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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM322244
Substrate
n/a
Meas. Tech.
Human alpha7 nAChR Binding Assay
Ki
3000±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; Koenig, G; Mcriner, AJ Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors US Patent  US10183938 Publication Date 1/22/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM322244
Synonyms:
(R)-N-(2,2-dimethylquinuclidin-3-yl)benzo[d]thiazole-2-carboxamide | US10183938, Compound (R)-29
Type:
Small organic molecule
Emp. Form.:
C17H21N3OS
Mol. Mass.:
315.433
SMILES:
CC1(C)[C@H](NC(=O)c2nc3ccccc3s2)C2CCN1CC2 |wD:3.3,(3.67,-2.1,;3.67,-.56,;2.34,-1.33,;2.9,.77,;1.36,.77,;.59,-.56,;1.36,-1.9,;-.95,-.56,;-1.85,-1.81,;-3.32,-1.33,;-4.65,-2.1,;-5.98,-1.33,;-5.98,.21,;-4.65,.98,;-3.32,.21,;-1.85,.68,;3.67,2.1,;4.71,1.59,;5.28,.59,;5.21,-.56,;5.98,.77,;5.21,2.1,)|
Structure:
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