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TargetOxysterols receptor LXR-alpha
LigandBDBM304622
Substrate/Competitorn/a
Meas. Tech.LXR alpha/beta Radioligand Binding Assay
Ki 60.0±n/a nM
Citation Claremon, DADong, CFan, YLeftheris, KLotesta, SDSingh, SBTice, CMZhao, WZheng, YZhuang, L Piperazine derivatives as liver X receptor modulators US Patent US10144715 Publication Date 12/4/2018
More Info.:Get all data from this article,  Assay Method
 
Oxysterols receptor LXR-alpha
Name:Liver X receptor (LXR alpha AND LXR beta)
Synonyms:Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 | Oxysterols receptor LXR-alpha
Type:Receptor
Mol. Mass.:50403.85
Organism:Homo sapiens (Human)
Description:His-tagged hLXR.
Residue:447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
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  Blast E-value cutoff:
BDBM304622
NameBDBM304622
Synonyms:(S)-1-(((1s,4R)-4-(difluoromethyl)cyclohexyl)methyl)-4-(3-(methylsulfonyl)phenyl)-2-phenylpiperazine | US10144715, Compound 48-17
TypeSmall organic molecule
Emp. Form.C25H30F2N2O3S
Mol. Mass.476.579
SMILESCS(=O)(=O)c1cccc(c1)N1CCN([C@H](C1)c1ccccc1)C(=O)C1CC[C@@H](CC1)C(F)F |r,wD:14.17,27.33,(2.97,10.89,;3.74,9.56,;5.07,10.33,;5.07,8.79,;2.97,8.22,;3.74,6.89,;2.97,5.56,;1.43,5.56,;.66,6.89,;1.43,8.22,;-.88,6.89,;-1.65,8.22,;-3.19,8.22,;-3.96,6.89,;-3.19,5.56,;-1.65,5.56,;-3.96,4.22,;-5.5,4.22,;-6.27,2.89,;-5.5,1.55,;-3.96,1.55,;-3.19,2.89,;-5.5,6.89,;-6.27,5.56,;-6.27,8.22,;-7.81,8.22,;-8.58,9.56,;-7.81,10.89,;-6.27,10.89,;-5.5,9.56,;-8.58,12.22,;-10.12,12.22,;-7.81,13.56,)|
Structure
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