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Target
Vasopressin V1b receptor
Ligand
BDBM175060
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
<1.00±n/a nM
Comments
extracted
Citation
 Geneste, H; Hornberger, W; Jantos, K; Kling, A; Van Gaalen, M Oxindole compounds carrying a nitrogen-bound spiro substituent and use thereof for treating vasopressin-related diseases US Patent  US9688678 Publication Date 6/27/2017 
Target
Name:
Vasopressin V1b receptor
Synonyms:
AVPR V1b | AVPR V3 | AVPR1B | AVPR3 | Antidiuretic hormone receptor 1b | V1BR_HUMAN | V1bR | VASOPRESSIN V1B | VPR3 | Vasopressin V1b receptor | Vasopressin V1b receptor (V1b) | Vasopressin V3 | Vasopressin V3 receptor
Type:
Enzyme
Mol. Mass.:
46985.01
Organism:
Homo sapiens (Human)
Description:
P47901
Residue:
424
Sequence:
MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
  
Inhibitor
Name:
BDBM175060
Synonyms:
US9688678, 21 (+-)-3-(2,5-dimethoxyphenyl)-1-[(5-methoxy-2-pyridyl)sulfonyl]-3-[2-(1-methyl-4-piperidyl)-2,6-diazaspiro[3.3]heptan-6-yl]-2-oxo-indoline-5-carbonitrile
Type:
Small organic molecule
Emp. Form.:
C34H40N6O6S
Mol. Mass.:
660.783
SMILES:
COc1ccc(nc1)S(=O)(=O)N1C2C=CC(=CC2C(N2CC3(CN(C3)C3CCN(C)CC3)C2)(C1=O)c1cc(OC)ccc1OC)C#N |c:14,16|
Structure:
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