| Reaction Details |
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| Report a problem with these data |
| Target | Plasmepsin I |
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| Ligand | Statine-like inhibitor 16 |
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| Substrate/Competitor | Peptide Substrate |
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| Meas. Tech. | Enzyme Inhibition Measurements |
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| pH | 4.5±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 0.5±n/a nM |
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| Citation |  Johansson, PO; Chen, Y; Belfrage, AK; Blackman, MJ; Kvarnstrom, I; Jansson, K; Vrang, L; Hamelink, E; Hallberg, A; Rosenquist, A; Samuelsson, B Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs.J Med Chem.47:3353-66(2004)[PubMed] |
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| More Info. |
Get all data from this article
, Inhibition_Run data
, Solution Info
, Assay Method
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| Plasmepsin I |
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| Name | Plasmepsin I |
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| Synonyms | EC 3.4.23.38 | PFAPG | Plasmepsin-1 precursor |
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| Type | Enzyme |
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| Mol. Mass. | 51461 |
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| Organism | Plasmodium falciparum |
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| Description | n/a |
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| Residue | 452 |
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| Sequence | MALSIKEDFSSAFAKNESAVNSSTFNNNMKTWKIQKRFQILYVFFFLLITGALFYYLIDN
VLFPKNKKINEIMNTSKHVIIGFSIENSHDRIMKTVKQHRLKNYIKESLKFFKTGLTQKP
HLGNAGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNL
YDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTL
GQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRF
YEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVV
KIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKN
TFILGDPFMRKYFTVFDYDNHTVGFALAKKKL
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| Statine-like inhibitor 16 |
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| Name | Statine-like inhibitor 16 |
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| Synonyms: | (3S,4S)-5-[(4-bromophenyl)methoxy]-N-[(1S)-1-{[(1S)-1-carbamoyl-3-methylbutyl]carbamoyl}ethyl]-3-hydroxy-4-[(2S)-3-methyl-2-(pyridin-2-ylformamido)butanamido]pentanamide | Pyridine-2-carboxylic Acid ((S)-1-{(1S,2S)-1-(4-Bromobenzyloxymethyl)3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)ethylcarbamoyl]-2-hydroxypropylcarbamoyl}-2-methylpropyl)amide |
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| Type | Small organic molecule |
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| Emp. Form. | C32H45BrN6O7 |
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| Mol. Mass. | 705.64 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](COCc1ccc(Br)cc1)NC(=O)[C@@H](NC(=O)c1ccccn1)C(C)C)C(N)=O |r| |
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| Structure | |
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| Peptide Substrate |
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| Name | Peptide Substrate |
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| Synonyms | n/a |
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| Type | Peptide |
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| Mol. Mass. | n/a |
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| Organism | n/a |
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| Description | n/a |
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| Residue | 8 |
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| Sequence | DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS
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