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PubMed code 9464368

Compile data set for download or QSAR
Found 78 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062577
PNG
(6-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC1CN2CC1CCC2
Show InChI InChI=1/C12H19N3OS2/c1-2-6-17-12-11(13-18-14-12)16-10-8-15-5-3-4-9(10)7-15/h9-10H,2-8H2,1H3
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n/an/a 0.550n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062579
PNG
(3-(4-Pentylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C14H23N3OS2/c1-2-3-4-9-19-14-13(15-20-16-14)18-12-10-17-7-5-11(12)6-8-17/h11-12H,2-10H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50003359
PNG
(5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2...)
Show SMILES CCCCCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062589
PNG
(3-(4-Butylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-az...)
Show SMILES CCCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C13H21N3OS2/c1-2-3-8-18-13-12(14-19-15-13)17-11-9-16-6-4-10(11)5-7-16/h10-11H,2-9H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062585
PNG
(3-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C12H19N3OS2/c1-2-7-17-12-11(13-18-14-12)16-10-8-15-5-3-9(10)4-6-15/h9-10H,2-8H2,1H3
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n/an/a 2.90n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062570
PNG
(3-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC1CN2CCC1C2
Show InChI InChI=1/C11H17N3OS2/c1-2-5-16-11-10(12-17-13-11)15-9-7-14-4-3-8(9)6-14/h8-9H,2-7H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062570
PNG
(3-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC1CN2CCC1C2
Show InChI InChI=1/C11H17N3OS2/c1-2-5-16-11-10(12-17-13-11)15-9-7-14-4-3-8(9)6-14/h8-9H,2-7H2,1H3
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n/an/a 4.40n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062589
PNG
(3-(4-Butylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-az...)
Show SMILES CCCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C13H21N3OS2/c1-2-3-8-18-13-12(14-19-15-13)17-11-9-16-6-4-10(11)5-7-16/h10-11H,2-9H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50003359
PNG
(5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2...)
Show SMILES CCCCCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062587
PNG
(5-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC12CCN(C1)CCC2
Show InChI InChI=1/C12H19N3OS2/c1-2-8-17-11-10(13-18-14-11)16-12-4-3-6-15(9-12)7-5-12/h2-9H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062570
PNG
(3-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC1CN2CCC1C2
Show InChI InChI=1/C11H17N3OS2/c1-2-5-16-11-10(12-17-13-11)15-9-7-14-4-3-8(9)6-14/h8-9H,2-7H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062595
PNG
(3-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yl)-1-aza-...)
Show SMILES CCCSc1nsnc1C1CN2CCC1C2
Show InChI InChI=1/C11H17N3S2/c1-2-5-15-11-10(12-16-13-11)9-7-14-4-3-8(9)6-14/h8-9H,2-7H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062595
PNG
(3-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yl)-1-aza-...)
Show SMILES CCCSc1nsnc1C1CN2CCC1C2
Show InChI InChI=1/C11H17N3S2/c1-2-5-15-11-10(12-16-13-11)9-7-14-4-3-8(9)6-14/h8-9H,2-7H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062579
PNG
(3-(4-Pentylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C14H23N3OS2/c1-2-3-4-9-19-14-13(15-20-16-14)18-12-10-17-7-5-11(12)6-8-17/h11-12H,2-10H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062591
PNG
(3-(4-Ethylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-az...)
Show SMILES CCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C11H17N3OS2/c1-2-16-11-10(12-17-13-11)15-9-7-14-5-3-8(9)4-6-14/h8-9H,2-7H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062587
PNG
(5-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC12CCN(C1)CCC2
Show InChI InChI=1/C12H19N3OS2/c1-2-8-17-11-10(13-18-14-11)16-12-4-3-6-15(9-12)7-5-12/h2-9H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062593
PNG
(3-(4-Hexylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-az...)
Show SMILES CCCCCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C15H25N3OS2/c1-2-3-4-5-10-20-15-14(16-21-17-15)19-13-11-18-8-6-12(13)7-9-18/h12-13H,2-11H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062579
PNG
(3-(4-Pentylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C14H23N3OS2/c1-2-3-4-9-19-14-13(15-20-16-14)18-12-10-17-7-5-11(12)6-8-17/h11-12H,2-10H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062586
PNG
(3-(4-Butoxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyc...)
Show SMILES CCCCOc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C13H21N3O2S/c1-2-3-8-17-12-13(15-19-14-12)18-11-9-16-6-4-10(11)5-7-16/h10-11H,2-9H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062584
PNG
(3-(4-Hexyloxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bic...)
