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Target
RAC-alpha serine/threonine-protein kinase
Ligand
BDBM11822
Substrate
Biotinylated Peptide Substrate
Meas. Tech.
PKB In Vitro Kinase Assay
pH
7.5±n/a
Temperature
295.15±n/a K
IC50
5±n/a nM
Citation
 Breitenlechner, CB; Wegge, T; Berillon, L; Graul, K; Marzenell, K; Friebe, WG; Thomas, U; Schumacher, R; Huber, R; Engh, RA; Masjost, B Structure-based optimization of novel azepane derivatives as PKB inhibitors. J Med Chem 47:1375-90 (2004) [PubMed]  Article 
Target
Name:
RAC-alpha serine/threonine-protein kinase
Synonyms:
AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)
Type:
Enzyme
Mol. Mass.:
55681.25
Organism:
Homo sapiens (Human)
Description:
P31749
Residue:
480
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
  
Inhibitor
Name:
BDBM11822
Synonyms:
(3R,4R)-3-(isonicotinoylamino)azepan-4-yl 4-(2-fluoro-6-hydroxy-3-methoxybenzoyl)benzoate dihydrochloride | (3R,4R)-3-(pyridine-4-amido)azepan-4-yl 4-[(2-fluoro-6-hydroxy-3-methoxyphenyl)carbonyl]benzoate dihydrochloride | Azepane Derivative 1
Type:
Small organic molecule
Emp. Form.:
C27H26FN3O6
Mol. Mass.:
507.5102
SMILES:
COc1ccc(O)c(C(=O)c2ccc(cc2)C(=O)O[C@@H]2CCCNC[C@H]2NC(=O)c2ccncc2)c1F |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Biotinylated Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1764.91
Organism:
n/a
Description:
n/a
Residue:
17
Sequence:
ITINSGRARTSSFAEPG