Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
Targettafia
LigandBDBM326336
Substrate/Competitorn/a
Meas. Tech.Enzyme Inhibitory Assay
IC50 4.50±n/a nM
Citation Nagata, TKobayashi, JOnishi, YKishida, MNoguchi, K Cyclopropanecarboxylic acid derivative US Patent US9662310 Publication Date 5/30/2017
More Info.:Get all data from this article,  Assay Method
 
tafia
Name:Carboxypeptidase B2 isoform A
Synonyms:CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:Enzyme
Mol. Mass.:48432.74
Organism:Homo sapiens (Human)
Description:Q96IY4
Residue:423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM326336
NameBDBM326336
Synonyms:(1R*,2S*)-2-(3-Aminopropyl)-1-[1-(3,3-dimethylbutyl)-1H-imidazol-4-yl]cyclopropanecarboxylic acid | US9662310, Example 1 | US9662310, Example 28
TypeSmall organic molecule
Emp. Form.C16H27N3O2
Mol. Mass.293.4045
SMILESCC(C)(C)CCn1cnc(c1)[C@]1(C[C@@H]1CCCN)C(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a