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Target
Caspase-2
Ligand
BDBM10309
Substrate
Caspase-2 Fluorogenic Substrate
Meas. Tech.
Caspase Inhibition Assay
Ki
>50000±n/a nM
Citation
 Lee, D; Long, SA; Murray, JH; Adams, JL; Nuttall, ME; Nadeau, DP; Kikly, K; Winkler, JD; Sung, CM; Ryan, MD; Levy, MA; Keller, PM; DeWolf, WE Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem 44:2015-26 (2001) [PubMed]  Article 
Target
Name:
Caspase-2
Synonyms:
CASP-2 | CASP2 | CASP2_HUMAN | Caspase-2 subunit p12 | Caspase-2 subunit p13 | Caspase-2 subunit p18 | ICH-1 protease | ICH-1L/1S | ICH1 | NEDD-2 | NEDD2 | Neural precursor cell expressed developmentally down-regulated protein 2
Type:
Enzyme
Mol. Mass.:
50688.29
Organism:
Homo sapiens (Human)
Description:
P42575
Residue:
452
Sequence:
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
  
Inhibitor
Name:
BDBM10309
Synonyms:
5-(pyrrolidine-1-sulfonyl)-2,3-dihydro-1H-indole-2,3-dione | 5-[1-(Pyrrolidinyl)sulfonyl]isatin | Isatin Sulfonamide 20
Type:
Small organic molecule
Emp. Form.:
C12H12N2O4S
Mol. Mass.:
280.3
SMILES:
O=C1Nc2ccc(cc2C1=O)S(=O)(=O)N1CCCC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-2 Fluorogenic Substrate
Synonyms:
Ac-VDVAD-AMC
Type:
n/a
Mol. Mass.:
1830.24
Organism:
n/a
Description:
AMC=7-Amino-4-methylcoumarin
Residue:
20
Sequence:
ACVALASPVALALAASPAMC