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Target
Voltage-dependent calcium channel gamma-2 subunit
Ligand
BDBM311834
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
IC50
0.316±n/a nM
Citation
 Ameriks, MK; Laforteza, BN; Lebold, TP; Ravula, S; Savall, BM; Shireman, BT Fused azaheterocyclic compounds and their use as AMPA receptor modulators US Patent  US10155769 Publication Date 12/18/2018 
Target
Name:
Voltage-dependent calcium channel gamma-2 subunit
Synonyms:
CACNG2 | CCG2_HUMAN | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35977.54
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
323
Sequence:
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV
  
Inhibitor
Name:
BDBM311834
Synonyms:
8-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-7-isopropyl-imidazo[1,2-c]pyrimidine | US10155769, Example 72
Type:
Small organic molecule
Emp. Form.:
C17H14ClF2N5
Mol. Mass.:
361.776
SMILES:
CC(C)c1ncn2cc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)F
Structure:
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