Target

Ligand

Substrate

Meas. Tech.

Kinase Inhibition SPA Assay

pH

7±n/a

Temperature

295.15±n/a K

Citation

 Coghlan, MP; Culbert, AA; Cross, DA; Corcoran, SL; Yates, JW; Pearce, NJ; Rausch, OL; Murphy, GJ; Carter, PS; Roxbee Cox, L; Mills, D; Brown, MJ; Haigh, D; Ward, RW; Smith, DG; Murray, KJ; Reith, AD; Holder, JC Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 7:793-803 (2000) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method

Name:

Glycogen synthase kinase-3 alpha

Synonyms:

GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha)

Type:

Enzyme

Mol. Mass.:

50991.79

Organism:

Homo sapiens (Human)

Description:

P49840

Residue:

483

Sequence:

MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGVGASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLTNSS

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM8289

Synonyms:

3-(3-chlorophenyl)-4-(2,3-dihydro-1H-indol-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione | 4-arylmaleimide deriv. 8d

Type:

Small organic molecule

Emp. Form.:

C18H13ClN2O2

Mol. Mass.:

324.761

SMILES:

Clc1cccc(c1)C1=C(N2CCc3ccccc23)C(=O)NC1=O |c:8|

Structure:

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Similarity to this molecule at least:

Name:

Biotinylated Peptide Substrate

Synonyms:

n/a

Type:

Peptide

Mol. Mass.:

3615.87

Organism:

n/a

Description:

n/a

Residue:

32

Sequence:

ITINKYRRAAVPPSPSLSRHSSPHQSPEDEEE