Show SMILES CCCCCCOc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C15H25N3O2S/c1-2-3-4-5-10-19-14-15(17-21-16-14)20-13-11-18-8-6-12(13)7-9-18/h12-13H,2-11H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062597
PNG
(3-(4-Pentyloxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bi...)
Show SMILES CCCCCOc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C14H23N3O2S/c1-2-3-4-9-18-13-14(16-20-15-13)19-12-10-17-7-5-11(12)6-8-17/h11-12H,2-10H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50455268
PNG
(CHEMBL2111844)
Show SMILES CCCSc1nsnc1O[C@@H]1CC2CCN(C2)C1
Show InChI InChI=1/C12H19N3OS2/c1-2-5-17-12-11(13-18-14-12)16-10-6-9-3-4-15(7-9)8-10/h9-10H,2-8H2,1H3/t9?,10-/s2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062581
PNG
(3-(4-Methylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C10H15N3OS2/c1-15-10-9(11-16-12-10)14-8-6-13-4-2-7(8)3-5-13/h7-8H,2-6H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062575
PNG
(3-(4-Ethoxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyc...)
Show SMILES CCOc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C11H17N3O2S/c1-2-15-10-11(13-17-12-10)16-9-7-14-5-3-8(9)4-6-14/h8-9H,2-7H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50455268
PNG
(CHEMBL2111844)
Show SMILES CCCSc1nsnc1O[C@@H]1CC2CCN(C2)C1
Show InChI InChI=1/C12H19N3OS2/c1-2-5-17-12-11(13-18-14-12)16-10-6-9-3-4-15(7-9)8-10/h9-10H,2-8H2,1H3/t9?,10-/s2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062591
PNG
(3-(4-Ethylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-az...)
Show SMILES CCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C11H17N3OS2/c1-2-16-11-10(12-17-13-11)15-9-7-14-5-3-8(9)4-6-14/h8-9H,2-7H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062585
PNG
(3-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C12H19N3OS2/c1-2-7-17-12-11(13-18-14-12)16-10-8-15-5-3-9(10)4-6-15/h9-10H,2-8H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062588
PNG
(3-(3-Butoxy-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.2]o...)
Show SMILES CCCCOc1nccnc1OC1CN2CCC1CC2
Show InChI InChI=1/C15H23N3O2/c1-2-3-10-19-14-15(17-7-6-16-14)20-13-11-18-8-4-12(13)5-9-18/h6-7,12-13H,2-5,8-11H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062593
PNG
(3-(4-Hexylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-az...)
Show SMILES CCCCCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C15H25N3OS2/c1-2-3-4-5-10-20-15-14(16-21-17-15)19-13-11-18-8-6-12(13)7-9-18/h12-13H,2-11H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062577
PNG
(6-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC1CN2CC1CCC2
Show InChI InChI=1/C12H19N3OS2/c1-2-6-17-12-11(13-18-14-12)16-10-8-15-5-3-4-9(10)7-15/h9-10H,2-8H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062572
PNG
(CHEMBL129152 | [2-(4-Butoxy-[1,2,5]thiadiazol-3-yl...)
Show SMILES CCCCOc1nsnc1OCC[N+](C)(C)C
Show InChI InChI=1S/C11H22N3O2S/c1-5-6-8-15-10-11(13-17-12-10)16-9-7-14(2,3)4/h5-9H2,1-4H3/q+1
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n/an/a 36n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062588
PNG
(3-(3-Butoxy-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.2]o...)
Show SMILES CCCCOc1nccnc1OC1CN2CCC1CC2
Show InChI InChI=1/C15H23N3O2/c1-2-3-10-19-14-15(17-7-6-16-14)20-13-11-18-8-4-12(13)5-9-18/h6-7,12-13H,2-5,8-11H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062572
PNG
(CHEMBL129152 | [2-(4-Butoxy-[1,2,5]thiadiazol-3-yl...)
Show SMILES CCCCOc1nsnc1OCC[N+](C)(C)C
Show InChI InChI=1S/C11H22N3O2S/c1-5-6-8-15-10-11(13-17-12-10)16-9-7-14(2,3)4/h5-9H2,1-4H3/q+1
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062580
PNG
(3-Butoxy-4-(1-methyl-pyrrolidin-3-yloxy)-[1,2,5]th...)
Show SMILES CCCCOc1nsnc1OC1CCN(C)C1
Show InChI InChI=1/C11H19N3O2S/c1-3-4-7-15-10-11(13-17-12-10)16-9-5-6-14(2)8-9/h9H,3-8H2,1-2H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062584
PNG
(3-(4-Hexyloxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bic...)
