Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM173768
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
9.30±n/a nM
Citation
 Kilburn, JP; Rasmussen, LK; Jessing, M; Eldemenky, EM; Chen, B; Jiang, Y; Hopper, AT Benzamide-containing compounds and their use in the treatment of pain US Patent  US9649308 Publication Date 5/16/2017 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM173768
Synonyms:
US9102591, 2,3-dichloro-N-[3-(1-fluorocyclopropyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]propyl]benzamide | US9649308, 2,3-dichloro-N-[3-(1-fluorocyclopropyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]propyl]benzamide
Type:
Small organic molecule
Emp. Form.:
C18H15Cl2F4N3O
Mol. Mass.:
436.231
SMILES:
FC(F)(F)c1ncc(cn1)C(CNC(=O)c1cccc(Cl)c1Cl)CC1(F)CC1
Structure:
Search PDB for entries with ligand similarity: