Reaction Details Report a problem with these data
Target
Intermediate conductance calcium-activated potassium channel protein 4
Ligand
BDBM314285
Substrate
n/a
Meas. Tech.
Electrophysiology Assay
IC50
15.0±n/a nM
Citation
 Green, L; Wang, H Oxazolidinone and imidazolidinone compounds US Patent  US9611232 Publication Date 4/4/2017 
Target
Name:
Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:
IK1 | IKCA1 | KCA4 | KCNN4 | KCNN4_HUMAN | Putative Gardos channel | SK4
Type:
PROTEIN
Mol. Mass.:
47723.22
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361891
Residue:
427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
  
Inhibitor
Name:
BDBM314285
Synonyms:
US9611232, Example 17
Type:
Small organic molecule
Emp. Form.:
C23H19FN2O3
Mol. Mass.:
390.407
SMILES:
NC(=O)CN1[C@@H](c2ccccc2F)C(OC1=O)(c1ccccc1)c1ccccc1 |r|
Structure:
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