Show SMILES CCCCCCOc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C15H25N3O2S/c1-2-3-4-5-10-19-14-15(17-21-16-14)20-13-11-18-8-6-12(13)7-9-18/h12-13H,2-11H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062586
PNG
(3-(4-Butoxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyc...)
Show SMILES CCCCOc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C13H21N3O2S/c1-2-3-8-17-12-13(15-19-14-12)18-11-9-16-6-4-10(11)5-7-16/h10-11H,2-9H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062581
PNG
(3-(4-Methylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C10H15N3OS2/c1-15-10-9(11-16-12-10)14-8-6-13-4-2-7(8)3-5-13/h7-8H,2-6H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062580
PNG
(3-Butoxy-4-(1-methyl-pyrrolidin-3-yloxy)-[1,2,5]th...)
Show SMILES CCCCOc1nsnc1OC1CCN(C)C1
Show InChI InChI=1/C11H19N3O2S/c1-3-4-7-15-10-11(13-17-12-10)16-9-5-6-14(2)8-9/h9H,3-8H2,1-2H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062578
PNG
(3-(4-Propoxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicy...)
Show SMILES CCCOc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C12H19N3O2S/c1-2-7-16-11-12(14-18-13-11)17-10-8-15-5-3-9(10)4-6-15/h9-10H,2-8H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062578
PNG
(3-(4-Propoxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicy...)
Show SMILES CCCOc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C12H19N3O2S/c1-2-7-16-11-12(14-18-13-11)17-10-8-15-5-3-9(10)4-6-15/h9-10H,2-8H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062597
PNG
(3-(4-Pentyloxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bi...)
Show SMILES CCCCCOc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C14H23N3O2S/c1-2-3-4-9-18-13-14(16-20-15-13)19-12-10-17-7-5-11(12)6-8-17/h11-12H,2-10H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062573
PNG
(3-[4-(2-Methylsulfanyl-ethyl)-[1,2,5]thiadiazol-3-...)
Show SMILES CSCCc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C12H19N3OS2/c1-17-7-4-10-12(14-18-13-10)16-11-8-15-5-2-9(11)3-6-15/h9,11H,2-8H2,1H3
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n/an/a 58.7n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062576
PNG
(3-(4-Chloro-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyc...)
Show SMILES Clc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C9H12ClN3OS/c10-8-9(12-15-11-8)14-7-5-13-3-1-6(7)2-4-13/h6-7H,1-5H2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062573
PNG
(3-[4-(2-Methylsulfanyl-ethyl)-[1,2,5]thiadiazol-3-...)
Show SMILES CSCCc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C12H19N3OS2/c1-17-7-4-10-12(14-18-13-10)16-11-8-15-5-2-9(11)3-6-15/h9,11H,2-8H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062575
PNG
(3-(4-Ethoxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyc...)
Show SMILES CCOc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C11H17N3O2S/c1-2-15-10-11(13-17-12-10)16-9-7-14-5-3-8(9)4-6-14/h8-9H,2-7H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062592
PNG
(3-(4-Ethylsulfanylmethyl-[1,2,5]thiadiazol-3-yloxy...)
Show SMILES CCSCc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C12H19N3OS2/c1-2-17-8-10-12(14-18-13-10)16-11-7-15-5-3-9(11)4-6-15/h9,11H,2-8H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062590
PNG
(CHEMBL129558 | [2-(4-Butoxy-[1,2,5]thiadiazol-3-yl...)
Show SMILES CCCCOc1nsnc1OCCN(C)C
Show InChI InChI=1S/C10H19N3O2S/c1-4-5-7-14-9-10(12-16-11-9)15-8-6-13(2)3/h4-8H2,1-3H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062590
PNG
(CHEMBL129558 | [2-(4-Butoxy-[1,2,5]thiadiazol-3-yl...)
Show SMILES CCCCOc1nsnc1OCCN(C)C
Show InChI InChI=1S/C10H19N3O2S/c1-4-5-7-14-9-10(12-16-11-9)15-8-6-13(2)3/h4-8H2,1-3H3
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n/an/a 68.5n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062592
PNG
(3-(4-Ethylsulfanylmethyl-[1,2,5]thiadiazol-3-yloxy...)
Show SMILES CCSCc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C12H19N3OS2/c1-2-17-8-10-12(14-18-13-10)16-11-7-15-5-3-9(11)4-6-15/h9,11H,2-8H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062583
PNG
(3-(4-Butoxy-furazan-3-yloxy)-1-aza-bicyclo[2.2.2]o...)
Show SMILES CCCCOc1nonc1OC1CN2CCC1CC2
Show InChI InChI=1/C13H21N3O3/c1-2-3-8-17-12-13(15-19-14-12)18-11-9-16-6-4-10(11)5-7-16/h10-11H,2-9H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062576
PNG
(3-(4-Chloro-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyc...)
