Cell Reactant:
Serine/threonine-protein kinase Aurora-B
Syringe Reactant:
BDBM189379
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
08/03/16
ΔG°:
-8.61±0.48 (kcal/mole)
pH:
8±0
Temperature:
298.15±0 (K)
ΔH° :
-3.11±0.48 (kJ/mole)
ΔS° :
-0.02±0 (kJ/mole-K)
Citation
 Karthigeyan, DSurabhi, SMizar, PSoumik, SBanerjee, ASinha, SHDasgupta, DNarayana, CKundu, TK A Dual Non-ATP Analogue Inhibitor of Aurora Kinases A and B, Derived from Resorcinol with a Mixed Mode of Inhibition. Chem Biol Drug Des 87:958-67 (2016) [PubMed]  Article 
Cell React
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Syringe React
Name:
BDBM189379
Synonyms:
5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | Felodipine
Type:
Small organic molecule
Emp. Form.:
C18H19Cl2NO4
Mol. Mass.:
384.254
SMILES:
CCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(Cl)c1Cl)C(=O)OC |c:5,10|
Structure:
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