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TargetActivated thrombin-activatable fibrinolysis inhibitor (TAFIa)
LigandBDBM173906
Substrate/Competitorn/a
Meas. Tech.TAFI Activity Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 7.70±n/a nM
Commentsextracted
Citation Kallus, CBroenstrup, MEvers, AGlobisch, ASchreuder, HWagner, M Macrocyclic urea and sulfamide derivatives as inhibitors of TAFIa US Patent US9688645 Publication Date 6/27/2017
More Info.:Get all data from this article,  Assay Method
 
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)
Name:Carboxypeptidase B2 isoform A
Synonyms:CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:Enzyme
Mol. Mass.:48432.74
Organism:Homo sapiens (Human)
Description:Q96IY4
Residue:423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
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BDBM173906
NameBDBM173906
Synonyms:US9688645, 3-1
TypeSmall organic molecule
Emp. Form.C25H38N4O6
Mol. Mass.490.5924
SMILESCC(C)[C@H]1COC\C=C\COc2ccc(C[C@@H](NC(=O)N[C@@H](CCCCN)C(O)=O)C(=O)N1)cc2 |r,t:7|
Structure
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n/a