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TargetAromatase (CYP19)
LigandBDBM9484
Substrate/CompetitorBDBM8592
Meas. Tech.CYP19 Assay
pH7.4±n/a
Temperature303.15±n/a K
Comments27% inhibition uM inhibitor.
Citation Leonetti, FFavia, ARao, AAliano, RPaluszcak, AHartmann, RWCarotti, A Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors. J Med Chem47:6792-803 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Aromatase (CYP19)
Name:Cytochrome P450 19A1
Synonyms:Aromatase | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM | Tyrosine Kinase FLT3
Type:Enzyme
Mol. Mass.:57888.92
Organism:Homo sapiens (human)
Description:P11511
Residue:503
Sequence:
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
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  Blast E-value cutoff:
BDBM9484
BDBM8592
NameBDBM9484
Synonyms:7-methoxy-4-(pyridin-4-yl)-2H-chromen-2-one | Coumarin deriv. 33
TypeSmall organic molecule
Emp. Form.C15H11NO3
Mol. Mass.253.2527
SMILESCOc1ccc2c(cc(=O)oc2c1)-c1ccncc1
Structure
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