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Targettafia
LigandBDBM326397
Substrate/Competitorn/a
Meas. Tech.Enzyme Inhibitory Assay
IC50 7.90±n/a nM
Citation Nagata, TKobayashi, JOnishi, YKishida, MNoguchi, K Cyclopropanecarboxylic acid derivative US Patent US9662310 Publication Date 5/30/2017
More Info.:Get all data from this article,  Assay Method
 
tafia
Name:Carboxypeptidase B2 isoform A
Synonyms:CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB
Type:Enzyme
Mol. Mass.:48432.74
Organism:Homo sapiens (Human)
Description:Q96IY4
Residue:423
Sequence:
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM326397
NameBDBM326397
Synonyms:(1R,2S)-2-[(2R)-2-(Aminomethyl)butyl]-1-(1-phenyl-1H-imidazol-4-yl)cyclopropanecarboxylic acid | US9662310, Example 62
TypeSmall organic molecule
Emp. Form.C24H33N3O4
Mol. Mass.427.5365
SMILESCC[C@@H](CNC(=O)OC(C)(C)C)C[C@H]1C[C@]1(C(=O)OC)c1cn(cn1)-c1ccccc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a