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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM508348
Substrate
n/a
Meas. Tech.
Phosphate Sensor Fluorescence Assay
IC50
<200±n/a nM
Citation
 Alam, M; Cleary, L; Fleury, M; Pei, Z; Steel, R; Sutton, J; Knox, JE; Newby, ZE 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors US Patent  US11046691 Publication Date 6/29/2021 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM508348
Synonyms:
1-(3-chloropyridin-2-yl)-7-ethyl-4- (methylamino)quinazolin-2(1H)-one | US11046691, Compound 659 | US11084798, Cpd No 659 | US11130759, Cpd. No. 659
Type:
Small organic molecule
Emp. Form.:
C16H15ClN4O
Mol. Mass.:
314.77
SMILES:
CCc1ccc2c(NC)nc(=O)n(-c3ncccc3Cl)c2c1 |(-4.05,-1.95,;-4.05,-.41,;-2.72,.36,;-2.67,1.93,;-1.33,2.69,;,1.92,;1.33,2.69,;1.33,4.23,;,5,;2.67,1.92,;2.67,.38,;4,-.38,;1.33,-.39,;1.33,-1.93,;2.67,-2.69,;2.67,-4.23,;1.33,-5,;,-4.23,;,-2.69,;-1.33,-1.92,;,.38,;-1.33,-.38,)|
Structure:
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