1'-(2',3'...)
Show SMILES Fc1ccc2CCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C11H9FN2O2/c12-7-2-1-6-3-4-11(8(6)5-7)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022409
PNG
(CHEMBL81242 | spiro[tetrahydro-1H-imidazole-4,1'-(...)
Show SMILES S=C1NC(=S)C2(CCCc3ccccc23)N1
Show InChI InChI=1/C12H12N2S2/c15-10-12(14-11(16)13-10)7-3-5-8-4-1-2-6-9(8)12/h1-2,4,6H,3,5,7H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022412
PNG
(8'-chloro-5'-methoxyspiro[tetrahydro-1H-imidazole-...)
Show SMILES COc1ccc(Cl)c2c1CCCC21NC(=O)NC1=O
Show InChI InChI=1/C13H13ClN2O3/c1-19-9-5-4-8(14)10-7(9)3-2-6-13(10)11(17)15-12(18)16-13/h4-5H,2-3,6H2,1H3,(H2,15,16,17,18)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022427
PNG
(CHEMBL81625 | Thiochroman-4-carboxylic acid)
Show SMILES OC(=O)C1CCSc2ccccc12
Show InChI InChI=1/C10H10O2S/c11-10(12)8-5-6-13-9-4-2-1-3-7(8)9/h1-4,8H,5-6H2,(H,11,12)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022446
PNG
(8'-fluoro-5'-methoxyspiro[tetrahydro-1H-imidazole-...)
Show SMILES COc1ccc(F)c2c1CCCC21NC(=O)NC1=O
Show InChI InChI=1/C13H13FN2O3/c1-19-9-5-4-8(14)10-7(9)3-2-6-13(10)11(17)15-12(18)16-13/h4-5H,2-3,6H2,1H3,(H2,15,16,17,18)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50003655
PNG
(PHENYTOIN | Phenytoin)
Show SMILES O=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022476
PNG
(2'-methylspiro[tetrahydro-1H-imidazole-4,1'-(1',2'...)
Show SMILES CC1CCc2ccccc2C11NC(=O)NC1=O
Show InChI InChI=1/C13H14N2O2/c1-8-6-7-9-4-2-3-5-10(9)13(8)11(16)14-12(17)15-13/h2-5,8H,6-7H2,1H3,(H2,14,15,16,17)
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Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022469
PNG
(CHEMBL79251 | spiro[2,3-dihydro-1H-indene-1,3'-(te...)
Show SMILES C1CC2(CCc3ccccc23)CN1
Show InChI InChI=1/C12H15N/c1-2-4-11-10(3-1)5-6-12(11)7-8-13-9-12/h1-4,13H,5-9H2
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022483
PNG
(7'-methoxyspiro[tetrahydro-1H-imidazole-4,1'-(1',2...)
Show SMILES COc1ccc2CCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C13H14N2O3/c1-18-9-5-4-8-3-2-6-13(10(8)7-9)11(16)14-12(17)15-13/h4-5,7H,2-3,6H2,1H3,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022478
PNG
(1'-methylspiro[tetrahydro-1H-imidazole-4,4'-(1',2'...)
Show SMILES CN1CCC2(NC(=O)NC2=O)c2ccccc12
Show InChI InChI=1/C12H13N3O2/c1-15-7-6-12(10(16)13-11(17)14-12)8-4-2-3-5-9(8)15/h2-5H,6-7H2,1H3,(H2,13,14,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022400
PNG
(CHEMBL82425 | Chroman-4-carboxylic acid)
Show SMILES OC(=O)C1CCOc2ccccc12
