Compile Data Set for Download or QSAR
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Found 20 Enz. Inhib. hit(s) with all data for entry = 50005260
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034949(2-Amino-6-(3,5-dichloro-phenylamino)-3H-pyrimidin-...)
Affinity DataIC50:  770nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Affinity DataIC50:  850nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034950(2-Amino-6-(3,4-dichloro-phenylamino)-3H-pyrimidin-...)
Affinity DataIC50:  850nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Affinity DataIC50:  880nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034947(2-(3,5-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Affinity DataIC50:  910nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034963(CHEMBL51501 | N*2*-(3,5-Dichloro-phenyl)-9H-purine...)
Affinity DataIC50:  920nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034952(6-(3,5-Dichloro-phenylamino)-1H-pyrimidine-2,4-dio...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50028342(6-(3,4-Dichloro-phenylamino)-1H-pyrimidine-2,4-dio...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034961(6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA primase(Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Affinity DataIC50:  5.90E+4nMAssay Description:Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition against coupled primase-DNA polymerase I assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition against coupled primase-DNA polymerase I assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50013091(2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]-dTTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034961(6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]-dTTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034955(CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]-dTTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034961(6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Stanford University Medical School

Curated by ChEMBL
LigandPNGBDBM50034961(6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed