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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM6121
Substrate
cdc2 substrate peptide
Meas. Tech.
Kinase inhibition Assay
IC50
5.1±n/a nM
Citation
 Boschelli, DH; Ye, F; Wu, B; Wang, YD; Barrios Sosa, AC; Yaczko, D; Powell, D; Golas, JM; Lucas, J; Boschelli, F Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity. Bioorg Med Chem Lett 13:3797-800 (2003) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM6121
Synonyms:
3-quinolinecarbonitrile 4 | 6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]-4-[(3,4,5-trimethoxyphenyl)amino]quinoline-3-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C28H35N5O5
Mol. Mass.:
521.608
SMILES:
COc1cc2c(Nc3cc(OC)c(OC)c(OC)c3)c(cnc2cc1OCCCN1CCN(C)CC1)C#N
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
cdc2 substrate peptide
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
358.43
Organism:
n/a
Description:
100 uM ATP as co-substrate
Residue:
3
Sequence:
NA