Show InChI InChI=1/C10H10O3/c11-10(12)8-5-6-13-9-4-2-1-3-7(8)9/h1-4,8H,5-6H2,(H,11,12)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022404
PNG
(6-phenyl-1,3-diazaspiro[4.4]nonane-2,4-dione | CHE...)
Show SMILES O=C1NC(=O)C2(CCCC2c2ccccc2)N1
Show InChI InChI=1/C13H14N2O2/c16-11-13(15-12(17)14-11)8-4-7-10(13)9-5-2-1-3-6-9/h1-3,5-6,10H,4,7-8H2,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022420
PNG
(1',3'-dihydro-2H,5H-spiro[imidazolidine-4,2'-inden...)
Show SMILES O=C1NC(=O)C2(Cc3ccccc3C2)N1
Show InChI InChI=1S/C11H10N2O2/c14-9-11(13-10(15)12-9)5-7-3-1-2-4-8(7)6-11/h1-4H,5-6H2,(H2,12,13,14,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022443
PNG
(5-(5-chloro-2-methoxyphenyl)-5-methyltetrahydro-1H...)
Show SMILES COc1ccc(Cl)cc1C1(C)NC(=O)NC1=O
Show InChI InChI=1/C11H11ClN2O3/c1-11(9(15)13-10(16)14-11)7-5-6(12)3-4-8(7)17-2/h3-5H,1-2H3,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022451
PNG
(1,2,3,4-Tetrahydro-naphthalene-1-carboxylic acid |...)
Show SMILES OC(=O)C1CCCc2ccccc12
Show InChI InChI=1/C11H12O2/c12-11(13)10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10H,3,5,7H2,(H,12,13)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022488
PNG
(CHEMBL82772 | spiro[1,2,3,4-tetrahydronaphthalene-...)
Show SMILES O=C1CC2(CN1)CCCc1ccccc21
Show InChI InChI=1/C13H15NO/c15-12-8-13(9-14-12)7-3-5-10-4-1-2-6-11(10)13/h1-2,4,6H,3,5,7-9H2,(H,14,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022497
PNG
(6-hexahydro-1-pyridinylmethylspiro[3,4-dihydro-2H-...)
Show SMILES O=C1NC(=O)C2(CCOc3ccc(CN4CCCCC4)cc23)N1
Show InChI InChI=1/C17H21N3O3/c21-15-17(19-16(22)18-15)6-9-23-14-5-4-12(10-13(14)17)11-20-7-2-1-3-8-20/h4-5,10H,1-3,6-9,11H2,(H2,18,19,21,22)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022411
PNG
(6-chloro-(4'R)-spiro[3,4-dihydro-2H-chromene-4,5'-...)
Show SMILES OC1=NC(=O)[C@]2(CCOc3ccc(Cl)cc23)O1
Show InChI InChI=1S/C11H8ClNO4/c12-6-1-2-8-7(5-6)11(3-4-16-8)9(14)13-10(15)17-11/h1-2,5H,3-4H2,(H,13,14,15)/t11-/m1/s1
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022405
PNG
(2',5'-dioxospiro[3,4-dihydro-2H-chromene-4,4'-(tet...)
Show SMILES NC(=O)c1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C12H11N3O4/c13-9(16)6-1-2-8-7(5-6)12(3-4-19-8)10(17)14-11(18)15-12/h1-2,5H,3-4H2,(H2,13,16)(H2,14,15,17,18)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022457
PNG
(2',3'-dihydro-2H,5H-spiro[imidazolidine-4,1'-inden...)
Show SMILES O=C1NC(=O)C2(CCc3ccccc23)N1
Show InChI InChI=1/C11H10N2O2/c14-9-11(13-10(15)12-9)6-5-7-3-1-2-4-8(7)11/h1-4H,5-6H2,(H2,12,13,14,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022414