Show SMILES Clc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C9H12ClN3OS/c10-8-9(12-15-11-8)14-7-5-13-3-1-6(7)2-4-13/h6-7H,1-5H2
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n/an/a 99n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062574
PNG
(3-(Azetidin-3-yloxy)-4-butoxy-[1,2,5]thiadiazole |...)
Show SMILES CCCCOc1nsnc1OC1CNC1
Show InChI InChI=1S/C9H15N3O2S/c1-2-3-4-13-8-9(12-15-11-8)14-7-5-10-6-7/h7,10H,2-6H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50034625
PNG
(Aceclidine | Acetic acid 1-aza-bicyclo[2.2.2]oct-3...)
Show SMILES CC(=O)OC1CN2CCC1CC2
Show InChI InChI=1/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062594
PNG
(3-(4-Methoxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicy...)
Show SMILES COc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C10H15N3O2S/c1-14-9-10(12-16-11-9)15-8-6-13-4-2-7(8)3-5-13/h7-8H,2-6H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062582
PNG
(3-Butoxy-4-(pyrrolidin-3-yloxy)-[1,2,5]thiadiazole...)
Show SMILES CCCCOc1nsnc1OC1CCNC1
Show InChI InChI=1/C10H17N3O2S/c1-2-3-6-14-9-10(13-16-12-9)15-8-4-5-11-7-8/h8,11H,2-7H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062577
PNG
(6-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC1CN2CC1CCC2
Show InChI InChI=1/C12H19N3OS2/c1-2-6-17-12-11(13-18-14-12)16-10-8-15-5-3-4-9(10)7-15/h9-10H,2-8H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062594
PNG
(3-(4-Methoxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicy...)
Show SMILES COc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C10H15N3O2S/c1-14-9-10(12-16-11-9)15-8-6-13-4-2-7(8)3-5-13/h7-8H,2-6H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062583
PNG
(3-(4-Butoxy-furazan-3-yloxy)-1-aza-bicyclo[2.2.2]o...)
Show SMILES CCCCOc1nonc1OC1CN2CCC1CC2
Show InChI InChI=1/C13H21N3O3/c1-2-3-8-17-12-13(15-19-14-12)18-11-9-16-6-4-10(11)5-7-16/h10-11H,2-9H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062574
PNG
(3-(Azetidin-3-yloxy)-4-butoxy-[1,2,5]thiadiazole |...)
Show SMILES CCCCOc1nsnc1OC1CNC1
Show InChI InChI=1S/C9H15N3O2S/c1-2-3-4-13-8-9(12-15-11-8)14-7-5-10-6-7/h7,10H,2-6H2,1H3
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n/an/a 351n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062582
PNG
(3-Butoxy-4-(pyrrolidin-3-yloxy)-[1,2,5]thiadiazole...)
Show SMILES CCCCOc1nsnc1OC1CCNC1
Show InChI InChI=1/C10H17N3O2S/c1-2-3-6-14-9-10(13-16-12-9)15-8-4-5-11-7-8/h8,11H,2-7H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062596
PNG
(3-([1,2,5]Thiadiazol-3-yloxy)-1-aza-bicyclo[2.2.2]...)
Show SMILES C1CN2CCC1C(C2)Oc1cnsn1
Show InChI InChI=1/C9H13N3OS/c1-3-12-4-2-7(1)8(6-12)13-9-5-10-14-11-9/h5,7-8H,1-4,6H2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-oxotremorine-M (Oxo-M) radioligand in rat hippocampus membranes


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50062596
PNG
(3-([1,2,5]Thiadiazol-3-yloxy)-1-aza-bicyclo[2.2.2]...)
Show SMILES C1CN2CCC1C(C2)Oc1cnsn1
Show InChI InChI=1/C9H13N3OS/c1-3-12-4-2-7(1)8(6-12)13-9-5-10-14-11-9/h5,7-8H,1-4,6H2
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(RAT)
BDBM50034625
PNG
(Aceclidine | Acetic acid 1-aza-bicyclo[2.2.2]oct-3...)
Show SMILES CC(=O)OC1CN2CCC1CC2
Show InChI InChI=1/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for muscarinic acetylcholine receptor M1 using [3H]-Pirenzepine (Pz) radioligand in rat hippocampus membranes.


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50062585
PNG
(3-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C12H19N3OS2/c1-2-7-17-12-11(13-18-14-12)16-10-8-15-5-3-9(10)4-6-15/h9-10H,2-8H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50062597
PNG
(3-(4-Pentyloxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bi...)
