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Target
Caspase-4
Ligand
BDBM10298
Substrate
Caspase-4 Fluorogenic Substrate
Meas. Tech.
Caspase Inhibition Assay
Ki
5000±n/a nM
Citation
 Lee, D; Long, SA; Murray, JH; Adams, JL; Nuttall, ME; Nadeau, DP; Kikly, K; Winkler, JD; Sung, CM; Ryan, MD; Levy, MA; Keller, PM; DeWolf, WE Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem 44:2015-26 (2001) [PubMed]  Article 
Target
Name:
Caspase-4
Synonyms:
CASP-4 | CASP4 | CASP4_HUMAN | Caspase 4 | Caspase-4 subunit 1 | Caspase-4 subunit 2 | ICE(rel)-II | ICH-2 protease | ICH2 | TX protease
Type:
Enzyme
Mol. Mass.:
43257.75
Organism:
Homo sapiens (Human)
Description:
P49662
Residue:
377
Sequence:
MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN
  
Inhibitor
Name:
BDBM10298
Synonyms:
1-benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione | Isatin analog 2
Type:
Small organic molecule
Emp. Form.:
C15H10N2O4
Mol. Mass.:
282.2509
SMILES:
O=C1N(Cc2ccccc2)c2ccc(cc2C1=O)N(=O)=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-4 Fluorogenic Substrate
Synonyms:
Ac-LEED-AMC
Type:
n/a
Mol. Mass.:
1334.60
Organism:
n/a
Description:
AMC=7-Amino-4-methylcoumarin
Residue:
14
Sequence:
ACLEGLGLASPAMC