PNG
(CHEMBL79787 | Indan-1-yl-urea 3-formaldehyde)
Show SMILES O=CNC(=O)NC1CCc2ccccc12
Show InChI InChI=1/C11H12N2O2/c14-7-12-11(15)13-10-6-5-8-3-1-2-4-9(8)10/h1-4,7,10H,5-6H2,(H2,12,13,14,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022432
PNG
(CHEMBL81709 | N-(1-carbamoyl-2,3-dihydro-1H-1-inde...)
Show SMILES NC(=O)C1(CCc2ccccc12)NC=O
Show InChI InChI=1/C11H12N2O2/c12-10(15)11(13-7-14)6-5-8-3-1-2-4-9(8)11/h1-4,7H,5-6H2,(H2,12,15)(H,13,14)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022465
PNG
(3',4'-dihydro-2'H,5H-spiro[imidazolidine-4,1'-naph...)
Show SMILES O=C1NCNC11CCCc2ccccc12
Show InChI InChI=1/C12H14N2O/c15-11-12(14-8-13-11)7-3-5-9-4-1-2-6-10(9)12/h1-2,4,6,14H,3,5,7-8H2,(H,13,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022479
PNG
(2,5-dioxospiro[tetrahydro-1H-imidazole-4,1'-(1',2'...)
Show SMILES OC(=O)C1CCC2(NC(=O)NC2=O)c2ccccc12
Show InChI InChI=1/C13H12N2O4/c16-10(17)8-5-6-13(11(18)14-12(19)15-13)9-4-2-1-3-7(8)9/h1-4,8H,5-6H2,(H,16,17)(H2,14,15,18,19)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022482
PNG
(5',8'-dichlorospiro[tetrahydro-1H-imidazole-4,4'-(...)
Show SMILES Clc1ccc(Cl)c2c1SCCC21NC(=O)NC1=O
Show InChI InChI=1/C11H8Cl2N2O2S/c12-5-1-2-6(13)8-7(5)11(3-4-18-8)9(16)14-10(17)15-11/h1-2H,3-4H2,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022493
PNG
((Indane-1-carbonyl)-urea(1/4H2O) | CHEMBL78305)
Show SMILES NC(=O)NC(=O)C1CCc2ccccc12
Show InChI InChI=1/C11H12N2O2/c12-11(15)13-10(14)9-6-5-7-3-1-2-4-8(7)9/h1-4,9H,5-6H2,(H3,12,13,14,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022489
PNG
(1',2'-dimethylspiro[tetrahydro-1H-imidazole-4,4'-(...)
Show SMILES Cc1cc2c(CCCC22NC(=O)NC2=O)n1C
Show InChI InChI=1/C12H15N3O2/c1-7-6-8-9(15(7)2)4-3-5-12(8)10(16)13-11(17)14-12/h6H,3-5H2,1-2H3,(H2,13,14,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50421832
PNG
(CHEMBL2310845)
Show SMILES CN1C(O)=NC(=O)[C@]11CCOc2ccc(F)cc12
Show InChI InChI=1/C12H11FN2O3/c1-15-11(17)14-10(16)12(15)4-5-18-9-3-2-7(13)6-8(9)12/h2-3,6H,4-5H2,1H3,(H,14,16,17)/t12-/s2
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified human placenta aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022468
PNG
(6',7'-dimethoxyspiro[tetrahydro-1H-imidazole-4,1'-...)
Show SMILES COc1cc2CCCC3(NC(=O)NC3=O)c2cc1OC
Show InChI InChI=1/C14H16N2O4/c1-19-10-6-8-4-3-5-14(9(8)7-11(10)20-2)12(17)15-13(18)16-14/h6-7H,3-5H2,1-2H3,(H2,15,16,17,18)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022496
PNG
(6-chlorospiro[3,4-dihydro-2H-chromene-4,5'-(hexahy...)
