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TargetAlpha-1A adrenergic receptor
LigandBDBM317597
Substrate/Competitorn/a
Meas. Tech.Binding Assay
IC50 13.0±n/a nM
Citation Becker-Pelster, EMBuchgraber, PBuchmüller, AEngel, KGöller, AHimmel, HKast, RKeldenich, JSchmeck, CTinel, HWunder, F Substituted bipiperidinyl derivatives US Patent US9624199 Publication Date 4/18/2017
More Info.:Get all data from this article,  Assay Method
 
Alpha-1A adrenergic receptor
Name:Alpha-1A adrenergic receptor
Synonyms:ADRA1A | ADRA1C | Adrenergic alpha1A | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha adrenergic receptor 1a | Alpha-1C adrenergic receptor | Alpha-adrenergic receptor 1c | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1 | adrenergic Alpha1C
Type:Cell-surface receptors
Mol. Mass.:51511.67
Organism:Homo sapiens (Human)
Description:P35348
Residue:466
Sequence:
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
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  Blast E-value cutoff:
BDBM317597
NameBDBM317597
Synonyms:US9624199, 7 | [3-(Cyclopropylmethoxy)-1,4′-bipiperidin-1′-yl][6-(morpholin-4-yl)pyridin-3-yl]methanone
TypeSmall organic molecule
Emp. Form.C24H36N4O3
Mol. Mass.428.5676
SMILESO=C(N1CCC(CC1)N1CCCC(C1)OCC1CC1)c1ccc(nc1)N1CCOCC1
Structure
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