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Target
Voltage-dependent calcium channel gamma-2 subunit
Ligand
BDBM311831
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
IC50
0.316±n/a nM
Citation
 Ameriks, MK; Laforteza, BN; Lebold, TP; Ravula, S; Savall, BM; Shireman, BT Fused azaheterocyclic compounds and their use as AMPA receptor modulators US Patent  US10155769 Publication Date 12/18/2018 
Target
Name:
Voltage-dependent calcium channel gamma-2 subunit
Synonyms:
CACNG2 | CCG2_HUMAN | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35977.54
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
323
Sequence:
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV
  
Inhibitor
Name:
BDBM311831
Synonyms:
7-Chloro-5-[2-cyclopropyl-7-(trifluoromethyl)imidazo[1,2-c]pyrimidin-8-yl]indolin-2-one | US10155769, Example 69
Type:
Small organic molecule
Emp. Form.:
C18H12ClF3N4O
Mol. Mass.:
392.762
SMILES:
FC(F)(F)c1ncn2cc(nc2c1-c1cc2CC(=O)Nc2c(Cl)c1)C1CC1
Structure:
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