Show SMILES Clc1ccc2OCCC3(C(=O)NC(=O)NC3=O)c2c1
Show InChI InChI=1S/C12H9ClN2O4/c13-6-1-2-8-7(5-6)12(3-4-19-8)9(16)14-11(18)15-10(12)17/h1-2,5H,3-4H2,(H2,14,15,16,17,18)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022448
PNG
(6-Fluoro-chroman-4-carboxylic acid | CHEMBL78020)
Show SMILES OC(=O)C1CCOc2ccc(F)cc12
Show InChI InChI=1/C10H9FO3/c11-6-1-2-9-8(5-6)7(10(12)13)3-4-14-9/h1-2,5,7H,3-4H2,(H,12,13)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-4 - 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022475
PNG
(6'-(tert-butyl)spiro[tetrahydro-1H-imidazole-4,4'-...)
Show SMILES CC(C)(C)c1ccc2SCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C15H18N2O2S/c1-14(2,3)9-4-5-11-10(8-9)15(6-7-20-11)12(18)16-13(19)17-15/h4-5,8H,6-7H2,1-3H3,(H2,16,17,18,19)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022408
PNG
(CHEMBL82299 | Indan-1-carboxylic acid)
Show SMILES OC(=O)C1CCc2ccccc12
Show InChI InChI=1/C10H10O2/c11-10(12)9-6-5-7-3-1-2-4-8(7)9/h1-4,9H,5-6H2,(H,11,12)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022417
PNG
(1,3-dimethylspiro[tetrahydro-1H-imidazole-4,1'-(1'...)
Show SMILES CN1C(=O)N(C)C2(CCCc3ccccc23)C1=O
Show InChI InChI=1/C14H16N2O2/c1-15-12(17)14(16(2)13(15)18)9-5-7-10-6-3-4-8-11(10)14/h3-4,6,8H,5,7,9H2,1-2H3
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022430
PNG
(1',5',6',7'-tetrahydro-2H,5H-spiro[imidazolidine-4...)
Show SMILES O=C1NC(=O)C2(CCCc3[nH]ccc23)N1
Show InChI InChI=1/C10H11N3O2/c14-8-10(13-9(15)12-8)4-1-2-7-6(10)3-5-11-7/h3,5,11H,1-2,4H2,(H2,12,13,14,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022442
PNG
(8'-chlorospiro[tetrahydro-1H-imidazole-4,4'-(3',4'...)
Show SMILES Clc1cccc2c1SCCC21NC(=O)NC1=O
Show InChI InChI=1/C11H9ClN2O2S/c12-7-3-1-2-6-8(7)17-5-4-11(6)9(15)13-10(16)14-11/h1-3H,4-5H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022450
PNG
(1,3-diazaspiro[4.5]decane-2,4-dione | CHEMBL79885)
Show SMILES O=C1NC(=O)C2(CCCCC2)N1
Show InChI InChI=1S/C8H12N2O2/c11-6-8(10-7(12)9-6)4-2-1-3-5-8/h1-5H2,(H2,9,10,11,12)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022460
PNG
(CHEMBL81558 | Indan-2-carboxylic acid)
Show SMILES OC(=O)C1Cc2ccccc2C1
Show InChI InChI=1S/C10H10O2/c11-10(12)9-5-7-3-1-2-4-8(7)6-9/h1-4,9H,5-6H2,(H,11,12)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022431
PNG
(2,3-dihydro-2'H,4'H-spiro[indene-1,5'-[1,3]oxazoli...)
Show SMILES OC1=NC(=O)C2(CCc3ccccc23)O1
Show InChI InChI=1/C11H9NO3/c13-9-11(15-10(14)12-9)6-5-7-3-1-2-4-8(7)11/h1-4H,5-6H2,(H,12,13,14)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-4 - 10E-6