Show SMILES CCCCCOc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C14H23N3O2S/c1-2-3-4-9-18-13-14(16-20-15-13)19-12-10-17-7-5-11(12)6-8-17/h11-12H,2-10H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50062579
PNG
(3-(4-Pentylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C14H23N3OS2/c1-2-3-4-9-19-14-13(15-20-16-14)18-12-10-17-7-5-11(12)6-8-17/h11-12H,2-10H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50062570
PNG
(3-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC1CN2CCC1C2
Show InChI InChI=1/C11H17N3OS2/c1-2-5-16-11-10(12-17-13-11)15-9-7-14-4-3-8(9)6-14/h8-9H,2-7H2,1H3
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n/an/an/an/a 162n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50062579
PNG
(3-(4-Pentylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C14H23N3OS2/c1-2-3-4-9-19-14-13(15-20-16-14)18-12-10-17-7-5-11(12)6-8-17/h11-12H,2-10H2,1H3
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Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50003359
PNG
(5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2...)
Show SMILES CCCCCCOc1nsnc1C1=CCCN(C)C1
Show InChI InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3
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n/an/an/an/a 200n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50034625
PNG
(Aceclidine | Acetic acid 1-aza-bicyclo[2.2.2]oct-3...)
Show SMILES CC(=O)OC1CN2CCC1CC2
Show InChI InChI=1/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3
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n/an/an/an/a 4.47E+3n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50062577
PNG
(6-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC1CN2CC1CCC2
Show InChI InChI=1/C12H19N3OS2/c1-2-6-17-12-11(13-18-14-12)16-10-8-15-5-3-4-9(10)7-15/h9-10H,2-8H2,1H3
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n/an/an/an/a 1n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50062574
PNG
(3-(Azetidin-3-yloxy)-4-butoxy-[1,2,5]thiadiazole |...)
Show SMILES CCCCOc1nsnc1OC1CNC1
Show InChI InChI=1S/C9H15N3O2S/c1-2-3-4-13-8-9(12-15-11-8)14-7-5-10-6-7/h7,10H,2-6H2,1H3
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n/an/an/an/a 6.20E+3n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50062584
PNG
(3-(4-Hexyloxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bic...)
Show SMILES CCCCCCOc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C15H25N3O2S/c1-2-3-4-5-10-19-14-15(17-21-16-14)20-13-11-18-8-6-12(13)7-9-18/h12-13H,2-11H2,1H3
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n/an/an/an/a 259n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50062570
PNG
(3-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-a...)
Show SMILES CCCSc1nsnc1OC1CN2CCC1C2
Show InChI InChI=1/C11H17N3OS2/c1-2-5-16-11-10(12-17-13-11)15-9-7-14-4-3-8(9)6-14/h8-9H,2-7H2,1H3
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n/an/an/an/a 1.90n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50062593
PNG
(3-(4-Hexylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-az...)
Show SMILES CCCCCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C15H25N3OS2/c1-2-3-4-5-10-20-15-14(16-21-17-15)19-13-11-18-8-6-12(13)7-9-18/h12-13H,2-11H2,1H3
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n/an/an/an/a 225n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50062589
PNG
(3-(4-Butylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-az...)
Show SMILES CCCCSc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C13H21N3OS2/c1-2-3-8-18-13-12(14-19-15-13)17-11-9-16-6-4-10(11)5-7-16/h10-11H,2-9H2,1H3
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n/an/an/an/a 22.3n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50062586
PNG
(3-(4-Butoxy-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyc...)
Show SMILES CCCCOc1nsnc1OC1CN2CCC1CC2
Show InChI InChI=1/C13H21N3O2S/c1-2-3-8-17-12-13(15-19-14-12)18-11-9-16-6-4-10(11)5-7-16/h10-11H,2-9H2,1H3
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n/an/an/an/a 102n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M1


(Homo sapiens (Human))
BDBM50062582
PNG
(3-Butoxy-4-(pyrrolidin-3-yloxy)-[1,2,5]thiadiazole...)
Show SMILES CCCCOc1nsnc1OC1CCNC1
Show InChI InChI=1/C10H17N3O2S/c1-2-3-6-14-9-10(13-16-12-9)15-8-4-5-11-7-8/h8,11H,2-7H2,1H3
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n/an/an/an/a 4.87E+3n/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration required for stimulation of phosphoinositol (PI) hydrolysis in the A9 L cell line transfected with the Muscarinic acetylcholi...


J Med Chem 41: 379-92 (1998)


Article DOI: 10.1021/jm970125n
BindingDB Entry DOI: 10.7270/Q2SX6CBC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%