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022454
PNG
(3',4'-dihydro-2'H-spiro[imidazolidine-4,1'-naphtha...)
Show SMILES O=C1NC(=O)C2(CCCc3ccccc23)N1
Show InChI InChI=1/C12H12N2O2/c15-10-12(14-11(16)13-10)7-3-5-8-4-1-2-6-9(8)12/h1-2,4,6H,3,5,7H2,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022402
PNG
(6'-methoxyspiro[tetrahydro-1H-imidazole-4,1'-(1',2...)
Show SMILES COc1ccc2c(CCCC22NC(=O)NC2=O)c1
Show InChI InChI=1/C13H14N2O3/c1-18-9-4-5-10-8(7-9)3-2-6-13(10)11(16)14-12(17)15-13/h4-5,7H,2-3,6H2,1H3,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-4- 10E-5


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase


(Bos taurus (Cattle))
BDBM50227017
PNG
(CHEMBL421333)
Show SMILES O=C1NC(=O)C2(CCOc3ccc(cc23)-c2ccccc2)N1
Show InChI InChI=1/C17H14N2O3/c20-15-17(19-16(21)18-15)8-9-22-14-7-6-12(10-13(14)17)11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H2,18,19,20,21)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022428
PNG
(6,7-dihydro-2'H,5H,5'H-spiro[1-benzothiophene-4,4'...)
Show SMILES O=C1NC(=O)C2(CCCc3sccc23)N1
Show InChI InChI=1/C10H10N2O2S/c13-8-10(12-9(14)11-8)4-1-2-7-6(10)3-5-15-7/h3,5H,1-2,4H2,(H2,11,12,13,14)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022399
PNG
(6-methylsulfonylspiro[3,4-dihydro-2H-chromene-4,4'...)
Show SMILES CS(=O)(=O)c1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C12H12N2O5S/c1-20(17,18)7-2-3-9-8(6-7)12(4-5-19-9)10(15)13-11(16)14-12/h2-3,6H,4-5H2,1H3,(H2,13,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase


(Bos taurus (Cattle))
BDBM50226986
PNG
(CHEMBL79228)
Show SMILES OC(=O)C1CCSc2ccc(Cl)cc12
Show InChI InChI=1/C10H9ClO2S/c11-6-1-2-9-8(5-6)7(10(12)13)3-4-14-9/h1-2,5,7H,3-4H2,(H,12,13)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022429
PNG
(6N,6N-dimethyl-2',5'-dioxospiro[3,4-dihydro-2H-chr...)
Show SMILES CN(C)S(=O)(=O)c1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C13H15N3O5S/c1-16(2)22(19,20)8-3-4-10-9(7-8)13(5-6-21-10)11(17)14-12(18)15-13/h3-4,7H,5-6H2,1-2H3,(H2,14,15,17,18)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022463
PNG
(3,4-dihydro-2H,2'H,6'H-spiro[naphthalene-1,3'-pipe...)
Show SMILES O=C1CCC2(CCCc3ccccc23)C(=O)N1
Show InChI InChI=1/C14H15NO2/c16-12-7-9-14(13(17)15-12)8-3-5-10-4-1-2-6-11(10)14/h1-2,4,6H,3,5,7-9H2,(H,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022466
PNG
(6,7-dihydro-2'H,5H,5'H-spiro[1-benzofuran-4,4'-imi...)
Show SMILES O=C1NC(=O)C2(CCCc3occc23)N1
Show InChI InChI=1/C10H10N2O3/c13-8-10(12-9(14)11-8)4-1-2-7-6(10)3-5-15-7/h3,5H,1-2,4H2,(H2,11,12,13,14)
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Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022477
PNG
(CHEMBL421713 | spiro[tetrahydro-1H-imidazole-4,1'-...)
Show SMILES O=C1NCC2(CCc3ccccc23)N1
Show InChI InChI=1/C11H12N2O/c14-10-12-7-11(13-10)6-5-8-3-1-2-4-9(8)11/h1-4H,5-7H2,(H2,12,13,14)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022474
PNG
(2'-phenylspiro[tetrahydro-1H-imidazole-4,1'-(1',2'...)
Show SMILES O=C1NC(=O)C2(N1)C(CCc1ccccc21)c1ccccc1
Show InChI InChI=1/C18H16N2O2/c21-16-18(20-17(22)19-16)14-9-5-4-8-13(14)10-11-15(18)12-6-2-1-3-7-12/h1-9,15H,10-11H2,(H2,19,20,21,22)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022495
PNG
(6,7,8,9-tetrahydro-2'H,5'H-spiro[benzo[7]annulene-...)
Show SMILES O=C1NC(=O)C2(CCCCc3ccccc23)N1
Show InChI InChI=1/C13H14N2O2/c16-11-13(15-12(17)14-11)8-4-3-6-9-5-1-2-7-10(9)13/h1-2,5,7H,3-4,6,8H2,(H2,14,15,16,17)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50421833
PNG
(CHEMBL2310844)
Show SMILES CN1C(=O)N(C)[C@@]2(CCOc3ccc(F)cc23)C1=O
Show InChI InChI=1/C13H13FN2O3/c1-15-11(17)13(16(2)12(15)18)5-6-19-10-4-3-8(14)7-9(10)13/h3-4,7H,5-6H2,1-2H3/t13-/s2
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibitory activity towards partially purified human placenta aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022421
PNG
(6-(tert-butyl)spiro[3,4-dihydro-2H-chromene-4,4'-(...)
Show SMILES CC(C)(C)c1ccc2OCCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C15H18N2O3/c1-14(2,3)9-4-5-11-10(8-9)15(6-7-20-11)12(18)16-13(19)17-15/h4-5,8H,6-7H2,1-3H3,(H2,16,17,18,19)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022439
PNG
(6'-hydroxyspiro[tetrahydro-1H-imidazole-4,1'-(2',3...)
Show SMILES Oc1ccc2CCC3(NC(=O)NC3=O)c2c1
Show InChI InChI=1/C11H10N2O3/c14-7-2-1-6-3-4-11(8(6)5-7)9(15)12-10(16)13-11/h1-2,5,14H,3-4H2,(H2,12,13,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of partially purified calf lens aldose reductase; value ranges from 10E-4 to 10e-5 M


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase


(Bos taurus (Cattle))
BDBM50226990
PNG
(CHEMBL311334)
Show SMILES O=C1NC(=O)C2(CCOc3c2ccc2ccccc32)N1
Show InChI InChI=1/C15H12N2O3/c18-13-15(17-14(19)16-13)7-8-20-12-10-4-2-1-3-9(10)5-6-11(12)15/h1-6H,7-8H2,(H2,16,17,18,19)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase


(Bos taurus (Cattle))
BDBM50226992
PNG
(CHEMBL81682)
Show SMILES Clc1ccc2OCCC3(CC(=O)NC3=O)c2c1
Show InChI InChI=1/C12H10ClNO3/c13-7-1-2-9-8(5-7)12(3-4-17-9)6-10(15)14-11(12)16/h1-2,5H,3-4,6H2,(H,14,15,16)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022392
PNG
(5',6',7'-trimethoxyspiro[tetrahydro-1H-imidazole-4...)
Show SMILES COc1cc2CCC3(NC(=O)NC3=O)c2c(OC)c1OC
Show InChI InChI=1/C14H16N2O5/c1-19-8-6-7-4-5-14(12(17)15-13(18)16-14)9(7)11(21-3)10(8)20-2/h6H,4-5H2,1-3H3,(H2,15,16,17,18)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022452
PNG
(CHEMBL312031 | spiro[2,3-dihydro-1H-indene-1,3'-(t...)
Show SMILES O=C1CC2(CCc3ccccc23)C(=O)N1
Show InChI InChI=1/C12H11NO2/c14-10-7-12(11(15)13-10)6-5-8-3-1-2-4-9(8)12/h1-4H,5-7H2,(H,13,14,15)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
Aldose reductase (ALR2)


(Bos taurus (Cattle))
BDBM50022472
PNG
(4'-phenylspiro[tetrahydro-1H-imidazole-4,1'-(1',2'...)
Show SMILES O=C1NC(=O)C2(CCC(c3ccccc3)c3ccccc23)N1
Show InChI InChI=1/C18H16N2O2/c21-16-18(20-17(22)19-16)11-10-13(12-6-2-1-3-7-12)14-8-4-5-9-15(14)18/h1-9,13H,10-11H2,(H2,19,20,21,22)
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Pfizer Central Research

Curated by ChEMBL


Assay Description
In vitro inhibition of partially purified calf lens aldose reductase


J Med Chem 31: 230-43 (1988)


Article DOI: 10.1021/jm00396a037
BindingDB Entry DOI: 10.7270/Q27D2VQF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%